Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: 536 • 2014 ACR/ARHP Annual Meeting
Secukinumab, a Monoclonal Antibody to Interleukin-17A, Significantly Improves Signs and Symptoms of Active Ankylosing Spondylitis: Results of a Phase 3, Randomized, Placebo-Controlled Trial with Subcutaneous Loading and Maintenance Dosing
Joachim Sieper¹, Jürgen Braun², Xenofon Baraliakos², Dominique L. Baeten³, Maxime Dougados⁴, Paul Emery⁵, Atul A. Deodhar⁶, Brian Porter⁷, Mats Andersson⁸, Shephard Mpofu⁸ and Hanno Richards⁹, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ⁴INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France., Paris, France, ⁵University of Leeds, Leeds, United Kingdom, ⁶Oregon Health and Sciences University, Portland, OR, ⁷Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁸Novartis Pharma AG, Basel, Switzerland, ⁹Clinical Immunology / Dermatology, Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Previous data indicate that interleukin (IL)-17, a key pro-inflammatory cytokine, might play a role in the pathogenesis of ankylosing spondylitis (AS). We assessed the…
Abstract Number: 2832 • 2014 ACR/ARHP Annual Meeting
The Effect of Co-Medication with Conventional Synthetic Disease Modifying Anti-Rheumatic Drugs on TNF Inhibitor Drug Survival in Patients with Ankylosing Spondylitis: Results from a Nationwide Prospective Study
Elisabeth Lie^1,2, Lars Erik Kristensen³, Helena Forsblad-d'Elia¹, Johan Askling⁴ and Lennart T. Jacobsson¹, ¹Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ²Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Section of Rheumatology, Department of Clinical Sciences, Lund University, Malmö, Sweden, ⁴Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden
Background/Purpose For rheumatoid arthritis it is well established that co-medication (co-med) with methotrexate (MTX) increases the efficacy and drug survival of TNF inhibitors (TNFi), while…
Abstract Number: 2564 • 2014 ACR/ARHP Annual Meeting
Ileocolonoscopic Findings in the Korean Patients with Ankylosing Spondylitis
Soo Min Ahn, Bin Yoo, Chang-Keun Lee, Yong-Gil Kim, Seokchan Hong, Seung-Hyeon Bae and Doo-Ho Lim, Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
Background/Purpose: The prevalence of concurrent Ankylosing spondylitis (AS) and inflammatory bowel disease, either Crohn's disease (CD) or Ulcerative colitis (UC), is estimated at 5-10%. Up…
Abstract Number: 1285 • 2014 ACR/ARHP Annual Meeting
Prevalence of Risk Factors for Gastrointestinal Side Effects of Drugs for the Treatment of Pain in Rheumatic Diseases and the Provision of Gastroprotective Treatment – Results of a Large Non-Intervention Study
Gustavo Citera¹, Edgardo Smecuol², Alberto Millán³, Manuel Robles⁴ and Ruben Mantilla⁵, ¹Universidad de Buenos Aires, Buenos Aires, Argentina, ²Hospital Municipal de Gastroenterología, Buenos Aires, Argentina, ³Hospital Universitario de Caracas, Caracas, Venezuela, ⁴Centro Médico Toluca, Toluca, Mexico, ⁵Clínica de Artritis y Rehabilitación (CAYRE), Bogota, Colombia
Background/Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) are the long established first-line treatment for the management of pain associated with rheumatic diseases but carry a risk of…
Abstract Number: 589 • 2014 ACR/ARHP Annual Meeting
Patients with Nr-Axspa Show a Statistically Higher Disease Burden in Clinical Practice Compared with Patients with Radiographic Axial Spa
Lennart TH Jacobsson¹, Tomas Husmark², Elke Theander³, Kenneth Henriksson⁴, Katharina Büsch⁵ and Martin Johansson⁵, ¹Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ²Rheumatology, Falu Hospital, Falun, Sweden, ³Skane University Hospital Malmö, Lund University, Malmö, Sweden, ⁴Rheumatology city clinic, Stockholm, Sweden, Stockholm, Sweden, ⁵AbbVie AB, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose The ASAS axial SpA classification criteria was published in 2009 but so far there has been limited research on axial SpA patients in clinical…
Abstract Number: 463 • 2014 ACR/ARHP Annual Meeting
Golimumab 5-Year Safety: an Analysis of Pooled Data from the Long Term Extensions of Randomized, Double-Blind, Placebo-Controlled Studies in Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing Spondylitis
Jonathan Kay¹, Roy Fleischmann², Edward C. Keystone³, Elizabeth C. Hsia^4,5, Neil Goldstein⁴, Benjamin Hsu⁴, Yiying Zhou⁴, Jürgen Braun⁶ and Arthur Kavanaugh⁷, ¹UMass Memorial Medical Center, Worcester, MA, ²Southwestern Medical Center, Department of Medicine, Metroplex Clinical Research Center, University of Texas, Dallas, TX, ³University of Toronto, Mount Sinai Hospital, Toronto, ON, Canada, ⁴Janssen Research & Development, LLC., Spring House, PA, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Rheumazentrum Ruhrgebiet, Herne, Germany, ⁷University of California San Diego, La Jolla, CA
Background/Purpose: To present an analysis of pooled data through approx 5yrs of follow-up from 5 completed golimumab(GLM) Ph3 SC trials across rheumatological indications. Methods: SC…
Abstract Number: 2618 • 2014 ACR/ARHP Annual Meeting
Impact of Ustekinumab on Active Inflammation and Post-Inflammatory Structural Changes As Detected By Magnetic Resonance Imaging in Patients with Active Ankylosing Spondylitis: Results of a 28-Week, Prospective, Open-Label, Proof-of-Concept Study
Denis Poddubnyy¹, Kay-Geert Hermann¹, Johanna Callhoff², Joachim Listing² and Joachim Sieper¹, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²German Rheumatism Research Center, Berlin, Germany
Background/Purpose Ustekinumab – a fully human monoclonal antibody against interleukins 12 and 23 – has been shown to be effective in reduction of symptoms of…
Abstract Number: 2561 • 2014 ACR/ARHP Annual Meeting
Low Cardio-Respiratory Fitness Is Associated with Increased Arterial Stiffness in Patients with Ankylosing Spondylitis
Inger Jorid Berg¹, Anne Grete Semb², Silje H. Sveaas^3,4, Camilla Fongen³, Désirée van der Heijde^3,5, Tore K. Kvien³, Hanne Dagfinrud³ and Sella A. Provan³, ¹Dep of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Health Sience, University of Oslo, Oslo, Norway, ⁵Leiden University Medical Center, Leiden, Netherlands
Background/Purpose We have previously shown that patients with ankylosing spondylitis (AS) have lower cardio-respiratory fitness (CRF) than population controls. CRF is inversely associated to risk…
Abstract Number: 1159 • 2014 ACR/ARHP Annual Meeting
Long-Term Quality of Life, Productivity Impairment, Disease Severity and Health Care Costs in Relation to Functional Impairment in Ankylosing Spondylitis Patients in the Czech Republic
Liliana Sedova^1,2, Monika Urbanova³, Jiri Stolfa^2,3, David Suchy⁴, Andrea Smrzova⁵, Tomas Mlcoch⁶, Jiri Klimes⁷ and Tomas Dolezal⁷, ¹rheumatology, Institute of Rheumatology, Prague, Czech Republic, ²Clinic of Rheumatology, Charles University Prague, Prague, Czech Republic, ³Inpatients´ Clinic, Institute of Rheumatology Prague, Prague, Czech Republic, ⁴Department of Clinical Pharmacology, Rheumatology, University hospital Plzen, Plzen, Czech Republic, ⁵3rd internal clinic, University hospital Olomouc, Olomouc, Czech Republic, ⁶Institute of Health Economics and Technology Assessment, Prague, Dominica, ⁷Institute of Health Economics and Technology Assessment, Charles University, Prague, Czech Republic
Background/Purpose To describe the quality-of-life (QoL), productivity impairment, clinical indicators and health care costs in relationship to functional status described by Bath Ankylosing Spondylitis Functional…
Abstract Number: 588 • 2014 ACR/ARHP Annual Meeting
Blacks with As Have Greater Disease Severity Than Whites
Farokh Jamalyaria¹, Michael M. Ward², MinJae Lee³, Lianne S. Gensler⁴, Laura A. Diekman⁵, Mohammad H. Rahbar⁶, Amirali Tahanan⁶, Shervin Assassi⁷, Michael H. Weisman⁸ and John D. Reveille^9,10, ¹University of Texas Health Science Center at Houston, Houston, TX, ²Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD, ³Medicine, University of Texas Health Science Center at Houston, Houston, TX, ⁴Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁵Rheumatology, The University of Texas Health Science Center at Houston, Houston, TX, ⁶The University of Texas Health Science Center at Houston, Houston, TX, ⁷Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁸Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁹Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ¹⁰Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX
Background/Purpose : To compare clinical parameters in African American (AA) patients with ankylosing spondylitis (AS) to white patients. Methods: 539 AS patients (47 B, 492…
Abstract Number: 318 • 2014 ACR/ARHP Annual Meeting
HLA-B27 Subtypes in Enthesitis Related Arthritis Category of Juvenile Idiopathic Arthritis
Rajni Srivastava¹, Shikha Agnihotry², Rakesh Aggarwal³ and Amita Aggarwal¹, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Bioinformatics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ³Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: HLA-B27 has a high degree of genetic polymorphism, with more than 105 known subtypes. Enthesitis Related Arthritis (ERA) is most common form of Juvenile Idiopathic Arthritis…
Abstract Number: 2617 • 2014 ACR/ARHP Annual Meeting
No Evidence of Accelerated Atheromatosis, Increased Arterial Stiffness or Hypertrophy in Ankylosing Spondylitis: A Systematic Case-Control Study
Aikaterini I. Arida¹, Maria Konsta¹, Alexios Iliopoulos², Maria Tektonidou³, George Konstantonis¹, George D. Kitas⁴, Athanasios D. Protogerou¹ and Petros P. Sfikakis¹, ¹First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, ²Department of Rheumatology, Veterans Administration Hospital, Athens, Greece, ³First Department of Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, ⁴The Dudley Group of Hospitals NHS Foundation Trust, Dudley, and Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom
Background/Purpose: Chronic inflammatory arthritis is associated with increased cardiovascular disease (CVD) risk. The mechanisms behind this link include chronic inflammation, comorbidities and disease-related drugs. CV…
Abstract Number: 2553 • 2014 ACR/ARHP Annual Meeting
Compromised Volumetric Bone Density, Bone Microarchitecture and Bone Strength in Patients with Ankylosing Spondylitis: High-Resolution Peripheral Quantitative Computerized Tomography (HRpQCT) Based Study
Nisha Nigil Haroon¹, Eva Szabo², Janet Raboud³, Ammepa Anton⁴, Robert Josse¹, Robert D. Inman¹ and Angela Cheung¹, ¹Department of Medicine, University of Toronto, Toronto, ON, Canada, ²Osteoporosis Program, UHN, TOronto, ON, Canada, ³Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, University Health Network, Toronto, ON, Canada
Background/Purpose Patients with ankylosing spondylitis (AS) have high fracture risk. BMD, bone microarchitecture and strength determine fracture risk. However, in AS, DXA-based BMD measurements of…
Abstract Number: 852 • 2014 ACR/ARHP Annual Meeting
Safety and Efficacy of Certolizumab Pegol over 96 Weeks in Patients with Axial Spondyloarthritis, Including Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis
Joachim Sieper¹, Martin Rudwaleit², Désirée M. van der Heijde³, Walter P. Maksymowych⁴, Maxime Dougados⁵, Philip J. Mease⁶, Jürgen Braun⁷, Atul A. Deodhar⁸, Bengt Hoepken⁹, Tommi Nurminen⁹ and Robert B. M. Landewé¹⁰, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Endokrinologikum, Berlin, Germany, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Medicine, University of Alberta, Edmonton, AB, Canada, ⁵Université Paris René Descartes and Hôpital Cochin, Paris, France, ⁶Division of Rheumatology Research, Swedish Medical Center and University of Washington, Seattle, WA, ⁷Rheumazentrum Ruhrgebiet, Ruhr-University Bochum, Herne, Germany, ⁸Oregon Health and Sciences University, Portland, OR, ⁹UCB Pharma, Monheim, Germany, ¹⁰Department of Rheumatology, Amsterdam Rheumatology Center, Amsterdam, Netherlands
Background/Purpose: Previous reports of RAPID-axSpA (NCT01087762) demonstrated efficacy and safety of certolizumab pegol (CZP) in patients (pts) with axial spondyloarthritis (axSpA) including pts with ankylosing…
Abstract Number: 587 • 2014 ACR/ARHP Annual Meeting
Clinical Characteristics of Nonradiographic Axial Spondyloarthritis in Korea: A Comparison with Ankylosing Spondylitis
Hyungjin Kim¹, Hyemin Jeong¹, Seulkee Lee¹, Inyoung Kim¹, Jiwon Hwang², Jaejoon Lee¹, Jinseok Kim³, Eun-Mi Koh⁴ and Hoon-Suk Cha⁵, ¹Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Department of Medicine,Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ³1753-3, Ara-1 Dong, Jeju National University Hospital, Jeju, South Korea, ⁴Dept of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁵Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Background/Purpose: To evaluate the clinical characteristics and outcomes of nonradiographic axial spondyloarthritis (nr-axSpA) in Korean patients. Methods: A retrospective analysis evaluated 155 patients with nr-axSpA…

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