ACR Meeting Abstracts

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Abstracts tagged "Animal models"

  • Abstract Number: 991 • 2019 ACR/ARP Annual Meeting

    Identification of Citrullinated Peptide Specific T-cells in Humanized Mice Immunized with Citrullinated Peptides

    Matthew McElwee1, Thamotharampillai Dileepan 1 and Marc Jenkins 1, 1University of Minnesota, Minneapolis, MN

    Background/Purpose: Seropositive rheumatoid arthritis (RA) is a T-cell mediated disease that is characterized by the presence of antibodies to proteins that have undergone the post-translational…
  • Abstract Number: 992 • 2019 ACR/ARP Annual Meeting

    Identification of CJ-15314, a Novel Highly Selective JAK1 Inhibitor, for the Treatment of Rheumatoid Arthritis

    So Young Ki1, Dongkyu Kim 1, Juhyun Lee 1, Byoung Seok Moon 1 and Shin-Young Ryu 1, 1CJ Healthcare, Icheon-si, Republic of Korea

    Background/Purpose: Janus kinases (JAKs) play critical roles in mediating various cytokine signaling. First-generation non-selective JAK inhibitors such as tofacitinib and baricitinib are widely used for…
  • Abstract Number: 994 • 2019 ACR/ARP Annual Meeting

    Increased Antibody and T-cell Responses Following Treatment of Collagen-Induced Arthritis in C57Bl/6 Mice with Organic Dust Inhalants

    Michael Duryee1, Jill Poole 1, Amy Nelson 1, Katherine Janike 1, Kathryn Rentfro 1, Lynell Klassen 1, James O'Dell 2, Bryant England 3, Geoffrey Thiele 2 and Ted Mikuls 2, 1University of Nebraska Medical Center, Omaha, NE, 2VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE, 3VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha

    Background/Purpose: Increasing evidence suggests that inhalant exposures, such as tobacco smoke or silica, are implicated in the initiation of autoimmunity leading to rheumatoid arthritis (RA).…
  • Abstract Number: 55 • 2019 ACR/ARP Annual Meeting

    A Novel Subclass of Intravascular Non-classical, Tissue Resident Synovial Monocyte Is Critical for Rheumatoid Arthritis Pathogenesis

    Anna Montgomery 1, Shang-Yang Chen 1, Deborah Winter 2 and Harris Perlman2, 1Northwestern University, Chicago, 2Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago

    Background/Purpose: There are at least three populations of circulating monocytes; classical, intermediate and non-classical. We demonstrated that circulating non-classical monocytes are required for the effector…
  • Abstract Number: 995 • 2019 ACR/ARP Annual Meeting

    Inhibition of Endoplasmic Reticulum Stress Using 4-phenylbutyric Acid Ameliorates the Severity of Collagen-induced Arthritis in Mice via Attenuation of Proliferation and Inflammatory Responses of Synovial Fibroblasts

    Wan-Hee Yoo1, Yunjung Choi 2, Eun-gyeong Lee 2, Chang-hoon Lee 3 and Myeung-Su Lee 3, 1Department of Internal Medicine, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical, Research Institute of Chonbuk National University Hospital, Jeonju, Korea, JeonJu, Republic of Korea, 2Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, JeonJu, Republic of Korea, 3Wonkwang University College of Medicine, Iksan, Republic of Korea

    Background/Purpose: Several studies have recently revealed the pathological role of endoplasmic reticulum (ER) stress in the pathogenesis of inflammatory diseases. In addition, 4-phenylbutyric acid (4-PBA) was…
  • Abstract Number: 83 • 2019 ACR/ARP Annual Meeting

    Dysfunction of TRIM21 Promotes Aberrant Plasmablast Differentiation in Systemic Lupus Erythematosus Due to the Reduction of TRIM21-mediated Ubiquitylation of IRF5

    Yosuke Kunishita1, Ryusuke Yoshimi 1, Reikou Kamiyama 1, Daiga Kishimoto 1, Koji Yoshida 1, Eijin Hashimoto 1, Yumiko Sugiyama 2, Takaaki Komiya 1, Natsuki Sakurai 1, Yohei Kirino 3 and Hideaki Nakajima 3, 1Department of Stem Cell and Immune Regulation / Yokohama City University Graduate School of Medicine, Yokohama, Japan, 2Department of Rheumatic Diseases / Yokohama City University Medical Center, Yokohama, Japan, 3Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Background/Purpose: TRIM21 is a member of the tripartite motif family proteins and is one of the autoantigens which react with anti-SS-A antibody (Ab) present in…
  • Abstract Number: 996 • 2019 ACR/ARP Annual Meeting

    The Role of Flip in Differentiation and Survival of Synovial Tissue Resident Macrophages

    Qi Huang1, Renee Doyle 1, Shang-Yang Chen 2, Alexander Misharin 3, Deborah Winter 4 and Richard Pope 5, 1Northwestern University Feinberg School of Medicine, Chicago, IL, 2Northwestern University, Chicago, 3Northwestern University Feinberg School of Medicine, chicago, 4Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, 5Northwestern University Feinberg School of Medicine, Division of Rheumatology, chicago, IL

    Background/Purpose: We previously identified that under homeostatic conditions Flip was necessary for macrophage (MΦ) survival.  The mechanisms responsible for the differentiation of monocyte-derived MΦs into…
  • Abstract Number: 85 • 2019 ACR/ARP Annual Meeting

    Selective Inhibition of the Immunoproteasome with KZR-616 Blocks Multiple Cell Signaling Pathways, Plasma Cell Signatures and Myeloid Cell Associated Damage in the NZB/W Lupus Nephritis Model

    Tony Muchamuel1, Janet Anderl 1, R Andrea Fan 1, Henry Johnson 1, Dustin McMinn 1 and Christopher Kirk 1, 1Kezar Life Sciences, South San Francisco, CA

    Background/Purpose: The immunoproteasome is a distinct class of proteasome found predominantly in immune effector cells and has been shown to play a distinct role in…
  • Abstract Number: 998 • 2019 ACR/ARP Annual Meeting

    Stimulation of Splenic Neurovascular Bundle Protect Mice from Developing Collagen-induced Arthritis

    Thomas Simon1, Clara Panzolini 2, Julien Lavergne 2, Arun Srihar 3, Margriet Vervoordeldonk 3, nicolas Glaichenhaus 2 and Philippe Blancou 2, 1CNRS/IPMC, Valbonne, France, 2IPMC/CNRS, VALBONNE, France, 3Galvani Bioelectronics, Stevenage, United Kingdom

    Background/Purpose: Vagus nerve (VN) stimulation has shown the potential to improve the disease development in animal models of arthritis and in patients with RA. However,…
  • Abstract Number: 89 • 2019 ACR/ARP Annual Meeting

    Difference of Induced CD4+ and Natural Regulatory T Cells in Targeting Inflamed Synovial Tissues in Autoimmune Arthritis

    Ximei Zhang1, Julie Wang 2, Nancy Olsen 3, Wael Jarjour 4 and Song Guo Zheng 4, 1Ohio State College of Medicine, Columbus, 2Ohio State University, columbus, 3Penn State University, Hershey, PA, 4Ohio State College of Medicine, Columbus, OH

    Background/Purpose: Enhanced evidence supports that autoimmune diseases often result from an imbalance between regulatory T cells (Tregs) and interleukin-17-producing T helper (Th17) cells. However, under…
  • Abstract Number: 999 • 2019 ACR/ARP Annual Meeting

    Targeted Drug Delivery Using a Novel Joint-homing Peptide for Arthritis Therapy

    Rakeshchandra Meka1, Shivaprasad Venkatesha 1, Bodhraj Acharya 1 and Kamal Moudgil 1, 1University of Maryland School of Medicine and Baltimore VA Medical Center, Baltimore, Baltimore, MD

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disease characterized by inflammation of the synovial tissue of the joints, which if not controlled early…
  • Abstract Number: 100 • 2019 ACR/ARP Annual Meeting

    Targeting ITK Signaling Ameliorates Collagen-Induced Arthritis via Shifting the Balance Between Th17 and Regulatory Th17 Cells

    Ye Chen1, Julie Wang 2, Nancy Olsen 3, Wael Jarjour 4 and Song Guo Zheng 4, 1Ohio State University, Columbus, OH, 2Ohio State University, columbus, 3Penn State University, Hershey, PA, 4Ohio State College of Medicine, Columbus, OH

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease that cannot be cured and current approaches have some severe side effects. Although the pathogenesis is…
  • Abstract Number: 1000 • 2019 ACR/ARP Annual Meeting

    RKIP, as an Upstream Regulator of Intracellular Signaling, Exerts Anti-arthritic Effect in Fibroblast-like Synoviocyte and Collagen-induced Arthritis

    Sang-Il Lee1, Hae Sook Noh 2 and Yun-Hong Cheon 1, 1Divison of Rheumatology, Gyeongsang National University Hospital, Jin-Ju, Republic of Korea, 2Gyeongsang University Hospital, Jinju, Republic of Korea

    Background/Purpose: Nuclear factor-kappaB (NF-kappaB) and extracellular-signal-regulated kinase (ERK) have been implicated as a therapeutic target for the treatment of rheumatoid arthritis (RA). Raf kinase inhibitory…
  • Abstract Number: 101 • 2019 ACR/ARP Annual Meeting

    CD126 Negative CD4+Foxp3+ Cell Represents a Superior Treg Subset in Treating Autoimmune Diseases

    Ye Chen1, Julie Wang 2, Nancy Olsen 3, Wael Jarjour 4 and Song Guo Zheng 4, 1Ohio State University, Columbus, OH, 2Ohio State University, columbus, 3Penn State University, Hershey, PA, 4Ohio State College of Medicine, Columbus, OH

    Background/Purpose: Regulatory T (Treg) cells play an important role in maintaining immunologic homeostasis. Abnormal Treg cells were found in some autoimmune diseases. Transferred natural Treg…
  • Abstract Number: 1001 • 2019 ACR/ARP Annual Meeting

    Oral Collagen Type V Supplementation Inhibits Cartilage Degeneration in Experimental Arthritis

    Lizandre Keren Silveira 1, José Eduardo Rodrigues 1, Silvana Atayde 1, Sergio Catanozi 1, Antonio dos Santos Filho 2, Vera Luiza Capelozzi 1, Ricardo Fuller 2, Ana Paula Velosa 2 and Walcy Teodoro1, 1Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil, 2Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil

    Background/Purpose: It is known that collagen V (col V) can generate autoimmunity when exposed. In contrast, induction of tolerance with col V supplementation is able…
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