Abstracts tagged "Animal models"

Abstract Number: 3190 • 2015 ACR/ARHP Annual Meeting
Netrin-1 and Its Receptor Unc5b Are Novel Targets for the Treatment of Inflammatory Arthritis
Aranzazu Mediero¹, Tuere Wilder² and Bruce Cronstein³, ¹Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, ²Dept of Med, Div of Rheum, NYU School of Medicine, New York, NY, ³Medicine, Division of Rheumatology, NYU School of Medicine, NEW YORK, NY
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation and destruction of the joints and some extra-articular tissues. Netrin-1 is a laminin-like…
Abstract Number: 1034 • 2015 ACR/ARHP Annual Meeting
Immunomodulation By a Second-Generation Peptidyl Arginine Deiminase Inhibitor Abrogates Collagen-Induced Arthritis in a Therapeutic Protocol
Anne-Marie Quirke¹, Joanna Kawalkowska², Fatemeh Ghari³, Venkataraman Subramaniam⁴, Paul Thompson⁵, Richard O. Williams¹, Nick La Thangue³ and Patrick J. Venables¹, ¹Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, ²Kennedy Institute for Rheumatology, University of Oxford, Oxford, United Kingdom, ³Department of Oncology, University of Oxford, Oxford, United Kingdom, ⁴Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, MA, ⁵University of Massachusetts, Worcester, MA
Background/Purpose: Citrullination is a post translational modification of arginine catalysed by peptidyl arginine deiminases (PADs) and may be important in generating pathogenic autoantibodies to citrullinated…
Abstract Number: 2555 • 2015 ACR/ARHP Annual Meeting
14-3-3η As a Novel RA Drug Target: Anti-14-3-3η Monoclonal Antibody Delays the Onset and Mitigates the Severity of Arthritis in CIA Mice
Abedelnasser Abulrob¹, Mario Mercier¹, Slavisa Corluka¹, Roger MacKenzie¹, Shalini Raphael¹, Sara Michienzi², Jane Savill², Yuan Gui², Walter Maksymowych³ and Anthony Marotta², ¹National Research Council of Canada, Ottawa, ON, Canada, ²Augurex Life Sciences Corp., Vancouver, BC, Canada, ³Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: As an extracellular ligand, 14-3-3η potently and concentration-dependently upregulates the expression of multiple factors including TNFα, IL-6, and RANKL and its clinical detection is…
Abstract Number: 3191 • 2015 ACR/ARHP Annual Meeting
Siglec9 Suppresses Arthritis in Collagen-Induced Mice Model and Inhibits M1 Activation of RAW264.7 Macrophages
Takuya Matsumoto¹, Nobunori Takahashi¹, Toshihisa Kojima¹ and Naoki Ishiguro², ¹Department of Orthopedic Surgery, Nagoya University Hospital, Nagoya, Japan, ²Department of Orthopedic Suregery, Nagoya University Hospital, Nagoya, Japan
Background/Purpose: Siglecs (Sialic acid-binding immunoglobulin-type lectins) are type1 transmembrane proteins and expressed on cell surface of various immunocytes. Siglec9 is a member of CD33 related…
Abstract Number: 1053 • 2015 ACR/ARHP Annual Meeting
Phosphatidylinositol-3-Kinase Delta Pathway a Novel Therapeutic Target for Sjogren’s Syndrome
Saba Nayar¹, Joana Campos¹, Christopher Buckley¹, Rodger Allen², W.A. Fahy², Andrew Payne² and Francesca Barone¹, ¹University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom, ²UCB Pharma, Slough, United Kingdom
Background/Purpose: Sjögren’s syndrome (SS) is a chronic autoimmune disease characterized by B cell hyper-activation and exocrine gland infiltration that results in loss of glandular function,…
Abstract Number: 2557 • 2015 ACR/ARHP Annual Meeting
Comparable Therapeutic Potential of Umbilical Cord Mesenchymal Stem Cells in Collagen Induced Arthritis with Anti-Tumor Necrosis Factor or Anti-CD20
Yue Sun, Wei Kong, Weiwei Chen, Genhong Yao, Xuebing Feng and Lingyun Sun, Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Tremendous progress has been made in the development of non-conventional therapies for rheumatoid arthritis (RA). Mesenchymal stem cells (MSC) present multiple immunosuppressive capacities and…
Abstract Number: 3192 • 2015 ACR/ARHP Annual Meeting
KCa3.1 Ion Channel in the Pathogenesis of Rheumatoid Arthritis: KCa3.1-/- Mice Do Not Develop CIA
Siba Raychaudhuri¹, Smriti K. Raychaudhuri² and Heike Wulff³, ¹Med/Rheumatology, Univ California Davis/VA Sacramento, Davis, CA, ²Rheumatology/Immunology, VA Sacramento Medical Center, Davis, CA, ³Pharmacology, UC Davis School of Medicine, Davis, CA
Background/Purpose: KCa3.1 is a Ca2+-activated K+ channel that modulates Ca2+-dependent signaling processes such as activation and cellular proliferation. KCa3.1 is expressed in CCR7+ naïve and…
Abstract Number: 1106 • 2015 ACR/ARHP Annual Meeting
Efficacy of Abbv-105, a Selective and Irreversible Inhibitor of Bruton’s Tyrosine Kinase (BTK), in Multiple Models of Inflammation
Christian Goess¹, Candace Graff², Ting Ting Zhang², Gregory Preston², Richard McCarthy¹, Matthew Perham¹, Jacqueline Loud¹, Christopher M. Harris¹, Sara Murdock¹, Erik Sampson³, Michael Hoemann⁴, Michael Friedman⁴, Robert Talanian³, Jeremy Edmunds⁴ and Andrew Long¹, ¹Immunology Pharmacology, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ²DMPK, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ³AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ⁴Chemistry, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA
Background/Purpose: Bruton’s Tyrosine Kinase (BTK) is a non-receptor tyrosine kinase required for intracellular signaling pathways downstream of several key immunoreceptors, including the B cell receptor,…
Abstract Number: 2558 • 2015 ACR/ARHP Annual Meeting
The Role of Leukocyte Associated Immunoglobulin-like Receptor-1 (LAIR-1) in Collagen-Induced Arthritis
Seunghyun Kim¹, John E. Coligan², Jeoung-Eun Park³, John M. Stuart⁴, Andrew Kang⁵ and Linda Myers⁵, ¹Rheumatology, University of Tennessee Health Science Center, Memphis, TN, ²NIH, Bethesda, MD, ³University of Tennessee, Memphis, TN, ⁴University of Tennessee/Veterans Affairs, Memphis, TN, ⁵University of Tennessee Health Science Center, Memphis, TN
Background/Purpose: Several observations implicate a critical role for T cell dysregulation as a central problem in RA. We present a method for suppressing T cell…
Abstract Number: 1123 • 2015 ACR/ARHP Annual Meeting
Regulatory B Cells Regulate Skin and Lung Fibrosis and Immunological Abnormalities in a Topoisomerase I and Complete Freund’s Adjuvant-Induced Scleroderma Model Via an Antigen-Specific Manner
Ayumi Yoshizaki¹, Takashi Taniguchi¹, Kouki Nakamura¹, Ryosuke Saigusa¹, Takashi Yamashita¹, Takehiro Takahashi¹, Tetsuo Toyama¹, Yohei Ichimura¹, Yoshihide Asano² and Shinichi Sato¹, ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Immune cells play a critical role in systemic sclerosis (SSc). B cells have more functions than producing antibodies, including antigen-presentation, various cytokine production, and…
Abstract Number: 2559 • 2015 ACR/ARHP Annual Meeting
PRO-Resolving Mediators Issued from Apoptotic CELL Efferocytosis (SUPERMAPO) Modulate Antigen Presenting CELL Properties Toward a Tolerogenic Profile: Efficacy in the Treatment of Collagen- Induced Arthritis
Francis Bonnefoy¹, Romain Vallion², Mélanie Couturier³, Anna Daoui³, Eric Toussirot⁴ and Sylvain Perruche¹, ¹UMR1098 INSERM, EFS Bourgogne Franche Comté, Besançon, France, ²INSERM UMR 1098, EFS Bourgogne Franche Comté, Besançon, France, ³INSERM UMR1098, EFS Bourgogne Franche Comté, Besançon, France, ⁴Service de Rhumatologie, CHU J Minjoz, Besancon, France
Background/Purpose: Pro-resolving mediators produced by macrophages eliminating apoptotic effector cells during the resolution of inflammation have been shown to stop inflammation, favor tissue repair and…
Abstract Number: 1173 • 2015 ACR/ARHP Annual Meeting
G Protein Coupled Receptor Kinase 3 Regulation of Inflammatory Arthritis
Matthew J. Billard¹, Roman Timoshchenko², D. Stephen Serafin² and Teresa K. Tarrant³, ¹Medicine, University of North Carolina, Chapel Hill, NC, ²Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ³Rheumatology, University of North Carolina, Chapel Hill, NC
Background/Purpose: Chemokine receptors are G Protein Coupled Receptor (GPCR) family members that direct cell migration, differentiation, and survival in inflammatory conditions, but neutralization strategies…
Abstract Number: 2560 • 2015 ACR/ARHP Annual Meeting
The Mer Tyrosine Kinase Receptor Plays a Protective Role in Joint Inflammation By Mediating Efferocytosis
Claire E.J. Waterborg¹, Silke Beermann¹, Miranda B. Bennink¹, Carla V. Rothlin², Greg Lemke³ and Fons A.J. van de Loo¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Department of Immunobiology, Yale University School of Medicine, New Haven, CT, ³Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a hyper-inflammatory response in synovial joints. In joints of patients with active RA, few…
Abstract Number: 1427 • 2015 ACR/ARHP Annual Meeting
Analgesic Effects of the Novel Alpha-2-Delta Ligand Mirogabalin (DS-5565) in Experimental Animal Models of Fibromyalgia
Yuki Domon¹, Naohisa Arakawa¹, Shun-ichi Yasuda², Kensuke Saeki², Mayumi Kano², Masami Kato² and Yutaka Kitano¹, ¹Biological Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan, ²Hashima Laboratory, Nihon Bioresearch Inc., Gifu, Japan
Background/Purpose: Mirogabalin (DS-5565) is a novel ligand of the α2δ subunit of voltage-gated calcium channels. Mirogabalin possesses unique binding characteristics to α2δ subunits, and potent…
Abstract Number: 2563 • 2015 ACR/ARHP Annual Meeting
Immune Regulation By Migrating Mesenchymal Stem Cells Ameliorate Inflammatory Arthritis in Mice
Seung Min Jung, Yoojun Nam and Ji Hyeon Ju, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Mesenchymal stem cells (MSCs) function as immune regulators in inflammatory conditions. However, it is unclear how to control local inflammation by systemically administered MSCs. We…

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