Abstracts tagged "Animal models"

Abstract Number: 83 • 2019 ACR/ARP Annual Meeting
Dysfunction of TRIM21 Promotes Aberrant Plasmablast Differentiation in Systemic Lupus Erythematosus Due to the Reduction of TRIM21-mediated Ubiquitylation of IRF5
Yosuke Kunishita¹, Ryusuke Yoshimi ¹, Reikou Kamiyama ¹, Daiga Kishimoto ¹, Koji Yoshida ¹, Eijin Hashimoto ¹, Yumiko Sugiyama ², Takaaki Komiya ¹, Natsuki Sakurai ¹, Yohei Kirino ³ and Hideaki Nakajima ³, ¹Department of Stem Cell and Immune Regulation / Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Rheumatic Diseases / Yokohama City University Medical Center, Yokohama, Japan, ³Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Background/Purpose: TRIM21 is a member of the tripartite motif family proteins and is one of the autoantigens which react with anti-SS-A antibody (Ab) present in…
Abstract Number: 996 • 2019 ACR/ARP Annual Meeting
The Role of Flip in Differentiation and Survival of Synovial Tissue Resident Macrophages
Qi Huang¹, Renee Doyle ¹, Shang-Yang Chen ², Alexander Misharin ³, Deborah Winter ⁴ and Richard Pope ⁵, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Northwestern University, Chicago, ³Northwestern University Feinberg School of Medicine, chicago, ⁴Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, ⁵Northwestern University Feinberg School of Medicine, Division of Rheumatology, chicago, IL
Background/Purpose: We previously identified that under homeostatic conditions Flip was necessary for macrophage (MΦ) survival. The mechanisms responsible for the differentiation of monocyte-derived MΦs into…
Abstract Number: 85 • 2019 ACR/ARP Annual Meeting
Selective Inhibition of the Immunoproteasome with KZR-616 Blocks Multiple Cell Signaling Pathways, Plasma Cell Signatures and Myeloid Cell Associated Damage in the NZB/W Lupus Nephritis Model
Tony Muchamuel¹, Janet Anderl ¹, R Andrea Fan ¹, Henry Johnson ¹, Dustin McMinn ¹ and Christopher Kirk ¹, ¹Kezar Life Sciences, South San Francisco, CA
Background/Purpose: The immunoproteasome is a distinct class of proteasome found predominantly in immune effector cells and has been shown to play a distinct role in…
Abstract Number: 998 • 2019 ACR/ARP Annual Meeting
Stimulation of Splenic Neurovascular Bundle Protect Mice from Developing Collagen-induced Arthritis
Thomas Simon¹, Clara Panzolini ², Julien Lavergne ², Arun Srihar ³, Margriet Vervoordeldonk ³, nicolas Glaichenhaus ² and Philippe Blancou ², ¹CNRS/IPMC, Valbonne, France, ²IPMC/CNRS, VALBONNE, France, ³Galvani Bioelectronics, Stevenage, United Kingdom
Background/Purpose: Vagus nerve (VN) stimulation has shown the potential to improve the disease development in animal models of arthritis and in patients with RA. However,…
Abstract Number: 89 • 2019 ACR/ARP Annual Meeting
Difference of Induced CD4+ and Natural Regulatory T Cells in Targeting Inflamed Synovial Tissues in Autoimmune Arthritis
Ximei Zhang¹, Julie Wang ², Nancy Olsen ³, Wael Jarjour ⁴ and Song Guo Zheng ⁴, ¹Ohio State College of Medicine, Columbus, ²Ohio State University, columbus, ³Penn State University, Hershey, PA, ⁴Ohio State College of Medicine, Columbus, OH
Background/Purpose: Enhanced evidence supports that autoimmune diseases often result from an imbalance between regulatory T cells (Tregs) and interleukin-17-producing T helper (Th17) cells. However, under…
Abstract Number: 999 • 2019 ACR/ARP Annual Meeting
Targeted Drug Delivery Using a Novel Joint-homing Peptide for Arthritis Therapy
Rakeshchandra Meka¹, Shivaprasad Venkatesha ¹, Bodhraj Acharya ¹ and Kamal Moudgil ¹, ¹University of Maryland School of Medicine and Baltimore VA Medical Center, Baltimore, Baltimore, MD
Background/Purpose: Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disease characterized by inflammation of the synovial tissue of the joints, which if not controlled early…
Abstract Number: 100 • 2019 ACR/ARP Annual Meeting
Targeting ITK Signaling Ameliorates Collagen-Induced Arthritis via Shifting the Balance Between Th17 and Regulatory Th17 Cells
Ye Chen¹, Julie Wang ², Nancy Olsen ³, Wael Jarjour ⁴ and Song Guo Zheng ⁴, ¹Ohio State University, Columbus, OH, ²Ohio State University, columbus, ³Penn State University, Hershey, PA, ⁴Ohio State College of Medicine, Columbus, OH
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease that cannot be cured and current approaches have some severe side effects. Although the pathogenesis is…
Abstract Number: 1000 • 2019 ACR/ARP Annual Meeting
RKIP, as an Upstream Regulator of Intracellular Signaling, Exerts Anti-arthritic Effect in Fibroblast-like Synoviocyte and Collagen-induced Arthritis
Sang-Il Lee¹, Hae Sook Noh ² and Yun-Hong Cheon ¹, ¹Divison of Rheumatology, Gyeongsang National University Hospital, Jin-Ju, Republic of Korea, ²Gyeongsang University Hospital, Jinju, Republic of Korea
Background/Purpose: Nuclear factor-kappaB (NF-kappaB) and extracellular-signal-regulated kinase (ERK) have been implicated as a therapeutic target for the treatment of rheumatoid arthritis (RA). Raf kinase inhibitory…
Abstract Number: 101 • 2019 ACR/ARP Annual Meeting
CD126 Negative CD4+Foxp3+ Cell Represents a Superior Treg Subset in Treating Autoimmune Diseases
Ye Chen¹, Julie Wang ², Nancy Olsen ³, Wael Jarjour ⁴ and Song Guo Zheng ⁴, ¹Ohio State University, Columbus, OH, ²Ohio State University, columbus, ³Penn State University, Hershey, PA, ⁴Ohio State College of Medicine, Columbus, OH
Background/Purpose: Regulatory T (Treg) cells play an important role in maintaining immunologic homeostasis. Abnormal Treg cells were found in some autoimmune diseases. Transferred natural Treg…
Abstract Number: 1001 • 2019 ACR/ARP Annual Meeting
Oral Collagen Type V Supplementation Inhibits Cartilage Degeneration in Experimental Arthritis
Lizandre Keren Silveira ¹, José Eduardo Rodrigues ¹, Silvana Atayde ¹, Sergio Catanozi ¹, Antonio dos Santos Filho ², Vera Luiza Capelozzi ¹, Ricardo Fuller ², Ana Paula Velosa ² and Walcy Teodoro¹, ¹Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil, ²Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil
Background/Purpose: It is known that collagen V (col V) can generate autoimmunity when exposed. In contrast, induction of tolerance with col V supplementation is able…
Abstract Number: 109 • 2019 ACR/ARP Annual Meeting
Targeting CD6 Expression Attenuates T Cell Activity in Murine Collagen Induced Arthritis
Yan Li ¹, Jeffrey H. Ruth ², Stephanie Rasmussen ³, Kalana S. Athukorala ², Daniel P. Weber ², M. Asif Amin ², Phillip Campbell ³, Nora Singer ⁴, David Fox⁵ and Feng Lin ¹, ¹Cleveland Clinic, Cleveland, OH, ²University of Michigan, Ann Arbor, MI, ³Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ⁴The MetroHealth System -Case Western Reserve University School of Medicine, Cleveland, OH, ⁵Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence,University of Michigan, Ann Arbor, MI
Background/Purpose: CD6, an important regulator of T cell function, interacts with the ligands CD166 and CD318. We previously examined CD318 expression on synovial tissues (STs)…
Abstract Number: 1040 • 2019 ACR/ARP Annual Meeting
Proposition of a Novel Animal Model of Systemic Sclerosis Induced by Type V Collagen in C57BL/6 Mice Reproducing Fibrosis, Vasculopathy and Autoimmunity
Walcy Teodoro¹, Ana Paula Velosa ², Zelita Aparecida Queiroz ¹, Lais Araujo ³, Sergio Catanozi ¹, Antonio dos Santos Filho ⁴, Cleonice Bueno ⁴, Margarete Vendramini ⁴, Sandra Moraes Fernezlian ¹, Esmeralda Eher ⁴, Jurandir Tomaz de Miranda ¹, Fernanda Lopes ⁴, Sandra G. Pasoto ⁵, Percival Degrava Sampaio-Barros ⁶ and Vera Luiza Capelozzi ¹, ¹Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil, ²Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, São Paulo, Sao Paulo, Brazil, ³Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, São Paulo, Sao Paulo, Brazil, ⁴Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Sao Paulo, Sao Paulo, Brazil, ⁵Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), Sao Paulo, Brazil., Sao Paulo, Brazil, ⁶Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR, Brazil, Sao Paulo, Brazil
Background/Purpose: A better knowledge of the mechanisms and biomarkers of skin and lung damage in systemic sclerosis (SSc) related fibrosis remain a challenge. Our aim was…
Abstract Number: 978 • 2019 ACR/ARP Annual Meeting
Light Mediated Therapeutics in Arthritis
Victoria Wickenheisser¹, Emily Rabjohns ², Emilia Zywot ³, Natalia Orlova ³, Christina Marvin ³, Song Ding ⁴, David Lawrence ⁴ and Teresa Tarrant ⁵, ¹Duke University School of Medicine, Durham, ²Department of Rheumatology, Duke University Hospital, Durham, NC, ³UNC Department of Chemistry, Chapel Hill, NC, ⁴Division of Medicinal Chemistry and Chemical Biology The UNC Eshelman School of Pharmacy at UNC, Chapel Hill, NC, ⁵Department of Medicine Division of Rheumatology and Immunology, Duke University Hospital, Durham, NC
Background/Purpose: Rheumatoid arthritis (RA) therapies are constrained by the failure to deliver sufficient quantities of drug to the inflamed site, systemic side effects, and the…
Abstract Number: 1052 • 2019 ACR/ARP Annual Meeting
The PPAR Agonist Lanifibranor Protects Against Right Ventricular Hypertrophy in a Mouse Model of Systemic Sclerosis Associated Pulmonary Hypertension
Emma Derrett-Smith ¹, Kristina Clark¹, Shiwen Xu ¹, David Abraham ¹, Olivier Lacombe ², Pierre Broqua ², Jean-Louis Junien ², Irena Konstantinova ² and Christopher Denton ³, ¹University College London, London, United Kingdom, ²Inventiva, Daix, France, ³University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom
Background/Purpose: The TβRIIΔk-fib transgenic mouse model of systemic sclerosis (SSc) develops constitutive structural vasculopathy with vessel wall fibrosis and is susceptible to pulmonary hypertension (PH)…
Abstract Number: 980 • 2019 ACR/ARP Annual Meeting
Sema3B Expression Is Reduced in Rheumatoid Arthritis Patients and Has a Protective Role in a Murine Model of Arthritis
Ana Igea ¹, Tiago Carvalheiro ², Beatriz Malvar Fernandez ², Angela Rodriguez-Trillo ³, Trudy McGarry ⁴, Carmen Conde ⁵, Douglas Veale ⁶, Ursula Fearon ⁷, Africa Gonzalez ¹, Timothy R.D. Radstake ⁸, Kris A. Reedquist ² and Samuel Garcia⁹, ¹Department of Immunology, Centro de Investigaciones Biomédicas (CINBIO), Centro de Investigación Singular de Galicia, Instituto de Investigación Sanitaria Galicia Sur, Universidad de Vigo, Vigo, Spain, ²Department of Rheumatology and Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands, ³laboratorio de Reumatología Experimental y Observacional, Instituto de Investigación Sanitaria de Santiago (IDIS)-Hospital Clinico (CHUS), Santiago de Compostela, Spain, ⁴Department of Molecular Rheumatology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland, ⁵Laboratorio de Reumatología Experimental y Observacional, y Servicio de Reumatología, Instituto de Investigacion Sanitaria de Santiago (IDIS), Hospital Clínico Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Spain, ⁶EULAR Centre For Arthritis And Rheumatic Diseases and The Conway Institute, Dublin, Ireland, ⁷Molecular Rheumatology, Trinity Biomedical Sciences Institute, TCD, Dublin, Ireland, ⁸Department of Rheumatology/Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Utrecht, Netherlands, ⁹Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht, Spain
Background/Purpose: The semaphorin family is a large group of proteins initially described in axon guidance. However, semaphorins also play a role in other processes involved…

1
2
3
…
25
Next Page »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].