Date: Monday, November 9, 2015
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Ankylosing spondylitis (AS) is a chronic, progressive disease characterized by inflammation of entheses. Inflammation is associated with cortical new bone formation leading to progressive ankylosis of the spine and sacroiliac joints but also with trabecular bone loss leading to osteoporosis. The aim of this study is to investigate the association of spinal radiologic progression with bone mineral density in male AS patients.
Methods: Clinical and radiographic data were collected in 116 male AS patients. Spinal radiographs were scored using the modified Stoke AS Spinal Score (mSASSS) and spinal bone mineral density (BMD) of anteroposterior (AP) and lateral (Lat) views was measured by dual-energy x-ray absorptiometry (DEXA).
Results: Seventy three (62.9%) patients had syndesmophyte(s) at their lumbar spine (L-spine) and 45 patients (38.8%) were treated by tumor necrosis factor (TNF) inhibitors. mSASSS and BMD were significantly higher in patients with syndesmophyte(s) (All P < 0.05). For the 2nd and 3rd lumbar vertebra, BMD of AP view was significantly higher in vertebrae with syndesmophyte(s) (P = 0.001) while BMD of Lat view was decreased and did not differ between those with and without syndesmophyte(s). Moreover, L-spine mSASSS was positively correlated with BMD of AP view (γ = 0.239, P = 0.010) while negatively correlated with BMD of Lat view (γ = -0.209, P = 0.025). These correlations were significant when adjusted for age, HLA-B27, smoking, treatment drugs (NSAIDs, TNF inhibitors, statins and bisphosphonate), body mass index and C-reactive protein.
Conclusion: Trabecular BMD was decreased and correlated with severity of radiologic progression in L-spine of male AS patients, suggesting a parallel progression between cortical bone formation and trabecular bone loss.
To cite this abstract in AMA style:Kim KJ, Baek IW, Yoon CH, Kim WU, Cho CS. A Close Correlation Between Radiologic Progression Severity and Trabecular Bone Loss in Male Patients with Ankylosing Spondylitis [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/a-close-correlation-between-radiologic-progression-severity-and-trabecular-bone-loss-in-male-patients-with-ankylosing-spondylitis/. Accessed November 22, 2019.
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