Abstract Number: 2558 • 2015 ACR/ARHP Annual Meeting
The Role of Leukocyte Associated Immunoglobulin-like Receptor-1 (LAIR-1) in Collagen-Induced Arthritis
Background/Purpose: Several observations implicate a critical role for T cell dysregulation as a central problem in RA. We present a method for suppressing T cell…Abstract Number: 1123 • 2015 ACR/ARHP Annual Meeting
Regulatory B Cells Regulate Skin and Lung Fibrosis and Immunological Abnormalities in a Topoisomerase I and Complete Freund’s Adjuvant-Induced Scleroderma Model Via an Antigen-Specific Manner
Background/Purpose: Immune cells play a critical role in systemic sclerosis (SSc). B cells have more functions than producing antibodies, including antigen-presentation, various cytokine production, and…Abstract Number: 2559 • 2015 ACR/ARHP Annual Meeting
PRO-Resolving Mediators Issued from Apoptotic CELL Efferocytosis (SUPERMAPO) Modulate Antigen Presenting CELL Properties Toward a Tolerogenic Profile: Efficacy in the Treatment of Collagen- Induced Arthritis
Background/Purpose: Pro-resolving mediators produced by macrophages eliminating apoptotic effector cells during the resolution of inflammation have been shown to stop inflammation, favor tissue repair and…Abstract Number: 1173 • 2015 ACR/ARHP Annual Meeting
G Protein Coupled Receptor Kinase 3 Regulation of Inflammatory Arthritis
Background/Purpose: Chemokine receptors are G Protein Coupled Receptor (GPCR) family members that direct cell migration, differentiation, and survival in inflammatory conditions, but neutralization strategies…Abstract Number: 2560 • 2015 ACR/ARHP Annual Meeting
The Mer Tyrosine Kinase Receptor Plays a Protective Role in Joint Inflammation By Mediating Efferocytosis
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a hyper-inflammatory response in synovial joints. In joints of patients with active RA, few…Abstract Number: 1427 • 2015 ACR/ARHP Annual Meeting
Analgesic Effects of the Novel Alpha-2-Delta Ligand Mirogabalin (DS-5565) in Experimental Animal Models of Fibromyalgia
Background/Purpose: Mirogabalin (DS-5565) is a novel ligand of the α2δ subunit of voltage-gated calcium channels. Mirogabalin possesses unique binding characteristics to α2δ subunits, and potent…Abstract Number: 2563 • 2015 ACR/ARHP Annual Meeting
Immune Regulation By Migrating Mesenchymal Stem Cells Ameliorate Inflammatory Arthritis in Mice
Background/Purpose: Mesenchymal stem cells (MSCs) function as immune regulators in inflammatory conditions. However, it is unclear how to control local inflammation by systemically administered MSCs. We…Abstract Number: 1435 • 2015 ACR/ARHP Annual Meeting
Central Pain Sensitization in Rheumatoid Arthritis – Role of ACPA?
Background/Purpose: Chronic pain continues to be a significant problem for patients with rheumatoid arthritis (RA), even when the disease is medically controlled or in remission.…Abstract Number: 2564 • 2015 ACR/ARHP Annual Meeting
Nuclear Receptor 4A2 Is Selectively Upregulated in the Human TNF-Alpha Transgenic Model of Rheumatoid Arthritis
Background/Purpose: The orphan nuclear receptor 4A2 (NR4A2 / NURR1) is emerging as a critical transcription factor in chronic inflammatory joint diseases. We have demonstrated elevated…Abstract Number: 1575 • 2015 ACR/ARHP Annual Meeting
Serum Vascular Cell Adhesion Molecule-1 (VCAM-1) Levels Are Associated with Vascular Dysfunction and Increased Cardiovascular Risk in an Animal Model and Patients with Rheumatoid Arthritis
Background/Purpose: Mortality is increased in Rheumatoid arthritis (RA) patients mainly due to cardiovascular (CV) disease; however the biologic mechanisms are unknown. Increased CV risk in…Abstract Number: 2566 • 2015 ACR/ARHP Annual Meeting
Novel Therapeutic Compound Tuftsin-Phosphorylcholine Attenuate Collagen Induced Arthritis
Background/Purpose: Treatment with helminthes and ova from helminthes, improved clinical findings of several autoimmune diseases in patients and in animal models. We aimed to decipher…Abstract Number: 1754 • 2015 ACR/ARHP Annual Meeting
BANK1 Controls the Development of SLE By Modulating TLR7 Signaling and Type I IFN-Induced Translation Initiation Pathway in B Cells
Background/Purpose: BANK1 is a susceptibility gene for SLE, and we have shown that stimulation of TLR9 agonist leads to a reduction in the activation of…Abstract Number: 2568 • 2015 ACR/ARHP Annual Meeting
The Osteoimmunological Mechanistic Basis of Low-Dose Radiotherapy in TNF Driven Arthritis
Background/Purpose: Today many treatment options for Rheumatoid Arthritis (RA) and degenerative inflammatory musculoskeletal diseases are available, however, not all patients respond properly or have to…Abstract Number: 1772 • 2015 ACR/ARHP Annual Meeting
Anti-Pentraxin 3 Antibodies Ameliorate Disease Manifestations and Lupus-like Nephritis in New Zealand Black/New Zealand White F1 Mice
Background/Purpose: Pentraxin 3 (PTX3) is an acute-phase protein released by different cell types including renal epithelial cells and immune-competent cells. PTX3 is able to either…Abstract Number: 2572 • 2015 ACR/ARHP Annual Meeting
Protective and Therapeutic Effects of Growth Hormone on Collagen-Induced Arthritis
Background/Purpose: Inflammatory (M1) macrophages and T helper 17 (TH17) cells are central to rheumatoid arthritis (RA) pathogenesis. Although the growth hormone [GH]/insulin-like growth factor 1…
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