ACR Meeting Abstracts

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Abstracts tagged "anti-citrullinated protein/peptide antibodies (ACPA)"

  • Abstract Number: 1690 • 2012 ACR/ARHP Annual Meeting

    Citrullination within the Atherosclerotic Plaque: A New Potential Target for Anti-Citrullinated Protein Antibodies

    Jeremy Sokolove1, Orr Share1, Matthew Brennan1, Lauren J. Lahey1, Amy H. Kao2, Eswar Krishnan3, Mary Chester M. Wasko4 and William H. Robinson5, 1Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 2Lupus Center of Excellence, Allegheny Singer Research Institute, Pittsburgh, PA, 3Medicine, Standford University, Palo Alto, CA, 4West Penn Allegheny Health System, Temple University School of Medicine, Pittsburgh, PA, 5Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Patients with rheumatoid arthritis (RA) are at increased risk for cardiovascular disease due to accelerated atherosclerosis. This risk has mainly been limited to seropositive…
  • Abstract Number: 1604 • 2012 ACR/ARHP Annual Meeting

    Parity and the Risk of Developing Rheumatoid Arthritis: Results From the Swedish Epidemiological Investigation of Rheumatoid Arthritis Study

    Cecilia Orellana1, Lars Klareskog2, Lars Alfredsson1 and Camilla Bengtsson1, 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is more common among women than among men and the gender difference in incidence seems to be most striking before menopause…
  • Abstract Number: 1200 • 2012 ACR/ARHP Annual Meeting

    Anti-Cyclic Citrullinated Peptide Antibodies in Idiopathic Pulmonary Fibrosis Are Not Citrulline-Specific: Implications for the Pathogenesis of Rheumatoid Arthritis

    Elena B. Lugli1, Muslima Chowdhury1, Peter J. Charles2, Michael G. Crooks3, Simon P. Hart3, Patrick Venables1 and Benjamin A. Fisher4, 1Kennedy Institute of Rheumatology, Oxford University, London, United Kingdom, 2Oxford University, Kennedy Institute of Rheumatology, Oxford, United Kingdom, 3Castle Hill Hospital, Hull York Medical School, Cottingham, United Kingdom, 4Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom

    Background/Purpose: The association of rheumatoid arthritis (RA) with smoking and silica exposure has led to the hypothesis that the lung is the site where RA autoimmunity…
  • Abstract Number: 1201 • 2012 ACR/ARHP Annual Meeting

    Anti-Citrullinated Protein Antibody Specific Fc Glycosylation Patterns in Arthralgia Patients

    Hans Ulrich Scherer1, Yoann Rombouts2, Ewoud Ewing3, Lotte van de Stadt4, Maurice H.J. Selman5, André M. Deelder3, Tom W.J. Huizinga2, Manfred Wuhrer5, Dirkjan van Schaardenburg6 and René E.M. Toes2, 1Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands, 4Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 5Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands, 6Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) exhibit a specific, pro-inflammatory Fc glycosylation profile characterized by a low content of galactose and sialic acid residues. The absence…
  • Abstract Number: 1208 • 2012 ACR/ARHP Annual Meeting

    Stable Synovial Fluid Phenotype for Anti Citrullinated-Protein Antibodies in Established Rheumatoid Arthritis

    Vijay Joshua1, Lena Israelsson2, Lars Klareskog3, Anca Catrina1 and Vivianne Malmström4, 1Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 2Department of Medicine, Karolinska Institute, Stockholm, Sweden, 3Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, 4Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Presence of anti citrullinated-protein antibodies (ACPA) in the peripheral blood of patients with rheumatoid arthritis is a validated disease biomarker. We have previously shown…
  • Abstract Number: 1187 • 2012 ACR/ARHP Annual Meeting

    Smoking Status Is Associated with Inflammatory Cytokine Profile and Disease Activity in Anti-Citrullinated Protein Antibody Positive Rheumatoid Arthritis: Decreased Inflammation and Disease Improvement with Smoking Cessation?

    Catriona Cramb1, Jeremy Sokolove2, Geoffrey M. Thiele3, Gail S. Kerr4, Grant W. Cannon5, Andreas M. Reimold6, Ted R. Mikuls7 and William H. Robinson8, 1VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, 2Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 3Int Med/Sec of Rheum/Immun, Univ of Nebraska Med Ctr, Omaha, NE, 4Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, 5Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, 6Rheumatology, Dallas VA and University of Texas Southwestern, Dallas, TX, 7Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 8Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Smoking is a major risk factor for rheumatoid arthritis (RA) and has been associated with increased disease severity and lower rates disease remission.   We…
  • Abstract Number: 1010 • 2012 ACR/ARHP Annual Meeting

    Bone Loss Before Clinical Onset of Rheumatoid Arthritis o Subjects with Anti-Citrullinated Protein Antibodies

    Stephanie Finzel1, Veronika Lang2, Arnd Kleyer1, Juergen Rech3, Bernhard Manger1, Elizabeth Araujo1, Axel J. Hueber4, Ulrike Harre5 and Georg Schett1, 1Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Dept. of Medicine, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Germany, 3Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, 4Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 5Institute for Clinical Immunology, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are a major risk factor for rapid disease progression in rheumatoid arthritis (RA). We have recently shown that ACPA directly…
  • Abstract Number: 978 • 2012 ACR/ARHP Annual Meeting

    A Genome-Wide Interaction Study with Smoking Suggests New Risk Loci for Two Different Subsets of Rheumatoid Arthritis; Results From Swedish Epidemiological Investigation of Rheumatoid Arthritis Study

    Xia Jiang1, Henrik Källberg1, Leonid Padyukov2, Lars Klareskog3 and Lars Alfredsson1, 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 3Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is believed to have a multifactorial etiology, involving both genetic and environmental components, and can be divided into two major subsets…
  • Abstract Number: 411 • 2012 ACR/ARHP Annual Meeting

    Early Menopause, Smoking and Circulating Antibodies Against Citrullinated Peptides in the Pre-Clinical Phase of Rheumatoid Arthritis

    Mitra Pikwer1, Johan Rönnelid2, Monika Hansson3, Ulf Bergström1, Lennart T.H. Jacobsson4, Linda Mathsson2, Per Johan Jakobsson5, Guy B. Serre6, Rikard Holmdahl7, Lars Klareskog8 and Carl Turesson4, 1Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, 2Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, 3Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 4Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, 5Rheumatology unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 6Laboratory of Epidermis differentiation and Rheumatoid autoimmunity, Centre National de la Recherche Scientifique - Université de Toulouse, Toulouse, France, 7Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden, 8Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden

    Background/Purpose: Previous studies indicate that anti-citrullinated peptide antibodies (ACPAs) may be detected in individuals who later develop rheumatoid arthritis (RA) years before onset, and that…
  • Abstract Number: 414 • 2012 ACR/ARHP Annual Meeting

    First-Degree Relatives without Rheumatoid Arthritis Exhibit Reactivity to Multiple Anti-Citrullinated Protein Antibodies in Association with Rheumatoid Arthritis-Related Clinical Characteristics: Studies of the Etiology of Rheumatoid Arthritis

    Kendra A. Young1, Kevin D. Deane2, Lezlie A. Derber3, Jan M. Hughes-Austin4, Michael H. Weisman5, Jane H. Buckner6, Ted R. Mikuls7, James R. O'Dell8, Richard M. Keating9, Peter K. Gregersen10, V. Michael Holers11 and Jill M. Norris1, 1Epidemiology, Colorado School of Public Health, Aurora, CO, 2Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 3University of Colorado School of Medicine, Division of Rheumatology, Aurora, CO, 4Epidemiology, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, 5Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 6Benaroya Research Institute at Virginia Mason, Seattle, WA, 7Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 8Dept of Internal Medicine, Univ of Nebraska Med Ctr, Omaha, NE, 9Rheumatology Section, The University of Chicago, Chicago, IL, 10Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 11Rheumatology Division, University of Colorado School of Medicine, Aurora, CO

    Background/Purpose: Prior to diagnosis of rheumatoid arthritis (RA), there are increases in the number of citrullinated proteins that anti-citrullinated protein antibodies (ACPA) target, suggesting an…
  • Abstract Number: 421 • 2012 ACR/ARHP Annual Meeting

    Rheumatoid Factor, Not Antibodies to Citrullinated Proteins, Are Associated with High Disease Activity

    Josef S. Smolen1, Farideh Alasti2 and Daniel Aletaha3, 1Medical University of Vienna and Hietzing Hospital, Vienna, Austria, 2Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 3Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose: Autoantibodies in general, and rheumatoid factor (RF) and anti-citrullinated peptide antibodies (ACPA) in particular, are a hallmark of RA. After their characterization, ACPA have…
  • Abstract Number: 422 • 2012 ACR/ARHP Annual Meeting

    Antibodies to Citrulline From Rheumatoid Arthritis Patients Also Bind Homocitrulline

    Mathias Scinocca1, Radha Joseph2, David A. Bell3, Ewa Cairns3 and Lillian J. Barra3, 1Microbiology and Immunology, Schulich School of Medicine and Dentistry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, 2Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, 3Medicine, Division of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada

    Background/Purpose: Antibodies to citrullinated proteins/peptides (ACPA) are specific for Rheumatoid Arthritis (RA). One of ACPA’s targets is citrullinated fibrinogen (citfib) and it is found in…
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