Abstract Number: 656 • 2014 ACR/ARHP Annual Meeting
Breach of B Cell Tolerance in New Zealand Black Chromosome 1 Congenic Mice
Background/Purpose: Mapping studies in the lupus-prone New Zealand Black (NZB) mouse strain identified an interval from 170.8-181 Mb on chromosome 1 sufficient to induce B…Abstract Number: 2798 • 2014 ACR/ARHP Annual Meeting
C5orf30 a Novel Regulator of Inflammation and Tissue Damage in Rheumatoid Arthritis
Background/Purpose A recent genome wide association study identified the variant rs26232 in the first intron of the uncharacterized gene, C5orf30, as a rheumatoid arthritis (RA)…Abstract Number: 1004 • 2014 ACR/ARHP Annual Meeting
Elevated Levels of BMP2 Compensate for Loss of TGF-Beta in Articular Cartilage during Experimental Osteoarthritis
Background/Purpose: We have demonstrated that TGF-beta signaling via Smad2/3 is drastically reduced in articular cartilage (AC) with age and loss of Smad2/3-signaling predisposed AC for…Abstract Number: 655 • 2014 ACR/ARHP Annual Meeting
Hydroxycholorquine Is Cardioprotective in an In Vivo Rat Model of Myocardial Ischaemic Reperfusion Injury
Background/Purpose A significant amount of myocardial damage during a myocardial infarction (MI) occurs during the reperfusion stage which is known as ischaemic reperfusion (I/R) injury…Abstract Number: 2793 • 2014 ACR/ARHP Annual Meeting
BMP2 Requires TGF-Beta to Induce Osteophytes during Experimental Osteoarthritis
Background/Purpose: Osteophytes are a major hallmark of osteoarthritis (OA). Both TGF-beta and BMP2 can induce osteophytes in murine knee joints. We demonstrated that TGF-beta could…Abstract Number: 998 • 2014 ACR/ARHP Annual Meeting
β2 Adrenoceptor Signal Is Augmented in B Cells in the Course of Arthritis to Increase IL-10
Background/Purpose Splenic B cells from collagen-induced arthritis (CIA) mice react to a β2-adrenoceptor (AR) stimulus with increased IL-10 production and adoptive transfer of these cells…Abstract Number: 652 • 2014 ACR/ARHP Annual Meeting
Identification of Eat-2 As a Lupus Susceptibility Gene in New Zealand Black (NZB) Mice That Regulates Dendritic Cell Function
Background/Purpose: We have previously shown that B6 mice with an introgressed homozygous NZB chromosome (c) 1 interval (70 to 100 cM) develop high titres of…Abstract Number: 2353 • 2014 ACR/ARHP Annual Meeting
The Nitric Oxide Receptor Soluble Guanylyl Cyclase Is Found in Lymphatic Vessels of Arthritic Mice and Inhibition Alters Lymphatic Pulse
Background/Purpose: Rheumatoid arthritis (RA) is a chronic erosive inflammatory condition that is characterized by episodes of “flare” due to synovitis of an affected joint. It…Abstract Number: 922 • 2014 ACR/ARHP Annual Meeting
A Potential Role for TLR4 Activation in Osteoarthritis Associated Pain
Background/Purpose - Damage associated molecular patterns (DAMPs) result from cellular stress and extracellular matrix breakdown. They may contribute to osteoarthritis (OA) pathogenesis by promoting synovitis…Abstract Number: 648 • 2014 ACR/ARHP Annual Meeting
Influenza A (H1N1) Virus Infection Triggers Severe Pulmonary Inflammation in Lupus-Prone Mice Following Viral Clearance
Background/Purpose: Each year, up to one fifth of the United States population is infected with influenza virus. Although mortality rates are low, hundreds of thousands…Abstract Number: 2356 • 2014 ACR/ARHP Annual Meeting
Toluenesulfonylamido-Chalcone, 4-(p-toluenesulfonylamido)-4-Hydroxychalcone (TSAHC) Suppresses Inflammatory Response and Joint Destruction in an Experimental Arthritic Mice and Fibroblast-like Synoviocytes
Background/Purpose TSAHC, a toluenesulfonylamido-chalcone, 4-(p-toluenesulfonylamido)-4-hydroxychalcone is a compound to block proliferation and metastatic potential of cancer cells. Fibroblast-like synoviocytes of rheumatoid arthritis (RA-FLS) have inflammatory…Abstract Number: 938 • 2014 ACR/ARHP Annual Meeting
C1q Is Mandatory for Disease Development in Experimental Arthritis and Expression of Its Receptors Correlates with Disease Activity in Patients
Background/Purpose The complement system is a major effector mechanism of innate and adaptive immunity. It is activated in rheumatoid arthritis (RA) patients but the pathway…Abstract Number: 659 • 2014 ACR/ARHP Annual Meeting
Breakdown of Tolerance at the Tissue Level in Systemic Autoimmunity: Role of Tissue-Resident Dendritic Cells
Background/Purpose Systemic autoimmune diseases such as lupus affect multiple organs including skin and kidneys, usually in a diverse fashion where only certain organs are affected…Abstract Number: 2357 • 2014 ACR/ARHP Annual Meeting
Vascular Adhesion Molecule-1 Overexpression in Collagen-Induced Arthritis: Modeling Vascular Dysfunction in Rheumatoid Arthritis
Vascular adhesion molecule-1 Overexpression in collagen-induced arthritis: modeling vascular dysfunctionS in rheumatoid arthritis Background/Purpose: Rheumatoid Arthritis (RA) patients are at risk of developing primary coronary…Abstract Number: 936 • 2014 ACR/ARHP Annual Meeting
Active Invasion of Periodontal Bacteria into Synovial Joint Exacerbates Collagen-Induced Arthritis in Disease-Prone B10 Riii Mice
Background/Purpose: Periodontitis (PD) is a chronic immunoinflammatory disease caused by complex subgingival periodontal bacteria. Rheumatoid Arthritis (RA) and PD both are chronic inflammatory disorders characterized…
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