Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: L21 • 2014 ACR/ARHP Annual Meeting
Striking Discrepancy in the Development of Anti-Drug Antibodies (ADA) in Patients with Rheumatoid Arthritis (RA) and Ankylosing Spondylitis (AS) in Response to Infliximab (INF) and Its Biosimilar CT-P13
Jürgen Braun¹, Xenofon Baraliakos¹, Alex Kudrin², H. Kim³ and Sang Joon Lee², ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²CELLTRION, Inc., Incheon, South Korea, ³CELLTRION, Inc, Incheon, Republic of Korea, Incheon, South Korea
Background/Purpose: The differences between RA and AS have been recently highlighted (1). There is evidence that there are major clinical, pathophysiological and genetic differences. In…
Abstract Number: 2610 • 2014 ACR/ARHP Annual Meeting
The Role of IL-20 in the Pathogenesis of Ankylosing Spondylitis with Peripheral Joint Involvement
Göksal Keskin¹, Baris Mavi², Lale Ozisik³, Rahsan Ilikci⁴ and Mehmet Yildiz², ¹Immunology, Medical School of Ankara, Ankara, Turkey, ²Internal Medicine, Diskapi Training and Research Hospital, Ankara, Turkey, ³Internal Medicine, MD, Ankara, Turkey, ⁴Basic Immunology, BC, Ankara, Turkey
Background/Purpose The interleukin-20 (IL-20) is a pro-inflammatory cytokine of the IL-10 family and sequence amino acid is very similar. It has been reported to be…
Abstract Number: 2149 • 2014 ACR/ARHP Annual Meeting
Relationship Between the Magnitude of Bone Formation in the Anterior Vertebral Corners, As Assessed through 18F-Fluoride Uptake, and Lumbar Spine Bone Mineral Density in Patients with Ankylosing Spondylitis
Seung-Geun Lee¹, Eun-Kyoung Park¹, Geun-Tae Kim², Sang-Yeob Lee³ and Joung-Wokk Lee⁴, ¹Divsion of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, South Korea, ⁴Divsion of Rheumatology, Department of Internal Medicine, Busan St. Marys center, Busan, South Korea
Background/Purpose: 18F-fluoride uptake represents active osteoblastic bone synthesis. We investigated the relationship between the magnitude of bone formation in anterior vertebral corners, as assessed through…
Abstract Number: 612 • 2014 ACR/ARHP Annual Meeting
Association of Platelet Endothelial Cell Adhesion Molecule-1 and beta1 Integrin Gene Polymorphisms with Uveitis Development in Ankylosing Spondylitis
Seong-Wook Kang¹, Seung-Taek Song¹, Su-Jin Yoo², Mi-Kyoung Lim³, Dong-Hyuk Sheen⁴, In-Seol Yoo², Jinhyun Kim¹ and Seung-Cheol Shim¹, ¹Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ²Departmen of Internal medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ³Rheumatology, Eulji University Hospital, Daejeon, South Korea, ⁴Department of Internal Medicine, Eulji University Hospital, Daejeon, South Korea
Background/Purpose Genetic factors provide over 90% of the overall susceptibility to ankylosing spondylitis (AS) and recent studies have focused on non-major histocompatibility complex genes. The…
Abstract Number: 578 • 2014 ACR/ARHP Annual Meeting
Female Patients but Not Male Patients with Ankylosing Spondylitis Are at Increased Risk of Developing Ischemic Heart Disease: A Population-Based Cohort Study
Ivette Essers^1,2, Carmen Stolwijk^1,2, Annelies Boonen^3,4, Marie L. De Bruin⁵, Marloes Bazelier⁵, Frank de Vries^5,6,7,8 and Astrid Van Tubergen^1,2, ¹School for Public Health and Primary Care (CAPHRI), Maastricht University, Maastricht, Netherlands, ²Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ³Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ⁴Care and Public Health Research Institute, Maastricht University Medical Center, Maastricht, Netherlands, ⁵Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, Netherlands, ⁶Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Center, Maastricht, Netherlands, ⁷MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, United Kingdom, ⁸Care and Public Health Research Institute, Maastricht University, Maastricht, Netherlands
Background/Purpose: It is well recognized that rheumatoid arthritis is an independent risk factor for cardiovascular disease. For ankylosing spondylitis (AS), the literature on this risk…
Abstract Number: 2607 • 2014 ACR/ARHP Annual Meeting
Fatigue in Ankylosing Spondylitis: A Multivariable Analysis Implicates Inflammation As the Key Determinant of Disability
Mohamed Bedaiwi¹, Arane Thavaneswaran², Nigil Haroon³, Ammepa Anton⁴ and Robert D. Inman⁵, ¹Division of Rheumatology, Toronto Western Hospital, clinical and research fellow, Toronto, ON, Canada, ²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Toronto Western Research Institute, Toronto, ON, Canada, ⁴Rheumatology, University Health Network, Toronto, ON, Canada, ⁵Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Fatigue is one of the cardinal features of ankylosing spondylitis (AS). The clinical and laboratory correlates of fatigue in AS however are not well…
Abstract Number: 1919 • 2014 ACR/ARHP Annual Meeting
HLA-B27 Expression Shapes the Intestinal Microbiota
Mark Asquith¹, Phoebe Lin², Tejpal Gill³, Justine Debelius⁴, Patrick Stauffer⁵, Sean Davin⁵, Gail Ackermann⁴, Robert A. Colbert³, Rob Knight⁴ and James Rosenbaum^1,6, ¹Division of Rheumatology, Oregon Health and Science University, Portland, OR, ²Casey Eye Institute, Oregon Health and Science University, Portland, OR, ³NIAMS/NIH, Bethesda, MD, ⁴University of Colorado Boulder, Boulder, CO, ⁵Oregon Health and Science University, Portland, OR, ⁶Dever's Eye Institute, Legacy Hospital, Portland, OR
Background/Purpose The intestinal microbiota plays a central role in both health and disease. Beyond shaping local immune responses in the gut, it is increasingly clear…
Abstract Number: 608 • 2014 ACR/ARHP Annual Meeting
Identification of Novel Autoantibodies in Patients with Ankylosing Spondylitis Using Human Protein Microarray
Matthew Presby¹, Mark J. Soloski¹, John A. Flynn², Clifton O. Bingham III¹, Michael M. Ward³ and Grant H. Louie⁴, ¹Johns Hopkins University, Baltimore, MD, ²Dept of Medicine, Johns Hopkins University, Baltimore, MD, ³Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD, ⁴Rheumatology, Johns Hopkins University, Baltimore, MD
Background/Purpose: Ankylosing spondylitis (AS) is an immune-mediated disease for which the search for autoantibodies has been elusive. Conventional immunoserological approaches are slow and limited…
Abstract Number: 574 • 2014 ACR/ARHP Annual Meeting
Do Extra-Articular Manifestations Influence Outcome in Ankylosing Spondylitis? a 12 Year Follow-up Study
Ivette Essers^1,2, Sofia Ramiro^3,4, Carmen Stolwijk^1,2, Marc Blaauw⁵, Robert Landewé^6,7, Désirée M. van der Heijde⁸, Filip van Den Bosch⁹, Maxime Dougados¹⁰ and Astrid van Tubergen^2,11, ¹School for Public Health and Primary Care (CAPHRI), Maastricht University, Maastricht, Netherlands, ²Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ³Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Rheumatology, Hospital Garcia de Orta, Almada, Portugal, ⁵Department of Internal Medicine, Catharina Hospital, Eindhoven, Netherlands, ⁶Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁷Rheumatology, Atrium Medical Center, Heerlen, Netherlands, ⁸Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁹Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium, ¹⁰Rheumatology, Hopital Cochin, Descartes University, Paris, France, ¹¹Maastricht University Medical Center, Maastricht, Netherlands
Background/Purpose: Extra-articular manifestations (EAMs), such as acute anterior uveitis (AAU), inflammatory bowel disease (IBD), and psoriasis contribute to diagnosis, classification criteria, and choice of treatment…
Abstract Number: 2985 • 2014 ACR/ARHP Annual Meeting
Autoantibodies to 14-3-3η Are Novel Biomarkers Associated with Inflammation and Radiographic Progression in Ankylosing Spondylitis
Walter P. Maksymowych¹, Stephanie Wichuk¹, RG Lambert², Mairead Murphy³ and Anthony Marotta⁴, ¹Medicine, University of Alberta, Edmonton, AB, Canada, ²Radiology, University of Alberta, Edmonton, AB, Canada, ³Augurex Life Sciences Corp., North Vancouver, BC, Canada, ⁴1423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada
Background/Purpose 14-3-3η is a ubiquitous intracellular chaperone protein that is expressed extracellularly in rheumatoid arthritis and mediates inflammatory cascades that result in expression of inflammatory…
Abstract Number: 2582 • 2014 ACR/ARHP Annual Meeting
Serum Levels of Bone Morphogenetic Protein-7 and Sclerostin Are Elevated in Ankylosing Spondylitis, but Not Linked with Structural Damage
Weiping Kong¹, Xiaotong WANG¹, Tongliang Zhou², Yue Jin³, Qingwen TAO¹, Yuan Xu¹, Yingze Zhang¹, Jianming WANG¹ and Xiaoping Yan¹, ¹Department of TCM Rheumatology, China-Japan Friendship Hospital, BEIJING, China, ²CLINICAL RESEARCH INSTITUTE OF IMMUNOLOGY, China-Japan Friendship Hospital, BEIJING, China, ³COMBINATION OF WESTERN AND CHINESE MEDICINE, Beijing University of Chinese Medicine, BEIJING, China
Background/Purpose Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by new bone formation that progressively leads to ankylosis and functional disability. The mechanisms of…
Abstract Number: 1913 • 2014 ACR/ARHP Annual Meeting
Rosuvastatin Induced Carotid Plaque Regression in Patients with Inflammatory Joint Diseases
Silvia Rollefstad¹, Eirik Ikdahl¹, Jonny Hisdal², Inge C. Olsen³, Ingar Holme⁴, Hilde Berner Hammer⁵, Knut T. Smerud⁶, G Kitas⁷, Terje R. Pedersen⁸, Tore K. Kvien⁹ and Anne Grete Semb¹, ¹Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Section of Vascular Investigations, Uslo University Hospital-Aker, Oslo, Norway, ³Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Department of biostatistics, epidemiology and health economics, Oslo University Hospital, Oslo, Norway, ⁵Postboks 23 Vinderen, Diakonhjemmet Hospital, Oslo, Norway, ⁶Smerud Medical Research International AS, Oslo, Norway, ⁷The Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom, ⁸Faculty of Medicine, University of Oslo, Oslo, Norway, ⁹PsAID taskforce, EULAR, Zurich, Switzerland
Background/Purpose Patients with rheumatoid arthritis (RA) and carotid artery plaques (CP) have increased risk of acute coronary syndromes. Statin treatment with low density lipoprotein cholesterol…
Abstract Number: 619 • 2014 ACR/ARHP Annual Meeting
Effect of ERAP1 Knockdown on Conformation of HLA-B27 and Other HLA Class I Molecules in Human Monocytic Cells
Tri M. Tran¹, Sohee Hong¹, Jehad H. Edwan² and Robert A. Colbert¹, ¹NIAMS/NIH, Bethesda, MD, ²NIAMS NIH, Bethesda, MD
Background/Purpose Polymorphisms in endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) are associated with ankylosing spondylitis, Behcet’s disease, and psoriasis/psoriatic arthritis, where HLA class I alleles are…
Abstract Number: 573 • 2014 ACR/ARHP Annual Meeting
Three-Year Course and Prediction of Physical Functioning in Ankylosing Spondylitis Patients Treated with TNF-Inhibitors
Salima F.E. van Weely¹, Eva L. Kneepkens¹, Mike T. Nurmohamed¹, Joost Dekker^1,2 and Irene E. van der Horst-Bruinsma³, ¹Reade, centre for Rehabilitation and Rheumatology, Amsterdam, Netherlands, ²Rehabilitation Medicine, Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands, ³Rheumatology, VU University Medical Centre, Amsterdam, Netherlands
Background/Purpose: Currently, only limited information is available on the long-term course of limitations in physical functioning and spinal mobility in Ankylosing Spondylitis (AS) patients receiving…
Abstract Number: 2986 • 2014 ACR/ARHP Annual Meeting
Fat Metaplasia on MRI of the Sacroiliac Joints Is a Lead Indicator of Radiographic Progression in the Spine of Patients with Ankylosing Spondylitis
Walter P. Maksymowych¹, S Wichuk², P Chiowchanwisawakit³, RG Lambert⁴ and Sj Pedersen⁵, ¹Medicine, University of Alberta, Edmonton, AB, Canada, ²Department of Medicine, University of Alberta, Edmonton, AB, Canada, ³Mahidol University, Bangkok, Thailand, ⁴Radiology, University of Alberta, Edmonton, AB, Canada, ⁵Dept. of Rheumatology, Copenhagen Center for Arthritis Research, Copenhagen, Denmark
Fat Metaplasia on MRI of the Sacroiliac joints is a Lead Indicator of Radiographic Progression in the Spine of Patients with Ankylosing SpondylitisMaksymowych WP, Wichuk…

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