Abstracts tagged "Animal models"

Abstract Number: 2566 • 2015 ACR/ARHP Annual Meeting
Novel Therapeutic Compound Tuftsin-Phosphorylcholine Attenuate Collagen Induced Arthritis
Tomer Bashi¹, Miri Blank¹, Jasna Omersel², Alexander Volkov³, Iris Barshack³ and Yehuda Shoenfeld¹, ¹Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, ²Faculty of pharmacy, University of Ljublijana, Ljublijana, Slovenia, ³Sheba Medical Center, Institute of Pathology, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel
Background/Purpose: Treatment with helminthes and ova from helminthes, improved clinical findings of several autoimmune diseases in patients and in animal models. We aimed to decipher…
Abstract Number: 1754 • 2015 ACR/ARHP Annual Meeting
BANK1 Controls the Development of SLE By Modulating TLR7 Signaling and Type I IFN-Induced Translation Initiation Pathway in B Cells
Ying-Yu Wu¹, Ramesh Kumar², Harini Bagavant¹ and Marta E. Alarcon Riquelme³, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma Cty, OK, ³Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Center for Genomics and Oncological Research Pfizer-University of Granada-Junta de Andalucia, Oklahoma City, OK
Background/Purpose: BANK1 is a susceptibility gene for SLE, and we have shown that stimulation of TLR9 agonist leads to a reduction in the activation of…
Abstract Number: 2568 • 2015 ACR/ARHP Annual Meeting
The Osteoimmunological Mechanistic Basis of Low-Dose Radiotherapy in TNF Driven Arthritis
Lisa Deloch¹, Anja Derer¹, Axel J. Hueber², Barbara Happich³, Rainer Fietkau¹, Benjamin Frey¹ and Udo S. Gaipl¹, ¹Department of Radiation Oncology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, Rheumatology & Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Today many treatment options for Rheumatoid Arthritis (RA) and degenerative inflammatory musculoskeletal diseases are available, however, not all patients respond properly or have to…
Abstract Number: 1772 • 2015 ACR/ARHP Annual Meeting
Anti-Pentraxin 3 Antibodies Ameliorate Disease Manifestations and Lupus-like Nephritis in New Zealand Black/New Zealand White F1 Mice
Mariele Gatto¹, Nicola Bassi¹, Anna Ghirardello¹, Roberto Luisetto¹, Silvano Bettio¹, Luca Iaccarino¹, Leonardo Punzi² and Andrea Doria², ¹Department of Medicine-DIMED, University of Padova, Padova, Italy, ²Department of Medicine - DIMED, University of Padova, Padova, Italy
Background/Purpose: Pentraxin 3 (PTX3) is an acute-phase protein released by different cell types including renal epithelial cells and immune-competent cells. PTX3 is able to either…
Abstract Number: 2572 • 2015 ACR/ARHP Annual Meeting
Protective and Therapeutic Effects of Growth Hormone on Collagen-Induced Arthritis
Ricardo J. Villares¹, Gabriel Criado², Rosa P Gomariz³, Yasmina Juarranz³, Javier Leceta³, Graciela Cascio⁴, Jose L. Pablos⁵ and Mario Mellado⁶, ¹Immunology & Oncology, Centro Nacional de Biotecnología-CSIC, Madrid, Spain, ²Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ³Cellular Biology, School of Biology. Universidad Complutense de Madrid, Madrid, Spain, ⁴Immunoloy & Oncology, Centro Nacional de Biotecnología-CSIC, Madrid, Spain, ⁵Instituto de Investigacion Hospital, Madrid, Spain, ⁶Immunology and Oncology, Centro Nacional de Biotecnología. CNIC, Madrid, Spain
Background/Purpose: Inflammatory (M1) macrophages and T helper 17 (TH17) cells are central to rheumatoid arthritis (RA) pathogenesis. Although the growth hormone [GH]/insulin-like growth factor 1…
Abstract Number: 2006 • 2015 ACR/ARHP Annual Meeting
Effect Size of the Anti-Aggrecanase-2 Monoclonal Antibody CRB0017 in Rodent Models of Osteoarthritis
Gianfranco Caselli¹, Riccardo Chiusaroli², Michela Visintin³, Marco Lanza², Flora Ferrari², Dario Tremolada², Beatrice Barbetta², Giampaolo Giacovelli², Albino Bonazzi² and Lucio Claudio Rovati², ¹Pharmacology & Toxicology, Rottapharm Biotech Srl, Monza, Italy, ²Rottapharm Biotech Srl, Monza, Italy, ³Rottapharm Biotech Srl, Trieste, Italy
Background/Purpose : There is huge interest in the family of “A Disintegrin And Metalloproteinase with ThromboSpondin motifs” (ADAMTS) proteinases, especially aggrecanase-2 (ADAMTS-5), as therapeutic targets…
Abstract Number: 2574 • 2015 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Leads to Altered Gene Expression in the Brain and Behavioral Changes in Mice
Karin ME Andersson¹, Lovisa Leifsdottir², Malin Erlandsson¹, Marcela Pekna³, Milos Pekny³, Kjell Olmarker⁴ and Maria Bokarewa⁵, ¹Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, ²Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden, ³Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden, ⁴Musculoskeletal Research, Department of Medical Chemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden, ⁵Rheumatology and Inflammation Research, Göteborgs University, Göteborg, Sweden
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disorder characterized by joint inflammation and destruction. Pain is the major symptom in RA, which often persists despite…
Abstract Number: 2137 • 2015 ACR/ARHP Annual Meeting
Critical Role of Fibroblast-like Synoviocytes Glycolytic Metabolism in Rheumatoid Arthritis
Ricard Garcia-Carbonell¹, Ajit Divakaruni¹, Alessia Lodi², Ildefonso Vicente-Suarez³, Hilde Cheroutre⁴, Gerry Boss¹, Arindam Saha¹, Stefano Tiziani⁵, Anne Murphy⁶, Gary S. Firestein⁷ and Monica Guma⁶, ¹University of California, San Diego, La Jolla, CA, ²nutritional Sciences, University of Texas at Austin, Austin, TX, ³LIAI, La Jolla, CA, ⁴Autoimmune Research, LIAI, La Jolla, CA, ⁵Nutritional Sciences, University of Texas at Austin, Austin, TX, ⁶Pharmacology, University of California, San Diego, La Jolla, CA, ⁷Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA
Background/Purpose: Glucose metabolism is altered not only in tumor cell growth but also in immune cells on activation. However, little is known about glucose metabolism…
Abstract Number: 2578 • 2015 ACR/ARHP Annual Meeting
Cardiovascular Effects of Etanercept in an Animal Model of Rheumatoid Arthritis: Mechanisms Involved
Perle Totoson¹, Katy Maguin-Gaté¹, Alice Monnier², Anne Tessier², Christine Marie², Frank Verhoeven³, Clément Prati³, Daniel Wendling⁴ and Céline Demougeot¹, ¹EA 4267 FDE, FHU INCREASE, Université de Bourgogne Franche-Comté, Besançon, France, ²INSERM U1093, Université de Bourgogne Franche-Comté, Dijon, France, ³Service de Rhumatologie, CHRU J Minjoz, Besançon, France, ⁴Université de Franche-Comté, Besançon, France
Background/Purpose: Rheumatoid arthritis (RA) is associated with increased cardiovascular (CV) morbidity and mortality secondary to endothelial dysfunction (ED). Growing evidence suggests that TNFα-inhibitors may reduce…
Abstract Number: 2210 • 2015 ACR/ARHP Annual Meeting
Immunological Dysregulation and Inadequate Hypoxia Adaptation – HIF-Stabilization As Possible Prevention of Fracture Healing Disorders in RA or Immune-Suppressed Patients
Annemarie Lang^1,2,3, Sarah Fuegener², Paula Hoff^1,2, Katharina Schmidt-Bleek⁴, Timo Gaber^1,2 and Frank Buttgereit², ¹German Rheumatism Research Center (DRFZ), Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ³Berlin-Brandenburg School of Regenerative Therapies (BSRT), Berlin, Germany, ⁴Julius Wolff Institut, Charité University Medicine, Berlin, Germany
Background/Purpose: Patients suffering from rheumatoid arthritis (RA) are often affected by fracture-healing complications such as increased fracture healing time or non-unions. There is not much…
Abstract Number: 2580 • 2015 ACR/ARHP Annual Meeting
Age-Related Differences in Collagen-Induced Arthritis: Clinical, Imaging and Biological Characteristics in Juvenile Compared to Adult Animals
Tracy Wilson-Gerwing¹, Arash Panahifar², David M.L. Cooper² and Alan M. Rosenberg¹, ¹Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, ²Anatomy and Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada
Background/Purpose: Arthritis is among the most common chronic diseases in both children and adults. Joint inflammation is a feature in both age groups but there…
Abstract Number: 19 • 2015 ACR/ARHP Annual Meeting
Pentagalloyl Glucose (PGG) Exhibits Anti-Rheumatic Activity in Human RA Synovial Fibroblasts and Rat Adjuvant-Induced Arthritis
Sadiq Umar¹, Gates Roe¹, Sabrina Fechtner¹ and Salahuddin Ahmed², ¹Department of Pharmaceutical Science, Washington State University College of Pharmacy, Spokane, WA, ²Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, WA
Background/Purpose: Pentagalloyl glucose (PGG) is a natural polyphenolic and water-soluble gallotannin that exhibits anti-cancer and anti-inflammatory activities. In the present study, we evaluated the efficacy…
Abstract Number: 2550 • 2015 ACR/ARHP Annual Meeting
Metabolomic Profiling of Joints in Murine Models of Inflammatory Arthritis
Ilya gertsman¹, Jesus Rivera-Nieves², Maripat Corr², Bruce Barshop¹ and Monica Guma³, ¹pediatrics, University of California, San Diego, La Jolla, CA, ²Medicine, University of California, San Diego, La Jolla, CA, ³Pharmacology, University of California, San Diego, La Jolla, CA
Background/Purpose: Given the complexity and heterogeneous nature of rheumatoid arthritis (RA), it is unlikely that a single biomarker may provide sufficient discrimination; therefore biomarker signatures…
Abstract Number: 3104 • 2015 ACR/ARHP Annual Meeting
Abnormal DNA Methylation in a Novel PTPN11 Enhancer Increases Destructive Potential of Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS) and Joint Inflammation
Keisuke Maeshima¹, Stephanie M. Stanford², Deepa Hammaker¹, Cristiano Sacchetti², Rizi Ai³, Vida Zhang⁴, David L. Boyle⁵, Lifan Zeng⁶, German Muench⁷, Gen-Sheng Feng⁸, John Whitaker⁹, Zhong-Yin Zhang⁶, Wei Wang¹⁰, Nunzio Bottini² and Gary S. Firestein⁵, ¹Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ²Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ³Chemistry and Biochemistry, UC San Diego, La Jolla, CA, ⁴Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁵Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ⁶Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, ⁷La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁸Pathology and Division of Biological Sciences, UC San Diego, La Jolla, CA, ⁹Janssen Pharmaceuticals, La Jolla, CA, ¹⁰Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA
Background/Purpose: Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) mediate disease pathogenesis by invading the joint extracellular matrix. The PTPN11 gene, encoding the tyrosine phosphatase SHP-2, is overexpressed…
Abstract Number: 936 • 2015 ACR/ARHP Annual Meeting
IL-1 Receptor Antagonist Maintains Intestinal Microbial Homeostasis to Prevent Overt Toll-like Receptor 4-Dependent Intestinal Th17 Differentiation and Autoimmune Arthritis
Rebecca Rogier¹, Tom Ederveen¹, Jos Boekhorst², Harm Wopereis³, Johan Garssen⁴, Peter van der Kraan⁵, Sacha van Hijum², Marije Koenders⁶, Wim van den Berg⁶ and Shahla Abdollahi-Roodsaz^7,8, ¹Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ²Centre for Molecular Bioinformatics Nijmegen (CMBI), Radboud university medical center, Nijmegen, Netherlands, ³Danone Research, Wageningen, Netherlands, ⁴Danone Nutricia Research, Utrecht, Netherlands, ⁵Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁶Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁷Medicine, NYU School of Medicine, New York, NY, ⁸Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Interleukin-1 (IL-1) plays a pivotal role in inflammation and immunity. Activation of IL-1 receptor is physiologically inhibited by the IL-1 receptor antagonist (IL-1Ra). Mice…

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