ACR Meeting Abstracts

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Abstracts tagged "ANCA"

  • Abstract Number: 734 • 2013 ACR/ARHP Annual Meeting

    The Significance Of Anti-Myeloperoxidase and Anti-Proteinase 3 Antibodies In The Absence Of Anti-Neutrophil Cytoplasmic Antibody Immunofluorescence Positivity

    Deepak A. Rao1, Joseph F. Merola1, William R. O'Brien1, Kevin Wei1, Samuel U. Takvorian2, Paul F. Dellaripa3 and Peter H. Schur1, 1Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 3Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Identification of serum anti-neutrophil cytoplasmic antibodies (ANCA) for the detection of ANCA-associated vasculitis (AAV) is often performed by screening with indirect immunofluorescence (IF), followed…
  • Abstract Number: 736 • 2013 ACR/ARHP Annual Meeting

    Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Associated With Systemic Sclerosis In Japan: A Review Of The Literature

    Natsumi Nagao1, Yuri Sadanaga1, Satoko Tashiro1, Rie Suematsu1, Syuichi Koarada1, Akihide Ohta2 and Yoshifumi Tada1, 1Rheumatology, Saga University, Saga, Japan, 2Nursing, Saga University, Saga, Japan

    Background/Purpose: Cases of Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) during the course of systemic sclerosis (SSc) have recently been reported. Japanese cases of AAV associated…
  • Abstract Number: 149 • 2013 ACR/ARHP Annual Meeting

    Comparative Proteomic Analysis Of Neutrophils From Patients With Microscopic Polyangiitis and Granulomatosis With Polyangiitis

    Teisuke Uchida1, Kohei Nagai2, Toshiyuki Sato3, Nobuko Iizuka3, Mitsumi Arito3, Yukiko Takakuwa4, Hiromasa Nakano4, Seido Ooka4, Manae Kurokawa3, Naoya Suematsu3, Kazuki Okamoto3, Shoichi Ozaki5 and Tomohiro Kato3, 1Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, kawasaki, Japan, 2Department of Genetic Engineering, Faculty of Biology-Oriented Science and Technology, Kinki University, Wakayama, Japan, 3Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, Kawasaki, Japan, 4Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, 5Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, St. Marianna University School of Medicine, Kawasaki, Japan

    Background/Purpose: Both microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) belong to ANCA-associated vasculitis (AAV), in which neutrophils are thought to be involved in their…
  • Abstract Number: 738 • 2013 ACR/ARHP Annual Meeting

    Pulmonary Fibrosis In ANCA-Associated Vasculitis

    Cloé Comarmond1, Bruno Crestani2, Abdellatif Tazi3, Baptiste Hervier4, Sylvain Adam-Marchand5, Hilario Nunes6, Fleur Cohen-Aubart7, Marie Wislez8, Jacques Cadranel8, Bruno Housset9, Célia Lloret-Linares10, Pascal Sève11, Christian Pagnoux12, Sébastien Abad13, Juliette Camuset14, Boris Bienvenu15, Michael Duruisseaux16, Eric Hachulla17, Jean-Benoît Arlet18, Mohamed Hamidou19, Alfred Mahr20, Anne-Laure Brun21, Philippe Grenier21, Patrice Cacoub22 and David Saadoun23, 1Internal Medicine and Clinical Imunology, Referal Center for Autoimmune diseases, Internal Medicine and Clinical Imunology, Hôpital Pitié Salpétrière, Paris, France, 2Pneumology A, Hôpital Bichat, Paris, France, 3Hôpital Saint-Louis, Paris, France, 4Internal Medicine & Clinical Immunology Dpt, Pitié-Salpêtrière Hospital, APHP, Paris, France, 5Pneumology, Centre Hospitalier Universitaire de Tours, Tours, France, 6Department of Pneumology, Avicenne Hospital (AP-HP), Bobigny, France, 7Internal Medicine Dpt 2, Pitié-Salpêtrière Hospital, APHP, Paris, France, 8Pneumology, Hôpital Tenon, Paris, France, 9Pneumology, Centre Hospitalier Intercommunal de Créteil, Créteil, France, 10Médecine Interne A, Hôpital Lariboisière, Paris, France, 11Internal medicine, CHU Lyon, Lyon, France, 12Rheumatology, Mount Sinai Hospital, Toronto, Canada, Toronto, ON, Canada, 13Internal Medicine, Avicenne Hospital, Bobigny, France, 14Pneumology, Centre Hospitalier Victor Dupouy, Argenteuil, France, 15Division of Internal Medicine, Centre Hospitalier Régional Universitaire de Caen, Côte de Nacre, Caen, France, Caen, France, 16Pneumology, CHU de Grenoble, Grenoble, France, 17Internal Medicine, Lille CEDEX, France, 18Internal Medicine, HEGP, Paris, France, 19Internal Medicine Department, Nantes University Hospital, Nantes, France, 20Department of Internal Medicine, Hospital Saint-Louis, Paris, France, 21Radiology, Hôpital Pitié-Salpêtrière, Paris, France, 22Médecine Interne 2, Hopital Pitié-Salpétrière, Paris, France, 23Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France

    Background/Purpose: The association of pulmonary fibrosis (PF) with anti neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), especially microscopic polyangiitis (MPA), is rare but related to poor…
  • Abstract Number: 741 • 2013 ACR/ARHP Annual Meeting

    Granulomatosis With Polyangiitis Central Nervous System Involvement: Presentation and Management

    Gonzalo De Luna1,2, Benjamin Terrier3, Pierre Kaminsky4, Francois Maurier5, Roser Solans6, Raphaèle Seror7, Xavier Puéchal8, Luc Mouthon9 and Loic Guillevin10, 1Medecine Interne, Cochin University Hospital, Paris, France, 2Internal Medicine, Hospital Ramon y Cajal, Madrid, Spain, 3Internal Medicine, Cochin University Hospital, Paris, France, 4Université de Lorraine, Nancy, F-54000, France; CHU de Nancy, Orphan disease unit, Nancy, F-54000, France;, Nancy, France, 5HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, 6Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain, 7Rheumatology, Bicetre university hospital, LE Kremlin-Bicetre, France, 8National Referral Center for Rare Systemic Auto-immune Diseases, Hôpital Cochin, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, 9Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, 10Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France

    Background/Purpose: Granulomatosis with polyangiitis (GPA), a small-sized–vessel vasculitis, commonly involves ear, nose & throat (ENT), lungs and kidneys, and, more rarely, the central nervous system…
  • Abstract Number: 2782 • 2013 ACR/ARHP Annual Meeting

    Retreatment With Rituximab In The Rituximab In ANCA-Associated Vasculitis (RAVE) Trial

    Eli Miloslavsky1, Ulrich Specks2, Peter A Merkel3, Philip Seo4, Robert F. Spiera5, Carol A. Langford6, Gary S. Hoffman7, Cees G.M. Kallenberg8, E. William St Clair9, Nadia Tchao10, Linna Ding11, David Ikle12, Brett Jepson12, Paul Brunetta13 and John H. Stone14, 1Division of Rheumatology, Massachusetts General Hopsital, Boston, MA, 2Mayo Clinic, Rochester, MN, 3Division of Rheumatology, University of Pennsylvania and VA Medical Center, Philadelphia, PA, 4Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, 5Rheumatology, Hospital for Special Surgery, New York, NY, 6Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, 7Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, 8Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 9Medicine, Duke Unversity Medical Center, Durham, NC, 10Immune Tolerance Network, Bethesda, MD, 11NIAID, Bethesda, MD, 12Rho, Chapel Hill, NC, 13Biotherapeutics, Genentech, So San Francisco, CA, 14Rheumatology, Massachusetts General Hospital, Boston, MA

    Background/Purpose: Retrospective studies have demonstrated that repeat rituximab treatment may be effective in re-inducing remission in relapsing ANCA-associated vasculitis. We analyzed data from the Rituximab…
  • Abstract Number: 743 • 2013 ACR/ARHP Annual Meeting

    Efficacy Of Rituximab For Otolaryngologic (ENT) Manifestations Of Granulomatosis With Polyangiitis (GPA, Wegener’s granulomatosis)

    Lindsay Lally1, Robert Lebovics2, Wei-Ti Huang3 and Robert F. Spiera1, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Otolaryngology, St. Luke's-Roosevelt Hospital Center, New York, NY, 3Biostatistics, Hospital for Special Surgery, New York, NY

    Background/Purpose: ENT involvement is the most prevalent manifestation of GPA.  Rituximab (RTX) is a proven effective remission induction therapy for severe GPA with vasculitic manifestations. …
  • Abstract Number: 2784 • 2013 ACR/ARHP Annual Meeting

    Mononeuritis Multiplex Predicts The Need For Immunosuppressive Or Immunomodulatory Drugs For Eosinophilic Granulomatosis With Polyangiitis, Polyarteritis Nodosa and Microscopic Polyangiitis Patients Without Poor-Prognosis Factors

    Maxime Samson1, Xavier Puéchal2, Hervé Devilliers3, Camillo Ribi4, Pascal Cohen5, Boris Bienvenu6, Christian Pagnoux7, Luc Mouthon2, Loic Guillevin8 and French Vasculitis Study Group (FVSG)2, 1Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France; Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, 2Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, 3Dijon University Hospital, Department of internal medicine and systemic diseases, Dijon, France, 4Immunology and Allergology, Internal Medicine, University Hospitals of Geneva, Geneva, Switzerland, Geneva, Switzerland, 5National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, 6Division of Internal Medicine, Centre Hospitalier Régional Universitaire de Caen, Côte de Nacre, Caen, France, Caen, France, 7Rheumatology, Mount Sinai Hospital, Toronto, Canada, Toronto, ON, Canada, 8Department of Internal Medicine,, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France

    Background/Purpose: Patients with eosinophilic granulomatosis with polyangiitis (EGPA), polyarteritis nodosa (PAN) or microscopic polyangiitis (MPA) without poor-prognosis factors, as defined by their 1996 Five-Factor Scores…
  • Abstract Number: 747 • 2013 ACR/ARHP Annual Meeting

    Efficacy Of Glucocorticoids To Treat Limited Flares In ANCA-Associated Vasculitis

    Eli Miloslavsky1, Ulrich Specks2, Peter A. Merkel3, Philip Seo4, Robert F. Spiera5, Carol A. Langford6, Gary S. Hoffman7, Cees G.M. Kallenberg8, E. William St. Clair9, Nadia Tchao10, Linna Ding11, David Ikle12, Brett Jepson12, Paul Brunetta13 and John H. Stone14, 1Division of Rheumatology, Massachusetts General Hopsital, Boston, MA, 2Mayo Clinic, Rochester, MN, 3Division of Rheumatology, Vasculitis Center, University of Pennsylvania, Philadelphia, PA, 4Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, 5Rheumatology, Hospital for Special Surgery, New York, NY, 6Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, 7Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, 8Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 9Medicine, Duke University Medical Center, Durham, NC, 10Immune Tolerance Network, Bethesda, MD, 11NIAID, Bethesda, MD, 12Rho, Chapel Hill, NC, 13Biotherapeutics, Genentech, So San Francisco, CA, 14Rheumatology, Massachusetts General Hospital, Boston, MA

    Background/Purpose: The great majority of patients with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) achieve disease remission initially, but relapses occur in up to…
  • Abstract Number: 2785 • 2013 ACR/ARHP Annual Meeting

    Urinary Inflammatory Cells Strongly Reflect the Disease Activity and Renal Function in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis

    Yoko Wada1, Minoru Sakatsume2, Masaaki Nakano3 and Ichiei Narita1, 1Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, 2Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, 3School of Health Sciences, Faculty of Medicine, Niigata University, Niigata, Japan

    Background/Purpose: The antineutrophil cytoplasmic autoantibody (ANCA)- associated vasculitides (AAVs) include microscopic polyangiitis (MPA), granulomatosis with polyangitis (GPA; formerly Wegener’s), and eosinophilic granulomatosis with polyangitis (EGPA).…
  • Abstract Number: 1538 • 2012 ACR/ARHP Annual Meeting

    ANCA-Associated Vasculitis in Hispanic Americans: An Unrecognized Severity

    Ranadeep Mandhadi1, Fadi Aldaghlawi2, Asad Khan2, Vajiha Irshad3, Joel A. Block2 and Antoine Sreih4, 1Mount Sinai Hospital, Chicago, IL, 2Rush University Medical Center, Chicago, IL, 3Internal Medicine, Stroger Hospital of Cook County, Chicago, IL, 4Medicine/Rheumatology, Rush University Medical Center, Chicago, IL

    Background/Purpose: ANCA-associated vasculitis, once a disease thought to predominate in Caucasians, is now increasingly recognized in diverse ethnic populations. However, there has been little systematic…
  • Abstract Number: 1541 • 2012 ACR/ARHP Annual Meeting

    Does Leflunomide Have a Place As Remission Maintenance Therapy in ANCA-Associated Vasculitis? A Bayesian Network Meta-Analysis with Hypothesis Driven Sensitivity Analyses to Adjust for Potential Biases

    Glen S. Hazlewood1, Claudia Metzler2, George A. Tomlinson3, Wolfgang L. Gross4, Brian M. Feldman5, Loic Guillevin6 and Christian Pagnoux7, 1Medicine, University of Toronto, Toronto, ON, Canada, 2University of Lubeck, Bad Branstedy, Germany, 3University of Toronto, Toronto, ON, Canada, 4Dept of Clinical Rheumatology, Medical University at Lubeck, Lubeck, Germany, 5Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 6Internal Medicine, Cochin University Hospital, Paris, France, 7Rheumatology, Mount Sinai Hospital, Toronto, Canada, Toronto, ON, Canada

    Background/Purpose: Primary: To determine the relative treatment effects of maintenance therapy in adult patients with ANCA-associated vasculitis who have achieved remission, using a Bayesian network…
  • Abstract Number: 1542 • 2012 ACR/ARHP Annual Meeting

    The Efficacy of Rituximab Vs Cyclophosphamide for Treatment of Renal Disease in ANCA-Associated Vasculitis: The RAVE Trial Geetha D, Fervenza FC for the RAVE-Itn Research Group

    Duvuru Geetha1 and Fernando Fervenza2, 1Nephrology, Johns Hopkins University, Baltimore, MD, 2Mayo Clinic, Rochester, MN

    Background/Purpose: Rituximab (RTX) is non-inferior to cyclophosphamide (CYC) followed by azathioprine (AZA) for remission-induction in severe ANCA associated vasculitis (AAV) but details of outcomes among…
  • Abstract Number: 1543 • 2012 ACR/ARHP Annual Meeting

    Rituximab for ANCA-Associated Vasculitis: A Meta-Analysis of Randomized Trials

    Carolina Mejia1 and Carlos J. Lozada2, 1Internal Medicine, Mount Sinai Medical Center, Miami, FL, 2Dept of Medicine/Rheumatology, University of Miami Miller School of Medicine, Miami, FL

    Background/Purpose:  Over the past 40 years, cyclophosphamide/glucocorticoids combination therapy has been the standard regimen  for remission induction in ANCA-associated vasculitis.. Although a major advance in…
  • Abstract Number: 1545 • 2012 ACR/ARHP Annual Meeting

    Long-Term Follow-up of 118 Polyarteritis Nodosa and Microscopic Polyangiitis without Poor-Prognosis Factors

    Maxime Samson1, Xavier Puechal2, Hervé Devilliers3, Camillo Ribi4, Pascal Cohen5, Boris Bienvenu6, Christian Pagnoux7, Luc Mouthon8, Loic Guillevin9 and French Vasculitis Study Group FVSG10, 1Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France; Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, 2Internal Medicine, Hôpital Cochin, Paris, France, 3Internal medicine, Hôpital Général, Dijon, France, 4Internal Medicine, Hôpital Universitaire Cantonal de Genève, Geneve, Switzerland, 5National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, 6Division of Internal Medicine, Centre Hospitalier Régional Universitaire de Caen, Côte de Nacre, Caen, France, Caen, France, 7Rheumatology, Mount Sinai Hospital, Toronto, Canada, Toronto, ON, Canada, 8Internal Medicine, Hopital Cochim, Paris, France, 9Internal Medicine, Division of Internal Medicine, Hôpital Cochin, University Paris Descartes, Paris, France, 10Internal Medicine, Service de médecine interne, Centre de Références des Vascularites, Université Paris Descartes, APHP, Hôpital Cochin, 75005 Paris, France., Paris, France

    Background/Purpose: Polyarteritis nodosa (PAN) and microscopic polyangiitis (MPA) are 2 vasculitides characterized by necrotizing inflammation of the vessel wall. They share several clinical features and…
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