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Abstracts tagged "Anti-CCP antibodies and rheumatoid arthritis (RA)"

  • Abstract Number: 487 • 2019 ACR/ARP Annual Meeting

    Third Generation Anti-cyclic Citrullinated Peptide Antibodies Improve Prediction of Clinical Arthritis in Second Generation Anti-cyclic Citrullinated Peptide Positive Subjects at Risk of Rheumatoid Arthritis

    Andrea Di Matteo1, Kulveer Mankia 1, Laurence Duquenne 2, Leticia Garcia-Montoya 1, Diane Corscadden 3, Katie Mbara 3, Jacqueline Nam 1, Michael Mahler 4 and Paul Emery 1, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, England, United Kingdom, 3Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, 4Inova Diagnostics, San Diego, CA

    Background/Purpose: ACPA positive individuals with musculoskeletal symptoms are at increased risk of developing RA. In such individuals, ACPA are conventionally identified on the basis of…
  • Abstract Number: 1464 • 2018 ACR/ARHP Annual Meeting

    Newer Generation Cyclic Citrullinated Peptide (CCP) 3.1 Assay in the Diagnosis of Rheumatoid Arthritis

    James Son1, Lindsy J. Forbess2 and Mariko Ishimori3, 1Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, 2Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 3Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA

    Background/Purpose: Rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (CCP) are important serum markers used in clinical diagnosis of rheumatoid arthritis (RA). Multiple studies have…
  • Abstract Number: 1479 • 2018 ACR/ARHP Annual Meeting

    The Predictive Utility of Anti-Cyclic Citrullinated Peptide Antibodies to Diagnose Rheumatoid Arthritis in Patients with Hepatitis C and Polyarthralgias

    Divya Jayakumar1,2, Xinliang Huang1,2, Seth Eisen1,2, Prabha Ranganathan1,2 and Amy Joseph2,3, 1Rheumatology, VA St. Louis Health Care System, St Louis, MO, 2Rheumatology, Washington University School of Medicine, St Louis, MO, 3Rheumatology, VA St. Louis Health Care System, St. Louis, MO

    Background/Purpose: Joint pain is a common extra-hepatic manifestation of chronic hepatitis C (HCV) infection. HCV infection is often associated with the presence of autoantibodies such…
  • Abstract Number: 2500 • 2018 ACR/ARHP Annual Meeting

    Association between Anti-Citrullinated Protein Antibody Status, Erosive Disease and Healthcare Resource Utilization in Patients with RA

    Leslie R Harrold1, Lin Guo2, Sean E. Connolly3, Evo Alemao3, Sabrina Rebello4, Ying Shan4 and Joel Kremer5, 1University of Massachusetts Medical School, Worcester, MA, 2Corrona, LLC, Waltham, MA, 3Bristol-Myers Squibb, Princeton, NJ, 4Corrona, LLC, Southborough, MA, 5Albany Medical College and The Center for Rheumatology, Albany, NY

    Background/Purpose: Anti-citrullinated protein antibody (ACPA) is a highly specific biomarker for RA1 and ACPA-seropositive patients have a tendency toward severe erosive disease and more rapid…
  • Abstract Number: 2983 • 2018 ACR/ARHP Annual Meeting

    The Changing Faces of Rheumatoid Arthritis Patients at Presentation: A 20-Year Study

    Nathalie Carrier1, Sophie Roux2, Ariel Masetto2, Artur J deBrum Fernandes3, Patrick Liang4, Meryem Maoui5 and Gilles Boire4, 1Centre intégré universitaire de santé et de services sociaux de l'Estrie -Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, 2Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, 3Medicine, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, 4Rheumatology Division, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, 5Bristol-Myers Squibb Canada., St-Laurent, QC, Canada

    Background/Purpose: To analyze the evolution of baseline demographic, clinical, serological and genetic characteristics of patients with incident RA over 20 years. Methods: Since July 1998,…
  • Abstract Number: 11 • 2018 ACR/ARHP Annual Meeting

    PAD4-Independent Interaction of ACPA with Nuclear Antigens in Apoptotic Cells and Neutrophil Extracellular Traps (NETs) Defines a Subset of Autoantibodies

    Gustaf Wigerblad1, Katy A. Lloyd1, Peter Sahlström2, Karine Chemin2, Johanna Steen2, Philip J. Titcombe2,3, Diana Zhou2, Ragnhild Stålesen1, Bianka Marklein4, Elena Ossipova2, Johan Rönnelid5, Luca Piccoli6, Antonio Lanzavecchia6, Daniel L. Mueller3, Karl Skriner4, Lars Klareskog2, Fredrik Wermeling1, Vivianne Malmström2 and Caroline Grönwall7, 1Rheumatology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, 3The Center for Immunology, Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, 4Dept. of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany, 5Dept. of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden, 6Università della Svizzera italiana, Institute for Research in Biomedicine, Bellinzona, Switzerland, 7Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) bind a wide range of citrullinated proteins with high cross-reactivity. Recent findings suggest that certain, but…
  • Abstract Number: 202 • 2018 ACR/ARHP Annual Meeting

    Risk of Inflammatory Arthritis Development in the Family Members of Indigenous North American (INA) RA Patients

    Stacy Tanner1, Irene Smolik2, Brenden Dufault3, Carol Hitchon3, David Robinson1, Elizabeth Ferucci4 and Hani El-Gabalawy3, 1Rheumatology, University of Manitoba, Winnipeg, MB, Canada, 2Arthritis Center, University of Manitoba, Winnipeg, MB, Canada, 3University of Manitoba, Winnipeg, MB, Canada, 4Alaska Native Medical Center, Anchorage, AK

    Background/Purpose: INA populations have a high prevalence of seropositive RA, often with severe disease. The risk of RA in family members of RA patients, particularly…
  • Abstract Number: 512 • 2016 ACR/ARHP Annual Meeting

    Anti-Cyclic Citrullinated Protein Antibody (ACPA) Positivity in General Population and Follow-up Results for ACPA Positive Persons

    Yoichiro Haji1, Ryo Rokutanda2, Mitsumasa Kishimoto2 and Masato Okada2, 1Rheumatology, Daido Hospital, Nagoya, Japan, 2Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan

    Background/Purpose: To evaluate anti-cyclic citrullinated protein antibody positivity in the general population and to identify its prognosis. Methods: Anti-cyclic citrullinated protein antibody (ACPA) were measured…
  • Abstract Number: 574 • 2016 ACR/ARHP Annual Meeting

    Anti-CCP3.1 and Anti-CCP3-IgA Antibodies Are Associated with Increasing Age in Subjects without Rheumatoid Arthritis

    Heather Berens-Norman1,2, Sonia Khatter3, Wendy M. Kohrt4, Catherine Jankowski5, Michael Weisman6, Michael Mahler7, James R. O'Dell8, Ted R Mikuls8, Richard M. Keating9, Jane H. Buckner10, Peter K. Gregersen11, Jill M. Norris12, V. Michael Holers13, Kevin D. Deane13 and M. Kristen Demoruelle13, 1Division of Rheumatology, University of Colorado Denver, Aurora, CO, 2Division of Rheumatology, University of Colorado School of Medicine, Denver, CO, 3University of Colorado School of Medicine, Aurora, CO, 4Geriatric Medicine Division, University of Colorado Denver, Aurora, CO, 5University of Colorado College of Nursing, Aurora, CO, 6Cedars-Sinai Medical Center, Los Angeles, CA, 7Research and Development, Inova Diagnostics, San Diego, CA, 8Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, 9Division of Rheumatology, Scripps Health, La Jolla, CA, 10Benaroya Research Institute at Virginia Mason, Seattle, WA, 11The Feinstein Institute for Medical Research, Manhasset, NY, 12Epidemiology, Colorado School of Public Health, Aurora, CO, 13Rheumatology Division, University of Colorado Denver, Aurora, CO

    Background/Purpose: Serum anti-CCP antibodies are specific for RA in the setting of inflammatory arthritis (IA) and can be elevated for several years prior to the…
  • Abstract Number: 523 • 2015 ACR/ARHP Annual Meeting

    Elevated Antibody Response to Porphyromonas Gingivalis Detected in Sera Years before the Clinical Onset of Rheumatoid Arthritis

    Nastya Kharlamova1, Ulf Bergström2, Natalia Sherina3, Lennart T.H. Jacobsson2,4, Lennart Truedsson5, Karin Lundberg1 and Carl Turesson2, 1Rheumatology Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden, 2Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, 3Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 4Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden, 5Section of Microbiology, Immunology and Glycobiology, Department of Laboratory Medicine, Lund University, Lund, Sweden

    Background/Purpose: Chronic periodontitis has been associated with rheumatoid arthritis (RA), and Porphyromonas gingivalis has been proposed as the mechanistic link, due to its unique property…
  • Abstract Number: 2600 • 2015 ACR/ARHP Annual Meeting

    Signs of Immune Activation and Local Inflammation Are Present in the Bronchial Tissue of Patients with Untreated Early Rheumatoid Arthritis

    Gudrun Reynisdottir1,2, Helga Olsen3, Vijay Joshua4, Marianne Engström2, Magnus Skold3, Anders Eklund5, Johan Grunewald3 and Anca I Catrina2, 1Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 3Department of Medicine, Division of Respiratory Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 4Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 5Division of Respiratory Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden

    Background/Purpose: Events in the lungs might contribute to generation of anti citrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA). We investigated if signs of immune…
  • Abstract Number: 2607 • 2015 ACR/ARHP Annual Meeting

    Anti-Cyclic Citrullinated Peptide Antibodies and Rheumatoid Factor in Rheumatoid Arthritis Hispanics Exposed to Biomass Smoke

    Raymundo Vera-Pineda1, Alberto Cardenas-de La Garza2, Jorge Esquivel-Valerio3, Dionicio A. Galarza-Delgado2, Jose Ramon Azpiri-Lopez4, Iris J. Colunga-Pedraza2, Mario Alberto Garza-Elizondo2 and Jesus Zacarias Villarreal-Pérez5, 1Cardiology., Hospital Universitario, UANL., Monterrey, Mexico, 2Rheumatology, Hospital Universitario, UANL., Monterrey, Mexico, 3Rheumatology, Hospital Universitario.UANL, Monterrey, Mexico, 4Cardiology, Hospital Universitario, UANL., Monterrey, Mexico, 5Endocrinology, Hospital Universitario, UANL., Monterrey, Mexico

    Background/Purpose: Tobacco smoke has been associated to anti-cyclic citrullinated peptide (anti-CCP) antibodies positivity. Recently, in wood-smoke-induced chronic obstructive pulmonary disease (COPD) patients without rheumatoid arthritis…
  • Abstract Number: 2663 • 2015 ACR/ARHP Annual Meeting

    Evaluation of Anti-Cyclic Citrullinated Peptide Autoantibody Levels in Clinical Practice and Its Association with Disease Activity

    E Alemao1, KK Gandhi1, C Iannaccone2, M Frits2, JS Coblyn2, N Shadick2 and Michael Weinblatt2, 1Bristol-Myers Squibb, Princeton, NJ, 2Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Testing for anti-citrullinated peptide antibodies (ACPA) is included in the 2010 ACR classification criteria for RA. ACPA concentration, beyond ACPA positivity, is indicative of…
  • Abstract Number: 1320 • 2013 ACR/ARHP Annual Meeting

    Categorization Of Rheumatoid Arthritis Subjects By Rheumatoid Factor and Anti-Cyclic Citrullinated Autoantibody Status Identifies Rheumatoid Arthritis Subjects With Different Characteristics

    Swati Modi1, Mariely Nieves-Plaza2, Donald M. Jones3, Erich R Wilkerson4, Christine L. Amity5, Kelly A. Reckley6, Ilinca D. Metes7, Jason Lyons8, Heather Eng9, Stephen R. Wisniewski9 and Marc C. Levesque10, 1Rheumatology, University of Pittsburgh, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA, 3Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 4Medicine, University of Pittsburgh, Pittsburgh, PA, 5Rheumatology & Clinical Immun, Univ of Pittsburgh, Pittsburgh, PA, 6Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 7Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Pittsburgh, Pittsburgh, PA, 8School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, 9Epidemiology Data Center, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, 10Division of Rheumatology and Clinical Immunology, University of Pittsburgh Department of Medicine, Pittsburgh, PA

    Background/Purpose:  Rheumatoid factor (RF) and anti-citrullinated cyclic peptide (CCP) antibodies have been used to diagnose rheumatoid arthritis (RA) patients, although there is substantial heterogeneity among…
  • Abstract Number: 468 • 2013 ACR/ARHP Annual Meeting

    The Differential Role Of T Helper Cells In The Pathogenesis and Responsiveness To Abatacept Therapy In Rheumatoid Arthritis

    Shunsuke Fukuyo1, Shingo Nakayamada2, Kunihiro Yamaoka1, Satoshi Kubo1, Shigeru Iwata3, Kazuyoshi Saito1 and Yoshiya Tanaka1, 1The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 2First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 3The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, Kitakyushu, Japan

    Background/Purpose: Abatacept (ABT) works through a different mechanism of action from TNF inhibitors in the treatment of rheumatoid arthritis (RA). ABT decreases T cell responses…
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