Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: 2699 • 2016 ACR/ARHP Annual Meeting
Spa-Associated HLA-B*27 Subtypes Accumulate More in Endoplasmic Reticulum (ER) Compartment and in Association with β2-Microglobulin (β2m) Than Non-Associated HLA-B Alleles
Nadège Jah¹, Gilles Chiocchia², Maxime A. Breban³ and Claudine Andre¹, ¹Infection and inflammation, INSERM UMR1173, Montigny-le-Bretonneux, France, ²Infection and Inflammation, INSERM-U1173, University of Versailles Saint-Quentin-en-Yvelines, France, Montigny-le-Bretonneux, France, ³Rheumatology, Ambroise Paré Hospital (AP-HP), Versailles Saint Quentin en Yvelines University, INSERM UMR1173, Boulogne-Billancourt, France
Background/Purpose: Mechanisms underlying the striking association of SpA with the MHC class I molecule HLA-B27 remain poorly understood. SpA-like disease develops spontaneously in B*2705 transgenic…
Abstract Number: 681 • 2016 ACR/ARHP Annual Meeting
Can Bridging Syndesmophytes Independantly Affect Spinal Mobility?
Ismail Sari¹, Ahmed Omar¹, Mansour Alazmi¹, Renise Ayearst², Robert D Inman¹ and Nigil Haroon¹, ¹Rheumatology, Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada, ²Medicine, University Health Network, Toronto, ON, Canada
Background/Purpose: One of the hallmark characteristics of the disease is new bone formation that manifests as syndesmophytes and spinal fusion. Spinal fusion results from bridging…
Abstract Number: 732 • 2016 ACR/ARHP Annual Meeting
Long-Term Effect of TNF Inhibitors on Radiographic Progression in Ankylosing Spondylitis Is Associated with Syndesmophytes at Baseline and Time-Averaged CRP Levels
Maria Konsta^1,2, Grigorios Sakellariou³, Alexios Iliopoulos⁴, PETROS P SFIKAKIS⁵ and I.E. Van der Horst - Bruinsma⁶, ¹Amsterdam Rheumatology and Immunology Center,VUmc and Reade, Amsterdam, Netherlands, ²First Department of Propaedeutic and Internal Medicine, Laikon Hospital, Athens University Medical School, Greece, Athens, Greece, ³Rheumatology, Veterans Administration Hospital, Athens, Greece, ⁴Department of Rheumatology, Veterans Administration Hospital, Athens, Greece, ⁵First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, ⁶GENRA Consortium, Amsterdam, Netherlands
Background/Purpose: Although the radiographic progression in AS is associated with both baseline and time-averaged level of CRP in TNF naïve patients, the effect of level…
Abstract Number: 1660 • 2016 ACR/ARHP Annual Meeting
Role of Immune System Cells and Induction of Netosis-Mediated Cell Death in the Development of Atherosclerosis in Ankylosing Spondylitis
Yolanda Jiménez-Gómez¹, Pilar Font-Ugalde¹, Patricia Ruiz-Limon², Maria Carmen Abalos-Aguilera², M. Carmen Castro-Villegas³, Nuria Barbarroja¹, Carlos Perez-Sanchez¹, Ivan Arias de la Rosa², Isabel Arias², Rafaela Ortega-Castro¹, Jerusalem Calvo-Gutierrez¹, Chary Lopez-Pedrera¹, Alejandro Escudero-Contreras² and Eduardo Collantes-Estévez¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain
Background/Purpose: Ankylosing Spondylitis (AS) is a chronic inflammatory disease associated with the development of atherosclerosis. Our aims were: 1) To evaluate the involvement of immune…
Abstract Number: 2705 • 2016 ACR/ARHP Annual Meeting
Decreased Expression of Autophagy Genes and Their Association with Spinal Damage in Patients with Ankylosing Spondylitis
Min-Chan Park¹, Hye Won Kim², Jason Jungsik Song¹ and Yong-Beom Park¹, ¹Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose: However, a role of autophagy in ankylosing spondylitis has not been clearly elucidated and the association of autophagy-related gene expression levels with inflammatory or…
Abstract Number: 682 • 2016 ACR/ARHP Annual Meeting
Which Is the Most Reliable Imaging Method for Detection of Structural Changes in the Sacroiliac Joints of Patients with Ankylosing Spondylitis? a Cross-Sectional Study Comparing MRI, CT and Conventional Radiographs
Xenofon Baraliakos¹, Florian Hoffmann², Xiaohu Deng³, Yanyan Wang⁴, Feng Huang⁵ and Jürgen Braun², ¹Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Chinese PLA General Hospital, Chinese PLA General Hospital, Beijing, China, ⁴Rheumatology, Chinese PLA General Hospital, Beijing, China, ⁵Chinese PLA General Hospital, Beijing, China
Background/Purpose: Magnetic resonance imaging (MRI) is the gold standard for detection of inflammation and fat metaplasia in the sacroiliac joints (SIJ) and the spine of…
Abstract Number: 734 • 2016 ACR/ARHP Annual Meeting
Lateral Spine BMD Measurement and Trabecular Bone Score Can Represent a Bone Loss in Patients with Advanced Ankylosing Spondylitis
Min Kyung Chung¹, Seo Hwa Kim², Haneul Kim¹, Jung Hee Koh¹, Jennifer Lee³, Seung-Ki Kwok⁴, Sung-Hwan Park⁵ and Ji Hyeon Ju⁵, ¹Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, ²Division of Rheumatology,, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, ³Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ⁴[email protected], Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: It is well known that osteoporosis is paradoxically common in patients with ankylosing spondylitis (AS) in spite of their new bone formation and extraosseous…
Abstract Number: 1662 • 2016 ACR/ARHP Annual Meeting
The Association Between Radiologic Progression and Serum Levels of Potential Markers of Bone Formation in Ankylosing Spondylitis Patients
Ali Erhan Ozdemirel¹, Firas Doghanji², Orhan Kucuksahin³, Duygu Tecer⁴, Sebnem Ataman⁵, Ayse Peyman Yalcin² and huseyin tutkak⁶, ¹Rheumatology Department, Dıskapı Yıldırım Beyazıt Training And Research Hospital, Ankara, Turkey, ²Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey, ³Rheumatology, Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey, ⁴Physical Medicine and Rehabilitation, Division of Rheumatology, Faculty of Medicine, Gazi University, Ankara, Turkey, ⁵Rheumatology Department, Ankara University Faculty of Medicine, Ankara, Turkey, ⁶ankara university immunology, ankara, Turkey
Background/Purpose: The association between inflammation and spinal damage in Ankylosing Spondylitis (AS) remains unclear. Tumor necrosis factor-α (TNF- α) plays pivotal role in inflammatory process…
Abstract Number: 2708 • 2016 ACR/ARHP Annual Meeting
Type 17 Immunity in Spondyloarthritis Is Expanded Across Multiple Lymphocyte Subsets
Davide Simone¹, Hussein Al Mossawi¹, Anna Ridley², Jelle De Wit¹, Takuya Sekine¹, Nuha Ansar¹, Karen Doig¹ and Paul Bowness¹, ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom
Background/Purpose: The spondyloarthritides (SpA) are a group of chronic inflammatory disorders involving the axial spine and the peripheral joints. Genetic, functional and clinical trial evidences…
Abstract Number: 683 • 2016 ACR/ARHP Annual Meeting
Risk Factors of Uveitis in Ankylosing Spondylitis
Feng Wang¹, Qin Xue², Li Sun³ and Niansong Wang⁴, ¹Nephrology and Rheumatology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China, ²Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China, ³Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing, China, ⁴Shanghai Jiao Tong University Affiliated Sixth People's Hospital, shanghai, China
Background/Purpose: Uveitis is the most common extra-articular manifestation in patients with ankylosing spondylitis (AS).The prevalence and characteristics of uveitis in AS have been studied in previous literatures while…
Abstract Number: 735 • 2016 ACR/ARHP Annual Meeting
Impact of Time Since Diagnosis, Age, and Number of Prior Non-Steroidal Anti-Inflammatory Drugs on Response to Adalimumab (HUMIRA) in Patients with Ankylosing Spondylitis
Joachim Sieper¹, Atul A. Deodhar², Maja Hojnik³, Ying Zhang⁴ and Maxime Dougados⁵, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Oregon Health and Science University, Portland, OR, ³AbbVie, Ljubljana, Slovenia, ⁴AbbVie, North Chicago, IL, ⁵René Descartes University and Hôpital Cochin, Paris, France
Background/Purpose: Ankylosing spondylitis (AS) patients (pts) were found to respond better to TNF inhibitors (TNFi) if treated early in the disease course. The objective of…
Abstract Number: 1674 • 2016 ACR/ARHP Annual Meeting
Do TNF Inhibitors Change the Progression of Sacroiliitis?
Deeba Minhas¹, MinJae Lee^2,3, Mohammad H. Rahbar³, Lianne S. Gensler⁴, John D. Reveille⁵ and Michael Weisman¹, ¹Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ²Medicine, University of Texas Health Science Center at Houston, Houston, TX, ³Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, ⁴Medicine/Rheumatology, UCSF, San Francisco, CA, ⁵Rheumatology, University of Texas-McGovern Medical School, Houston, TX
Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory arthritis affecting the sacroiliac (SI) joints and spine causing structural changes seen on clinical radiography. Studies have…
Abstract Number: 2714 • 2016 ACR/ARHP Annual Meeting
Association of Polymorphisms of Activation-Induced Cytidine Deaminase with Ankylosing Spondylitis
Seung Cheol Shim¹, In-Seol Yoo¹, Chan Keol Park¹, Ji-Young Kim¹, Young Mo Kim², Dong-Hyuk Sheen³ and Seok-Rae Park⁴, ¹Division of Rheumatology, Department of Internal Medicine, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Korea, The Republic of, ²Department of Orthopedic Surgery, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Korea, The Republic of, ³Division of Rheumatology, Eulji University, Daejeon, Korea, The Republic of, ⁴Department of Microbiology, College of Medicine, Konyang University, Daejeon, Korea, The Republic of
Background/Purpose: There was a biased repertoire of the immunoglobulin (Ig) heavy chain variable (VH) segment gene in B cells in patients with ankylosing spondylitis (AS).…
Abstract Number: 685 • 2016 ACR/ARHP Annual Meeting
Paradoxical Psoriasis Secondary to Anti-Tnfa Agents in Patients with Ankylosing Spondylitis: A Nationwide Population-Based Cohort Study
Ki-Jo Kim¹, Jung Min Bae², Young Bin Joo³, In-Woon Baek⁴, Kyung-Su Park³ and Chul-Soo Cho⁴, ¹Internal Medicine, St. Vincent’s Hospital, The Catholic University of Korea, Suwon, Korea, The Republic of, ²Dermatology, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea, The Republic of, ³Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Korea, The Republic of, ⁴Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Anti-tumor necrosis factor-alpha (anti-TNFa) agents are established as the mainstay of treatment for ankylosing spondylitis (AS). Recently, paradoxical induction or exacerbation of psoriatic skin…
Abstract Number: 736 • 2016 ACR/ARHP Annual Meeting
A Multi-Center, Open Label, Randomized Clinical Tries of Etanercept and Celecoxib Alone/Combined Treatment in Effectiveness and Safety of Ankylosing Spondylitis
Jieruo Gu¹, Liudan Tu², Minjing Zhao³, Zhiming Lin⁴, Zetao Liao⁵, Shuangyan Cao⁶, Qinghong Yu⁷ and Zhizhong Ye⁸, ¹Rheumatology, Third affiliated hospital of Sun Yat-sen Universtiy, Guangzhou, China, ²The Third Hospital of Sun Yat-sen University, Guangzhou, China, ³The Third Affiliated Hospital of Sun Yat-sen University, guangzhou, China, ⁴Rheumatology, 3rd Affiliated Hospital of Sun Yat-Sen Uni, Guangzhou, China, ⁵Rheumatology, 3rd Affiliated Hoapital of Sun Yat-Sen Uni, Guangzhou, China, ⁶Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ⁷Department of Rheumatology, Fourth People’s Hospital of Shenzhen City, Xiangmi Lake branch, Guangzhou, China, ⁸Department of Rheumatology，ZhuJiang Hospital of Southern Medical University, Guangzhou, China
Background/Purpose: To compare the clinical、radiographic and magnatic resonance imaging change in active ankylosing spondylitis patients with etanercept and celecoxib alone/combined treatment，and to evaluate the effectiveness…

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