Abstract Number: 0914 • ACR Convergence 2026
Reactive Aldehyde Species Inhibitor ADX-246 Attenuates Autoantigen Expression and Tissue Fibrosis in a Pre-Clinical Model of Rheumatoid Arthritis-Associated Interstitial Lung Disease
Background/Purpose: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is the most overrepresented cause of death in RA. Moreover, treatment options for RA-ILD are limited. Malondialdehyde-acetaldehyde (MAA)…Abstract Number: 2009 • ACR Convergence 2026
Early intervertebral bone formation in recent-onset arthritis revealed by X-ray phase-contrast imaging: evidence for parallel, non-sequential bone and inflammatory processes
Frank Verhoeven1, cécile olivier2, Sébastien Aubry3, sophie hecquet4, céline viennet4, perle totson4, xavier Romand5, Athan Baillet6, ludovic broche7, Daniel Wendling8, celine demougeot9, clément prati10 and emmanuel brun2 Affiliations: 1Université Marie et Louis Pasteur, Service de rhumatologie CHU de Besancon, Besancon, France, 2Université Grenoble Alpes - INSERM, UA7 STROBE,, grenoble, France, 3CHU Besancon, besancon, France, 4Université Marie et Louis Pasteur, UMR 1098 Right, EFS, INSERM, UMR 1098,, Besancon, France, 5Rheumatology department, CHU Grenoble Alpes Sud, Grenoble, France, Grenoble, France, 6CHU Grenoble, Grenoble, France, 7Université Grenoble Alpes - INSERM, UA7 STROBE, Grenoble, France, 8Université Marie et Louis Pasteur, Service de rhumatologie, CHU de Besançon, Besançon, Franche-Comte, France, 92. Université Marie et Louis Pasteur, UFR Santé, UMR1098, EFS, INSERM,, Besancon, France, 10Université Marie et Louis Pasteur, CHU de Besançon, Rhumatologie, Besancon, France
Background/Purpose: Spinal structural progression in axial spondyloarthritis is classically associated with inflammation, particularly inflammatory corner lesions. However, intervertebral ossification follows a variable and still incompletely…Abstract Number: 0967 • ACR Convergence 2026
Aiolos restrains pathogenic CD8⁺ T-Cell Responses in antigen-Induced arthritis
Background/Purpose: AIOLOS, a transcription factor encoded by IKZF3, regulates lymphocyte differentiation and activation. Polymorphisms of IKZF3 have been linked to immune-mediated diseases, and human AIOLOS…Abstract Number: 2017 • ACR Convergence 2026
CX3CR1 and MHCII define four synovial macrophage populations with conserved inflammatory response across rheumatoid arthritis mouse models.
Background/Purpose: Macrophages in the synovial lining of the joint are critical for the maintenance of the healthy tissue while also contributing to the pathogenesis of…Abstract Number: 0974 • ACR Convergence 2026
Preclinical Characterization of ATG-207, a Masked and TGFβRIII-Biased αCD3-TGF-β Bi-specific Fusion Protein, for the Treatment of T cell-related Autoimmune Diseases
Background/Purpose: T cell-mediated autoimmune diseases are characterized by persistent pathogenic effector T-cell activity and inadequate regulatory T-cell (Treg) function, resulting in loss of durable immune…Abstract Number: 2035 • ACR Convergence 2026
FBXW11 inhibition reprograms activated rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) to a non-inflammatory phenotype and suppresses inflammatory arthritis
Background/Purpose: Neddylation is a key cellular regulatory mechanism that targets proteins for degradation. This process is aberrant in RA FLS due to deficient expression of…Abstract Number: 0995 • ACR Convergence 2026
A Novel APRIL/BAFF Dual-Target Humanized Mouse Model of SLE for Preclinical Evaluation of Therapeutics Targeting APRIL/BAFF
Background/Purpose: APRIL (a proliferation-inducing ligand) modulates B cell differentiation and plasma cell survival to sustain humoral immunity, serving as a promising therapeutic target for B cell-associated diseases. Telitacicept, a…Abstract Number: 2062 • ACR Convergence 2026
Environmental Conditions Impact the Severity of Lung Involvement in Collagen Induced Arthritis
Background/Purpose: The collagen-induced arthritis (CIA) model is commonly used in the study of rheumatoid arthritis (RA) with the incidence of arthritis ranging from 60-80% with…Abstract Number: 1000 • ACR Convergence 2026
Combined Rapamycin and Metformin Therapy Attenuates Lupus Manifestations While Mitigating Metabolic Toxicity in MRL/lpr Mice
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by immune dysregulation and multi-organ involvement. Rapamycin, an mTORC1 inhibitor, has demonstrated immunosuppressive…Abstract Number: 2088 • ACR Convergence 2026
Leveraging Mouse Models to Demonstrate Multicellular Targeting Advantages of CD40 Blockade Over CD20 Depletion in Antigen Presenting Cell Driven Autoimmunity
Background/Purpose: CD40, a receptor of the tumor necrosis factor (TNF) receptor superfamily, is primarily expressed on antigen-presenting cells (APC) including B cells, macrophages, and dendritic…Abstract Number: 1037 • ACR Convergence 2026
Anti-TL1A and anti-TNF Show Comparable Efficacy in a Mouse CIA Model Using Transgenic Mice Expressing Human TL1A
Background/Purpose: Despite the availability of several classes of biologic and targeted synthetic disease-modifying anti-rheumatic drugs (bDMARDs and tsDMARDs), there remains an unmet need for safe…Abstract Number: 2816 • ACR Convergence 2026
CD14 Deficiency in Mice Protects Against Age-associated Mobility Loss, Pain, and Multi-joint Degeneration
Background/Purpose: Osteoarthritis (OA) is a leading cause of pain and disability in older adults, with no disease-modifying therapies available. Aging is a key risk factor…Abstract Number: 1082 • ACR Convergence 2026
MRT-8102, an Orally Bioavailable NEK7-Selective Molecular Glue Degrader, Suppresses NLRP3 Inflammasome Activation and Demonstrates Efficacy in a Rabbit Model of Gouty Arthritis
Background/Purpose: Monosodium urate (MSU) crystals in gout, as well as calcium pyrophosphate dihydrate (CPPD) crystals in pseudogout, drive activation of the NLRP3 inflammasome and interleukin‑1…Abstract Number: 2819 • ACR Convergence 2026
Neurovascular Remodeling and Dorsal Root Ganglion Spatial Transcriptomic Alterations in a Murine ACLT Model of Osteoarthritis
Background/Purpose: Osteoarthritis (OA) is a leading cause of chronic pain and disability worldwide. Increasing evidence suggests that neurovascular remodeling contributes to OA progression and pain.However,…Abstract Number: 1083 • ACR Convergence 2026
PS-1001, a Novel Pan-Inflammasome Inhibitor Targeting the Adaptor Protein ASC: A Platform Candidate for Inflammasome-Driven Inflammatory Diseases
Background/Purpose: Aberrant inflammasome activation drives pathology across inflammatory and autoinflammatory diseases. It encompasses common immune-mediated conditions and rare monogenic or acquired systemic autoinflammatory syndromes, with…
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