Abstracts tagged "Angiogenesis"

Abstract Number: 1602 • 2012 ACR/ARHP Annual Meeting
Tie2 Signalling Induces a Pro-Inflammatory and Pro-Angiogenic Phenotype in Differentiated Macrophages, Independently of Macrophage Polarization Conditions, and Contributes to Production of Cytokines Elevated in Early Rheumatoid Arthritis
Samuel Garcia¹, Sarah Krausz², Carmen A. Ambarus³, Bea Malvar Fernandez², Dominique L. Baeten⁴, Paul P. Tak⁵ and Kris A. Reedquist², ¹Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁵Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: Angiopoietin (Ang) -1 and -2 signalling to the Tie2 tyrosine kinase receptor has an essential role in blood vessel remodeling and angiogenesis. Ang-1, Ang-2…
Abstract Number: 1603 • 2012 ACR/ARHP Annual Meeting
Inhibitor of DNA Binding 1 As a Secreted Angiogenic Transcription Factor in Rheumatoid Arthritis
Takeo Isozaki¹, M. Asif Amin², Alisa E. Koch³, Ali Arbab⁴, Stephanie A. Shuman¹, Christine M. Ha¹, G. Kenneth Haines III⁵ and Jeffrey H. Ruth⁶, ¹Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ²Department of Medicine, University of Michigan, Ann Arbor, MI, ³Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI, ⁴Diagnostic Radiology, Henry Ford Hospital and Medical Centers, Detroit, MI, ⁵Department of Pathology, Yale University, New Haven, CT, ⁶Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Rheumatoid arthritis (RA) is characterized by enhanced blood vessel development in joint synovium. This involves the recruitment of endothelial progenitor cells (EPCs), allowing for…
Abstract Number: 1506 • 2012 ACR/ARHP Annual Meeting
Primary Human Scleroderma Dermal Endothelial Cells Exhibit Defective Angiogenesis
Pei-Suen Tsou¹, Bradley J. Rabquer², Beatrix Balogh², Ann Kendzicky², Bashar Kahaleh³, Elena Schiopu⁴, Dinesh Khanna⁵ and Alisa E. Koch⁶, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²University of Michigan Medical School, Ann Arbor, MI, ³Medicine/Rheumatology, University of Toledo, Toledo, OH, ⁴Rheumatology/Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁵Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁶Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Angiogenesis, the formation of new blood vessels, plays a critical role in a number of pathological processes including systemic sclerosis (scleroderma, SSc). SSc is…
Abstract Number: 1511 • 2012 ACR/ARHP Annual Meeting
Low Circulating Endothelial Progenitor Cell Levels and High VEGF Serum Levels Are Associated with the Late Nailfold Capillaroscopic Pattern in Systemic Sclerosis
Jerome Avouac¹, Maeva Vallucci², Vanessa Smith³, Barbara Ruiz², Alberto Sulli⁴, Carmen Pizzorni⁵, Gilles Chiocchia⁶, Maurizio Cutolo⁷ and Yannick Allanore⁸, ¹Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ²Paris Descartes University, INSERM U1016, Institut Cochin, Sorbonne Paris Cité, Paris, France, ³Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁴Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ⁵Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ⁶Immunology and Hematology Department, Institut Cochin - INSERM U1016 - CNRS (UMR 8104), Paris, France, ⁷Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ⁸Rheumatology, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France
Background/Purpose: To assess whether nailfold videocapillaroscopy (NVC) changes are associated with peripheral blood or serum levels of angiogenic biomarkers in systemic sclerosis (SSc). Methods: Endothelial…
Abstract Number: 1291 • 2012 ACR/ARHP Annual Meeting
A Phase Ib Clinical Trial with F8-IL10, an Anti-Inflammatory Immunocytokine for the Treatment of Rheumatoid Arthritis (RA), Used in Combination with Methotrexate (MTX)
Mauro Galeazzi¹, Caterina Baldi¹, Elena Prisco², Marco Bardelli¹, Dario Neri³, Leonardo Giovannoni⁴, Enrico Selvi¹ and Roberto Caporali², ¹Rheumatology, University of Siena, Siena, Italy, ²Rheumatology, University of Pavia, IRCCS Policlinico San Matteo Foundation, Pavia, Italy, ³Chemistry and Applied Biosciences, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland, ⁴Philogen S.p.A., Siena, Italy
Background/Purpose: Interleukin 10 (IL10) is an anti-inflammatory cytokine potentially efficacious for RA. F8-IL10 is a fusion protein in which the cytokine is fused with the…
Abstract Number: 1191 • 2012 ACR/ARHP Annual Meeting
Nicotinamide Adenine Dinucleotide Phosphate Oxidase Mediated Angiogenesis and Inflammation in the Arthritic Joint
Monika Biniecka¹, Wei Gao², Chin Teck Ng¹, Emese Balogh², Douglas J. Veale² and Ursula Fearon², ¹Rheumatology, Translation Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ²Dublin Academic Medical Centre, St. Vincent's University Hospital, Translation Rheumatology Research Group, Dublin, Ireland
Background/Purpose: To examine the role of Nicotinamide Adenine Dinucleotide Phosphate Oxidase (NADPH oxidase)-derived Reactive Oxygen Species (ROS) and NADPH oxidase-dependent redox signaling events in regulating…
Abstract Number: 879 • 2012 ACR/ARHP Annual Meeting
Fucosyltransferase 1 (fut1) Is Overexpressed in Rheumatoid Arthritis Synovial Tissue and Modifies Cytokine Production
Takeo Isozaki¹, Jeffrey H. Ruth², M. Asif Amin¹, Phillip L. Campbell¹, Steven E. Domino³, G. Kenneth Haines III⁴ and Alisa E. Koch⁵, ¹Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ²Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, ⁴Department of Pathology, Yale University, New Haven, CT, ⁵Internal Medicine - Rheumatology, University of Michigan Medical School, Ann Arbor, MI
Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by inflammation and joint destruction. Angiogenesis and cytokine production are involved in the pathogenesis of…
Abstract Number: 667 • 2012 ACR/ARHP Annual Meeting
Interferon-Alpha Impairs the Survival and Function of Circulating Angiogenic Cells in Vitro: A Model of Failed Endothelial Repair in SLE
John A. Reynolds¹, David W. Ray², Terence O'Neill³, M. Yvonne Alexander⁴ and Ian N. Bruce⁵, ¹Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, United Kingdom, Manchester, United Kingdom, ²Institute of Human Development, Institute of Human Development, The University of Manchester, Manchester, United Kingdom, ³Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom, ⁴Healthcare Science Research Institute, Faculty of Science and Engineering, Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁵Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit and NIHR Manchester Musculoskeletal Biomedical Research Unit, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Patients with Systemic Lupus Erythematosus have an increased risk of cardiovascular disease (CVD). No specific targeted therapies for CVD in lupus exist and there…
Abstract Number: 589 • 2012 ACR/ARHP Annual Meeting
NGF and Trka: A Novel Therapeutic Target in Chronic Inflammation
Siba P. Raychaudhuri¹, Ananya Datta Mitra² and Smriti K. Raychaudhuri², ¹Rheumatology, VA Sacramento Medical Center/UC Davis School of Medicine, Mather, CA, ²Rheumatology, VA Sacramento Medical Center, Mather, CA
Background/Purpose: Outside the nervous system, several studies have established the regulatory role of nerve growth factor (NGF) and its high affinity receptor, TrkA. A clinical…
Abstract Number: 2454 • 2012 ACR/ARHP Annual Meeting
Expression of TLR5 Strongly Correlates with Levels of TNF-a and DAS28 in RA Monocytes and Ligation of TLR5 Induces Angiogenesis in RA
Nathan D. Chamberlain¹, Michael Volin², Olga M. Vila³, Shiva Arami⁴, Suncica Volkov⁵ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ³University of Illinois at Chicago, Chicago, IL, ⁴Medicine - Rheumatology, University of Illinois at Chicago, Chicago, IL, ⁵Rheumatology/MC 733, University of Illinois at Chicago, Chicago, IL
Background/Purpose: This study was performed to determine whether expression of TLR5 is associated with Rheumatoid Arthritis (RA) disease activity as well as to examine the…
Abstract Number: 2392 • 2012 ACR/ARHP Annual Meeting
Blood Vessel Instability and Oxidative Damage in Giant Cell Arteritis
Danielle Molloy¹, Jennifer McCormick², Mary Connolly², Muhammad Haroon³, Douglas J. Veale², Conor Murphy⁴, Ursula Fearon² and Eamonn S. Molloy¹, ¹Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland, ²Rheumatology, Dublin Academic Medical Center, St. Vincent's University Hospital, Dublin, Ireland, ³Department of Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ⁴Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland
Background/Purpose: Giant cell arteritis (GCA) is the most common form of primary vasculitis. The pathogenesis is incompletely understood, but involves neoangiogenesis and inflammatory infiltration of…
Abstract Number: 1806 • 2012 ACR/ARHP Annual Meeting
A Novel Angiopoetin2/TEK Tyrosine Kinase Receptor Mediated Effect On Leukocyte Cell Influx and Oxidative Damage in Inflammatory Arthritis
Emese Balogh¹, Chin T. Ng¹, Douglas J. Veale², Ursula Fearon¹ and Monika Biniecka¹, ¹Rheumatology, Translation Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ²Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland
Background/Purpose: The Angiopoietin2 (Ang2)/TEK Tyrosine Kinase Receptor (Tie2) signalling pathway acts synergistically with VEGF/flk as critical regulators of new vessel growth, morphology and stability possibly…
Abstract Number: 1780 • 2012 ACR/ARHP Annual Meeting
Association Between Chondrocyte Hypertrophy and Angiogenesis of Cartilage in Osteoarthritis
Laurence Pesesse¹, Christelle Sanchez², Jean-Pierre Delcour³, Caroline Baudouin⁴, Philippe Msika⁴ and Yves Henrotin⁵, ¹Bone and Cartilage Research Unit, University of Liège, Liège, Belgium, ²Bone and Cartilage Research Unit, University of Liège, Liege, Belgium, ³Orthopedic surgery, Centre hospitalier du Bois de l'Abbaye, Seraing, Belgium, ⁴IRD Direction, Laboratoires Expanscience, Epernon, France, ⁵University of Liège, Bone and Cartilage Research Unit, Liège, Belgium
Background/Purpose: Chondrocyte hypertrophy is commonly observed in OA cartilage, associated with matrix mineralization and vascularization. In our previous work, we demonstrated that hypertrophic differentiation of…

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