Abstracts tagged "Anti-CCP antibodies and rheumatoid arthritis (RA)"

Abstract Number: 487 • 2019 ACR/ARP Annual Meeting
Third Generation Anti-cyclic Citrullinated Peptide Antibodies Improve Prediction of Clinical Arthritis in Second Generation Anti-cyclic Citrullinated Peptide Positive Subjects at Risk of Rheumatoid Arthritis
Andrea Di Matteo¹, Kulveer Mankia ¹, Laurence Duquenne ², Leticia Garcia-Montoya ¹, Diane Corscadden ³, Katie Mbara ³, Jacqueline Nam ¹, Michael Mahler ⁴ and Paul Emery ¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, England, United Kingdom, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, ⁴Inova Diagnostics, San Diego, CA
Background/Purpose: ACPA positive individuals with musculoskeletal symptoms are at increased risk of developing RA. In such individuals, ACPA are conventionally identified on the basis of…
Abstract Number: 11 • 2018 ACR/ARHP Annual Meeting
PAD4-Independent Interaction of ACPA with Nuclear Antigens in Apoptotic Cells and Neutrophil Extracellular Traps (NETs) Defines a Subset of Autoantibodies
Gustaf Wigerblad¹, Katy A. Lloyd¹, Peter Sahlström², Karine Chemin², Johanna Steen², Philip J. Titcombe^2,3, Diana Zhou², Ragnhild Stålesen¹, Bianka Marklein⁴, Elena Ossipova², Johan Rönnelid⁵, Luca Piccoli⁶, Antonio Lanzavecchia⁶, Daniel L. Mueller³, Karl Skriner⁴, Lars Klareskog², Fredrik Wermeling¹, Vivianne Malmström² and Caroline Grönwall⁷, ¹Rheumatology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, ³The Center for Immunology, Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, ⁴Dept. of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany, ⁵Dept. of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁶Università della Svizzera italiana, Institute for Research in Biomedicine, Bellinzona, Switzerland, ⁷Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) bind a wide range of citrullinated proteins with high cross-reactivity. Recent findings suggest that certain, but…
Abstract Number: 202 • 2018 ACR/ARHP Annual Meeting
Risk of Inflammatory Arthritis Development in the Family Members of Indigenous North American (INA) RA Patients
Stacy Tanner¹, Irene Smolik², Brenden Dufault³, Carol Hitchon³, David Robinson¹, Elizabeth Ferucci⁴ and Hani El-Gabalawy³, ¹Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ²Arthritis Center, University of Manitoba, Winnipeg, MB, Canada, ³University of Manitoba, Winnipeg, MB, Canada, ⁴Alaska Native Medical Center, Anchorage, AK
Background/Purpose: INA populations have a high prevalence of seropositive RA, often with severe disease. The risk of RA in family members of RA patients, particularly…
Abstract Number: 1464 • 2018 ACR/ARHP Annual Meeting
Newer Generation Cyclic Citrullinated Peptide (CCP) 3.1 Assay in the Diagnosis of Rheumatoid Arthritis
James Son¹, Lindsy J. Forbess² and Mariko Ishimori³, ¹Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, ²Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ³Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA
Background/Purpose: Rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (CCP) are important serum markers used in clinical diagnosis of rheumatoid arthritis (RA). Multiple studies have…
Abstract Number: 1479 • 2018 ACR/ARHP Annual Meeting
The Predictive Utility of Anti-Cyclic Citrullinated Peptide Antibodies to Diagnose Rheumatoid Arthritis in Patients with Hepatitis C and Polyarthralgias
Divya Jayakumar^1,2, Xinliang Huang^1,2, Seth Eisen^1,2, Prabha Ranganathan^1,2 and Amy Joseph^2,3, ¹Rheumatology, VA St. Louis Health Care System, St Louis, MO, ²Rheumatology, Washington University School of Medicine, St Louis, MO, ³Rheumatology, VA St. Louis Health Care System, St. Louis, MO
Background/Purpose: Joint pain is a common extra-hepatic manifestation of chronic hepatitis C (HCV) infection. HCV infection is often associated with the presence of autoantibodies such…
Abstract Number: 2500 • 2018 ACR/ARHP Annual Meeting
Association between Anti-Citrullinated Protein Antibody Status, Erosive Disease and Healthcare Resource Utilization in Patients with RA
Leslie R Harrold¹, Lin Guo², Sean E. Connolly³, Evo Alemao³, Sabrina Rebello⁴, Ying Shan⁴ and Joel Kremer⁵, ¹University of Massachusetts Medical School, Worcester, MA, ²Corrona, LLC, Waltham, MA, ³Bristol-Myers Squibb, Princeton, NJ, ⁴Corrona, LLC, Southborough, MA, ⁵Albany Medical College and The Center for Rheumatology, Albany, NY
Background/Purpose: Anti-citrullinated protein antibody (ACPA) is a highly specific biomarker for RA1 and ACPA-seropositive patients have a tendency toward severe erosive disease and more rapid…
Abstract Number: 2983 • 2018 ACR/ARHP Annual Meeting
The Changing Faces of Rheumatoid Arthritis Patients at Presentation: A 20-Year Study
Nathalie Carrier¹, Sophie Roux², Ariel Masetto², Artur J deBrum Fernandes³, Patrick Liang⁴, Meryem Maoui⁵ and Gilles Boire⁴, ¹Centre intégré universitaire de santé et de services sociaux de l'Estrie -Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, ²Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, ³Medicine, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, ⁴Rheumatology Division, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, ⁵Bristol-Myers Squibb Canada., St-Laurent, QC, Canada
Background/Purpose: To analyze the evolution of baseline demographic, clinical, serological and genetic characteristics of patients with incident RA over 20 years. Methods: Since July 1998,…
Abstract Number: 512 • 2016 ACR/ARHP Annual Meeting
Anti-Cyclic Citrullinated Protein Antibody (ACPA) Positivity in General Population and Follow-up Results for ACPA Positive Persons
Yoichiro Haji¹, Ryo Rokutanda², Mitsumasa Kishimoto² and Masato Okada², ¹Rheumatology, Daido Hospital, Nagoya, Japan, ²Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan
Background/Purpose: To evaluate anti-cyclic citrullinated protein antibody positivity in the general population and to identify its prognosis. Methods: Anti-cyclic citrullinated protein antibody (ACPA) were measured…
Abstract Number: 574 • 2016 ACR/ARHP Annual Meeting
Anti-CCP3.1 and Anti-CCP3-IgA Antibodies Are Associated with Increasing Age in Subjects without Rheumatoid Arthritis
Heather Berens-Norman^1,2, Sonia Khatter³, Wendy M. Kohrt⁴, Catherine Jankowski⁵, Michael Weisman⁶, Michael Mahler⁷, James R. O'Dell⁸, Ted R Mikuls⁸, Richard M. Keating⁹, Jane H. Buckner¹⁰, Peter K. Gregersen¹¹, Jill M. Norris¹², V. Michael Holers¹³, Kevin D. Deane¹³ and M. Kristen Demoruelle¹³, ¹Division of Rheumatology, University of Colorado Denver, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Denver, CO, ³University of Colorado School of Medicine, Aurora, CO, ⁴Geriatric Medicine Division, University of Colorado Denver, Aurora, CO, ⁵University of Colorado College of Nursing, Aurora, CO, ⁶Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Research and Development, Inova Diagnostics, San Diego, CA, ⁸Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁹Division of Rheumatology, Scripps Health, La Jolla, CA, ¹⁰Benaroya Research Institute at Virginia Mason, Seattle, WA, ¹¹The Feinstein Institute for Medical Research, Manhasset, NY, ¹²Epidemiology, Colorado School of Public Health, Aurora, CO, ¹³Rheumatology Division, University of Colorado Denver, Aurora, CO
Background/Purpose: Serum anti-CCP antibodies are specific for RA in the setting of inflammatory arthritis (IA) and can be elevated for several years prior to the…
Abstract Number: 523 • 2015 ACR/ARHP Annual Meeting
Elevated Antibody Response to Porphyromonas Gingivalis Detected in Sera Years before the Clinical Onset of Rheumatoid Arthritis
Nastya Kharlamova¹, Ulf Bergström², Natalia Sherina³, Lennart T.H. Jacobsson^2,4, Lennart Truedsson⁵, Karin Lundberg¹ and Carl Turesson², ¹Rheumatology Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden, ²Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ³Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden, ⁵Section of Microbiology, Immunology and Glycobiology, Department of Laboratory Medicine, Lund University, Lund, Sweden
Background/Purpose: Chronic periodontitis has been associated with rheumatoid arthritis (RA), and Porphyromonas gingivalis has been proposed as the mechanistic link, due to its unique property…
Abstract Number: 2600 • 2015 ACR/ARHP Annual Meeting
Signs of Immune Activation and Local Inflammation Are Present in the Bronchial Tissue of Patients with Untreated Early Rheumatoid Arthritis
Gudrun Reynisdottir^1,2, Helga Olsen³, Vijay Joshua⁴, Marianne Engström², Magnus Skold³, Anders Eklund⁵, Johan Grunewald³ and Anca I Catrina², ¹Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ³Department of Medicine, Division of Respiratory Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁴Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁵Division of Respiratory Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
Background/Purpose: Events in the lungs might contribute to generation of anti citrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA). We investigated if signs of immune…
Abstract Number: 2607 • 2015 ACR/ARHP Annual Meeting
Anti-Cyclic Citrullinated Peptide Antibodies and Rheumatoid Factor in Rheumatoid Arthritis Hispanics Exposed to Biomass Smoke
Raymundo Vera-Pineda¹, Alberto Cardenas-de La Garza², Jorge Esquivel-Valerio³, Dionicio A. Galarza-Delgado², Jose Ramon Azpiri-Lopez⁴, Iris J. Colunga-Pedraza², Mario Alberto Garza-Elizondo² and Jesus Zacarias Villarreal-Pérez⁵, ¹Cardiology., Hospital Universitario, UANL., Monterrey, Mexico, ²Rheumatology, Hospital Universitario, UANL., Monterrey, Mexico, ³Rheumatology, Hospital Universitario.UANL, Monterrey, Mexico, ⁴Cardiology, Hospital Universitario, UANL., Monterrey, Mexico, ⁵Endocrinology, Hospital Universitario, UANL., Monterrey, Mexico
Background/Purpose: Tobacco smoke has been associated to anti-cyclic citrullinated peptide (anti-CCP) antibodies positivity. Recently, in wood-smoke-induced chronic obstructive pulmonary disease (COPD) patients without rheumatoid arthritis…
Abstract Number: 2663 • 2015 ACR/ARHP Annual Meeting
Evaluation of Anti-Cyclic Citrullinated Peptide Autoantibody Levels in Clinical Practice and Its Association with Disease Activity
E Alemao¹, KK Gandhi¹, C Iannaccone², M Frits², JS Coblyn², N Shadick² and Michael Weinblatt², ¹Bristol-Myers Squibb, Princeton, NJ, ²Brigham and Women's Hospital, Boston, MA
Background/Purpose: Testing for anti-citrullinated peptide antibodies (ACPA) is included in the 2010 ACR classification criteria for RA. ACPA concentration, beyond ACPA positivity, is indicative of…
Abstract Number: 1320 • 2013 ACR/ARHP Annual Meeting
Categorization Of Rheumatoid Arthritis Subjects By Rheumatoid Factor and Anti-Cyclic Citrullinated Autoantibody Status Identifies Rheumatoid Arthritis Subjects With Different Characteristics
Swati Modi¹, Mariely Nieves-Plaza², Donald M. Jones³, Erich R Wilkerson⁴, Christine L. Amity⁵, Kelly A. Reckley⁶, Ilinca D. Metes⁷, Jason Lyons⁸, Heather Eng⁹, Stephen R. Wisniewski⁹ and Marc C. Levesque¹⁰, ¹Rheumatology, University of Pittsburgh, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Medicine, University of Pittsburgh, Pittsburgh, PA, ⁵Rheumatology & Clinical Immun, Univ of Pittsburgh, Pittsburgh, PA, ⁶Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁷Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁸School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, ⁹Epidemiology Data Center, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, ¹⁰Division of Rheumatology and Clinical Immunology, University of Pittsburgh Department of Medicine, Pittsburgh, PA
Background/Purpose: Rheumatoid factor (RF) and anti-citrullinated cyclic peptide (CCP) antibodies have been used to diagnose rheumatoid arthritis (RA) patients, although there is substantial heterogeneity among…
Abstract Number: 468 • 2013 ACR/ARHP Annual Meeting
The Differential Role Of T Helper Cells In The Pathogenesis and Responsiveness To Abatacept Therapy In Rheumatoid Arthritis
Shunsuke Fukuyo¹, Shingo Nakayamada², Kunihiro Yamaoka¹, Satoshi Kubo¹, Shigeru Iwata³, Kazuyoshi Saito¹ and Yoshiya Tanaka¹, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, Kitakyushu, Japan
Background/Purpose: Abatacept (ABT) works through a different mechanism of action from TNF inhibitors in the treatment of rheumatoid arthritis (RA). ABT decreases T cell responses…

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