Abstracts tagged "Angiogenesis"

Abstract Number: 937 • 2013 ACR/ARHP Annual Meeting
Inhibitor Of DNA Binding 1 Mediates Angiogenesis In Rheumatoid Arthritis By Recruitment Of Endothelial Progenitor Cells
Takeo Isozaki¹, Alisa E. Koch², M. Asif Amin¹, Ali S. Arbab³, Gautam Edhayan⁴, Christine M. Ha⁴, Pei-Suen Tsou⁴, Sean C. Friday⁴, David A. Fox⁴ and Jeffrey H. Ruth⁴, ¹Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ²University of Michigan Medical School, Ann Arbor, MI, ³Diagnostic Radiology, Henry Ford Hospital and Medical Centers, Detroit, MI, ⁴Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Endothelial progenitor cells (EPCs) are known to induce vasculoproliferative responses within rheumatoid arthritis (RA) synovial tissue (ST). Inhibitor of DNA-Binding 1 (Id1) is a…
Abstract Number: 946 • 2013 ACR/ARHP Annual Meeting
Interleukin-34 Regulates Angiogenesis and Cell Proliferation In Inflammatory Arthritis, This Effect Is Potentiated By Hypoxia
Emese Balogh¹, Mary Connolly¹, Monika Biniecka¹, Jennifer McCormick², Douglas J. Veale³ and Ursula Fearon², ¹Rheumatology, Translation Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ²Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, ³Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland
Background/Purpose: Interleukin-34 (IL-34) is a cytokine implicated in macrophage differentiation, angiogenesis and osteoclastogenesis in inflammatory arthritis (IA). IA is characterized by synovial hypoxia, increased oxidative…
Abstract Number: 777 • 2013 ACR/ARHP Annual Meeting
A Unique Role For Galectin-9 In Angiogenesis and Inflammatory Arthritis
Martin O'Brien¹, Qiang Shu², Pei-Suen Tsou³, William Stinson⁴, Jeffrey H. Ruth³, Takeo Isozaki⁵, Alisa E. Koch⁶, David A. Fox⁵ and M. Asif Amin⁵, ¹Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ²Department of Internal Medicine, University of Michigan Medical School and Qilu Hospital of Shandong University, Ann Arbor, MI, ³Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁴Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁵Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁶VA Medical Service, Ann Arbor, MI
Background/Purpose: Galectin-9 (Gal-9) is a mammalian lectin which contributes to T-cell autoimmunity and tumor biology. Here, we examined the contribution of Gal-9 in angiogenesis and…
Abstract Number: 658 • 2013 ACR/ARHP Annual Meeting
Elevated 8-Isoprostane In Scleroderma: Implications Of Its Role In Inhibiting Vascular Endothelial Growth Factor-Induced Angiogenesis
Pei-Suen Tsou¹, George Zakhem², Beatrix Balogh², M. Asif Amin³, Phillip Campbell⁴, Gautam Edhayan¹, Ray Ohara², Elena Schiopu⁵, Dinesh Khanna⁶, Alisa E. Koch^3,7 and David A. Fox¹, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²University of Michigan Medical School, Ann Arbor, MI, ³Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁴Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁵Rheumatology/Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁶Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁷Department of Veteran's Affairs and University of Michigan, Ann Arbor, MI
Background/Purpose: Scleroderma (SSc) is a complex disease characterized by inflammation, vasculopathy, and excessive disposition of extracellular matrix. Various studies have demonstrated a paradoxical increase in…
Abstract Number: 641 • 2013 ACR/ARHP Annual Meeting
Vitamin D Increases The Number and Function Of Myeloid Angiogenic Cells In Systemic Lupus Erythematosus
John A. Reynolds¹, David W. Ray², Terence O'Neill³, M. Yvonne Alexander⁴ and Ian N. Bruce⁵, ¹Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, United Kingdom, Manchester, United Kingdom, ²Institute of Human Development, Institute of Human Development, The University of Manchester, Manchester, United Kingdom, ³Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, ⁴Healthcare Science Research Institute, Faculty of Science and Engineering, Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁵Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit and NIHR Manchester Musculoskeletal Biomedical Research Unit, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Patients with Systemic Lupus Erythematosus (SLE) have an increased prevalence of cardiovascular disease (CVD). Vitamin D deficiency is common in SLE and an independent…
Abstract Number: 2870 • 2013 ACR/ARHP Annual Meeting
Higher Disease Activity and Serum Levels Of Angiogenic Factors In Patients With Rheumatoid Arthritis In Clinical Remission With Synovitis On Ultrasound
Julio Ramirez¹, Virginia Ruiz-Esquide², Isaac Pomés³, Raquel Celis⁴, Jaume Pomés³, Sonia Cabrera¹, M. Victoria Hernández⁵, Oscar M Epis⁶, Jose L. Pablos⁷, Raimon Sanmarti¹ and Juan D. Cañete², ¹Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ²Rheumatology, Hospital Clinic, Barcelona, Spain, ³Radiology, Hospital Clínic, Barcelona, Spain, ⁴Arthritis Unit, Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, ⁵Arthritis Unit, Department of Rheumatology, Hospital Clinic, Barcelona, Barcelona, Spain, ⁶A.O. Ospedale Niguarda Cà Granda, Milan, Italy, ⁷Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain
Background/Purpose: To identify and characterize subclinical synovitis in patients with rheumatoid arthritis in clinical remission using power Doppler ultrasound and serum levels of angiogenic factors.…
Abstract Number: 2571 • 2013 ACR/ARHP Annual Meeting
Pigment Epithelium Derived Factor Secreted By Activated Fibroblasts Can Contribute To Impaired Angio and Vasculogenesis In Scleroderma
Vasiliki Liakouli^1,2, Georgia Mavria³, Justin Gillespie⁴, Margherita Scarcia³, Paola Cipriani², Roberto Giacomelli², Paul Emery⁵ and Francesco Del Galdo⁵, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK., Leeds, United Kingdom, ²Rheumatology Unit, University of Aquila, L'Aquila, IT, L'Aquila, Italy, ³Signal Transduction and Angiogenesis group, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK, Leeds, United Kingdom, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disorder characterized by tissue fibrosis and vasculopathy. This latter comprises both neointima proliferation and defective angio and vasculogenesis.…
Abstract Number: 2219 • 2013 ACR/ARHP Annual Meeting
Active Immunization Against VEGF-Derived Oligopeptides Improves Joint Inflammation and Destruction In Collagen-Induced Arthritis
Emilie Duvallet¹, Laure Foulboeuf¹, Luca Semerano², Nadia Belmellat¹, Marc Lecouvey³, Eric Assier¹, Sylviane Muller⁴ and Marie-Christophe Boissier⁵, ¹EA4222, Li2P, University Paris 13, Sorbonne Paris Cité, EA4222, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France, ²INSERM UMR U1125, University Paris 13, Sorbonne Paris Cité, Bobigny, France, ³CSPBAT Paris 13 University, Bobigny, France, ⁴Institut de Biologie Moléculaire et Cellulaire, CNRS, Strasbourg, France, ⁵INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France
Background/Purpose: We have demonstrated in experimental models the efficacy of vaccination against cytokines, using a heterocomplex of keyhole limpet hemocyanin (KLH) and human TNF, called…
Abstract Number: 1846 • 2013 ACR/ARHP Annual Meeting
Mitochondrial Dysfunction Induces An Inflammatory, Tissue-Degrading, and Angiogenic Response In Normal Human Synoviocytes
M. Noa Valcárcel-Ares¹, Romina R. Riveiro-Naveira¹, Jesus Loureiro¹, Carlos Vaamonde-García¹, Laura Hermida-Carballo¹, Francisco J. Blanco² and Maria J. López-Armada¹, ¹Aging and Inflammation Research Lab, INIBIC-CHU A Coruña, A Coruña, Spain, ²Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain
Background/Purpose: Tissues affected with inflammatory arthritis (IA) are subjected to great levels of oxidative stress. Synoviocytes from IA patients present a higher rate of mitochondrial…
Abstract Number: 1780 • 2012 ACR/ARHP Annual Meeting
Association Between Chondrocyte Hypertrophy and Angiogenesis of Cartilage in Osteoarthritis
Laurence Pesesse¹, Christelle Sanchez², Jean-Pierre Delcour³, Caroline Baudouin⁴, Philippe Msika⁴ and Yves Henrotin⁵, ¹Bone and Cartilage Research Unit, University of Liège, Liège, Belgium, ²Bone and Cartilage Research Unit, University of Liège, Liege, Belgium, ³Orthopedic surgery, Centre hospitalier du Bois de l'Abbaye, Seraing, Belgium, ⁴IRD Direction, Laboratoires Expanscience, Epernon, France, ⁵University of Liège, Bone and Cartilage Research Unit, Liège, Belgium
Background/Purpose: Chondrocyte hypertrophy is commonly observed in OA cartilage, associated with matrix mineralization and vascularization. In our previous work, we demonstrated that hypertrophic differentiation of…
Abstract Number: 1777 • 2012 ACR/ARHP Annual Meeting
The Bioenergetic Role of HIF-1 and HIF-2 During Angiogenesis of Human Microvascular Endothelial Cells
Martin Hahne¹, Cindy Strehl¹, Manuela Jakstadt¹, Paula Hoff¹, Timo Gaber¹, Gerd Burmester¹ and Frank Buttgereit², ¹Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ²Charité - Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: Hypoxia and angiogenesis are features of inflamed and injured tissues. The transcription factors Hypoxia inducible factor (HIF)-1 and (HIF)-2 control cellular metabolic response to…
Abstract Number: 1599 • 2012 ACR/ARHP Annual Meeting
NF-Kb Inducing Kinase (NIK) Is a Key Regulator of Inflammation-Induced Angiogenesis
A.R. Noort¹, K.P.M. van Zoest¹, P. Koolwijk², D.V. Novack³, M.J. Siemerink⁴, P. P. Tak⁵ and S.W. Tas⁶, ¹Division of Clinical Immunology & Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Physiology, Institute for Cardiovascular Research (ICaR-VU) / VU University Medical Center, Amsterdam, Netherlands, ³Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, ⁴Department of Ophthalmology and Department of Cell Biology and Histology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ⁵Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands, ⁶Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: In rheumatoid arthritis (RA) synovial tissue (ST) angiogenesis can be observed already in the earliest phase of disease, which may be critical in the…
Abstract Number: 1602 • 2012 ACR/ARHP Annual Meeting
Tie2 Signalling Induces a Pro-Inflammatory and Pro-Angiogenic Phenotype in Differentiated Macrophages, Independently of Macrophage Polarization Conditions, and Contributes to Production of Cytokines Elevated in Early Rheumatoid Arthritis
Samuel Garcia¹, Sarah Krausz², Carmen A. Ambarus³, Bea Malvar Fernandez², Dominique L. Baeten⁴, Paul P. Tak⁵ and Kris A. Reedquist², ¹Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁵Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: Angiopoietin (Ang) -1 and -2 signalling to the Tie2 tyrosine kinase receptor has an essential role in blood vessel remodeling and angiogenesis. Ang-1, Ang-2…
Abstract Number: 1603 • 2012 ACR/ARHP Annual Meeting
Inhibitor of DNA Binding 1 As a Secreted Angiogenic Transcription Factor in Rheumatoid Arthritis
Takeo Isozaki¹, M. Asif Amin², Alisa E. Koch³, Ali Arbab⁴, Stephanie A. Shuman¹, Christine M. Ha¹, G. Kenneth Haines III⁵ and Jeffrey H. Ruth⁶, ¹Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ²Department of Medicine, University of Michigan, Ann Arbor, MI, ³Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI, ⁴Diagnostic Radiology, Henry Ford Hospital and Medical Centers, Detroit, MI, ⁵Department of Pathology, Yale University, New Haven, CT, ⁶Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Rheumatoid arthritis (RA) is characterized by enhanced blood vessel development in joint synovium. This involves the recruitment of endothelial progenitor cells (EPCs), allowing for…
Abstract Number: 1506 • 2012 ACR/ARHP Annual Meeting
Primary Human Scleroderma Dermal Endothelial Cells Exhibit Defective Angiogenesis
Pei-Suen Tsou¹, Bradley J. Rabquer², Beatrix Balogh², Ann Kendzicky², Bashar Kahaleh³, Elena Schiopu⁴, Dinesh Khanna⁵ and Alisa E. Koch⁶, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²University of Michigan Medical School, Ann Arbor, MI, ³Medicine/Rheumatology, University of Toledo, Toledo, OH, ⁴Rheumatology/Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁵Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁶Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Angiogenesis, the formation of new blood vessels, plays a critical role in a number of pathological processes including systemic sclerosis (scleroderma, SSc). SSc is…

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