ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Animal Model"

  • Abstract Number: L04 • ACR Convergence 2022

    Psoriatic Arthritis Disease Subtypes Mediated by CD8 T Cells Are Phenocopied in a Novel Humanized Murine Model of Psoriasis and Arthritis

    Maria de la Luz Garcia-Hernandez1, Javier Rangel-Moreno1, Ananta Paine2, Soumyaroop Bhattacharya3, Jeffrey Fox4, Ernest Meyer5, Brian Isett5, Riyue Bao6, Tullia Bruno6 and Christopher Ritchlin7, 1University of Rochester, Rochester, NY, 2ORNA Tx, Southborough, MA, 3Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, 4CMSR, University of Rochester Medical Center, Rochester, NY, 5UPMC Hillman Cancer Center, Pittsburgh, PA, 6University of Pittsburgh, Pittsburgh, PA, 7University of Rochester Medical Center, Rochester, NY

    Background/Purpose: A pivotal clinical characteristic of psoriatic arthritis (PsA) is disease manifestations in several domains (skin, entheses, joints, spine) and multiple domain involvement is prevalent,…
  • Abstract Number: 0316 • ACR Convergence 2022

    Targeting Oxidized Macrophage Migration Inhibitory Factor (oxMIF) – a Novel Treatment Approach for Rheumatoid Arthritis

    Christine Landlinger1, Maroua Ferhat1, ferdinando Nicoletti2 and Michael Thiele1, 1OncoOne R&D, Vienna, Austria, 2University of Catania, Catania, Italy

    Background/Purpose: Macrophage migration inhibitory factor (MIF) is a primary mediator of adaptive and innate immune responses, as well as a primary counter-regulator of glucocorticoids (GCs),…
  • Abstract Number: 1709 • ACR Convergence 2022

    Role of Corneal Langerhans Dendritic Cells in Lupus Keratitis

    Ram Singh1 and Angel Gutierrez2, 1UCLA David Geffen School of Medicine, Los Angeles, CA, 2University of California Los Angeles, Los Angeles, CA

    Background/Purpose: Patients with lupus and other systemic autoimmune diseases develop ocular surface inflammation that is sometimes severe and debilitating. Pathogenesis of autoimmune keratitis remains unclear.…
  • Abstract Number: 0586 • ACR Convergence 2022

    Transcription Factor Fli-1 Impacts CXCL13 Expression and Renal Inflammation in Lupus-like Nephritis of Adult MRL/lpr Mouse

    Shuzo Sato1, Xian Zhang2, Naoki Matsuoka1, Yuya Sumichika1, Kenji Saito1, Shuhei Yoshida1, Haruki Matsumoto1, Jumpei Temmoku1, Yuya Fujita1, Tomoyuki Asano1, Hiroshi Watanabe1 and Kiyoshi Migita1, 1Fukushima Medical University, Fukushima, Japan, 2Medical University of South Carolina, Charleston, SC

    Background/Purpose: Friend leukemia virus integration 1 (Fli-1) belongs to the Ets family of transcription factors and plays an important role in the development of lupus…
  • Abstract Number: 1713 • ACR Convergence 2022

    Bank1 Signaling Shapes the Gut Microbiota Composition by Controlling the Gut Mucosal B-cell Response in Lupus

    Georgina Galicia-Rosas, María Botía Sánchez, Daniel Toro-Domínguez, Lorena Albadalejo and Marta Alarcon-Riquelme, Center for Genomics and Oncological Research (GENYO), Granada, Spain

    Background/Purpose: Mucosa-associated commensal bacteria have been shown to be involved in the pathogenesis of systemic lupus erythematosus (SLE). However, its exact role remains to be…
  • Abstract Number: 0654 • ACR Convergence 2022

    Lymphatic Dysfunction and Immune Activation in Lupus

    william ambler1, Madhavi Somaraju1, JiHyun Sim1, Ethan Seltzer1, Noa Schwartz2, Ecem Sevim3, Doruk Erkan1, Jinyeon Shin4, Rahgu Kataru4, Babak Mehrara5 and theresa Lu1, 1Hospital for Special Surgery, New York, NY, 2Albert Einstein College of Medicine, New York, NY, 3Montefiore Medical Center - Wakefield Campus, New York, NY, 4Memorial Sloan Kettering, New York, NY, 5Department of Surgery, Division of Plastic and Reconstructive Surgery, Memorial Sloan Kettering, New York, NY

    Background/Purpose: Systemic lupus erythematosus is a prototypic autoimmune disease in which patients frequently have photosensitivity. Exposure to ultraviolet radiation (UVR) causes the eruption of cutaneous…
  • Abstract Number: 1714 • ACR Convergence 2022

    The Circadian Clock Gene Bmal1 Negatively Regulates Autoantibody Production in SLE

    Shuichiro Nakabo1, Donavon Sandoval-Heglund1, Victoria Hoffmann2, Mingzeng Zhang1, Norio Hanata1, Zerai Manna1, Elaine Poncio1, Sarfaraz Hasni3 and Mariana Kaplan4, 1NIAMS/NIH, Bethesda, MD, 2ORS/ORF/NIH, Bethesda, MD, 3National Institutes of Health, Bethesda, MD, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

    Background/Purpose: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects multiple organs including kidney and skin. While its etiology and pathogenesis are still…
  • Abstract Number: 0669 • ACR Convergence 2022

    Understanding How Type I Interferon Modulates Langerhans Cell ADAM17 to Promote Photosensitivity in Lupus

    Thomas Li1, Ethan Seltzer1, Victoria Zyulina1, Keila Veiga2, Noa Schwartz3, Yurii Chinenov1, David Oliver1, Jose Lora4, Ali Jabbari5, Yong Liu1, Hafsa Munir1, William Shipman1, Marvin Sandoval1, Isabel Sollohub1, william ambler1, Bikash Mishra4, sarah taber1, karen onel1, Mehdi Rashighi6, james krueger7, Niroshana Anandasabapathy4, Carl Blobel1 and theresa Lu1, 1Hospital for Special Surgery, New York, NY, 2Maria Fareri Children's Hospital, New York, NY, 3Albert Einstein College of Medicine, New York, NY, 4Weill Cornell Medicine, New York, NY, 5University of Iowa, Iowa City, IA, 6University of Massachusetts Medical School, Worcester, MA, 7Rockefeller University, New York, NY

    Background/Purpose: Photosensitivity is a hallmark symptom of lupus erythematosus (LE), in which patients develop inflammatory skin lesions in response to ultraviolet radiation (UVR). In examining…
  • Abstract Number: 1715 • ACR Convergence 2022

    Ezh2 Knockout in B Cells Impairs Plasmablast Differentiation and Ameliorates Lupus-like Disease in MRL/lpr Mice

    Xiaoqing Zheng1, Mikhail Dozmorov2, Colleen Strohlein1, Sheldon Bastacky1 and Amr Sawalha1, 1University of Pittsburgh, Pittsburgh, PA, 2Virginia Commonwealth University, Richmond, VA

    Background/Purpose: Enhancer of zeste homolog 2 (EZH2) has been shown to regulate early B cell development and the differentiation of antibody secreting cells (ASCs). We…
  • Abstract Number: 0694 • ACR Convergence 2022

    Evaluation of the Effect of UCB4470 (anti-mouse FcRn) on Amelioration of Thrombosis in a Mouse Model of Antiphospholipid (aPL)-induced Thrombosis

    Maria Laura Bertolaccini1, Yiannis Ioannou2, Helen Neale3, Prakash Saha1 and Alberto Smith1, 1King's College London, London, United Kingdom, 2UCB Biopharma SRL, London, United Kingdom, 3UCB Biopharma SRL, Slough, United Kingdom

    Background/Purpose: FcRn (the neonatal Fc receptor) is a receptor expressed by antigen-presenting cells, such as monocytes, macrophages, and dendritic cells, as well as on neutrophils.…
  • Abstract Number: 1718 • ACR Convergence 2022

    Parenchymal INFγ Response Regulates Murine Lupus Nephritis

    Minjung Kim1, Anthony Marinov1, Mark Shlomchik2 and Jeremy Tilstra2, 1University of Pittsburgh, Pittsburgh, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Lupus nephritis is the most common life-threatening end-organ complication of SLE. Interstitial infiltrates, specifically T cells, are major predictors of disease outcomes. We recently…
  • Abstract Number: 1094 • ACR Convergence 2022

    Mechanical Loading-induced BHLHE40 Promotes Inflammatory Arthritis

    Eric Gracey1, Carolien Vlieghe2, Isabelle Cambre1, Elisabeth Gilis1, Flore Stappers3, Guillaume Planckaert1, Rik Lories4, Aline Bozec5 and Dirk Elewaut6, 1Ghent University, Gent, Belgium, 2VIB-UGent Center for Inflammation Research, Ghent University, Belgium, Gent, Belgium, 3VIB-UGent Center for Inflammation Research, Ghent University, Ghent, Belgium, 4KU Leuven, Leuven, Belgium, 5Universitätsklinikum Erlangen, Erlangen, Germany, 6Department of Rheumatology, Ghent University Hospital, Belgium, VIB-UGent Center for Inflammation Research, Ghent University, Heusden, Belgium

    Background/Purpose: Force induced microdamage to joint tissue is hypothesized to trigger inflammatory events in the joint leading to arthritis. Patients with inflammatory arthritis, such as…
  • Abstract Number: 1719 • ACR Convergence 2022

    NLRP12 Deficiency Mice Present Severer Lupus Nephritis in a Pristane-Induced Lupus Like Model

    Yen Po Tsao1, Fang-Yu Tseng2, Ming-Han Chen3 and SZUTING CHEN2, 1Taipei Veterans General Hospital, Taipei, Taiwan, 2National Yang Ming Chao Tung University, Taipei, Taiwan, 3Division of Allergy, Immunology & Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Taipei, Taiwan

    Background/Purpose: Systemic lupus erythematous (SLE) is a systemic autoimmune disease that interferon (IFN) signature involved in the progress. NLRP12 (NOD-like receptor family (NLR) pyrin domain…
  • Abstract Number: 1095 • ACR Convergence 2022

    A20(Tnfaip3) in Keratinocytes Restricts an Early Antiviral Gene Program Associated with Psoriatic Skin and Joint Disease

    Bahram Razani1, Jared Liu1, Ryan Tobias1, Sugandh Kumar1, Zhi-Ming Huang1, Wilson Liao2, Barbara Malynn3 and Averil Ma3, 1Dept. of Dermatology, UCSF, San Francisco, 2Dept. of Dermatology, San Francisco, 3Division of Gastroenterology, UCSF, San Francisco

    Background/Purpose: A20 (Tnfaip3) levels are reduced in psoriatic plaques and polymorphisms in the TNFAIP3 gene locus are associated with increased risk for both psoriasis and psoriatic…
  • Abstract Number: 1723 • ACR Convergence 2022

    CXCR4-targeted Functionally Selective Immunomodulator Shows Robust Efficacy in Pristane-induced Murine Lupus Model

    Annegret Van der Aa1, Simon Tessier1, Jean-Philippe Herbeuval2 and Joël Crouzet1, 1Ermium Therapeutics SAS, Paris, France, 2CBMIT, CNRS UMR 8601, Université Paris Cité, Paris, France

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex, heterogeneous autoimmune disease. There is still a high unmet need to improve current treatment options. The chemokine…
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