Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: 1727 • 2015 ACR/ARHP Annual Meeting
MRI Vertebral Corner Inflammation Followed By Fat Deposition Is the Strongest Contributor to the Development of New Bone at the Same Vertebral Corner: A Multi-Level Longitudinal Analysis in Patients with Ankylosing Spondylitis
Pedro Machado¹, Xenofon Baraliakos², Désirée van der Heijde³, Juergen Braun² and Robert Landewé⁴, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Dept. of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Syndesmophyte formation in ankylosing spondylitis (AS) is still insufficiently understood. Previous studies have suggested an association between MRI vertebral corner inflammation (VCI) and vertebral…
Abstract Number: 2812 • 2015 ACR/ARHP Annual Meeting
Cytokine Secretion By Peripheral Blood Mononuclear Cells in Patients with Axial Spondyloarthritis and the Effect of Thymoquinone on Cytokine Profile
Erkan Kilic¹, Cagri Sakalar², Huriye Aksu³, Mustafa Cakir³, Gamze Kilic¹ and Salih Ozgocmen⁴, ¹Dept. PRM, Erciyes University, Faculty of Medicine,Division of Rheumatology, Kayseri, Turkey, ²Genome and Stem Cell Center (GEN-KOK), Erciyes University, Faculty of Medicine, Medical Biology, Kayseri, Turkey, ³Genome and Stem Cell Senter (GEN-KOK), Erciyes University, Faculty of Medicine, Medical Biology, Kayseri, Turkey, ⁴Dept.PRM, Erciyes University, Faculty of Medicine,Division of Rheumatology, Kayseri, Turkey
Background/Purpose: Axial spondyloarthritis (axSpA) defines a group of chronic inflammatory diseases which includes non-radiographic axSpA (nr-axSpA) who do not have definite sacroiliitis on pelvic X-rays.…
Abstract Number: 980 • 2015 ACR/ARHP Annual Meeting
Association of Platelet Endothelial Cell Adhesion Molecule-1 and ß1 Integrin Gene Polymorphisms with Uveitis Development in Ankylosing Spondylitis
Seung-Cheol Shim¹, In-Seol Yoo², Su-Jin Yoo¹, Young Kim¹, Mi-Kyoung Lim³, Dong-Hyuk Sheen⁴ and Jinhyun Kim⁵, ¹Rheumatology, Chungnam National University School of Medicine, Daejeon, South Korea, ²Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ³Medicine, Eulji University Hospital, Daejeon, South Korea, ⁴Rheumatology, Eulji University Hospital, Daejeon, South Korea, ⁵Internal medicine, Chungnam National University School of Medicine, Daejeon, South Korea
Background/Purpose: Genetic factors provide over 90% of the overall susceptibility to ankylosing spondylitis (AS) and recent studies have focused on non-major histocompatibility complex genes. The…
Abstract Number: 1729 • 2015 ACR/ARHP Annual Meeting
Predictors and Clinical Factors Associated with Change in Spinal Inflammation Assessed on MRI over 2 Years: Data from Tasmanian Ankylosing Spondylitis Study
Hussain Ijaz Khan¹, Louisa Chou², Patricia Lewis³, Anitra Wilson³, Janet Millner⁴ and Jane Zochling³, ¹Musculoskeletal Unit, Menzies Institute of Medical Research, Hobart, Australia, ²Menzies Institute of Medical Research, University of Tasmania, Hobart, 7000, Australia, ³Menzies Institute of Medical Research, Hobart, Australia, ⁴Physiotherapy, Royal Hobart Hospital, Hobart, Australia
Background/Purpose: Ankylosing Spondylitis (AS) is debilitating disease affecting the axial skeleton which is often difficult to diagnose in early stages. Magnetic Resonance Imaging (MRI) is…
Abstract Number: 2818 • 2015 ACR/ARHP Annual Meeting
Associations of IL23R, BMP6 and PTGS1 Polymorphisms with Radiographic Severity of Ankylosing Spondylitis
Gulsen Ozen¹, Rabia Deniz², Fatih Eren³, Can Erzik³, Ali Ugur Unal¹, Sibel Z. Aydin⁴, Nevsun Inanc¹, Haner Direskeneli¹ and Pamir Atagunduz¹, ¹Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, ²Marmara University Faculty of Medicine, Istanbul, Turkey, ³Department of Medical Biology, Marmara University Faculty of Medicine, Istanbul, Turkey, ⁴Department of Rheumatology, Koc University Faculty of Medicine, Istanbul, Turkey
Background/Purpose: Ankylosing spondylitis (AS) is an inflammatory disease affecting spine which may lead to new bone formation and disability. However, the radiographic severity of AS…
Abstract Number: 1057 • 2015 ACR/ARHP Annual Meeting
Are Ankylosing Spondylitis, Psoriatic Arthritis and Undifferentiated Spondylarthritis Associated with an Increased Risk of Cardiovascular Disease?
Karin Bengtsson¹, Helena Forsblad-d'Elia², Elisabeth Lie¹, Eva Klingberg¹, Mats Dehlin¹, Sofia Exarchou³, Ulf Lindström¹, Johan Askling⁴ and Lennart TH Jacobsson¹, ¹Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ²Departments of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, ³Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ⁴Clinical Epidemiology Unit and Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden
Background/Purpose: It is unclear whether and to what extent different phenotypes of spondylarthritis (SpA) are associated with an increased risk of cardiovascular events such as…
Abstract Number: 1731 • 2015 ACR/ARHP Annual Meeting
Radiographic Damage of Facet Joints and Vertebral Bodies in the Cervical Spine in Patients with Ankylosing Spondylitis Treated with TNF Inhibitors
Fiona Maas¹, Suzanne Arends¹, Elisabeth Brouwer¹, Eveline van der Veer², Hendrika Bootsma¹, Rizwana Chaudhry¹, Monique Efde³, Freke Wink³ and Anneke Spoorenberg¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ³Rheumatology, Medical Center Leeuwarden, Leeuwarden, Netherlands
Background/Purpose: In ankylosing spondylitis (AS), syndesmophyte formation and ankylosis of the vertebral bodies are characteristic radiographic changes that are evaluated during follow-up. However, the facet…
Abstract Number: 2829 • 2015 ACR/ARHP Annual Meeting
Enhanced Expression of the Transcription Factor T-Bet Alters Pro-Inflammatory Cytokine Profile in Ankylosing Spondylitis
Max C. Lau¹, Patricia Keith¹, Mary-Ellen Costello¹, Linda A. Bradbury¹, Kelly A. Hollis¹, Gethin P. Thomas², Matthew A. Brown^1,3 and Tony J. Kenna¹, ¹The University of Queensland Diamantina Institute, Brisbane, Australia, ²Translational Reserch Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, ³Translational Research Institute, Brisbane, Australia
Background/Purpose: TBX21 encodes T-bet, a T-box transcription factor, and lies within a locus with genome-wide significant association with AS (rs11657479, odds ratio=1.13, P=6.16x10-10). T-bet is…
Abstract Number: 1059 • 2015 ACR/ARHP Annual Meeting
Increased Risk of Atrioventricular Block, Atrial Fibrillation and Pacemaker Implantation in Ankylosing Spondylitis, Undifferentiated Spondylarthritis and Psoriatic Arthritis Compared to the General Population
Karin Bengtsson¹, Helena Forsblad-d'Elia², Elisabeth Lie¹, Eva Klingberg¹, Mats Dehlin¹, Sofia Exarchou³, Ulf Lindström¹, Johan Askling⁴ and Lennart TH Jacobsson¹, ¹Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ²Departments of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, ³Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ⁴Clinical Epidemiology Unit and Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden
Background/Purpose: There is a known association between conduction disturbances and ankylosing spondylitis (AS). The risk of conduction disturbances in other phenotypes of spondylarthritis (SpA) is…
Abstract Number: 1732 • 2015 ACR/ARHP Annual Meeting
Slow Spinal Radiographic Progression in Patients with Ankylosing Spondylitis Treated with TNF Inhibitors
Fiona Maas¹, Suzanne Arends¹, Ivette Essers², Elisabeth Brouwer¹, Eveline van der Veer³, Freke Wink⁴, Monique Efde⁴, Hendrika Bootsma¹ and Anneke Spoorenberg¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ³Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁴Rheumatology, Medical Center Leeuwarden, Leeuwarden, Netherlands
Background/Purpose: Assessing radiographic progression in ankylosing spondylitis (AS) is challenging. The results regarding the effect of tumor necrosis factor-alpha (TNF-α) blocking therapy on spinal radiographic…
Abstract Number: 2832 • 2015 ACR/ARHP Annual Meeting
Characterization of Leukocyte Subsets in Ankylosing Spondylitis Patients
Yolanda Jiménez Gómez, Chary Lopez-Pedrera, Pilar Font, Patricia Ruiz-Limon, Carlos Perez-Sanchez, Nuria Barbarroja, M. Carmen Castro Villegas, Jerusalem Calvo-Gutierrez, MariCarmen Abalos-Aguilera, Alejandro Escudero-Contreras and Eduardo Collantes-Estevez, IMIBIC-Reina Sofia University Hospital, Rheumatology Unit, Cordoba, Spain
Background/Purpose: AS is a chronic inflammatory disease, of unknown aetiology, characterized by pathological ossification. We aimed: 1) To analyze the profile of inflammation, oxidative status…
Abstract Number: 30 • 2015 ACR/ARHP Annual Meeting
Complications of Inflammatory Arthritis in First Nations and Non-First Nations Populations of Alberta, Canada
Cheryl Barnabe¹, Gilaad Kaplan², J Antonio Avina-Zubieta³, Diane Lacaille⁴, Brenda Hemmelgarn⁵ and JM Esdaile⁶, ¹Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²Division of Gastroenterology, University of Calgary, Calgary, AB, Canada, ³Arthritis Research Canada / University of British Columbia, Vancouver, BC, Canada, ⁴Arthritis Research Centre, University of British Columbia, Vancouver, BC, Canada, ⁵Division of Nephrology, University of Calgary, Calgary, AB, Canada, ⁶Rheumatology, Arthritis Research Canada, Richmond, BC, Canada
Background/Purpose: With markedly improved control of the acute effects of inflammatory arthritis, the major causes of morbidity and premature death now arise from the complications…
Abstract Number: 1061 • 2015 ACR/ARHP Annual Meeting
Patients with Fibromyalgia (FM) Do Not Fulfill Classification Criteria for Axial Spondyloarthritis (axSpA) but Patients with Axspa May Fulfill Classification Criteria for FM
Xenofon Baraliakos¹, Andrea Regel¹, Uta Kiltz¹, Hans-Jürgen Menne², Friedrich Dybowski³, Manfred Igelmann⁴, Ludwig Kalthoff³, Dietmar Krause⁵, Ertan Saracbasi¹, Elmar Schmitz-Bortz⁶ and Jürgen Braun¹, ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Rheumatology practice, Dortmund, Germany, ³Private rheumatology office, Herne, Germany, ⁴Private Rheumatology office, Bochum, Germany, ⁵Internistische und rheumatologische Gemeinschaftspraxis, Gladbeck, Germany, ⁶Rheumatology practice, Hattingen, Germany
Background/Purpose: Both patients with axial spondyloarthritis (axSpA) and patients with fibromyalgia (FM) are suffering from pain. The new ASAS classification criteria for axSpA have been…
Abstract Number: 1733 • 2015 ACR/ARHP Annual Meeting
A Close Correlation Between Radiologic Progression Severity and Trabecular Bone Loss in Male Patients with Ankylosing Spondylitis
Ki-Jo Kim^1,2, In-Woon Baek³, Chong-Hyeun Yoon^4,5, Wan-Uk Kim⁶ and Chul-Soo Cho³, ¹Internal Medicine, St. Vincent’s Hospital, The Catholic University of Korea, Suwon, South Korea, ²St. Mary's Hospital, Seoul, South Korea, ³Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁵Internal Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Uijeongbu, South Korea, ⁶Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Ankylosing spondylitis (AS) is a chronic, progressive disease characterized by inflammation of entheses. Inflammation is associated with cortical new bone formation leading to progressive…
Abstract Number: 2838 • 2015 ACR/ARHP Annual Meeting
Evidence of Serological IL-23/IL-17 Axis Activation in Ankylosing Spondylitis Patients with Long-Term TNF Blockade: The Missing Therapy Target?
Fernanda M. Milanez¹, Carla G.S. Saad¹, Vilma S. T. Viana¹, Julio C. B. Moraes¹, Grégory V. Périco², Celio R. Gonçalves¹ and Eloisa Bonfá¹, ¹Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Unidade Radiologica Criciuma, Criciuma, Brazil
Background/Purpose: Spondyloarthritis (Spa) is a group of inflammatory diseases in which ankylosing spondylitis (AS) is the prototype. Despite recent advances in pathophysiology and treatment, this…

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