ACR Meeting Abstracts

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Abstracts tagged "anti-TNF therapy"

  • Abstract Number: 571 • 2019 ACR/ARP Annual Meeting

    Effect of Long-term Treatment with TNF-α Inhibitor on Lipid Profile in Spondyloarthritis: Data from Nationwide Korean College of Rheumatology Biologics (KOBIO) Registry

    Jina Yeo1, Mi Ryoung Seo 1, Hee Jung Ryu 1, Hyo-Jin Choi 1 and Han Joo Baek 1, 1Division of Rheumatology / Department of Internal Medicine / Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea

    Background/Purpose: In spondyloarthritis (SpA), the lipid profile changes due to the systemic inflammatory response. Theoretically, the proinflammatory state is associated with a decrease in total…
  • Abstract Number: 1476 • 2019 ACR/ARP Annual Meeting

    Impact of Alternate Mechanism of Action Biologics and Tofacitinib on TNF-α Inhibitor Prescribing in Psoriatic Arthritis: Results from Annual National Patient Chart Audits

    Lynn Price1, Phil Pouliot 1 and Lauren Schmitt 1, 1Spherix Global Insights, Exton, PA

    Background/Purpose: TNF-α inhibitor therapy has long been the standard of care for adult patients diagnosed with moderate to severe psoriatic arthritis (PsA), though several new…
  • Abstract Number: 2856 • 2019 ACR/ARP Annual Meeting

    Drug Retention of Biological DMARDs Targeting IL-12/IL-23 or IL-17 versus TNF Inhibitors, After a First Line TNF Inhibitor, in Patients with Psoriatic Arthritis – an Analysis in the Swiss SCQM Register

    Burkhard Moeller1, Eleftherios Papagiannoulis 2, Lisa Christ 3, Adrian Ciurea 4, Thomas Hugle 5, Ruediger B. Mueller 6, Michael J. Nissen 7, Almut Scherer 8, Godehard Scholz 3, Peter M. Villiger 1 and Nikhil Yawalkar 3, 1University Hospital Bern, Bern, Switzerland, 2SCQM Zurich, Zurich, Switzerland, 3Inselspital-University Hospital Bern, Bern, Switzerland, 4University Hospital Zürich, Zürich, Switzerland, 5University Hospital Lausanne, Lausanne, Switzerland, 6Clinic of Rheumatology, Medical University Hospital Aarau, Aarau, Aargau, Switzerland, 7University Hospital Geneva, Geneva, Switzerland, 8SCQM Foundation, Zürich, Switzerland

    Background/Purpose: Tumor necrosis factor inhibitors (TNFi) were the first approved biological disease modifying antirheumatic drugs (bDMARDs) for psoriatic arthritis (PsA). IL-12/23 and IL-17-specific antibodies provide…
  • Abstract Number: 581 • 2019 ACR/ARP Annual Meeting

    Allograft Inflammatory factor-1 Drives Th17 Like Pathologic Signature and Predict Poor Response to TNF Inhibitor in Ankylosing Spondylitis

    Jeong Seok Lee1, Eunyoung Lee 2, Ji Yong Choi 3, Yeong-Wook Song 4, Eui-Cheol Shin 1 and Eun Young Lee 2, 1Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, 2Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Seoul, Republic of Korea, 3Seoul National University College of Medicine, Seoul, Republic of Korea, 4Seoul National University Hospital, Seoul, Republic of Korea

    Background/Purpose: Ankylosing spondylitis (AS) is an inflammatory disease that commonly treated with TNF inhibitors for controlling active inflammation. To predict treatment response to TNF inhibitors…
  • Abstract Number: 1499 • 2019 ACR/ARP Annual Meeting

    Golimumab Persistence in Biologic Naive and Non-Naive Patients with Axial Spondyloarthritis: Results of the GO PRACTICE Study

    René-Marc Flipo 1, Florence Tubach 2, Jean Ouaniche 3, Philippe Goupille4, Eric Lespessailles 5, Najat Gouyette 6, Naoual Harid 7, Jean-Marie Fayette 8, Philippe Bertin 9 and Bruno Fautrel 10, 1Roger Salengro University-Hospital, Lille , France, Lille, France, 2Pitié Salpétrière University-Hospital, Paris, Ile-de-France, France, 3Private Practice , Toulon, France, Toulon, France, 4Tours University-Hospital, Tours, France, Tours, France, 5Orléans Regional Hospitals, Orléans ,France, Orléans, France, 6MSD France, Courbevoie ,France, Courbevoie, Ile-de-France, France, 7MSD France, Courbevoie, France, Courbevoie, Ile-de-France, France, 8ClinSearch, Malakoff, France, Malakoff, Ile-de-France, France, 9Limoges University-Hospital , Limoges, France, Limoges, France, 10Pitié-Salpêtrière Hospital, Department of Rheumatology, AP-HP, Sorbonne University, UPMC university, Paris, Ile-de-France, France

    Background/Purpose: The pivotal GO AFTER study [1] and the ongoing observational GO BEYOND study investigate GLM efficacy in rheumatoid arthritis (RA) patients who previously received…
  • Abstract Number: 2857 • 2019 ACR/ARP Annual Meeting

    Decision Tree Analysis to Identify Inflammatory Arthritis Patient Subgroups with Different Levels of Treatment Persistence with First-Line Subcutaneous TNF-alpha Inhibitors

    Emma Hernlund 1, Johan Klint 1, Axel Svedbom 1, Johan Dalén 1, Christopher Black 2 and Amy Puenpatom2, 1ICON plc, Stockholm, Sweden, Stockholm, Sweden, 2Merck & Co., Inc., Kenilworth, NJ, United States, Kenilworth, NJ

    Background/Purpose: The advent of biologic medications, such as subcutaneous TNF-alpha inhibitors (SC-TNFi), has transformed the management of inflammatory arthritis (IA) during the last decades. However,…
  • Abstract Number: 619 • 2019 ACR/ARP Annual Meeting

    Relation of Therapies for Ankylosing Spondylitis to Risk of Total Hip and Knee Arthroplasty

    Rachael Stovall1, Christine Peloquin 2, David Felson 3, Tuhina Neogi 2 and Maureen Dubreuil 4, 1Boston Medical Center, Boston, MA, 2Boston University School of Medicine, Boston, MA, 3Boston University School of Medicine, Department of Rheumatology, Boston, 4Boston University School of Medicine, Boston

    Background/Purpose: Ankylosing spondylitis (AS) is an inflammatory arthritis that predominantly affects the axial skeleton, but commonly affects peripheral joints as well. Peripheral joint involvement often…
  • Abstract Number: 1512 • 2019 ACR/ARP Annual Meeting

    Retention Rates and Response of Anti-TNF Treatments in the Enteropathic Spondylitis: HUR-BIO Real Life Results

    Gozde Kubra Yardımcı 1, Bayram Farisoğulları 1, Alper Sarı 1, Levent Kilic 2, Berkan Armagan 3, Emre Bilgin 1, Ertugrul Cagri Bolek 1, Omer Karadag 4, Ali Akdoğan 1, Şule Apras Bilgen 2, Ali İhsan Ertenli 1, Sedat Kiraz 2 and Umut Kalyoncu5, 1Hacettepe University Vasculitis Centre, Ankara, Turkey, Ankara, Turkey, 2Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, 3Department of Internal Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey., Ankara, Turkey, 4Hacettepe University Vasculitis Centre, Ankara, Turkey / Vasculitis and Lupus Clinic, Addenbrooke’s Hospital, University of Cambridge, UK, Ankara, Turkey, 5Hacettepe University Department of Rheumatology, Ankara, Turkey

    Background/Purpose: Enteropathic spondylitis (eSpA) is younger brother of spondyloarthritis, and the retention rate of biological DMARD in eSpA was not yet clear.  The objective of this study was to…
  • Abstract Number: 2873 • 2019 ACR/ARP Annual Meeting

    Antimicrobial Use Is High in Patients with Rheumatoid Arthritis, and Further Increases with First-Line TNFi Therapy – Nationwide Results from Iceland

    Aron H Bjornsson1, Olafur Palsson 2, Mar Kristjansson 3, Petur S Gunnarsson 4, Gerdur Grondal 5, Bjorn Gudbjornsson 6 and Thorvardur J Love 7, 1Department of Medicine, Landspitali, Reykjavík, Iceland, 2Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, Lund, Sweden, 3Department of Infectious Diseases, Landspitali, Reykjavík, Iceland, 4Faculty of Pharmaceutical Sciences, University of Iceland and Hospital Pharmacy, Landspitali, Reykjavík, Iceland, 5Department of Rheumatology, Landspitali and Centre for Rheumatology Research, Landspitali, Reykjavík, Iceland, 6Centre for Rheumatology Research, Landspitali and Faculty of Medicine, University of Iceland, Reykjavik, Iceland, 7Faculty of Medicine, University of Iceland and Department of Science, Landspitali, Reykjavík, Iceland

    Background/Purpose: Severe infections, frequently resulting in hospitalization, are a well-known adverse effects of tumor necrosis factor inhibitors (TNFi). However, studies regarding outpatient treated infections are…
  • Abstract Number: 933 • 2019 ACR/ARP Annual Meeting

    Tumor Necrosis Factor Inhibitors Slow Radiologic Progression in Patients with Ankylosing Spondylitis: 18-year Longitudinal Cohort Study

    Bon San Koo1, Ji Seon Oh 2, Seo Young Park 3, Ga Young Ahn 4, Seunghun Lee 5, Kyung Bin Joo 6 and Tae-Hwan Kim 7, 1Department of Internal Medicine, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea, 2Department of Biomedical Informatics, Asan Medical Center, Seoul, Korea, Seoul, Republic of Korea, 3Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Seoul-t'ukpyolsi, Republic of Korea, 4Korea University Guro Hospital, Seoul, Republic of Korea, 5Dertment of Radiology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, 6Department of Radiology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Seoul-t'ukpyolsi, Republic of Korea, 7Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea

    Background/Purpose: It is difficult to evaluate the role of TNF inhibitor therapy in slowing the radiologic progression in patients with ankylosing spondylitis (AS) because of…
  • Abstract Number: 1518 • 2019 ACR/ARP Annual Meeting

    Tumour Necrosis Factor Inhibitor Monotherapy versus Combination Therapy with Conventional Synthetic Disease-modifying Anti-rheumatic Drugs for the Treatment of Psoriatic Arthritis: A Combined Analysis of European Biologics Databases

    Matthew Thomas 1, Gavin Shaddick 2, Rachel Charlton 1, Charlotte Cavill 3, Richard Holland 4, Florenzo Iannone 5, Giovanni Lapadula 6, Simona Lapriore 5, Jakub Závada 7, Michal Uher 8, Karel Pavelka 9, Lenka Szczukova 10, Prodromos Sidiropolous 11, Irini Flouri 11, Burkhard Moeller 12, Michael J. Nissen 13, Ruediger B. Mueller 14, Almut Scherer 15, Neil McHugh1 and Alison Nightingale 1, 1University of Bath, Bath, United Kingdom, 2University of Exeter, Exeter, United Kingdom, 3Royal National Hospital for Rheumatic Diseases, Royal United Hospitals NHS Trust, Bath, United Kingdom, 4Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 5University of Bari, Bari, Italy, 6Rheumatology Unit – Department of Emergency and Organs Transplantation, University and AOU Policlinico of Bari, Italy., Bari, Italy, 7Institute of Rheumatology, Prague, Prague, Czech Republic, 8Institute of Health Information and Statistics of the Czech Republic, and Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic, Brno, Czech Republic, 9Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague 2, Czech Republic, 10Masaryk University, Brno, Czech Republic, 11University of Crete, Crete, Greece, 12University Hospital Bern, Bern, Switzerland, 13University Hospital Geneva, Geneva, Switzerland, 14Clinic of Rheumatology, Medical University Hospital Aarau, Aarau, Aargau, Switzerland, 15SCQM Foundation, Zürich, Switzerland

    Background/Purpose: A large proportion of psoriatic arthritis (PsA) patients are prescribed a tumour necrosis factor inhibitor (TNFi) in combination with methotrexate (MTX), however the value…
  • Abstract Number: 935 • 2019 ACR/ARP Annual Meeting

    Reduction of Anterior Uveitis Flares in Patients with Axial Spondyloarthritis Following 1 Year of Treatment with Certolizumab Pegol: 48-Week Interim Results from a 96-Week Open-Label Study

    Irene van der Horst-Bruinsma1, Rianne van Bentum 1, Frank D. Verbraak 1, Thomas Rath 2, James T. Rosenbaum 3, Maria Misterska-Skóra 4, Bengt Hoepken 5, Oscar Irvin-Sellers 6, Brenda VanLunen 7, Lars Bauer 5 and Martin Rudwaleit 8, 1Amsterdam University Medical Center, Amsterdam, Netherlands, 2St Franziskus-Hospital, Münster, Germany, 3Devers Eye Institute and Oregon Health & Science University, Portland, OR, 4Wrocław Medical University, Wrocław, Poland, 5UCB Pharma, Monheim am Rhein, Germany, 6UCB Pharma, Slough, UK, Slough, United Kingdom, 7UCB Pharma, Raleigh, NC, 8Klinikum Bielefeld, Charité Berlin, Gent University, Bielefeld, Germany

    Background/Purpose: Acute anterior uveitis (AAU), inflammation of the anterior uveal tract, is the most common extraarticular manifestation in patients (pts) with axial spondyloarthritis (axSpA), reported…
  • Abstract Number: 2009 • 2019 ACR/ARP Annual Meeting

    Biomarkers Identified by Serum Inflammatory Profile Analysis to Predict Biologic Treatment Response in Rheumatoid Arthritis Patients

    Chary Lopez-Pedrera1, Nuria Barbarroja 2, Carlos Perez-Sanchez 3, Pilar Font 4, Alejandro Ibañez-Costa 1, Maria Luque-Tevar 1, Alejandra Patiño-Trives 1, Ivan Arias de la Rosa 4, Maria del Carmen Abalos-Aguilera 1, Rafaela Ortega 1, Alejandro Escudero 5, Laura Pérez-Sanchez 6, Jerusalem Calvo-Gutierrez 1, Rocío Segura-Ruiz 7, Carlos Rodriguez Escalera 8, Dolores Ruiz-Montesinos 9, Carmen Romero Barco 10, N. Mena-Vazquez 11, Julia Uceda Montañez 12, Mª Dolores Toledo Coello 13, M Angeles Aguirre 14 and Eduardo Collantes-Estevez 4, 1IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2University of Cordoba/IMIBIC/Reina Sofia Hospital and CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain, 3Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, Cordoba, Spain, 4University of Cordoba/IMIBIC/Reina Sofia Hospital, Cordoba, Spain, 5IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, 6MIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, 7Reina Sofia University Hospital/IMIBIC, Córdoba, Spain, 8Hospital Universitario de Jaén, Jaen, Spain, 9Hospital Virgen Macarena, Sevilla, 10Hospital Marítimo de Torremolinos, Málaga, Málaga, Spain, 11HU Malaga., Malaga, 12Hospital Universitario Virgen de Valme, Sevilla, Sevilla, Spain, 13Hospital Universitario de Jerez de la Frontera, Cádiz, Cádiz, Spain, 14IMIBIC/Reina Sofia Hospital/University of Cordoba,, Córdoba, Spain

    Background/Purpose: Biologic disease modifying antirheumatic drugs (b-DMARDs) have revolutionized the management of Rheumatoid Arthritis (RA). Despite this success, a high percentage of the patients undergoing…
  • Abstract Number: 936 • 2019 ACR/ARP Annual Meeting

    Earlier Treatment of Non-Radiographic Axial Spondyloarthritis with Certolizumab Pegol Results in Improved Clinical and Patient-Reported Outcomes

    Jonathan Kay1, Lianne Gensler 2, Atul Deodhar 3, Walter P. Maksymowych 4, Nigil Haroon 5, Simone Auteri 6, Natasha de Peyrecave 7, Thomas Kumke 8, Bengt Hoepken 9, Lars Bauer 9 and Martin Rudwaleit 10, 1UMass Memorial Medical Center and University of Massachusetts Medical School, Worcester, MA, 2University San Francisco California, San Francisco, CA, 3Oregon Health & Science University, Portland, OR, 4University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, 5Toronto Western Hospital, Krembil Research Institute, University of Toronto, Toronto, ON, Canada, 6UCB Pharma, Brussels, Belgium, 7UCB Pharma, Slough, United Kingdom, 8UCB Pharma, Monheim, Germany, 9UCB Pharma, Monheim am Rhein, Germany, 10Klinikum Bielefeld, Charité Berlin, Gent University, Bielefeld, Germany

    Background/Purpose: Patients (pts) with axial spondyloarthritis (axSpA) often experience delayed diagnosis, which can lead to treatment delay. However, there are indications that earlier treatment with…
  • Abstract Number: 2112 • 2019 ACR/ARP Annual Meeting

    Real Life Serious Infections in Patients with Chronic Inflammatory Arthritis on Treatment with TNF Inhibitors

    Alazne Ruiz 1, Juan Ramón De Dios 2, Belen Alvarez 1, Margarida Vasques Rocha 2, Claudia Stoye 2, Susana Gil 1, Orlando Pompei Fernández 2 and Jaime Calvo-Alen3, 1Hospital Universitario Araba, Vitoria, Pais Vasco, Spain, 2Araba University Hospital, Vitoria, Pais Vasco, Spain, 3Hospital Universitario Araba, Vitoria-Gasteiz, Spain

    Background/Purpose: To study frequency and associated factors for serious infections in patients with inflammatory arthritis treated with TNF inhibitorsMethods: All the medical records of the…
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