ACR Meeting Abstracts

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Abstracts tagged "Animal Model"

  • Abstract Number: 0058 • ACR Convergence 2021

    Effect of Anti-inflammatory Drugs on Intestinal Epithelial Damage and Bacterial Translocation in the Adjuvant-induced Arthritis Model

    Sophie Hecquet1, Perle Totoson2, Maude Tournier2, Clement Prati1, Daniel Wendling1, Céline Demougeot2 and Frank Verhoeven1, 1Service de rhumatologie, CHU de Besançon, Besançon, France, 2PEPITE EA4267, FHU INCREASE, Bourgogne Franche-Comté University, Besançon, France

    Background/Purpose: The intestine is no longer considered as an organ targeted by spondyloarthritis (SpA) but also an actor of the disease alongside environmental and immunological…
  • Abstract Number: 0459 • ACR Convergence 2021

    CCN1: An Angiogenic Actor Implicated in the Structural Damages of Rheumatoid Arthritis

    Jerome Avouac1, Alexia Steelandt2, Olivia Amiar2, Agathe Leblond2, Cindy Orvain2, Anne Cauvet2, Virginie Gonzalez2 and Yannick Allanore1, 1Université de Paris, Service de Rhumatologie, Hôpital Cochin, AP-HP.CUP, Paris, France, 2INSERM U1016, Institut Cochin, Paris, France

    Background/Purpose: We have previously shown that decreased expression of the deacetylase sirtuin-1 (SIRT1) contributes to the proliferative, activated and proangiogenic profile of endothelial cells (EC)…
  • Abstract Number: 0534 • ACR Convergence 2021

    Lymphatic Dysfunction in Murine Lupus Photosensitivity

    William Ambler1, Noa Schwartz2, Jin Yeon Shin3, Rahgu Kataru4, Camila Carballo5, Scott Rodeo6, Babak Mehrara4 and Theresa Lu7, 1Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery. HSS Research Institute, Hospital for Special Surgery, New York, NY, 2Department of Medicine, Division of Rheumatology, Albert Einstein College of Medicine, New York, NY, 3Department of Surgery, Division of Plastic and Reconstructive Surgery Memorial Sloan Kettering, New York, NY, 4Department of Surgery, Division of Plastic and Reconstructive Surgery, Memorial Sloan Kettering, New York, NY, 5HSS Research Institute, Hospital for Special Surgery, New York, NY, 6HSS Research Institute, Hospital for Special Surgery; Department of Orthopedics, Hospital for Special Surgery, New York, NY, 7Hospital for Special Surgery, New York, NY

    Background/Purpose: The lymphatic system is composed of vessels which carry fluid, soluble molecules, and cells from peripheral tissue to draining lymph nodes. Photosensitivity, an exaggerated…
  • Abstract Number: 0536 • ACR Convergence 2021

    The EIF4 Translational Inhibitor Pateamine a Improves Immunological and Neurological Functions in BXSB.yaa Lupus Mice

    Gonzalo Gómez-Hernández1, Nieves Varela1, Harini Bagavant2, Guillermo Barturen1, Marta E. Alarcon-Riquelme1 and Maria Morell1, 1GENYO.Center for Genomics and Oncological Research, Granada, Spain, 2Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by loss of tolerance and activation of the immune response. Clinical manifestations are heterogeneous and…
  • Abstract Number: 1017 • ACR Convergence 2021

    Osteoclast-Specific Transmembrane Protein (OC-STAMP) Regulates Osteoclastogenesis and Inhibits Inflammation in an Acute Arthritis Model

    Maria de la Luz Garcia-Hernandez1, Javier Rangel-Moreno1, Ananta Paine1, Jacob R. Jones1, Marc Nuzzo1, Lidsay N. Schnur2 and Christopher Ritchlin1, 1Division of Allergy, Immunology, and Rheumatology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, 2University of Rochester, Rochester, NY

    Background/Purpose: Dendritic Cell (DC)-Specific Transmembrane Protein (STAMP) expressed by osteoclast precursors is required for cell-cell fusion in the formation of the osteoclast (OC) polykaryon. Genetic…
  • Abstract Number: 1019 • ACR Convergence 2021

    Cigarette Smoking Induces Post-translational Protein Modifications in Both in Vitro and in Vivo Models of Rheumatoid Arthritis-associated Interstitial Lung Disease

    Alyssa Gregory1, Corrine Kliment1, Geoffrey Thiele2, Michael Duryee2, Ted Mikuls2, Bryant England2, Jill Poole2 and Dana Ascherman3, 1University of Pittsburgh School of Medicine, Pittsburgh, PA, 2University of Nebraska Medical Center, Omaha, NE, 3University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Cigarette smoking has been epidemiologically linked to the development of ACPA+ rheumatoid arthritis (RA) and, by extension, RA-associated interstitial lung disease (RA-ILD). Providing strong…
  • Abstract Number: 1020 • ACR Convergence 2021

    Enhancing Endothelial Cell Barrier Function via Sphingosine -1 Phosphate Receptor 1 (S1PR1) – a Novel Treatment for Experimental Arthritis

    Nathalie Burg, Ryan Malpass, Carl Blobel and Jane Salmon, Hospital for Special Surgery, New York, NY

    Background/Purpose: S1PR1 signaling plays critical roles in EC barrier function and vascular health, but until now, research on S1PR1 modulation in autoimmune rheumatic disease has…
  • Abstract Number: 1021 • ACR Convergence 2021

    Organic Dust Exposure Induces Post-translational Protein Modifications and a HLA-DR4-dependent Pro-inflammatory Lung Phenotype in a Murine Model of Interstitial Lung Disease

    Jill Poole1, Ted Mikuls1, Amy Nelson1, Rohit Gaurav1, Michael Duryee1, Geoffrey Thiele1, Bryant England1 and Dana Ascherman2, 1University of Nebraska Medical Center, Omaha, NE, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Environmental and occupational exposures have been epidemiologically linked to the development of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Previous investigation and modeling have also…
  • Abstract Number: 1432 • ACR Convergence 2021

    Modulation of Auto-Inflammation with a Novel Selective Cyclic GMP-AMP Synthase (cGAS) Inhibitor in a Trex1-/- Model

    Kelly Pike1, Alexandre Caron1, Emilie Bérubé1, Ramsay Beveridge1, Marc-Oliver Boily1, Jason Burch1, Valerie Dumais1, Nadine Fradet1, Samuel Gaudreault1, Daniel McKay1, Marianne Raymond1, Eleftheria Seliniotakis1, Daniel Sietsema3, Alexander Skeldon1, Miguel St.-Onge1, Li Wang2 and Michael Crackower2, 1Ventus Therapeutics, Montréal, QC, Canada, 2Ventus Therapeutics, Waltham, MA

    Background/Purpose: The detection of viral nucleic acids (NA) elicits a transient type I interferon (IFN) response central to antiviral immunity. Chronic type I IFN responses…
  • Abstract Number: 1468 • ACR Convergence 2021

    Intra-articular (IA) Injection of Empty Large Multilamellar Vesicles Liposomes Reduces Cartilage Degeneration in Rat Osteoarthritis Model

    Alison Bendele1, Jacob Favret1, Gadi Sarfati2, Ronny Pinkus2 and Roni Wechsler2, 1Bolder BioPATH Inc., Boulder, CO, 2Moebius Medical LTD, Tel Aviv, Israel

    Background/Purpose: A suspension of empty large multilamellar vesicles (MLV) liposomes composed of dimyristoylphosphatidylcholine (DMPC) and dipalmitoylphosphatidylcholine (DPPC), is currently under clinical development for symptomatic knee…
  • Abstract Number: 1471 • ACR Convergence 2021

    Oral Administration of Berberine Limits Post-traumatic Osteoarthritis Development and Associated Pain via AMP-activated Protein Kinase (AMPK) in Mice

    Jun Li1, Yun Wang2, Di Chen3 and Ru Liu Bryan4, 1Rush University Medical Center, Chicago, IL, 2Valo Health, Lexington, MA, 3Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China (People's Republic), 4University of California San Diego and VASDHS, San Diego, CA

    Background/Purpose: AMP-activated protein kinase (AMPK), a master regulator of energy balance and metabolism, is implicated to play an important role in cartilage homeostasis. Berberine is…
  • Abstract Number: 1507 • ACR Convergence 2021

    Role of CD4+ T Cells in the Pathogenesis of RA: Immunization with Citrullinated T Cell Epitopes Is Sufficient to Induce Immunological and Clinical Manifestations of Arthritis in DR4-Transgenic Mice

    Elena Tonti1, Bhargavi Duvvuri2, Sudeshna Dhar1, Derek Haaland3, Maggie Larche1 and Mark Larché1, 1McMaster University, Hamilton, ON, Canada, 2University of Washington, Seattle, WA, 3McMaster University, Hamilton, Ontario and The Waterside Clinic, Oro Medonte, ON, Canada

    Background/Purpose: Although the etiology of rheumatoid arthritis (RA) remains unclear, existing research suggests a complex interplay of both genetic and environmental factors. Citrullinated proteins/peptides, and…
  • Abstract Number: 1767 • ACR Convergence 2021

    CXCL5 Dampens Inflammation in Murine Lupus by Orchestral Suppression of Effector Cell Proliferation and Leukocyte Extravasation

    Xiubo Fan1, Chin Teck Ng1, Dianyang Guo1, Frances Lim1, Annie Law2, Julian Thumboo1, William Hwang3 and Andrea Low1, 1Singapore General Hospital, Singapore, Singapore, 2Singhealth, Singapore, Singapore, 3National Cancer Centre Singapore, Singapore, Singapore

    Background/Purpose: Systemic lupus erythematosus (SLE) is a potentially fatal autoimmune disease characterized by dysregulation of both innate and adaptive immunity. Current therapeutic options are limited,…
  • Abstract Number: 1890 • ACR Convergence 2021

    Cellular Origin and Functions of Osteoclasts in Inflammatory Arthritis

    Hannah Nelson1, Ellen Gravallese2, Julia Charles1 and Christian Jacome-Galarza1, 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: Inflammatory arthritis (IA) is an autoimmune disease targeting multiple joints and characterized by joint destruction caused by osteoclasts (OC), leading to physical disability. However,…
  • Abstract Number: 0843 • ACR Convergence 2020

    Rab4A Activation Predisposes to Hepatitis in Spontaneous and Pristane-Induced Mouse Models of Systemic Lupus Erythematosus

    Nick Huang1, Akshay Patel1, Zachary Oaks1 and Andras Perl1, 1SUNY Upstate Medical University, Syracuse, NY

    Background/Purpose: HRES-1/Rab4 or Rab4A, a GTPase responsible for mitochondrial oxidative stress1 and activation of the mechanistic target of rapamycin2, is overexpressed in T cells of…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

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