Abstracts tagged "Animal models"

Abstract Number: 1851 • 2016 ACR/ARHP Annual Meeting
The Effect of Narrow Band Ultraviolet A1 Light on Bleomycin-Induced Mouse Model of Scleroderma
Diana Karpec^1,2, Romualdas Rudys², Laima Leonaviciene², Zygmunt Mackiewicz², Ruta Bradunaite², Gailute Kirdaite², Rita Rugiene² and Algirdas Venalis^2,3, ¹Clinics of Rheumatology, Traumatology-Orthopedics and Reconstructive Surgery, Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania, ²State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania, ³Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania
Background/Purpose: Ultraviolet A1 (UVA1) phototherapy implications for systemic sclerosis still remain the area of research. The aim of the study was to evaluate narrow band…
Abstract Number: 457 • 2016 ACR/ARHP Annual Meeting
Novel Mechanism Mediated By the IL-23/Th17 Axis Contributing to Auto-Immune Arthritis
René Pfeifle¹, Tobias Rothe¹, Natacha Ipseiz¹, Stephan Culemann¹, Ulrike Harre², Gerhard Krönke³ and Georg Schett⁴, ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, ³Universitätsklinikum Erlangen, Erlangen, Austria, ⁴Department of Internal Medicine III, Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany
Background/Purpose: Checkpoints and mechanisms regulating the onset of rheumatoid arthritis (RA) remain largely elusive. Apart from B cells and auto-antibodies, Th17 cells were shown to…
Abstract Number: 1126 • 2016 ACR/ARHP Annual Meeting
Interleukin-1 Is Not Involved in Synovial Inflammation and Cartilage Destruction in Collagenase-Induced Osteoarthritis
Stephanie van Dalen¹, Arjen Blom¹, Annet Sloetjes¹, Monique M. Helsen¹, Johannes Roth², Thomas Vogl², Wim B. van den Berg¹, Martijn van den Bosch¹ and Peter L. E. M. van Lent¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Institute of Immunology, University of Münster, Münster, Germany
Background/Purpose: Osteoarthritis (OA) is characterized by severe cartilage destruction, with a putative role for synovial macrophages. Up to 50% of the patients also show low…
Abstract Number: 1859 • 2016 ACR/ARHP Annual Meeting
Fucosyltransferase-1 Mediated Fucosylation of TGF-βR1 Is Critical to TGF-β Signaling in Scleroderma and in Bleomycin-Induced Fibrosis
W. Alexander Stinson¹, Pei-Suen Tsou^1,2, Yuxuan Du³, Huadong Cui¹, Ellen Cealey³, Nicholas Lepore⁴, Ray A. Ohara¹, Gautam Edhayan¹, Sarah Arwani¹, Rachel Morgan¹, Dinesh Khanna^1,2, David A. Fox¹ and M. Asif Amin⁵, ¹Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²University of Michigan Scleroderma Program, Ann Arbor, MI, ³Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁴University of Michigan, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁵Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease characterized by systemic fibrosis. The dysregulation of transforming growth factor-β (TGF-β) signaling causes proliferation of myofibroblasts…
Abstract Number: 458 • 2016 ACR/ARHP Annual Meeting
The TAM Receptors Axl and Mer Play a Protective Role in a Temporal and Spatial Manner in Inflammatory Arthritis
Claire E.J. Waterborg¹, Paqui G. Través², Silke Beermann¹, Marije I. Koenders¹, Greg Lemke² and Fons A.J. van de Loo¹, ¹Experimental Rheumatology, Radboudumc, Nijmegen, Netherlands, ²Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by an unrestrained inflammatory response in selective, anatomically distinct synovial joints. The innate immune system…
Abstract Number: 1128 • 2016 ACR/ARHP Annual Meeting
Anti-Fractalkine Monoclonal Antibody Inhibits Cartilage Destruction and Bone Erosion in Collagen-Induced Arthritis Model
Kana Hoshino¹, Masayoshi Ohkuro², Wataru Ikeda¹, Tomoya Nakatani¹, Yoshikazu Kuboi³, Naoto Ishii¹, Toshihiko Yamauchi¹, Nobuyuki Yasuda¹ and Toshio Imai¹, ¹KAN Research Institute Inc., Chuo-ku, Kobe-shi, Japan, ²Research Project Promotion Group, EA Pharma Co., Ltd., Kawasaki-ku, Kawasaki-shi, Japan, ³Medicine Creation. Neuro Business Group, Eisai Co., Ltd., Tsukuba-shi, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic disease leading to joint destruction. In the previous Phase 1/2 clinical study, E6011, a novel humanized anti-fractalkine (FKN)…
Abstract Number: 1866 • 2016 ACR/ARHP Annual Meeting
Human and Experimental Tracheal Stenosis Is Characterized By a TGF-β-Dependent Fibrotic Component
Alicia Usategui¹, Juan L. Antón-Pacheco², Carmen M. García-Herrero¹, Manuel J. Del Rey¹, Vanessa Miranda¹, Iván Martínez³, Antonio P Gámez³ and Jose L. Pablos¹, ¹Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ²Servicio de Cirugía Pediátrica, Hospital 12 de Octubre, Madrid, Spain, ³Servicio de Cirugía Torácica, Hospital 12 de Octubre, Madrid, Spain
Background/Purpose: Acquired tracheal stenosis (ATS) is an unusual disease secondary to inflammatory diseases or to prolonged mechanical trauma. Tracheal mucosa undergoes inflammation and granulation tissue…
Abstract Number: 464 • 2016 ACR/ARHP Annual Meeting
an Anti-Fima Antibody Attenuates Porphyromonas Gingivalis-Associated Experimental Arthritis
Sang Hoon Jeong¹, Jennifer Lee², Seo Hwa Kim³, Haneul Kim⁴, Seung-Ki Kwok⁵, Sung-Hwan Park⁶ and Ji Hyeon Ju⁷, ¹The Catholic University of Korea, Seoul, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ³Division of Rheumatology,, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, ⁴Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, ⁵[email protected], Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁶Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ⁷Division of Rheumatology, Department of Internal Medicine,, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Evidence suggests that periodontal infection by Porphyromonas gingivalis(Pg) exacerbates rheumatoid arthritis (RA); however, the underlying mechanisms remain unknown. Here, we examined the pathogenic and therapeutic…
Abstract Number: 1435 • 2016 ACR/ARHP Annual Meeting
KCa1.1 Potassium Channels Are a Novel Therapeutic Target on Fibroblast-like Synoviocytes in Rheumatoid Arthritis
Mark Tanner¹, Redwan Huq¹, Rajeev Tajhya¹, Michael Pennington², Teresina Laragione³, Pércio Gulko⁴ and Christine Beeton⁵, ¹Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX, ²Peptides International, Louisville, KY, ³Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁴Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, ⁵Department of Molecular Physiology & Biophysics, Baylor College of Medicine, Houston, TX
Background/Purpose: Fibroblast-like synoviocytes (FLS) develop a high degree of invasiveness during rheumatoid arthritis (RA), leading to joint degradation. There are currently no therapeutics that specifically…
Abstract Number: 1914 • 2016 ACR/ARHP Annual Meeting
Immune Recognition of a Novel Citrullinated Epitope of Cartilage Proteoglycan Aggrecan in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis
Adrienn Markovics¹, Timea Ocsko¹, Robert S. Katz², Edit I Buzas³, Tibor T. Glant¹ and Katalin Mikecz¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rush University Medical Center, Chicago, IL, ³Semmelweis University, Budapest, Hungary
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease leading to the inflammatory destruction of synovial joints. Anti-citrullinated protein antibodies (ACPA) are frequently detected in the…
Abstract Number: 1575 • 2015 ACR/ARHP Annual Meeting
Serum Vascular Cell Adhesion Molecule-1 (VCAM-1) Levels Are Associated with Vascular Dysfunction and Increased Cardiovascular Risk in an Animal Model and Patients with Rheumatoid Arthritis
Ruth Davies¹, Daniela Iacono², Lauren A. Jordan¹, Jessica O Williams¹, Charlotte Rawlings¹, Derek Lang³, Anwen S. Williams¹ and Ernest H. Choy¹, ¹Cardiff University, Institute of Infection and Immunity, Tenovus Building, University Hospital of Wales, Cardiff, United Kingdom, ²Department of Clinical and Experimental Medicine. Rheumatology Section. Second University of Naples, Naples, Italy, ³Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom
Background/Purpose: Mortality is increased in Rheumatoid arthritis (RA) patients mainly due to cardiovascular (CV) disease; however the biologic mechanisms are unknown. Increased CV risk in…
Abstract Number: 2566 • 2015 ACR/ARHP Annual Meeting
Novel Therapeutic Compound Tuftsin-Phosphorylcholine Attenuate Collagen Induced Arthritis
Tomer Bashi¹, Miri Blank¹, Jasna Omersel², Alexander Volkov³, Iris Barshack³ and Yehuda Shoenfeld¹, ¹Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, ²Faculty of pharmacy, University of Ljublijana, Ljublijana, Slovenia, ³Sheba Medical Center, Institute of Pathology, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel
Background/Purpose: Treatment with helminthes and ova from helminthes, improved clinical findings of several autoimmune diseases in patients and in animal models. We aimed to decipher…
Abstract Number: 1754 • 2015 ACR/ARHP Annual Meeting
BANK1 Controls the Development of SLE By Modulating TLR7 Signaling and Type I IFN-Induced Translation Initiation Pathway in B Cells
Ying-Yu Wu¹, Ramesh Kumar², Harini Bagavant¹ and Marta E. Alarcon Riquelme³, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma Cty, OK, ³Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Center for Genomics and Oncological Research Pfizer-University of Granada-Junta de Andalucia, Oklahoma City, OK
Background/Purpose: BANK1 is a susceptibility gene for SLE, and we have shown that stimulation of TLR9 agonist leads to a reduction in the activation of…
Abstract Number: 2568 • 2015 ACR/ARHP Annual Meeting
The Osteoimmunological Mechanistic Basis of Low-Dose Radiotherapy in TNF Driven Arthritis
Lisa Deloch¹, Anja Derer¹, Axel J. Hueber², Barbara Happich³, Rainer Fietkau¹, Benjamin Frey¹ and Udo S. Gaipl¹, ¹Department of Radiation Oncology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, Rheumatology & Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Today many treatment options for Rheumatoid Arthritis (RA) and degenerative inflammatory musculoskeletal diseases are available, however, not all patients respond properly or have to…
Abstract Number: 1772 • 2015 ACR/ARHP Annual Meeting
Anti-Pentraxin 3 Antibodies Ameliorate Disease Manifestations and Lupus-like Nephritis in New Zealand Black/New Zealand White F1 Mice
Mariele Gatto¹, Nicola Bassi¹, Anna Ghirardello¹, Roberto Luisetto¹, Silvano Bettio¹, Luca Iaccarino¹, Leonardo Punzi² and Andrea Doria², ¹Department of Medicine-DIMED, University of Padova, Padova, Italy, ²Department of Medicine - DIMED, University of Padova, Padova, Italy
Background/Purpose: Pentraxin 3 (PTX3) is an acute-phase protein released by different cell types including renal epithelial cells and immune-competent cells. PTX3 is able to either…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].