Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: 2458 • 2016 ACR/ARHP Annual Meeting
Erectile Dysfunction in Men with Rheumatic Diseases: A Systematic Review
Omid Zahedi Niaki¹, Christian A. Pineau², Sasha Bernatsky^3,4 and Evelyne Vinet³, ¹Université de Montréal, Montreal, QC, Canada, ²McGill University Health Centre, Montreal, QC, Canada, ³Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ⁴Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Given the obvious female predominance of rheumatic diseases, significant attention has already been drawn to the impact of these conditions on female sexual function.…
Abstract Number: 676 • 2016 ACR/ARHP Annual Meeting
Syndesmophytes in the Thoracic Spine in Ankylosing Spondylitis As Detected By Computed Tomography and Association with Lumbar Radiographic Involvement
Sovira Tan and Michael Ward, NIAMS/NIH, Bethesda, MD
Background/Purpose: Because the thoracic spine has traditionally been excluded from radiographic examinations of spinal damage in ankylosing spondylitis (AS) due to poor visualization, little is…
Abstract Number: 718 • 2016 ACR/ARHP Annual Meeting
Radiographic Progression of Hip Arthritis in Patients with Ankylosing Spondylitis Treated with TNF Inhibitors
Maria Konsta¹, Michael Nurmohamed², J.C. van Denderen³, Ingrid Visman⁴ and I.E. Van der Horst - Bruinsma⁵, ¹Amsterdam Rheumatology and Immunology Center,VUmc and Reade, Amsterdam, Netherlands, ²Rheumatology, Amsterdam Rheumatology and immunology Center | Reade, Amsterdam, Netherlands, ³Center for Rheumatology and Rehabilitation, Jan van Breemen Institute, Amsterdam, Netherlands, ⁴Amsterdam Rheumatology and Immunology Center, VUmc and Reade, Amsterdam, Netherlands, ⁵GENRA Consortium, Amsterdam, Netherlands
Background/Purpose: Although current evidence suggests that anti-TNF treatment may not inhibit spinal radiographic progression, its effect on hip involvement in AS is not known. The…
Abstract Number: 1481 • 2016 ACR/ARHP Annual Meeting
Success Rate of Blood Pressure Goal Achievement in Patients with Inflammatory Joint Diseases
Silvia Rollefstad, Pia Norheim, Eirik Ikdahl and Anne Grete Semb, Preventive Cardio-Rheuma clinic, Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: The excess risk of cardiovascular disease (CVD) in patients with inflammatory joint diseases (IJD) is attributable to several risk factors, including a high prevalence…
Abstract Number: 2695 • 2016 ACR/ARHP Annual Meeting
Genetic Association of Ankylosing Spondylitis with TBX21 Influences T-Bet and Pro-Inflammatory Cytokine Expression in Humans and SKG Mice As a Model of Spondyloarthritis and Alters Host Microbiome and Response to Microbial Stimuli
Max Lau¹, Patricia Keith¹, Madeline McCready¹, Mary-Ellen Costello¹, Linda Bradbury¹, Kelly Holiis¹, Ranjeny Thomas², Gethin P. Thomas³, Matthew A. Brown¹ and Tony J. Kenna¹, ¹Translational Research Institute, Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia, ²Translational Research Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, ³Translational Reserch Institute, The University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose: TBX21 encodes the transcription factor T-bet and is genome-wide significant associated with ankylosing spondylitis (AS). T-bet is implicated in innate and adaptive immunity. However,…
Abstract Number: 677 • 2016 ACR/ARHP Annual Meeting
Low Functional Relevance of Radiographic Spinal Progression in Patients with Early Axial Spondyloarthritis
Denis Poddubnyy¹, Hildrun Haibel¹, Jürgen Braun², Martin Rudwaleit³ and Joachim Sieper¹, ¹Charité Medical University, Berlin, Germany, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany
Background/Purpose: It has been shown in the past that radiographic spinal progression is an important determinant of the functional outcome in patients with advanced axial…
Abstract Number: 724 • 2016 ACR/ARHP Annual Meeting
Diminished Spinal Radiographic Progression during Long-Term Treatment with TNF-α Inhibitors in Ankylosing Spondylitis Patients at Risk of Poor Radiographic Outcome
Fiona Maas¹, Suzanne Arends^1,2, Freke Wink², Reinhard Bos², Hendrika Bootsma³, Elisabeth Brouwer¹ and Anneke Spoorenberg^1,2, ¹Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology, Medical Center Leeuwarden, Leeuwarden, Netherlands, ³Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands, Groningen, Netherlands
Background/Purpose: In AS, spinal radiographic progression shows a very heterogeneous course. Our aim was to investigate which patient characteristics are of influence on the…
Abstract Number: 1517 • 2016 ACR/ARHP Annual Meeting
Does Inflammatory Arthritis Really Improve during Pregnancy? a Systematic Review and Meta-Analysis
Hannah Jethwa¹, Suzanne Lam², Colette Smith³ and Ian Giles⁴, ¹General Medicine, Wexham Park Hospital, London, United Kingdom, ²Croyden University Hospital, London, United Kingdom, ³Statistics, Royal Free Hospital Foundation Trust, London, United Kingdom, ⁴Centre for Rheumatology, University College London, Centre for Rheumatology, University College London, London, United Kingdom
Background/Purpose: Disease activity is considered to improve in approximately 75% of patients with rheumatoid arthritis (RA) during pregnancy. This figure, however, is derived from…
Abstract Number: 2699 • 2016 ACR/ARHP Annual Meeting
Spa-Associated HLA-B*27 Subtypes Accumulate More in Endoplasmic Reticulum (ER) Compartment and in Association with β2-Microglobulin (β2m) Than Non-Associated HLA-B Alleles
Nadège Jah¹, Gilles Chiocchia², Maxime A. Breban³ and Claudine Andre¹, ¹Infection and inflammation, INSERM UMR1173, Montigny-le-Bretonneux, France, ²Infection and Inflammation, INSERM-U1173, University of Versailles Saint-Quentin-en-Yvelines, France, Montigny-le-Bretonneux, France, ³Rheumatology, Ambroise Paré Hospital (AP-HP), Versailles Saint Quentin en Yvelines University, INSERM UMR1173, Boulogne-Billancourt, France
Background/Purpose: Mechanisms underlying the striking association of SpA with the MHC class I molecule HLA-B27 remain poorly understood. SpA-like disease develops spontaneously in B*2705 transgenic…
Abstract Number: 681 • 2016 ACR/ARHP Annual Meeting
Can Bridging Syndesmophytes Independantly Affect Spinal Mobility?
Ismail Sari¹, Ahmed Omar¹, Mansour Alazmi¹, Renise Ayearst², Robert D Inman¹ and Nigil Haroon¹, ¹Rheumatology, Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada, ²Medicine, University Health Network, Toronto, ON, Canada
Background/Purpose: One of the hallmark characteristics of the disease is new bone formation that manifests as syndesmophytes and spinal fusion. Spinal fusion results from bridging…
Abstract Number: 732 • 2016 ACR/ARHP Annual Meeting
Long-Term Effect of TNF Inhibitors on Radiographic Progression in Ankylosing Spondylitis Is Associated with Syndesmophytes at Baseline and Time-Averaged CRP Levels
Maria Konsta^1,2, Grigorios Sakellariou³, Alexios Iliopoulos⁴, PETROS P SFIKAKIS⁵ and I.E. Van der Horst - Bruinsma⁶, ¹Amsterdam Rheumatology and Immunology Center,VUmc and Reade, Amsterdam, Netherlands, ²First Department of Propaedeutic and Internal Medicine, Laikon Hospital, Athens University Medical School, Greece, Athens, Greece, ³Rheumatology, Veterans Administration Hospital, Athens, Greece, ⁴Department of Rheumatology, Veterans Administration Hospital, Athens, Greece, ⁵First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, ⁶GENRA Consortium, Amsterdam, Netherlands
Background/Purpose: Although the radiographic progression in AS is associated with both baseline and time-averaged level of CRP in TNF naïve patients, the effect of level…
Abstract Number: 1660 • 2016 ACR/ARHP Annual Meeting
Role of Immune System Cells and Induction of Netosis-Mediated Cell Death in the Development of Atherosclerosis in Ankylosing Spondylitis
Yolanda Jiménez-Gómez¹, Pilar Font-Ugalde¹, Patricia Ruiz-Limon², Maria Carmen Abalos-Aguilera², M. Carmen Castro-Villegas³, Nuria Barbarroja¹, Carlos Perez-Sanchez¹, Ivan Arias de la Rosa², Isabel Arias², Rafaela Ortega-Castro¹, Jerusalem Calvo-Gutierrez¹, Chary Lopez-Pedrera¹, Alejandro Escudero-Contreras² and Eduardo Collantes-Estévez¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain
Background/Purpose: Ankylosing Spondylitis (AS) is a chronic inflammatory disease associated with the development of atherosclerosis. Our aims were: 1) To evaluate the involvement of immune…
Abstract Number: 2705 • 2016 ACR/ARHP Annual Meeting
Decreased Expression of Autophagy Genes and Their Association with Spinal Damage in Patients with Ankylosing Spondylitis
Min-Chan Park¹, Hye Won Kim², Jason Jungsik Song¹ and Yong-Beom Park¹, ¹Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose: However, a role of autophagy in ankylosing spondylitis has not been clearly elucidated and the association of autophagy-related gene expression levels with inflammatory or…
Abstract Number: 5L • 2015 ACR/ARHP Annual Meeting
Tofacitinib in Patients with Ankylosing Spondylitis: A Phase 2, 16-Week, Randomized, Placebo-Controlled, Dose-Ranging Study
Désirée van der Heijde¹, Atul A Deodhar², James C Wei³, Edit Drescher⁴, Dona Fleishaker⁵, Thijs Hendrikx⁶, David Li⁶, Sujatha Menon⁵ and Keith S Kanik⁵, ¹Dept. of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Division of Arthritis & Rheumatic Diseases, Oregon Health & Science University, Portland, OR, ³Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan, ⁴Csolnoky Ferenc Hospital, Veszprém, Hungary, ⁵Pfizer Inc, Groton, CT, ⁶Pfizer Inc, Collegeville, PA
Background/Purpose: This was the first investigation of the effects of tofacitinib (TOFA) in adult patients (pts) with active ankylosing spondylitis (AS). TOFA is an oral…
Abstract Number: 6L • 2015 ACR/ARHP Annual Meeting
Effect of Interleukin-17A Inhibition on Spinal Radiographic Changes through 2 Years in Patients with Active Ankylosing Spondylitis: Results of a Phase 3 Study with Secukinumab
Xenofon Baraliakos¹, Atul A. Deodhar², Jürgen Braun¹, Dominique Baeten³, Maxime Dougados⁴, Joachim Sieper⁵, Paul Emery⁶, Aimee Readie⁷, Ruvie Martin⁷, Shephard Mpofu⁸ and Hanno Richards⁸, ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Division of Arthritis & Rheumatic Diseases, Oregon Health & Science University, Portland, OR, ³Clinical Immunology and Rheumatology, Academic Medical Center, Amsterdam, Netherlands, ⁴Hospital Cochin, Descartes Univ, Paris, France, ⁵University Hospital Charité, Berlin, Germany, ⁶NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, ⁷Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁸Novartis Pharma AG, Basel, Switzerland
Background/Purpose: In the MEASURE 1 trial (NCT01358175), secukinumab significantly improved the signs and symptoms of patients (pts) with active ankylosing spondylitis (AS) over 52 weeks…

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