Abstracts tagged "Animal models"

Abstract Number: 607 • 2014 ACR/ARHP Annual Meeting
The HLA-B27 Peptidome in Vivo in Transgenic Rats
Joel D. Taurog¹, Yael Haimovich², Eilon Barnea³, Michal Bassani-Sternberg³, Shira Yair-Sabag², Martha L. Dorris¹, Nimman Satumtira¹, Mylinh Nguyen⁴, Robert E. Hammer⁴, Tri M. Tran⁵, Robert A. Colbert⁵ and Arie Admon³, ¹Internal Medicine, Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, ²Technion-Israel Institute of Technology, Haifa, Israel, ³Biology, Technion-Israel Institute of Technology, Haifa, Israel, ⁴Biochemistry, UT Southwestern Medical Center, Dallas, TX, ⁵NIAMS/NIH, Bethesda, MD
Background/Purpose . In all current hypotheses for the association of B27 with SpA, the B27 peptide repertoire (peptidome) is likely to play a key role.…
Abstract Number: 2344 • 2014 ACR/ARHP Annual Meeting
Amelioration of Collagen-Induced Arthritis By Water-Soluble Fullerene C60(OH)₃₆ Nanoparticles through the Inhibition of Angiogenesis
Chia-Tse Weng^1,2, Shih-Yao Chen³, Yu-Hung Chen⁴, Chao-Liang Wu³, Ming-Fei Liu^1,2, Ai-Li Shiau⁵ and Chrong-Reen Wang^1,2, ¹Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, ²Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, ³Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan, ⁴Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, ⁵Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan
Background/Purpose Our previous study has shown that injection of 13-nm gold nanoparticles ameliorates collagen-induced arthritis (CIA) through the inhibition of angiogenesis by binding to VEGF.…
Abstract Number: 935 • 2014 ACR/ARHP Annual Meeting
Targeting Glycolysis in Rheumatoid Arthritis
Monica Guma¹, Alessia Lodi², Ajit Divakaruni³, Anne Murphy³, Stefano Tiziani⁴ and Gary S. Firestein⁵, ¹Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ²nutritional Sciences, University of Texas at Austin, Austin, TX, ³Pharmacology, University of California, San Diego, La Jolla, CA, ⁴Nutritional Sciences, University of Texas at Austin, Austin, TX, ⁵Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: Many of the signaling pathways activated in inflammation have a profound effect on cell metabolism. However, little is known about metabolome in rheumatoid arthritis…
Abstract Number: 346 • 2014 ACR/ARHP Annual Meeting
Treatment of Collagen Induced Artritis with Human Embrionic Stem Cell-Derived Multipotent Mesenchymal Stromal Cells (hESC-MSC)
Gabriel Criado¹, María J. Pérez-Lorenzo¹, María Galindo², Jose L. Pablos², Pablo Menéndez³ and Elena Gonzalo-Gil⁴, ¹Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ²Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ³Josep Carreras Leukemia Research Insitute, Barcelona, Spain, ⁴Grupo de Investigación en Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain
Background/Purpose Inhibition of TGFβ signaling in human Embryonic Stem Cells (hESC) generates mesenchymal stromal cells (hESC-MSC) with osteogenic, adipogenic and chondrogenic potential. These cells have…
Abstract Number: 2347 • 2014 ACR/ARHP Annual Meeting
Therapeutic Effect of a Novel Histone Deacetylase 6 Inhibitor, CKD-L, on Collagen Induced Arthritis and Peripheral Blood Mononuclear Cells from Patients with Rheumatoid Arthritis
Bo Ram Oh¹, Hyojin Lim², Daekwon Bae², Nina Ha², Young il Choi², Hyun Jung Yoo^3,4, Jin Kyun Park³, Eun Young Lee⁵, Eun Bong Lee³ and Yeong Wook Song^3,4, ¹Division of Rheumatology, Department of Molecular Medicine and Biophamaceutical Sciences, BK 21 plus Graduate School of Convergence Science Technology, Colleage of Medicine, Seoul National University, Seoul, South Korea, ²Department of Pharmacology and Toxicology, CKD Research Institute, CKD Pharmaceutical Company, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ⁴Department of Molecular Medicine and Biophamaceutical Sciences, BK 21 plus Graduate School of Convergence Science Technology, Colleage of Medicine, Seoul National University, Seoul, South Korea, ⁵Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose Epigenetic regulation plays an important role in inflammatory arthritis, including rheumatoid arthritis (RA). Histone deacetylase inhibitor (HDACi) has been recently reported to have therapeutic…
Abstract Number: 934 • 2014 ACR/ARHP Annual Meeting
Amelioration of Inflammatory Arthritis By Anti-TNF Therapy Is Associated with Restoration of Lymphatic Contraction
Echoe M. Bouta¹, Igor Kuzin², Karen de Mesy-Bentley¹, Ronald Wood³, Homaira Rahimi⁴, Rui-Cheng Ji⁵, Christopher T. Ritchlin⁶, Andrea Bottaro², Lianping Xing⁷ and Edward M. Schwarz⁸, ¹University of Rochester, Rochester, NY, ²Cooper Medical School, Camden, NJ, ³Department of Urology, University of Rochester Medical Center, Rochester, NY, ⁴Rheumatology, University of Rochester/Golisano Children's Hospit, Rochester, NY, ⁵Department of Anatomy, Biology and Medicine, Oita University, Oita, Japan, ⁶Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁷Pathology & Lab Medicine, University of Rochester, Rochester, NY, ⁸Center for Musculoskeletal Research, University of Rochester, Rochester, NY
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with episodic flares. In tumor necrosis factor transgenic (TNF-Tg) mice, a model of inflammatory-erosive arthritis,…
Abstract Number: 344 • 2014 ACR/ARHP Annual Meeting
Reduced Macrophages in the Synovium Contribute to the Effective Treatment of Spontanneous Arthritis Observeded in Human TNF-Transgenic Mice
Robert Birkett¹, Qi Quan Huang¹, Bo Shi² and Richard Pope³, ¹Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ²Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ³Medicine/Rheumatology Div, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose Macrophages in rheumatoid arthritis (RA) synovial tissue (ST) produce high levels of inflammatory cytokines/chemokines and exhibit enhanced differentiation into osteoclasts in the pannus, playing…
Abstract Number: 3004 • 2014 ACR/ARHP Annual Meeting
Autoantibody-Mediated Raynaud’s Phenomenon: Animal Model and Human Disease
Dana P. Ascherman^1,2, Yunjuan Zang³, Laisel Martinez⁴, Judith Pignac-Kobinger⁵, Irina Fernandez³ and Eric L. Greidinger^3,4, ¹Medicine/Rheumatology, University of Miami, Miami, FL, ²Rheumatology, Miami VAMC, Miami, FL, ³Rheumatology, University of Miami, Miami, FL, ⁴Miami VAMC, Miami, FL, ⁵University of Miami, Miami, FL
Background/Purpose: Raynaud’s Phenomenon (RP) is frequently seen in autoimmune conditions, but an autoimmune basis for RP has not been established. Methods: Sera derived from anti-RNP+…
Abstract Number: 2351 • 2014 ACR/ARHP Annual Meeting
Ligand of Glucocorticoid-Induced Tumor Necrosis Factor Receptor Enhances Th17 Cells Response in Collagen-Induced Arthritis Via P38 MAPK and STAT3 Pathway
Xinyi Tang¹ and Shengjun Wang², ¹Department of Laboratory Medicine, Jiangsu University Affi�liated People’s Hospital, Zhenjiang, China, ²Department of Laboratory Medicine, Jiangsu University Affiliated People’s Hospital, Zhenjiang, China
Background/Purpose Helper T lymphocyte-17 (Th17) has recognized to be an important factor in rheumatoid arthritis (RA) pathogenesis. The natural ligand of glucocorticoid-induced tumor necrosis factor…
Abstract Number: 856 • 2014 ACR/ARHP Annual Meeting
A Pathogenic Role for the Gut Microbiota in Murine Antiphospholipid Syndrome and Lupus
Silvio M. Vieira¹, Andrew Yu¹, Michael Hiltesperger¹, Odelya E. Pagovich¹, Eleni Tiniakou¹, William Ruff², John Sterpka¹ and Martin Kriegel^2,3, ¹Yale School of Medicine, New Haven, CT, ²Immunobiology, Yale School of Medicine, New Haven, CT, ³Medicine, Section of Rheumatology, Yale School of Medicine, New Haven, CT
Background/Purpose: The etiology of lupus-associated antiphospholipid syndrome (APS) is unknown but microbial triggers have been implicated in transient antiphospholipid antibody production in both mice and…
Abstract Number: 343 • 2014 ACR/ARHP Annual Meeting
The Caspase 8/RIPK3 Signaling Axis Has Opposing Roles in Myeloid and Dendritic Cells during Progression of a Murine Model of Acute Inflammatory Arthritis
Carla M. Cuda¹, Alexander Misharin², George Kenneth Haines III³ and Harris R. Perlman⁴, ¹Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Northwestern University, Chicago, IL, ³Pathology, The Mount Sinai Hospital, New York, NY, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose Rheumatoid arthritis (RA) manifests in persistent synovial inflammation, cellular infiltration and pro-inflammatory cytokine production, and results in progressive joint destruction. Both myeloid cells and…
Abstract Number: 3005 • 2014 ACR/ARHP Annual Meeting
Essential Role for Alternately Spliced Tenascin C and TLR4 Signaling in Persistent Organ Fibrosis
Swati Bhattacharyya^1,2, Wenxia Wang¹, Luisa Morales-Nebreda³, Katja Lakota³, Robert Lafyatis⁴, Monique E. Hinchcliff⁵, GR Scott Budinger³, Zenshiro Tamaki³ and John Varga⁶, ¹Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁴Rheumatology, Boston University School of Medicine, Boston, MA, ⁵Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁶Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose Transforming growth factor-beta stimulates collagen synthesis and myofibroblast differentiation, and is implicated as a key initiating factor in pathological tissue remodeling in scleroderma. However,…
Abstract Number: 2169 • 2014 ACR/ARHP Annual Meeting
Targeting ITGAM+ Cells Successfully Treats a Model of Anti-RNP-Associated Pulmonary Hypertension
Vineet Gupta¹, Yunjuan Zang², Karen Young³, Jian Huang³, Irina Fernandez² and Eric L. Greidinger^2,4, ¹Drug Discovery Center, Rush University Medical Center, Chicago, IL, ²Rheumatology, University of Miami, Miami, FL, ³Pediatrics, University of Miami, Miami, FL, ⁴Miami VAMC, Miami, FL
Background/Purpose: Aggressive immunotherapy has shown modest effectiveness for pulmonary hypertension in anti-RNP Autoimmunity, but with high morbidity. We studied the ability of an ITGAM-targeted therapy…
Abstract Number: 774 • 2014 ACR/ARHP Annual Meeting
Endothelin-1 Synergistically Increases TGF-β-Induced Hif1α Expression Under Normoxic Conditions during Endothelial-to-Mesenchymal Transition in Murine Endothelial Cells. a Novel Mechanism for the Fibrogenic Effects of Endothelin
Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Tissue hypoxia is a consequence of vascular damage and Hif-1α accumulation is a major mechanism of hypoxia response pathways. HIF-1α induces the transcriptional upregulation…
Abstract Number: 328 • 2014 ACR/ARHP Annual Meeting
Etanercept, Abatacept and Anakinra Treatment Ameliorates Inflammation and Pain in a Novel Mono-Arthritic Multi-Flare Model of Streptococcal Cell Wall Induced Arthritis: Further Characterization in a Rodent Model of Collagen Induced Arthritis
Kalyan Chakravarthy¹, Robert Faltus¹, Anwar Murtaza¹ and Milenko Cicmil², ¹Pharmacology, Merck Research Laboratories, Boston, MA, ²Merck Research Laboratories, Boston, MA
Background/Purpose: We developed a novel mono-arthritic multi-flare Rat Streptococcal Cell Wall (SCW) model which captures certain aspects of disease with flares and remission of inflammation…

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