ACR Meeting Abstracts

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Abstracts tagged "anti-TNF therapy"

  • Abstract Number: 1445 • 2019 ACR/ARP Annual Meeting

    Pre-Biologic Use of Janus Kinase Inhibitors for the Treatment of Rheumatoid Arthritis in the United States

    Lynn Price1, Phil Pouliot 1 and Lauren Schmitt 1, 1Spherix Global Insights, Exton, PA

    Background/Purpose: Tofacitinib was the first Janus kinase (JAK) inhibitor FDA approved for the treatment of RA in November 2012, five- and one-half years later, baricitinib,…
  • Abstract Number: 2400 • 2019 ACR/ARP Annual Meeting

    The Effect of Co-medication with Methotrexate and Other Conventional Synthetic Disease Modifying Anti-rheumatic Drugs on First Tumor Necrosis Inhibitor Drug Survival in Patients with Rheumatoid Arthritis: Results Form a Nationwide Registry

    Herman Mann1, Lucie Nekvindová 2, Jakub Závada 3, Zlatuše Křístková 2, Pavel Horák 4, Jiří Vencovský 1 and Karel Pavelka 1, 1Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague 2, Czech Republic, 2Institute of Biostatistics and Analyses Ltd., spinoff company of Masaryk University, Brno, Czech Republic, 3Institute of Rheumatology, Prague, Prague, Czech Republic, 4Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic

    Background/Purpose: Tumor necrosis factor inhibitors (TNFi) should be used for the treatment of rheumatoid arthritis (RA) in combination with conventional synthetic disease modifying anti‑rheumatic drugs…
  • Abstract Number: L05 • 2018 ACR/ARHP Annual Meeting

    Treatment-Naïve, Early Rheumatoid Arthritis Patients Demonstrate Reversible Abnormalities of Vascular Function on Cardiac MRI with RA Therapy with Preliminary Suggestion of Greater Improvement with Anti-TNF Compared to MTX/Conventional Therapy – a First, RCT Derived Longitudinal Study

    Maya H. Buch1, Bara Erhayiem2, Graham Fent2, Paul Baxter3, Elizabeth M.A. Hensor4, Adam McDiarmid2, Peter Swoboda5, Ananth Kidambi2, David Ripley2, Pankaj Garg2, Sarah Horton4, Raluca Bianca Dumitru4, Kamran Naraghi4, John Greenwood6, Paul Emery7, Sue Pavitt8 and Sven Plein2, 1Leeds Institute of Rheumatic & Musculosekeltal Medicine, University of Leeds & NIHR Biomedical Research Centre, Leeds, United Kingdom, 2Multidisciplinary Cardiovascular Research Centre, Leeds Institute of Cardiovascular & Metabolic Medicine, University of Leeds, Leeds, United Kingdom, 3Leeds Institute of Cardiovascular & Metabolic Medicine, University of Leeds, Leeds, United Kingdom, 4Leeds Institute of Rheumatic & Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 5Leeds Institute of Cardiovascular And Metabolic Medicine, University of Leeds, Leeds, United Kingdom, 6Leeds Institute of Cardiovascular And Metabolic Medicinee, University of Leeds, Leeds, United Kingdom, 7University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, 8Leeds School of Dentistry, University of Leeds, Leeds, United Kingdom

    Background/Purpose: We previously reported abnormal cardiac MRI (CMR)-determined aortic stiffness in patients with early, treatment-naive RA1,2. We now report on whether this vascular stiffness is…
  • Abstract Number: 639 • 2018 ACR/ARHP Annual Meeting

    Is a Primary Good Response to Nsaids Predictive of the Subsequent Response to the First TNF Inhibitor in Patients with Early Axial Spondyloarthritis ?

    Loukianos Couvaras1, Daniel Wendling2, Vanessa Pauly3, Vincent Pradel4, Anna Molto5, Pierre Lafforgue1 and Thao Pham6, 1Rheumatology, Aix-Marseille University, APHM, Marseille, France, 2service de rhumatologie, CHU J Minjoz, Besancon, France, 3Public Health, Aix-Marseille university, AP-HM, Marseille, France, 4Public Health, APHM, Marseille, France, 5Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, 6Rheumatology Department, Aix-Marseille University, APHM, Marseille, France

    Background/Purpose: Good response to NSAIDs is a SpA feature included in classification criteria for axial spondyloarthritis (axSpA). Among patients eligible for a TNF inhibitor (TNFi),…
  • Abstract Number: 2829 • 2018 ACR/ARHP Annual Meeting

    The Response to TNF-Blockers Treatment of Spa Patients Is Influenced By the Interplay between HLA-B27 and Gut Microbiota Composition at Baseline

    Marie Vallier1, Maxime Dougados2, Stephanie Ferreira3, Silvia Menegatti4, Elisabetta Bianchi5, Lars Rogge5, Mathias Chamaillard1 and Corinne Miceli-Richard2, 1CIIL - U1019 - NLRII, Institut Pasteur, Lille, France, 2Rheumatology Department, Paris Descartes University, Paris, France, 3Genoscreen, Lille, France, 4Immunology, Immunoregulation Unit, Institut Pasteur, Paris, France, 5Immunology, Institut Pasteur, Paris, France

    Background/Purpose: The response to TNF-blockers in axial spondyloarthritis (AxSpA) is at least partially influenced by HLA-B27 through a still poorly understood mechanism. Given that HLA-B27…
  • Abstract Number: 921 • 2018 ACR/ARHP Annual Meeting

    Multi-Omics Analysis Identifies a Gene Signature Associated with the Clinical Response to Anti-TNF Therapy in Rheumatoid Arthritis

    Adrià Aterido1, Jesús Tornero2, Francisco J Blanco3, Benjamin Fernandez Gutierrez4, Antonio Gonzalez5, Juan D. Cañete6, Joan Maymó7, Mercedes Alperi-López8, Alejandro Olivé-Marqués9, Hector Corominas10, Víctor Martínez-Taboada11, Isidoro Gonzalez-Alvaro12, Antonio Fernandez-Nebro13, Alba Erra14, Simón Sánchez-Fernández15, María López-Lasanta1, Mireia López-Corbeto1, Raül Tortosa1, Laia Codó16, Sara Marsal1 and Antonio Julià1, 1Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, 2Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain, 3Rheumatology Department, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 4Rheumatology Department, Hospital Clínico San Carlos, Madrid, Spain, 5Laboratorio Investigación 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, 6Rheumatology Service, Hospital Clínic of Barcelona, Barcelona, Spain, 7Rheumatology Department, Hospital del Mar, Barcelona, Spain, 8Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain, 9Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 10Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Barcelona, Spain, 11Rheumatology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 12Rheumatology Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, 13UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga Departamento de Medicina y Dermatología, Universidad de Málaga, MÁLAGA, Spain, 14Rheumatology Service, Hospital San Rafael, Barcelona, Spain, 15Rheumatology Department, Hospital General La Mancha Centro, Ciudad Real, Spain, 16Life Sciences Department, Barcelona Supercomputing Centre, Barcelona, Spain

    Background/Purpose: Rheumatoid arthritis (RA) is the most common inflammatory arthritis affecting up to 1% of the population. Tumor Necrosis Factor (TNF) inhibitors have significantly improved…
  • Abstract Number: 2831 • 2018 ACR/ARHP Annual Meeting

    High Need for Anti-TNF Therapy after Withdrawal Strategy in Early Peripheral Spondyloarthritis

    Philippe Carron1, Gaëlle Varkas2, Thomas Renson3, Roos Colman4, Dirk Elewaut5 and Filip van Den Bosch6, 1Department of Rheumatology, Ghent University Hospital and VIB Ghent University, Ghent, Belgium, 2Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, Ghent University Hospital and VIB Ghent University, Ghent, Belgium, 3Department of Rheumatology, Ghent University Hospital, Ghent, 9000, Belgium, 4Department of Public Health, Ghent University, Ghent, Belgium, Biostatistics Unit,Ghent University, Ghent, Belgium, Ghent, Belgium, 5Ghent University Hospital and VIB Ghent University, Ghent, Belgium, 6Rheumatology, Ghent University Hospital and VIB Ghent University, Gent, Belgium

    Background/Purpose: Treatment with TNFi in early stages of peripheral Spondyloarthritis (pSpA) results in higher rates of clinical remission, compared to treatment in more longstanding disease.…
  • Abstract Number: 961 • 2018 ACR/ARHP Annual Meeting

    The Association of Biologic Drug-Levels with Infection Risk: Results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

    Meghna Jani1, William G Dixon1, Mark Lunt1, Diederik De Cock1, John Isaacs2, Ann Morgan3, Kath Watson1, Anthony G. Wilson4, Anne Barton5,6 and Kimme L. Hyrich1,5, 1Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, 2Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, Great Britain, 4UCD School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland, 5National Institute of Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, 6Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University Of Manchester, Manchester, United Kingdom

      Background/Purpose: High dose tumour necrosis factor inhibitor (TNFi) drugs are associated with an increased serious infection (SI) risk[1]. It is feasible that high biologic…
  • Abstract Number: 2862 • 2018 ACR/ARHP Annual Meeting

    Magnitude of Response to TNF Inhibitors in Children with Spondyloarthritis and Sacroiliitis

    Rosemary Peterson1, Rui Xiao2, Timothy G. Brandon3, David M. Biko4, Michael Francavilla4, Nancy A. Chauvin5 and Pamela F. Weiss6, 1Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, 2Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 3Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, 4Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, 5Radiology, Penn State Hershey Medical Center, Hershey, PA, 6Pediatrics, Children's Hospital Philadelphia, Philadelphia, PA

    Background/Purpose: We aimed to quantify the magnitude of biologic effect on sacroiliitis in juvenile SpA by comparing the change in the Spondyloarthritis Research Consortium of…
  • Abstract Number: 1234 • 2018 ACR/ARHP Annual Meeting

    Incidence of Conversion of Screening Tests for M. Tuberculosis (PPD, GIF-release assay) in a Metropolitan Cohort of Patients Treated with TNF-α Inhibitors

    Hung Trinh and Darren Tabechian, Medicine, Division of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: Tumor necrosis factor alpha (TNF-α) inhibitors are used to reduce the inflammatory process in many autoimmune diseases. Due to the risk of reactivation of…
  • Abstract Number: 2877 • 2018 ACR/ARHP Annual Meeting

    The Comparative Effectiveness of First-Line Tumor Necrosis Factor Inhibitor (TNFi) Compared with Non-TNFi Agents in Patients with Rheumatoid Arthritis: Results from the Corrona Registry

    Dimitrios A. Pappas1, Gregory St. John2, Carol J. Etzel1, Stefano Fiore3, Taylor Blachley1, Toshio Kimura2, Rajeshwari Punekar3, Kelechi Emeanuru4, Susan Boklage2 and Joel Kremer1,5, 1Corrona LLC, Waltham, MA, 2Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 3Sanofi, Bridgewater, NJ, 4Corrona, LLC, Waltham, MA, 5Albany Medical College and The Center for Rheumatology, Albany, NY

    Background/Purpose: RA patients who are intolerant or have an inadequate response to conventional synthetic DMARDs (csDMARDs) can be treated with a biologic DMARD (bDMARD). Tumor…
  • Abstract Number: 1450 • 2018 ACR/ARHP Annual Meeting

    Clinical Radiology Reports Are Unreliable for Assessment of Radiographic Structural Progression in US Veterans with Rheumatoid Arthritis Initiating Tumor Necrosis Factor Inhibitor Therapy

    Kevin R. Lammert1, Alan R. Erickson2, Brian C. Sauer1 and Grant W. Cannon1, 1Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, 2Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Rheumatologists rely on hand radiograph findings including bone erosions (BE) and joint space narrowing (JSN) to make treatment decisions for patients with rheumatoid arthritis…
  • Abstract Number: 2879 • 2018 ACR/ARHP Annual Meeting

    Plasma IL-23 and IL-25 Predict Response to Anti-TNF-α Therapy in Rheumatoid Arthritis

    Niamh Fanning1, Melanie J Millier2, John Highton2, Christopher Frampton3, Paul A Hessian2 and Lisa K. Stamp3, 1Medicine, University of Otago, Christchurch, Christchurch, New Zealand, 2Department of Medicine, University of Otago, Dunedin, New Zealand, 3University of Otago, Christchurch, New Zealand

    Background/Purpose: TNF-α inhibitors are among the most widely used biological-DMARDs in rheumatoid arthritis (RA). Means to predict response would allow for a more effective, targeted…
  • Abstract Number: 1497 • 2018 ACR/ARHP Annual Meeting

    PRISM-RA: A Personalized Medicine Test That Accurately Predicts Rheumatoid Arthritis Patients Who Will Not Respond Adequately to Tumor Necrosis Factor Inhibitors

    Keith Johnson, Nancy Schoenbrunner and Dina Ghiassian, Scipher Medicine Inc, Waltham, MA

    Background/Purpose: Rheumatoid arthritis (RA) is a complex disease affecting about 1.3M adults in the US. The patient population is very heterogeneous; no single drug mechanism…
  • Abstract Number: 2888 • 2018 ACR/ARHP Annual Meeting

    Concomitant Csdmards Influence Clinical Response to TNF Inhibitors Only in Overweight Patients with Axial Spondyloarthritis

    Borja Hernández-Breijo1, Victoria Navarro-Compán1, Ana Martínez1, Andrea Jochems1, Alejandro Villalba2, Diana Peiteado3, Eva L. Kneepkens4, Gerrit Wolbink4, Theo Rispens5, Dora Pascual-Salcedo1, Alejandro Balsa1 and Chamaida Plasencia1, 1Immuno-Rheumatology research group, IdiPaz. La Paz University Hospital, Madrid, Spain, 2Rheumatology, La Paz University Hospital, Madrid, Spain, 3Hospital Universitario La Paz, Madrid, Spain, 4Rheumatology, Reade, Amsterdam, Netherlands, 5Immunopathology, Sanquin Research, Amsterdam, Netherlands

    Background/Purpose: In patients with axial spondyloarthritis (axSpA), the use of conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), such as methotrexate (MTX) and sulfasalazine (SSZ), as well…
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