Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: 103 • 2015 ACR/ARHP Annual Meeting
Axial Disease in Psoriatic Arthritis: Genetic Biomarkers of Psoriatic Spondyloarthritis
Deepak R. Jadon¹, John Bowes², Anne Barton³, Raj Sengupta¹, Alison L Nightingale⁴, Mark Lindsay⁵, Eleanor Korendowych¹, Graham Robinson⁶ and Neil J. McHugh⁷, ¹Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ²Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Centre for Musculoskeletal Research, Manchester, United Kingdom, ³Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University Of Manchester, Manchester, United Kingdom, ⁴Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, ⁵Pharmacy & Pharmacology, University of Bath, Bath, United Kingdom, ⁶Royal United Hospital, Bath, United Kingdom, ⁷Rheumatology, Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, United Kingdom
Background/Purpose: A lack of well-characterised clinical cohorts has impeded research of the genetics of axial disease in psoriatic arthritis (PsA). We sought to determine genetic…
Abstract Number: 1276 • 2015 ACR/ARHP Annual Meeting
Improvement in Work and Household Productivity for Patients with Rheumatoid Arthritis and Ankylosing Spondylitis Treated with Anti-TNFs in Routine Clinical Practice in Turkey
Sebnem Ataman¹, Mehmet Kirnap², Buminhan Seferoglu³, Zuhal Altay⁴, Aylin Rezvani⁵, Omer Kuru^6,7, Erhan Capkin⁸, Nazli Derya Bugdayci⁹, Ilhan Sezer¹⁰, Hasan Fatih CAY¹¹ and Akinci Tan¹², ¹Rheumatology Department, Ankara University Faculty of Medicine, Ankara, Turkey, ²Department of Physical Medicine and Rehabilitation, Erciyes University, Kayseri, Turkey, ³Physical Medicine and Rehabilitation, Ataturk University Medical School, Erzurum, Turkey, ⁴ELAZIG KARAYOLU UZERI, Inonu University, Turgut Ozal Medical Center, Malatya, Turkey, ⁵Department of Physical Medicine and Rehabilitation, Bezmialem Foundation University, İstanbul, Turkey, ⁶Kurupelit Mevkii Kurupelit 552, Ondokuz Mayis Univ.Tip Fak.Has.-Fizik Tedavi, Samsun, Turkey, ⁷Physical Medicine and Rehabilitation, Ondokuz Mayis University, Samsun, Turkey, ⁸PM&R AND RHEUMATOLOGY, Karadeniz Tecnical University, Faculty of Medicine, TRABZON, Turkey, ⁹Physical Treatment and Rehabilitation, Istanbul Physical Treatment and Rehabilitation Training and Research Hospital, Istanbul, Turkey, ¹⁰Rheumatology, Physical Medicine and Rheabilitation, Antalya Education and Research Hospital, Antalya, Turkey, ¹¹Rheumatology, Physical Medicine&Rehabilitation, Antalya Education and Research Hospital, Antalya, Turkey, ¹²Physical Med & Rehab, Hacettepe Univ, Ankara, Turkey
Background/Purpose: The impact of rheumatoid arthritis (RA) and ankylosing spondylitis (AS) on paid work is measured on the basis of employed people missing time from…
Abstract Number: 1745 • 2015 ACR/ARHP Annual Meeting
Predictors of Sustained Remission on Anti-TNF in an Observational Cohort of Patients with Ankylosing Spondylitis: The Role of MRI Parameters of Inflammation and Structural Damage
Susanne Juhl Pedersen¹, Stephanie Wichuk², Praveena Chiowchanwisawakit³, Zheng Zhao⁴, Sasha Bernatsky⁵, Robert GW Lambert⁶, Barbara Conner-Spady⁷, Don Spady⁸ and Walter Maksymowych⁹, ¹Copenhagen Center for Arthritis Research, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark, ²Department of Medicine, Medicine, University of Alberta, Edmonton, AB, Canada, ³Rheumatology, Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, ⁴Rheumatology, Chinese PLA General Hospital, Beijing, China, ⁵Rheum/Clin. Epid., McGill MUHC/RVH, Montreal, QC, Canada, ⁶Department of Radiology & Diagnostic Imaging, Radiology, University of Alberta, Edmonton, AB, Canada, ⁷Medicine, Medicine, University of Alberta, Edmonton, AB, Canada, ⁸Medicine, University of Alberta, Edmonton, AB, Canada, ⁹Medicine/Rheumatic Dis Unit, Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Sustained clinical remission is one of the key benchmarks for treatment of AS over the long term. We aimed to determine the factors predictive…
Abstract Number: 2877 • 2015 ACR/ARHP Annual Meeting
What Is the Location of Enthesitis in Ankylosing Spondylitis and Psoriatic Arthritis Patients and How Do They Respond to Anti-TNF Treatment?
John Kelsall¹, Denis Choquette², Proton Rahman³, Regan Arendse⁴, Michelle Teo⁵, Isabelle Fortin⁶, J Antonio Avina-Zubieta⁷, Emmanouil Rampakakis^8,9, Eliofotisti Psaradellis⁹, Karina Maslova¹⁰, Brendan Osborne¹¹, Cathy Tkaczyk¹¹, Francois Nantel¹² and Allen J Lehman¹⁰, ¹Mary Pack Arthritis Centre, Vancouver, Vancouver, BC, Canada, ²Rheumatology Department, Institut de Rhumatologie de Montréal and University of Montreal, Montreal, QC, Canada, ³Medicine, Memorial University, St John's, NF, Canada, ⁴University of Saskatchewan, Saskatoon, SK, Canada, ⁵Rheumatology, Penticton Regional Hospital, Penticton, BC, Canada, ⁶Centre de Rhumatologie de l'Est du Québec, Rimouski, QC, Canada, ⁷Arthritis Research Canada, Richmond, BC, Canada, ⁸JSS Medical Research, St-Laurent, QC, Canada, ⁹JSS Medical Research, Montreal, QC, Canada, ¹⁰Janssen Inc., Toronto, ON, Canada, ¹¹Medical Affairs, Janssen Inc., Toronto, ON, Canada, ¹²19 Green belt Dr, Janssen Inc., Toronto, ON, Canada
Background/Purpose: Enthesitis is characterized by inflammation at the insertion of ligaments, tendons, joint capsule, or fascia to bone, and represents a well-known characteristic feature of…
Abstract Number: 354 • 2015 ACR/ARHP Annual Meeting
Association Between Bone and Clinical Parameters in Ankylosing Spondylitis
Vladimira Boyadzhieva¹, Mariana Ivanova², Nikolay Stoilov¹, Rumen Stoilov³, Rasho Rashkov⁴, Didier Hans⁵ and Rozier Berengere⁵, ¹Rheumatology, University Hospital (MHAT) St Ivan Rilski, Sofia, Bulgaria, ²University Hospital "St. Iv. Rilski", Clinic of Rheumatology, Sofia, Bulgaria, ³University Hospital (MHAT) St Ivan Rilski, Sofia, Bulgaria, ⁴Department of Rheumatology, MHAT Sveti Ivan Rilski, Sofia, Bulgaria, ⁵Center of Bone Diseases, Lausanne University Hospital, Lausanne, Switzerland
Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory rheumatological disease of unknown origin that primarily affects the axial skeleton, including the sacroiliac joints and spine,…
Abstract Number: 1629 • 2015 ACR/ARHP Annual Meeting
Non-Interventional Clinical Study Investigating the Use of Golimumab in Patients with Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing Spondylitis in Germany – 3rd Interim Analysis
Matthias H. Thomas¹, Klaus Krüger², Pee Aries³, Martin Bohl-Buehler⁴, Jan Brandt-Juergens⁵, Verena Rickert⁶ and Siegfried Wassenberg⁷, ¹Medical Affairs, MSD Sharp & Dohme GmbH, Bünde, Germany, ²Praxiszentrum St. Bonifatius, München, Germany, ³Rheumatologie im Struenseehaus, Hamburg, Germany, ⁴Friedrich-Ebert-Str. 35, Rheumahaus, Potsdam, Germany, ⁵Praxis Brandt-Juergens/Karberg, Berlin, Germany, ⁶Medical Affairs, MSD Sharp&Dohme GmbH, Haar, Germany, ⁷Fachkrankenhaus, Ratingen, Germany
Background/Purpose: Golimumab (GOL) has shown its efficacy and safety in various randomized clinical trials with accurately selected patients. Data from daily clinical practice in Germany…
Abstract Number: 1747 • 2015 ACR/ARHP Annual Meeting
Predictors of Survival on Anti-TNF in an Observational Cohort of Patients with Ankylosing Spondylitis: The Role of MRI Parameters of Inflammation and Structural Damage
Walter Maksymowych¹, Zheng Zhao², Stephanie Wichuk¹, Praveena Chiowchanwisawakit³, Robert G Lambert⁴, Sasha Bernatsky⁵, Barbara Conner-Spady¹, Donald Spady¹ and Susanne Juhl Pedersen⁶, ¹Medicine, Medicine, University of Alberta, Edmonton, AB, Canada, ²Rheumatology, Chinese PLA General Hospital, Beijing, China, ³Rheumatology, Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, ⁴Radiology, Radiology, University of Alberta, Edmonton, AB, Canada, ⁵Rheum/Clin. Epid., McGill MUHC/RVH, Montreal, QC, Canada, ⁶Copenhagen Center for Arthritis Research, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
Background/Purpose: There has been no data reported evaluating MRI parameters of inflammation and structural damage. We aimed to identify factors influencing survival on anti-TNF therapy…
Abstract Number: 2882 • 2015 ACR/ARHP Annual Meeting
Baseline Extent of Damage at the Spine Predicts Radiographic Progression in Korean Patients Using Golimumab for Ankylosing Spondylitis
Jeong Seok Lee¹, Dae Young Yu², Stephen Xu³ and Eun Young Lee⁴, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul National University Hospital, Seoul, South Korea, ²Medical Affairs, Janssen Korea, Seoul, South Korea, ³Janssen Research & Development, LLC, Spring House, PA, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
Background/Purpose: Ankylosing spondylitis (AS) is a chronic rheumatic disease associated with radiographic damage of the spine. Golimumab had consistent efficacy in controlling disease activity through…
Abstract Number: 591 • 2015 ACR/ARHP Annual Meeting
Rosuvastatin Improves Endothelial Function in Patients with Inflammatory Joint Diseases, Longitudinal Associations with Atherosclerosis and Arteriosclerosis
Eirik Ikdahl¹, Jonny Hisdal², Silvia Rollefstad¹, Inge C Olsen³, Tore K. Kvien⁴, Terje R. Pedersen⁵ and Anne Grete Semb⁶, ¹Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Section of Vascular Investigations, Oslo University Hospital Aker, Oslo, Norway, ³Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁵Department of Preventive Cardiology, Ullevaal University Hospital, Oslo, Norway, ⁶Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Endothelial dysfunction is an early step in the formation of atherosclerotic lesions and can be quantified by the degree of flow mediated vasodilation (FMD)…
Abstract Number: 1686 • 2015 ACR/ARHP Annual Meeting
Body Mass Index Is Associated with Hip Arthritis in Patients with Ankylosing Spondylitis
Hyemin Jeong¹, Jiwon Hwang², Young Hee Eun¹, Eun-Jung Park³, Ji-Min Oh⁴, Hyungjin Kim⁵, Joong Kyong Ahn⁶, Jaejoon Lee¹, Chan Hong Jeon⁷, Eun-mi Koh⁸ and Hoon-Suk Cha⁹, ¹Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ³Department of Medicine, Jeju National University Hospital, Jeju University School of Medicine, Jeju, South Korea, ⁴Anyang SAM Hospital, Anyang, South Korea, ⁵Department of medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁶Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁷Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea, ⁸Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁹Division of Rheumatology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Background/Purpose: To evaluate the clinical courses and associated factors of hip arthritis in patients with ankylosing spondylitis (AS). Methods: In this retrospective analysis, we evaluated…
Abstract Number: 1748 • 2015 ACR/ARHP Annual Meeting
Degenerative Changes at the Lumbar Spine in Patients with Axial Spondyloarthritis and Non-Specific Mechanical Low Back Pain: A Magnetic Resonance Imaging Study
Serkan Senol¹, Gamze Kilic², Sevgi Baspinar², Erkan Kilic³ and Salih Ozgocmen⁴, ¹Division of Neuroradiology, Erciyes University, Faculty of Medicine, Radiology, Kayseri, Turkey, ²Dept. PRM, Erciyes University, Faculty of Medicine,Division of Rheumatology, Kayseri, Turkey, ³Dept PRM, Erciyes University, Faculty of Medicine,Division of Rheumatology, Kayseri, Turkey, ⁴Dept.PRM, Erciyes University, Faculty of Medicine,Division of Rheumatology, Kayseri, Turkey
Background/Purpose: Magnetic resonance imaging (MRI) has become an invaluable tool for early diagnosis of axial spondyloarthritis (axSpA) and several MRI-based studies have identified SpA-related inflammatory…
Abstract Number: 2887 • 2015 ACR/ARHP Annual Meeting
Safety and Tolerability of Secukinumab in Patients with Active Ankylosing Spondylitis: Pooled Safety Analysis of Two Phase 3, Randomized, Controlled Trials
Atul A. Deodhar¹, Dominique Baeten², Joachim Sieper³, Brian Porter⁴, Albert Widmer⁵ and Hanno Richards⁵, ¹Division of Arthritis & Rheumatic Diseases, Oregon Health & Science University, Portland, OR, ²Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³University Clinic Benjamin Franklin, Berlin, Germany, ⁴Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁵Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Secukinumab, an anti–interleukin-17A monoclonal antibody, improved the signs and symptoms of ankylosing spondylitis (AS) in 2 Phase 3, randomized, double-blind, placebo (PBO)-controlled studies, MEASURE…
Abstract Number: 653 • 2015 ACR/ARHP Annual Meeting
Clinical Responses and Improvements in Patient-Reported Outcomes Are Associated with Increased Productivity in the Workplace and at Home in Axial Spondyloarthritis Patients Treated with Certolizumab Pegol
Désirée van der Heijde¹, Juergen Braun², Martin Rudwaleit³, Oana Purcaru⁴ and Arthur Kavanaugh⁵, ¹Leiden University Medical Center, Leiden, Netherlands, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Klinikum Bielefeld, Bielefeld, Germany, ⁴UCB Pharma, Brussels, Belgium, ⁵University of California San Diego, La Jolla, CA
Background/Purpose: Axial spondyloarthritis (axSpA) includes ankylosing spondylitis (AS) and non-radiographic axSpA (nr-axSpA).1 AS significantly affects patient (pt) workplace productivity in both performance and disease-related absenteeism.2…
Abstract Number: 1691 • 2015 ACR/ARHP Annual Meeting
The Presence of Fibromialgia May Influence the Clinimetric Evaluation of Patients with Ankylosing Spondylitis, but Has No Impact on Disease Activity Assessment
Emilio Buschiazzo¹, Natalia Zamora², Fernando Andres Sommerfleck³, Romina Rojas Tessel⁴, Mariana Benegas⁵, Pablo Arturi^6,7, Maria Elena Crespo⁴, Emilce Schneeberger⁸ and Gustavo Citera², ¹Rheumatology, Hospital Sr Del Milagro, Salta, Argentina, ²Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ³Rheumatologia, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ⁴Hospital Sr Del Milagro, Salta, Argentina, ⁵Sanatorio Mitre, Buenos Aires, Argentina, ⁶Rheumatology, Instituto de Rehabilitacion Psicofisica and Fundacion Reumatologica Argentina, Buenos Aires, Argentina, ⁷Rheumatology, Hospital Italiano de La Plata, La Plata, Argentina, ⁸Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina
Background/Purpose: Fibromyalgia (FM) can be present concomitantly in patients with Ankylosing Spondylitis (AS). It may overestimate the evaluation of disease activity, resulting in more intensive…
Abstract Number: 2062 • 2015 ACR/ARHP Annual Meeting
How Reliable Is Self-Evaluation of Symptoms of Inflammatory Back Pain By Patients?
Denis Poddubnyy¹, Inge Spiller¹, Joachim Sieper¹ and Martin Rudwaleit^1,2, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Klinikum Bielefeld, Bielefeld, Germany
Background/Purpose: Inflammatory back pain (IBP) is regarded as an important clinical parameter of axial spondyloarthritis (axSpA) and is often used in a diagnostic approach. Usually…

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