Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: 712 • 2015 ACR/ARHP Annual Meeting
Factors Associated with Anti-TNF Treatment in a Longitudinally Followed Ankylosing Spondylitis (AS) Cohort
Mary Gibson¹, MinJae Lee², Michael M. Ward³, Lianne S. Gensler⁴, Matthew A. Brown⁵, Shervin Assassi⁶, Colton Pence¹, Laura A. Diekman⁷, Mohammad H. Rahbar⁸, Michael H. Weisman⁹ and John D. Reveille¹, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, TX, ³NIH/NIAMS, Bethesda, MD, ⁴Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁵The University of Queensland Diamantina Institute, Brisbane, Australia, ⁶Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁷Rheumatology, University of Texas Medical School, Houston, TX, ⁸The University of Texas Health Science Center at Houston, Houston, TX, ⁹Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA
Background/Purpose: TNF-α inhibitor therapy is recommended by ASAS/EULAR guidelines for ankylosing spondylitis (AS) patients with moderate-to-high disease activity despite inadequate response to NSAIDs in addition…
Abstract Number: 1725 • 2015 ACR/ARHP Annual Meeting
Reliable Evaluation of Structural Lesions of the Sacroiliac Joints on MRI in Patients with Axial Spondyloarthritis That Is Comparable to Evaluation of Inflammation Despite Minimal Calibration
Rosaline van den Berg¹, Susanne Juhl Pedersen², Victoria Navarro-Compán³, Stephanie Wichuk⁴, Manouk de Hooge⁵, Robert G Lambert⁶, Désirée van der Heijde⁵ and Walter Maksymowych⁷, ¹Leiden University Medical Center, Leiden, Netherlands, ²Copenhagen Center for Arthritis Research, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark, ³Rheumatology, University Hospital La Paz, Madrid, Spain, ⁴Medicine, Medicine, University of Alberta, Edmonton, AB, Canada, ⁵Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁶Radiology, Radiology, University of Alberta, Edmonton, AB, Canada, ⁷Medicine/Rheumatic Dis Unit, Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: There is growing recognition of the importance of structural lesions of the sacroiliac joints (SIJ) on MRI to the diagnostic evaluation of axial spondyloarthritis…
Abstract Number: 2810 • 2015 ACR/ARHP Annual Meeting
The Presence of HLA-B27 Increases Severity of Arthritis but Does Not Appear to Influence New Bone Formation in Different in Vitro and in Vivo Models
Barbara Neerinckx¹, Kerri Heritage², Jacqueline Shaw³, S. Kollnberger³, Paul Bowness³ and Rik Lories¹, ¹Rheumatology, UZ Leuven, Leuven, Belgium, ²Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven and University Hospitals Leuven., Leuven, Belgium, ³Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
Background/Purpose: The strong genetic association between the HLA-B27 gene and ankylosing spondylitis (AS) has been known for over 40 years. Among AS patients, HLA-B27 positivity…
Abstract Number: 973 • 2015 ACR/ARHP Annual Meeting
The Effect of TNF Inhibitor Treatment on Occurrence of Anterior Uveitis in Ankylosing Spondylitis: Results from the Swedish Biologics Register
Elisabeth Lie^1,2, Ulf Lindström², Tatiana Zverkova-Sandström², Inge C Olsen¹, Helena Forsblad-d'Elia³, Johan Askling⁴, Lars Erik Kristensen^5,6 and Lennart TH Jacobsson², ¹Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Dept. of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ³Departments of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, ⁴Clinical Epidemiology Unit & Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁵Musculoskeletal Statistics Unit, The Parker Institute, Dept. of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark, ⁶Section of Rheumatology, Department of Clinical Sciences, Lund University, Malmö, Sweden
Background/Purpose: Anterior uveitis is a relatively frequent extra-articular manifestation in ankylosing spondylitis (AS), with a prevalence of 25.8% in a recent meta-analysis. TNF inhibitor (TNFi)…
Abstract Number: 1727 • 2015 ACR/ARHP Annual Meeting
MRI Vertebral Corner Inflammation Followed By Fat Deposition Is the Strongest Contributor to the Development of New Bone at the Same Vertebral Corner: A Multi-Level Longitudinal Analysis in Patients with Ankylosing Spondylitis
Pedro Machado¹, Xenofon Baraliakos², Désirée van der Heijde³, Juergen Braun² and Robert Landewé⁴, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Dept. of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Syndesmophyte formation in ankylosing spondylitis (AS) is still insufficiently understood. Previous studies have suggested an association between MRI vertebral corner inflammation (VCI) and vertebral…
Abstract Number: 2812 • 2015 ACR/ARHP Annual Meeting
Cytokine Secretion By Peripheral Blood Mononuclear Cells in Patients with Axial Spondyloarthritis and the Effect of Thymoquinone on Cytokine Profile
Erkan Kilic¹, Cagri Sakalar², Huriye Aksu³, Mustafa Cakir³, Gamze Kilic¹ and Salih Ozgocmen⁴, ¹Dept. PRM, Erciyes University, Faculty of Medicine,Division of Rheumatology, Kayseri, Turkey, ²Genome and Stem Cell Center (GEN-KOK), Erciyes University, Faculty of Medicine, Medical Biology, Kayseri, Turkey, ³Genome and Stem Cell Senter (GEN-KOK), Erciyes University, Faculty of Medicine, Medical Biology, Kayseri, Turkey, ⁴Dept.PRM, Erciyes University, Faculty of Medicine,Division of Rheumatology, Kayseri, Turkey
Background/Purpose: Axial spondyloarthritis (axSpA) defines a group of chronic inflammatory diseases which includes non-radiographic axSpA (nr-axSpA) who do not have definite sacroiliitis on pelvic X-rays.…
Abstract Number: 980 • 2015 ACR/ARHP Annual Meeting
Association of Platelet Endothelial Cell Adhesion Molecule-1 and ß1 Integrin Gene Polymorphisms with Uveitis Development in Ankylosing Spondylitis
Seung-Cheol Shim¹, In-Seol Yoo², Su-Jin Yoo¹, Young Kim¹, Mi-Kyoung Lim³, Dong-Hyuk Sheen⁴ and Jinhyun Kim⁵, ¹Rheumatology, Chungnam National University School of Medicine, Daejeon, South Korea, ²Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ³Medicine, Eulji University Hospital, Daejeon, South Korea, ⁴Rheumatology, Eulji University Hospital, Daejeon, South Korea, ⁵Internal medicine, Chungnam National University School of Medicine, Daejeon, South Korea
Background/Purpose: Genetic factors provide over 90% of the overall susceptibility to ankylosing spondylitis (AS) and recent studies have focused on non-major histocompatibility complex genes. The…
Abstract Number: 1729 • 2015 ACR/ARHP Annual Meeting
Predictors and Clinical Factors Associated with Change in Spinal Inflammation Assessed on MRI over 2 Years: Data from Tasmanian Ankylosing Spondylitis Study
Hussain Ijaz Khan¹, Louisa Chou², Patricia Lewis³, Anitra Wilson³, Janet Millner⁴ and Jane Zochling³, ¹Musculoskeletal Unit, Menzies Institute of Medical Research, Hobart, Australia, ²Menzies Institute of Medical Research, University of Tasmania, Hobart, 7000, Australia, ³Menzies Institute of Medical Research, Hobart, Australia, ⁴Physiotherapy, Royal Hobart Hospital, Hobart, Australia
Background/Purpose: Ankylosing Spondylitis (AS) is debilitating disease affecting the axial skeleton which is often difficult to diagnose in early stages. Magnetic Resonance Imaging (MRI) is…
Abstract Number: 2818 • 2015 ACR/ARHP Annual Meeting
Associations of IL23R, BMP6 and PTGS1 Polymorphisms with Radiographic Severity of Ankylosing Spondylitis
Gulsen Ozen¹, Rabia Deniz², Fatih Eren³, Can Erzik³, Ali Ugur Unal¹, Sibel Z. Aydin⁴, Nevsun Inanc¹, Haner Direskeneli¹ and Pamir Atagunduz¹, ¹Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, ²Marmara University Faculty of Medicine, Istanbul, Turkey, ³Department of Medical Biology, Marmara University Faculty of Medicine, Istanbul, Turkey, ⁴Department of Rheumatology, Koc University Faculty of Medicine, Istanbul, Turkey
Background/Purpose: Ankylosing spondylitis (AS) is an inflammatory disease affecting spine which may lead to new bone formation and disability. However, the radiographic severity of AS…
Abstract Number: 1057 • 2015 ACR/ARHP Annual Meeting
Are Ankylosing Spondylitis, Psoriatic Arthritis and Undifferentiated Spondylarthritis Associated with an Increased Risk of Cardiovascular Disease?
Karin Bengtsson¹, Helena Forsblad-d'Elia², Elisabeth Lie¹, Eva Klingberg¹, Mats Dehlin¹, Sofia Exarchou³, Ulf Lindström¹, Johan Askling⁴ and Lennart TH Jacobsson¹, ¹Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ²Departments of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, ³Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ⁴Clinical Epidemiology Unit and Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden
Background/Purpose: It is unclear whether and to what extent different phenotypes of spondylarthritis (SpA) are associated with an increased risk of cardiovascular events such as…
Abstract Number: 1731 • 2015 ACR/ARHP Annual Meeting
Radiographic Damage of Facet Joints and Vertebral Bodies in the Cervical Spine in Patients with Ankylosing Spondylitis Treated with TNF Inhibitors
Fiona Maas¹, Suzanne Arends¹, Elisabeth Brouwer¹, Eveline van der Veer², Hendrika Bootsma¹, Rizwana Chaudhry¹, Monique Efde³, Freke Wink³ and Anneke Spoorenberg¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ³Rheumatology, Medical Center Leeuwarden, Leeuwarden, Netherlands
Background/Purpose: In ankylosing spondylitis (AS), syndesmophyte formation and ankylosis of the vertebral bodies are characteristic radiographic changes that are evaluated during follow-up. However, the facet…
Abstract Number: 2829 • 2015 ACR/ARHP Annual Meeting
Enhanced Expression of the Transcription Factor T-Bet Alters Pro-Inflammatory Cytokine Profile in Ankylosing Spondylitis
Max C. Lau¹, Patricia Keith¹, Mary-Ellen Costello¹, Linda A. Bradbury¹, Kelly A. Hollis¹, Gethin P. Thomas², Matthew A. Brown^1,3 and Tony J. Kenna¹, ¹The University of Queensland Diamantina Institute, Brisbane, Australia, ²Translational Reserch Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, ³Translational Research Institute, Brisbane, Australia
Background/Purpose: TBX21 encodes T-bet, a T-box transcription factor, and lies within a locus with genome-wide significant association with AS (rs11657479, odds ratio=1.13, P=6.16x10-10). T-bet is…
Abstract Number: 1059 • 2015 ACR/ARHP Annual Meeting
Increased Risk of Atrioventricular Block, Atrial Fibrillation and Pacemaker Implantation in Ankylosing Spondylitis, Undifferentiated Spondylarthritis and Psoriatic Arthritis Compared to the General Population
Karin Bengtsson¹, Helena Forsblad-d'Elia², Elisabeth Lie¹, Eva Klingberg¹, Mats Dehlin¹, Sofia Exarchou³, Ulf Lindström¹, Johan Askling⁴ and Lennart TH Jacobsson¹, ¹Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ²Departments of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden, ³Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ⁴Clinical Epidemiology Unit and Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden
Background/Purpose: There is a known association between conduction disturbances and ankylosing spondylitis (AS). The risk of conduction disturbances in other phenotypes of spondylarthritis (SpA) is…
Abstract Number: 1732 • 2015 ACR/ARHP Annual Meeting
Slow Spinal Radiographic Progression in Patients with Ankylosing Spondylitis Treated with TNF Inhibitors
Fiona Maas¹, Suzanne Arends¹, Ivette Essers², Elisabeth Brouwer¹, Eveline van der Veer³, Freke Wink⁴, Monique Efde⁴, Hendrika Bootsma¹ and Anneke Spoorenberg¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ³Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁴Rheumatology, Medical Center Leeuwarden, Leeuwarden, Netherlands
Background/Purpose: Assessing radiographic progression in ankylosing spondylitis (AS) is challenging. The results regarding the effect of tumor necrosis factor-alpha (TNF-α) blocking therapy on spinal radiographic…
Abstract Number: 2832 • 2015 ACR/ARHP Annual Meeting
Characterization of Leukocyte Subsets in Ankylosing Spondylitis Patients
Yolanda Jiménez Gómez, Chary Lopez-Pedrera, Pilar Font, Patricia Ruiz-Limon, Carlos Perez-Sanchez, Nuria Barbarroja, M. Carmen Castro Villegas, Jerusalem Calvo-Gutierrez, MariCarmen Abalos-Aguilera, Alejandro Escudero-Contreras and Eduardo Collantes-Estevez, IMIBIC-Reina Sofia University Hospital, Rheumatology Unit, Cordoba, Spain
Background/Purpose: AS is a chronic inflammatory disease, of unknown aetiology, characterized by pathological ossification. We aimed: 1) To analyze the profile of inflammation, oxidative status…

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