ACR Meeting Abstracts

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Abstracts tagged "Animal models"

  • Abstract Number: 865 • 2017 ACR/ARHP Annual Meeting

    Lasp-1 Regulates Cell-Matrix and Cell-Cell Contacts in Arthritic Mouse Models

    Denise Beckmann1, Annika Krause2, Uwe Hansen1, Hans Peter Kiener3, Thomas Kamradt4, Catherine S. Chew5, Thomas Pap2 and Adelheid Korb-Pap1, 1Institute of Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, 2Institute for Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, 3Rheumatology, Medical University of Vienna, Vienna, Austria, 4Institute of Immunology, University Hospital Jena, Jena, Germany, 5Institute of Molecular Medicine and Genetics, Medical College of GA, GA, GA

    Background/Purpose: In rheumatoid arthritis (RA) the attachment of synovial fibroblasts (SF) to articular cartilage is an important prerequisite in the process of cartilage degradation. The…
  • Abstract Number: 1708 • 2017 ACR/ARHP Annual Meeting

    Molecular Imaging Biomarkers for Personalized Medicine Strategies in Systemic Sclerosis-Related Interstitial Lung Disease

    Janine Schniering1, Martina Benesova2,3, Matthias Brunner4, Carol A. Feghali-Bostwick5, Roger Schibli2,3, Oliver Distler6, Cristina Müller2,3 and Britta Maurer6, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland, Zurich, Switzerland, 2Department of Chemistry and Applied Biosciences, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, Zurich, Switzerland, Zurich, Switzerland, 3Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, Villigen-PSI, Switzerland, Villigen PSI, Switzerland, 4Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, Zurich, Switzerland, 5Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC, 6Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: Interstitial lung disease (ILD) is a life-threatening complication in SSc. In recent years, distinct genomic and molecular subtypes in SSc-ILD were identified and molecular…
  • Abstract Number: 2928 • 2017 ACR/ARHP Annual Meeting

    STAT3 As an Important Integrator of Profibrotic Pathways in Systemic Sclerosis

    Debomita Chakraborty1, Barbora Šumová2, Tatjana Mallano3, Chih-Wei Chen3, Alfiya Distler3, Christina Bergmann3, Andreas Ramming4, Oliver Distler5, Georg Schett3, Ladislav Senolt6 and Jörg Distler3, 1Department of Internal Medicine 3- Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, 2Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, 3Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, 4Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, 5Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 6Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic

    Background/Purpose: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates key cellular processes such as proliferation, apoptosis, invasion, angiogenesis, metastasis…
  • Abstract Number: 61 • 2017 ACR/ARHP Annual Meeting

    Resolution of Systemic Joint Inflammatory Processes and Regeneration of Existing Bone Damage upon TNF Blockade As Monitored By In Vivo Multimodal PET-CT Imaging in Progressed Experimental Arthritis

    Silvia Hayer1, Markus Zeilinger2,3, Volker Weiss3,4, Markus Seibt5, Birgit Niederreiter1, Tetyana Shvets6, Monika Dumanic6, Florian Pichler6, Marcus Hacker6, Josef S. Smolen7, Kurt Redlich8 and Markus Mitterhauser6, 1Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 2Faulty of Engineering, University of Applied Sciences, Winer Neustadt, Austria, 3Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 4Faculty of Engineering, University of Applied Sciences, Wiener Neustadt, Austria, 5Department Internal Medicine III, Division Rheumatology, Medical University of Vienna, Vienna, Austria, 6Medical University of Vienna, Vienna, Austria, 7Medical University Vienna, Division of Rheumatology, Department of Internal Medicine III, Vienna, Austria, 8Division of Rheumatology, Medical University of Vienna, Vienna, Austria

    Background/Purpose: To use in vivo multimodal [18F]FDG (fluoro-D-glucose, tracer for inflammation) and [18F]Sodium Fluoride (bone tracer) positron emission tomography/computed tomography (PET-CT) imaging for the monitoring…
  • Abstract Number: 904 • 2017 ACR/ARHP Annual Meeting

    Deficient Autophagy Induces Lamin a/C Accumulation in Aging and Osteoarthritis

    Paloma Lopez de Figueroa1, Uxia Nogueira-Recalde2, Fernando Osorio3, Martin Lotz4, Carlos Lopez-Otin3, Francisco J Blanco2 and Beatriz Carames1, 1Cartilage Biology Group. Rheumatology Division, INIBIC-CHUAC, A Coruña, Spain, A Coruña, Spain, 2Cartilage Biology Group. Rheumatology Division, INIBIC-CHUAC, A Coruña, A Coruña, Spain, 3Degradome Lab, Universidad de Oviedo, Oviedo, Spain, 4Department of Molecular & Experience Medicine, Scripps Research Institute, LaJolla, CA

    Background/Purpose: Autophagy, an essential chondrocyte homeostasis mechanism, is defective in Aging and Osteoarthritis (OA). However, the targets regulating this mechanism are still unknown. Here, we…
  • Abstract Number: 1720 • 2017 ACR/ARHP Annual Meeting

    TGF-ß-Induced Tissue Fibrosis in TBRIcaCol1Cre Transgenic Mice Is Abrogated By the Second Generation Tyrosine Kinase Inhibitor SKI-606 (Bosutinib)

    Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA

    Background/Purpose: Bosutinib (SKI-606), a second-generation tyrosine kinase inhibitor that blocks the activity of the BCR-ABL kinase responsible for Philadelphia chromosome positive chronic myeloid leukemias, also…
  • Abstract Number: 69 • 2017 ACR/ARHP Annual Meeting

    The Effect of Myostatin Inhibition on Bone Loss in Murine Osteoporosis Models

    Tomoyuki Mukai1, Takafumi Mito1, Shunichi Fujita1, Shoko Kodama1, Akiko Nagasu1, Teruki Sone2, Shinichiro Nishimatsu3, Yutaka Ohsawa4, Yoshihide Sunada4 and Yoshitaka Morita1, 1Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan, 2Department of Nuclear Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan, 3Department of Natural Sciences, Kawasaki Medical School, Kurashiki, Okayama, Japan, 4Department of Neurology, Kawasaki Medical School, Kurashiki, Okayama, Japan

    Background/Purpose: Myostatin, also called as growth differentiation factor-8 (GDF-8), is a secreted member of TGF-β superfamily. Myostatin is a negative regulator of skeletal muscle mass…
  • Abstract Number: 1062 • 2017 ACR/ARHP Annual Meeting

    Ptpn22 Regulates Synovial Slam Family Receptor Expression during Toll-like Receptor-Driven Suppression of Inflammatory Arthritis

    David Ewart1, Juan Abrahante Lloréns2 and Erik J. Peterson3, 1Rheumatology, University of Minnesota, Minneapolis, MN, 2Informatics Institute (UMII), University of Minnesota, Minneapolis, MN, 3Center for Immunology/Department of Medicine, University of Minnesota, Minneapolis, MN

    Background/Purpose: Genetic factors contribute strongly to Rheumatoid arthritis (RA) risk. Protein tyrosine phosphatase non-receptor 22 [PTPN22] encodes the hematopoietic-specific Lymphoid Phosphatase [“Lyp”].  A PTPN22 coding…
  • Abstract Number: 1742 • 2017 ACR/ARHP Annual Meeting

    Involvement of T Helper 17 Cells in Inflammatory Arthritis Depends on the Host Intestinal Microbiota

    Heather Evans-Marin1, Rebecca Rogier2, Jose U. Scher3, Debbie M. Roeleveld2, Marije I. Koenders4 and Shahla Abdollahi-Roodsaz5,6, 1Division of Rheumatology, New York University School of Medicine, New York, NY, 2Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, 3New York University School of Medicine, New York, NY, 4Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 5Department of Medicine, Division of Rheumatoogy, New York University School of Medicine, New York, NY, 6Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands

    Background/Purpose: The intestinal microbiota has been associated with psoriatic and rheumatoid arthritis. One of the major effects of microbiota is the induction of mucosal T…
  • Abstract Number: 392 • 2017 ACR/ARHP Annual Meeting

    Effects of Synthetic Dmards on the Insulin Resistance and Obesity Associated with Rheumatoid Arthritis: An Obese Mouse Model of Arthritis

    Nuria Barbarroja1, Ivan Arias de la Rosa2, Miriam Ruiz-Ponce1, Sergio Rodriguez-Cuenca3, Maria Carmen Abalos-Aguilera2, Yolanda Jiménez-Gómez1, Patricia Ruiz-Limon2, Carlos Perez-Sanchez1, Eduardo Collantes-Estévez1, Antonio Vidal-Puig3, Alejandro Escudero-Contreras2 and Chary Lopez-Pedrera1, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbroke’s Hospital, University of Cambridge, Cambridge, United Kingdom

    Background/Purpose: Numerous studies have demonstrated the closely association between rheumatoid arthritis (RA) and metabolic complications such as obesity and insulin resistance (IR). Thus, there is…
  • Abstract Number: 1074 • 2017 ACR/ARHP Annual Meeting

    High Cholesterol Levels By ApoE Defenciency Reduce Bone Destruction in Murine Antigen-Induced Arthritis Via Inhibition of Osteoclastogenesis

    Giuliana Ascone1, Irene Di Ceglie1, Arjen B. Blom1, Birgitte Walgreen2, Annet W. Sloetjes1, Peter M. van der Kraan1, Ernst Lindhout3, Mike Martens3 and Peter L. van Lent4, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Experimental, Radboud university medical center, Nijmegen, Netherlands, 3Future Diagnostics Solutions (FDs), Wijchen, Netherlands, 4Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by immune complex- deposition in the synovium, leading to increased bone destruction. In RA, joint…
  • Abstract Number: 1793 • 2017 ACR/ARHP Annual Meeting

    Interleukin-17 Is Not a Determinant for the Pro- or Anti-Inflammatory Character of Interleukin-22 in Experimental Arthritis

    Debbie M. Roeleveld1, Loreto Parga Vidal2, Monique M. Helsen2, Birgitte Walgreen3, Bianka Marklein4, Karl Skriner5, Martin Hegen6, Peter L. van Lent2, Fons A.J. van de Loo2, Wim B. van den Berg2, Peter M. van der Kraan2 and Marije I. Koenders2, 1Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, 2Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 3Experimental, Radboud university medical center, Nijmegen, Netherlands, 4Humboldt University and Free University, Berlin, Germany, 5Department of Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Free University and Humboldt University Berlin, Berlin, Germany, 6Inflammation and Immunology Research Unit, Pfizer, Cambridge, MA

    Background/Purpose: High interleukin-22 (IL-22) levels are detected in serum and synovial fluid of rheumatoid arthritis (RA) patients and have been shown to positively correlate with…
  • Abstract Number: 393 • 2017 ACR/ARHP Annual Meeting

    The Role of Follicular Helper 17 T Cells in Glucose-6-Phosphate Isomerase Induced Arthritis

    Izumi Kurata, Isao Matsumoto, Atsumu Osada, Hiroshi Ebe, Hoshimi Kawaguchi, Yuya Kondo, Hiroto Tsuboi and Takayuki Sumida, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Background/Purpose: Follicular helper T (Tfh) cell is a novel T cell subset which promotes follicular B cell activation, differentiation to plasma cell and antibody production.…
  • Abstract Number: 1319 • 2017 ACR/ARHP Annual Meeting

    TAS05567 Is a Novel Potent and Selective Spleen Tyrosine Kinase Inhibitor That Attenuates Disease Severity in Animal Models of Autoimmune Diseases

    Hiroaki Hayashi, Ryuusuke Kaneko, Manabu Tayama, Shunsuke Demizu, Daichi Akasaka, Hiroki Irie, Aki Kawagishi, Yoshio Ogino, Teruhiro Utsugi, Eiji Sasaki and Yoshikazu Iwasawa, TAIHO PHARMACEUTICAL CO., LTD., Tsukuba, Japan

    Background/Purpose: Spleen tyrosine kinase (Syk) is a non-receptor cytoplasmic tyrosine kinase. B-cell receptor (BCR) and Fc receptor-mediated syk signaling pathways lead to activation of several…
  • Abstract Number: 1794 • 2017 ACR/ARHP Annual Meeting

    Overexpression of Interleuk-22 Induces Expression of the Negative Immune-Regulator SOCS3 and Potently Reduces Collagen-Induced Arthritis in Mice

    Debbie M. Roeleveld1, Monique M. Helsen2, Birgitte Walgreen3, Elly Vitters2, Fons A.J. van de Loo2, Peter L. van Lent2, Wim B. van den Berg2, Peter M. van der Kraan2 and Marije I. Koenders2, 1Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, 2Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 3Experimental, Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose: High interleukin-22 (IL-22) levels are detected in serum and synovial fluid of rheumatoid arthritis (RA) patients and have been shown to positively correlate with…
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