Abstract Number: 981 • 2019 ACR/ARP Annual Meeting
Adipocytokines and Obesity in the Context of Rheumatoid and Osteoarthritis Mouse Models
Background/Purpose: Adipocytokines are bioactive factors mainly produced by adipose tissue and exert many important effects on energy homeostasis as well as immune responses. Osteoarthritis (OA)…Abstract Number: 1775 • 2019 ACR/ARP Annual Meeting
Cholesterol Sequestering in Macrophages Contributes to the Lipid Paradox in Chronic Arthritis
Background/Purpose: Patients with active rheumatoid arthritis (RA) have increased cardiovascular mortality, paradoxically associated with reduced circulating lipid levels. Several disease-modifying antirheumatic drugs (DMARDs), such as…Abstract Number: 982 • 2019 ACR/ARP Annual Meeting
A Novel Role for Nod2 in Controlling Autoantibody Production and Arthritis in SKG Mice
Background/Purpose: Rheumatoid arthritis (RA) is a systemic inflammatory disease that manifests in a chronic and debilitating polyarthritis. Although the etiology of RA is unknown pathogenic…Abstract Number: 1974 • 2019 ACR/ARP Annual Meeting
The Rat Homolog to FX201, a Gene Therapy in Development for the Treatment of Osteoarthritis, Demonstrates Dose-Dependent Decreases in the Severity of Cartilage and Bone Lesions Following Anterior Cruciate Ligament Transection
Background/Purpose: Acute injury to the anterior cruciate ligament (ACL) is a common cause of posttraumatic OA in humans, and ACL transection (ACLT) in rats is…Abstract Number: 988 • 2019 ACR/ARP Annual Meeting
Translational Imaging of Treatment Effects for a Novel Anti-TNF-Steroid Antibody Drug Conjugate in a Rat Model of Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory joint disease of autoimmune etiology. If insufficiently treated, RA leads to joint damage and irreversible disability. Although there…Abstract Number: 2737 • 2019 ACR/ARP Annual Meeting
HIF-1α and miR-210 Differential and Lineage-specific Expression in Systemic Lupus Erythematosus
Background/Purpose: Hypoxia inducible factor 1 is a key transcription factor that regulates the cellular response to oxygen stress. In the adaptive immune system, HIF-1α is…Abstract Number: 989 • 2019 ACR/ARP Annual Meeting
Lineage Tracing of Murine Lymphatic Smooth Muscle Cells to Determine the Role of the Lymphatic System in Inflammatory Arthritis
Background/Purpose: Dysfunction of lymphatic vessel contraction has been implicated in inflammatory arthritis progression and arthritic flare in murine models. Previous studies have demonstrated that tumor…Abstract Number: 991 • 2019 ACR/ARP Annual Meeting
Identification of Citrullinated Peptide Specific T-cells in Humanized Mice Immunized with Citrullinated Peptides
Background/Purpose: Seropositive rheumatoid arthritis (RA) is a T-cell mediated disease that is characterized by the presence of antibodies to proteins that have undergone the post-translational…Abstract Number: 992 • 2019 ACR/ARP Annual Meeting
Identification of CJ-15314, a Novel Highly Selective JAK1 Inhibitor, for the Treatment of Rheumatoid Arthritis
Background/Purpose: Janus kinases (JAKs) play critical roles in mediating various cytokine signaling. First-generation non-selective JAK inhibitors such as tofacitinib and baricitinib are widely used for…Abstract Number: 994 • 2019 ACR/ARP Annual Meeting
Increased Antibody and T-cell Responses Following Treatment of Collagen-Induced Arthritis in C57Bl/6 Mice with Organic Dust Inhalants
Background/Purpose: Increasing evidence suggests that inhalant exposures, such as tobacco smoke or silica, are implicated in the initiation of autoimmunity leading to rheumatoid arthritis (RA).…Abstract Number: 55 • 2019 ACR/ARP Annual Meeting
A Novel Subclass of Intravascular Non-classical, Tissue Resident Synovial Monocyte Is Critical for Rheumatoid Arthritis Pathogenesis
Background/Purpose: There are at least three populations of circulating monocytes; classical, intermediate and non-classical. We demonstrated that circulating non-classical monocytes are required for the effector…Abstract Number: 995 • 2019 ACR/ARP Annual Meeting
Inhibition of Endoplasmic Reticulum Stress Using 4-phenylbutyric Acid Ameliorates the Severity of Collagen-induced Arthritis in Mice via Attenuation of Proliferation and Inflammatory Responses of Synovial Fibroblasts
Background/Purpose: Several studies have recently revealed the pathological role of endoplasmic reticulum (ER) stress in the pathogenesis of inflammatory diseases. In addition, 4-phenylbutyric acid (4-PBA) was…Abstract Number: 83 • 2019 ACR/ARP Annual Meeting
Dysfunction of TRIM21 Promotes Aberrant Plasmablast Differentiation in Systemic Lupus Erythematosus Due to the Reduction of TRIM21-mediated Ubiquitylation of IRF5
Background/Purpose: TRIM21 is a member of the tripartite motif family proteins and is one of the autoantigens which react with anti-SS-A antibody (Ab) present in…Abstract Number: 996 • 2019 ACR/ARP Annual Meeting
The Role of Flip in Differentiation and Survival of Synovial Tissue Resident Macrophages
Background/Purpose: We previously identified that under homeostatic conditions Flip was necessary for macrophage (MΦ) survival. The mechanisms responsible for the differentiation of monocyte-derived MΦs into…Abstract Number: 85 • 2019 ACR/ARP Annual Meeting
Selective Inhibition of the Immunoproteasome with KZR-616 Blocks Multiple Cell Signaling Pathways, Plasma Cell Signatures and Myeloid Cell Associated Damage in the NZB/W Lupus Nephritis Model
Background/Purpose: The immunoproteasome is a distinct class of proteasome found predominantly in immune effector cells and has been shown to play a distinct role in…
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