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Abstracts tagged "anti-citrullinated protein/peptide antibodies (ACPA)"

  • Abstract Number: 1767 • 2012 ACR/ARHP Annual Meeting

    Circulating Plasmablasts As a Source of Anti-Citrullinated Protein Antibodies in Patients with Rheumatoid Arthritis

    Priscilla Kerkman, Ellen I.H. van der Voort, Leendert A. Trouw, Tom W.J. Huizinga, René E.M. Toes and Hans Ulrich Scherer, Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Anti citrullinated protein antibodies (ACPA) are highly specific for rheumatoid arthritis (RA) and predict disease onset and severity. Accumulating evidence indicates that ACPA could…
  • Abstract Number: 27 • 2012 ACR/ARHP Annual Meeting

    Anti-Citrullinated Protein Antibodies As an Indicator of Bone Damage in the Citrullinated Collagen Induced Arthritis Model

    Anand Dusad1, Michael J. Duryee2, Dong Wang3, Carlos D. Hunter2, Bartlett C. Hamilton III4, James R. O'Dell5, Ted R. Mikuls6, Lynell W. Klassen5 and Geoffrey M. Thiele7, 1Rheumatology, University of Nebraska Medical Center, Omaha, NE, 2Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 3Pharmaceutical Sciences, Univ of Nebraska Medical Ctr, Omaha, NE, 4University of Nebraska Medical Center and Omaha VA Medical Center, Omaha, NE, 5Dept of Internal Medicine, Univ of Nebraska Med Ctr, Omaha, NE, 6Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 7Int Med/Sec of Rheum/Immun, Univ of Nebraska Med Ctr, Omaha, NE

    Background/Purpose: Although the pathogenesis and cause of rheumatoid arthritis (RA) remains uncertain, various disease-driving auto-antigens and auto-antibodies with different specificities have been used as diagnostic…
  • Abstract Number: 1768 • 2012 ACR/ARHP Annual Meeting

    The Absolute Concentration of Anti Citrullinated Protein Antibodies in Serum and Synovial Fluid in Relation to Total Immunoglobulin-Concentrations

    Annemiek Willemze, Jing Shi, Marlies Mulder, Gerrie Stoeken-Rijsbergen, Tom W. J. Huizinga, René E. M. Toes and Leendert A. Trouw, Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: The presence of anti-citrullinated protein antibodies (ACPA) is one of the most predictive factors for the development of rheumatoid arthritis (RA). Nonetheless, relatively little…
  • Abstract Number: 31 • 2012 ACR/ARHP Annual Meeting

    Anti Citrullinated Protein Antibodies From Synovial Fluid of Rheumatoid Arthritis Patients Enhance Osteoclastogenesis

    Akilan Krishnamurthy1, Nancy Vivar Pomiano2, Catia Cerqueira3, Elena Ossipova3, Karin Lundberg4, Ulrike Harre5, Vivianne Malmström6, Per Johan Jakobsson7, Lars Klareskog8, Georg Schett9 and Anca Catrina3, 1Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 3Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 4Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 5Institute for Clinical Immunology, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 6Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 7Rheumatology unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 8Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, 9Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Presence of anti CCP2 antibodies identifies a subgroup of RA patients that are more prone to develop bone erosions. We hypothesized that anti CCP2…
  • Abstract Number: 1690 • 2012 ACR/ARHP Annual Meeting

    Citrullination within the Atherosclerotic Plaque: A New Potential Target for Anti-Citrullinated Protein Antibodies

    Jeremy Sokolove1, Orr Share1, Matthew Brennan1, Lauren J. Lahey1, Amy H. Kao2, Eswar Krishnan3, Mary Chester M. Wasko4 and William H. Robinson5, 1Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 2Lupus Center of Excellence, Allegheny Singer Research Institute, Pittsburgh, PA, 3Medicine, Standford University, Palo Alto, CA, 4West Penn Allegheny Health System, Temple University School of Medicine, Pittsburgh, PA, 5Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk for cardiovascular disease due to accelerated atherosclerosis. This risk has mainly been limited to seropositive…
  • Abstract Number: 1604 • 2012 ACR/ARHP Annual Meeting

    Parity and the Risk of Developing Rheumatoid Arthritis: Results From the Swedish Epidemiological Investigation of Rheumatoid Arthritis Study

    Cecilia Orellana1, Lars Klareskog2, Lars Alfredsson1 and Camilla Bengtsson1, 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is more common among women than among men and the gender difference in incidence seems to be most striking before menopause…
  • Abstract Number: 1200 • 2012 ACR/ARHP Annual Meeting

    Anti-Cyclic Citrullinated Peptide Antibodies in Idiopathic Pulmonary Fibrosis Are Not Citrulline-Specific: Implications for the Pathogenesis of Rheumatoid Arthritis

    Elena B. Lugli1, Muslima Chowdhury1, Peter J. Charles2, Michael G. Crooks3, Simon P. Hart3, Patrick Venables1 and Benjamin A. Fisher4, 1Kennedy Institute of Rheumatology, Oxford University, London, United Kingdom, 2Oxford University, Kennedy Institute of Rheumatology, Oxford, United Kingdom, 3Castle Hill Hospital, Hull York Medical School, Cottingham, United Kingdom, 4Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom

    Background/Purpose: The association of rheumatoid arthritis (RA) with smoking and silica exposure has led to the hypothesis that the lung is the site where RA autoimmunity…
  • Abstract Number: 1201 • 2012 ACR/ARHP Annual Meeting

    Anti-Citrullinated Protein Antibody Specific Fc Glycosylation Patterns in Arthralgia Patients

    Hans Ulrich Scherer1, Yoann Rombouts2, Ewoud Ewing3, Lotte van de Stadt4, Maurice H.J. Selman5, André M. Deelder3, Tom W.J. Huizinga2, Manfred Wuhrer5, Dirkjan van Schaardenburg6 and René E.M. Toes2, 1Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands, 4Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 5Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands, 6Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) exhibit a specific, pro-inflammatory Fc glycosylation profile characterized by a low content of galactose and sialic acid residues. The absence…
  • Abstract Number: 1208 • 2012 ACR/ARHP Annual Meeting

    Stable Synovial Fluid Phenotype for Anti Citrullinated-Protein Antibodies in Established Rheumatoid Arthritis

    Vijay Joshua1, Lena Israelsson2, Lars Klareskog3, Anca Catrina1 and Vivianne Malmström4, 1Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 2Department of Medicine, Karolinska Institute, Stockholm, Sweden, 3Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, 4Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Presence of anti citrullinated-protein antibodies (ACPA) in the peripheral blood of patients with rheumatoid arthritis is a validated disease biomarker. We have previously shown…
  • Abstract Number: 1187 • 2012 ACR/ARHP Annual Meeting

    Smoking Status Is Associated with Inflammatory Cytokine Profile and Disease Activity in Anti-Citrullinated Protein Antibody Positive Rheumatoid Arthritis: Decreased Inflammation and Disease Improvement with Smoking Cessation?

    Catriona Cramb1, Jeremy Sokolove2, Geoffrey M. Thiele3, Gail S. Kerr4, Grant W. Cannon5, Andreas M. Reimold6, Ted R. Mikuls7 and William H. Robinson8, 1VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, 2Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 3Int Med/Sec of Rheum/Immun, Univ of Nebraska Med Ctr, Omaha, NE, 4Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, 5Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, 6Rheumatology, Dallas VA and University of Texas Southwestern, Dallas, TX, 7Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 8Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Smoking is a major risk factor for rheumatoid arthritis (RA) and has been associated with increased disease severity and lower rates disease remission.   We…
  • Abstract Number: 1010 • 2012 ACR/ARHP Annual Meeting

    Bone Loss Before Clinical Onset of Rheumatoid Arthritis o Subjects with Anti-Citrullinated Protein Antibodies

    Stephanie Finzel1, Veronika Lang2, Arnd Kleyer1, Juergen Rech3, Bernhard Manger1, Elizabeth Araujo1, Axel J. Hueber4, Ulrike Harre5 and Georg Schett1, 1Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Dept. of Medicine, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Germany, 3Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, 4Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 5Institute for Clinical Immunology, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are a major risk factor for rapid disease progression in rheumatoid arthritis (RA). We have recently shown that ACPA directly…
  • Abstract Number: 978 • 2012 ACR/ARHP Annual Meeting

    A Genome-Wide Interaction Study with Smoking Suggests New Risk Loci for Two Different Subsets of Rheumatoid Arthritis; Results From Swedish Epidemiological Investigation of Rheumatoid Arthritis Study

    Xia Jiang1, Henrik Källberg1, Leonid Padyukov2, Lars Klareskog3 and Lars Alfredsson1, 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 3Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is believed to have a multifactorial etiology, involving both genetic and environmental components, and can be divided into two major subsets…
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