Abstracts tagged "Angiogenesis"

Abstract Number: 1666 • 2013 ACR/ARHP Annual Meeting
Negative Temporal Artery Biopsies: Pathologic Findings Of Patients With Biopsy-Negative Giant Cell Arteritis Compared To Those Of Patients Without Arteritis
Francesco Muratore¹, Alberto Lo Gullo¹, Alberto Cavazza², Giuseppe Germanò¹, Luigi Boiardi¹ and Carlo Salvarani³, ¹Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ²Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ³Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy
Background/Purpose: Temporal artery biopsy (TAB) showing transmural inflammation is considered the gold standard for the diagnosis of giant cell arteritis (GCA). A negative TAB does…
Abstract Number: 1373 • 2013 ACR/ARHP Annual Meeting
Connective Tissue Growth Factor Promotes Angiogenesis Through Increased Notch-1 Signaling in Rheumatoid Arthritis
Kazuhisa Nozawa¹, Maki Fujishiro², Ayako Yamaguchi¹, Mikiko Kawasaki², Kazuhisa Iwabuchi², Mitsuaki Yanagida², Keigo Ikeda³, Shinji Morimoto⁴, Yoshinari Takasaki⁵ and Iwao Sekigawa³, ¹Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ²Institute for Environment and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan, ³Internal Medicine 2, Juntendo University Urayasu Hospital, Tomioka, Urayasu, Chiba, Japan, ⁴Juntendo University Urayasu Hospital, Tokyo, Japan, ⁵Division of Rheumatology, Department of Internal Medicine, Juntendo University, Tokyo, Japan
Background/Purpose: Increased angiogenesis has been associated with various inflammatory disease states including rheumatoid arthritis (RA), and it has been considered as one of main factors…
Abstract Number: 932 • 2013 ACR/ARHP Annual Meeting
Hypoxia and Signal Transducer and Activator Of Transcription 3 Signalling Interactions Regulate Pro-Inflammatory Pathways In Rheumatoid Arthritis
Wei Gao¹, Jennifer McCormick¹, Mary Connolly², Emese Balogh², Douglas J. Veale¹ and Ursula Fearon¹, ¹Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, ²Rheumatology, Translation Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland
Background/Purpose: Signal Transducer and Activator of Transcription 3 (STAT3), a critical transcription activator in angiogenesis, plays a crucial role in the pathogenesis of Rheumatoid Arthritis…
Abstract Number: 933 • 2013 ACR/ARHP Annual Meeting
Characterizing The Expression and Function Of CCL28 and Its Corresponding Receptor CCR10 In The Pathogenesis Of RA
Zhenlong Chen¹, Seung-jae Kim¹, Michael V. Volin², Suncica Volkov¹, William Swedler³, Nadera J. Sweiss⁴ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ³Section of Rheumatology, University of Illinois at Chicago, Chicago, IL, ⁴internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: This study was conducted to determine the expression pattern and function of CCL28 and its corresponding receptor CCR10 in the pathogenesis of rheumatoid arthritis…
Abstract Number: 937 • 2013 ACR/ARHP Annual Meeting
Inhibitor Of DNA Binding 1 Mediates Angiogenesis In Rheumatoid Arthritis By Recruitment Of Endothelial Progenitor Cells
Takeo Isozaki¹, Alisa E. Koch², M. Asif Amin¹, Ali S. Arbab³, Gautam Edhayan⁴, Christine M. Ha⁴, Pei-Suen Tsou⁴, Sean C. Friday⁴, David A. Fox⁴ and Jeffrey H. Ruth⁴, ¹Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ²University of Michigan Medical School, Ann Arbor, MI, ³Diagnostic Radiology, Henry Ford Hospital and Medical Centers, Detroit, MI, ⁴Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Endothelial progenitor cells (EPCs) are known to induce vasculoproliferative responses within rheumatoid arthritis (RA) synovial tissue (ST). Inhibitor of DNA-Binding 1 (Id1) is a…
Abstract Number: 946 • 2013 ACR/ARHP Annual Meeting
Interleukin-34 Regulates Angiogenesis and Cell Proliferation In Inflammatory Arthritis, This Effect Is Potentiated By Hypoxia
Emese Balogh¹, Mary Connolly¹, Monika Biniecka¹, Jennifer McCormick², Douglas J. Veale³ and Ursula Fearon², ¹Rheumatology, Translation Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ²Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, ³Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland
Background/Purpose: Interleukin-34 (IL-34) is a cytokine implicated in macrophage differentiation, angiogenesis and osteoclastogenesis in inflammatory arthritis (IA). IA is characterized by synovial hypoxia, increased oxidative…
Abstract Number: 777 • 2013 ACR/ARHP Annual Meeting
A Unique Role For Galectin-9 In Angiogenesis and Inflammatory Arthritis
Martin O'Brien¹, Qiang Shu², Pei-Suen Tsou³, William Stinson⁴, Jeffrey H. Ruth³, Takeo Isozaki⁵, Alisa E. Koch⁶, David A. Fox⁵ and M. Asif Amin⁵, ¹Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ²Department of Internal Medicine, University of Michigan Medical School and Qilu Hospital of Shandong University, Ann Arbor, MI, ³Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁴Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁵Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁶VA Medical Service, Ann Arbor, MI
Background/Purpose: Galectin-9 (Gal-9) is a mammalian lectin which contributes to T-cell autoimmunity and tumor biology. Here, we examined the contribution of Gal-9 in angiogenesis and…
Abstract Number: 658 • 2013 ACR/ARHP Annual Meeting
Elevated 8-Isoprostane In Scleroderma: Implications Of Its Role In Inhibiting Vascular Endothelial Growth Factor-Induced Angiogenesis
Pei-Suen Tsou¹, George Zakhem², Beatrix Balogh², M. Asif Amin³, Phillip Campbell⁴, Gautam Edhayan¹, Ray Ohara², Elena Schiopu⁵, Dinesh Khanna⁶, Alisa E. Koch^3,7 and David A. Fox¹, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²University of Michigan Medical School, Ann Arbor, MI, ³Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁴Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁵Rheumatology/Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁶Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁷Department of Veteran's Affairs and University of Michigan, Ann Arbor, MI
Background/Purpose: Scleroderma (SSc) is a complex disease characterized by inflammation, vasculopathy, and excessive disposition of extracellular matrix. Various studies have demonstrated a paradoxical increase in…
Abstract Number: 641 • 2013 ACR/ARHP Annual Meeting
Vitamin D Increases The Number and Function Of Myeloid Angiogenic Cells In Systemic Lupus Erythematosus
John A. Reynolds¹, David W. Ray², Terence O'Neill³, M. Yvonne Alexander⁴ and Ian N. Bruce⁵, ¹Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, United Kingdom, Manchester, United Kingdom, ²Institute of Human Development, Institute of Human Development, The University of Manchester, Manchester, United Kingdom, ³Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, ⁴Healthcare Science Research Institute, Faculty of Science and Engineering, Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁵Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit and NIHR Manchester Musculoskeletal Biomedical Research Unit, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Patients with Systemic Lupus Erythematosus (SLE) have an increased prevalence of cardiovascular disease (CVD). Vitamin D deficiency is common in SLE and an independent…
Abstract Number: 879 • 2012 ACR/ARHP Annual Meeting
Fucosyltransferase 1 (fut1) Is Overexpressed in Rheumatoid Arthritis Synovial Tissue and Modifies Cytokine Production
Takeo Isozaki¹, Jeffrey H. Ruth², M. Asif Amin¹, Phillip L. Campbell¹, Steven E. Domino³, G. Kenneth Haines III⁴ and Alisa E. Koch⁵, ¹Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ²Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, ⁴Department of Pathology, Yale University, New Haven, CT, ⁵Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by inflammation and joint destruction. Angiogenesis and cytokine production are involved in the pathogenesis of…
Abstract Number: 667 • 2012 ACR/ARHP Annual Meeting
Interferon-Alpha Impairs the Survival and Function of Circulating Angiogenic Cells in Vitro: A Model of Failed Endothelial Repair in SLE
John A. Reynolds¹, David W. Ray², Terence O'Neill³, M. Yvonne Alexander⁴ and Ian N. Bruce⁵, ¹Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, United Kingdom, Manchester, United Kingdom, ²Institute of Human Development, Institute of Human Development, The University of Manchester, Manchester, United Kingdom, ³Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ⁴Healthcare Science Research Institute, Faculty of Science and Engineering, Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁵Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit and NIHR Manchester Musculoskeletal Biomedical Research Unit, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Patients with Systemic Lupus Erythematosus have an increased risk of cardiovascular disease (CVD). No specific targeted therapies for CVD in lupus exist and there…
Abstract Number: 589 • 2012 ACR/ARHP Annual Meeting
NGF and Trka: A Novel Therapeutic Target in Chronic Inflammation
Siba P. Raychaudhuri¹, Ananya Datta Mitra² and Smriti K. Raychaudhuri², ¹Rheumatology, VA Sacramento Medical Center/UC Davis School of Medicine, Mather, CA, ²Rheumatology, VA Sacramento Medical Center, Mather, CA
Background/Purpose: Outside the nervous system, several studies have established the regulatory role of nerve growth factor (NGF) and its high affinity receptor, TrkA. A clinical…
Abstract Number: 2454 • 2012 ACR/ARHP Annual Meeting
Expression of TLR5 Strongly Correlates with Levels of TNF-a and DAS28 in RA Monocytes and Ligation of TLR5 Induces Angiogenesis in RA
Nathan D. Chamberlain¹, Michael Volin², Olga M. Vila³, Shiva Arami⁴, Suncica Volkov⁵ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ³University of Illinois at Chicago, Chicago, IL, ⁴Medicine - Rheumatology, University of Illinois at Chicago, Chicago, IL, ⁵Rheumatology/MC 733, University of Illinois at Chicago, Chicago, IL
Background/Purpose: This study was performed to determine whether expression of TLR5 is associated with Rheumatoid Arthritis (RA) disease activity as well as to examine the…
Abstract Number: 2392 • 2012 ACR/ARHP Annual Meeting
Blood Vessel Instability and Oxidative Damage in Giant Cell Arteritis
Danielle Molloy¹, Jennifer McCormick², Mary Connolly², Muhammad Haroon³, Douglas J. Veale², Conor Murphy⁴, Ursula Fearon² and Eamonn S. Molloy¹, ¹Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland, ²Rheumatology, Dublin Academic Medical Center, St. Vincent's University Hospital, Dublin, Ireland, ³Department of Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ⁴Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland
Background/Purpose: Giant cell arteritis (GCA) is the most common form of primary vasculitis. The pathogenesis is incompletely understood, but involves neoangiogenesis and inflammatory infiltration of…
Abstract Number: 1806 • 2012 ACR/ARHP Annual Meeting
A Novel Angiopoetin2/TEK Tyrosine Kinase Receptor Mediated Effect On Leukocyte Cell Influx and Oxidative Damage in Inflammatory Arthritis
Emese Balogh¹, Chin T. Ng¹, Douglas J. Veale², Ursula Fearon¹ and Monika Biniecka¹, ¹Rheumatology, Translation Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ²Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland
Background/Purpose: The Angiopoietin2 (Ang2)/TEK Tyrosine Kinase Receptor (Tie2) signalling pathway acts synergistically with VEGF/flk as critical regulators of new vessel growth, morphology and stability possibly…

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