ACR Meeting Abstracts

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Abstracts tagged "ANCA associated vasculitis"

  • Abstract Number: 1541 • ACR Convergence 2023

    Neurologic Involvement Does Not Affect Cumulative Survival Rates in Patients with ANCA-associated Vasculitis and Is Less Commonly Associated with Rapidly Progressive Glomerulonephritis in Patients with GPA

    Gatr-alnada Gheriani1 and Petar Lenert2, 1University of Iowa Hospital and Clinics, Tiffin, IA, 2University of Iowa Hospitals and Clinics, Iowa City, IA

    Background/Purpose: The aim of this study was to analyze the incidence of nervous system manifestations in a cohort of patients with Microscopic Polyangiitis (MPA) and…
  • Abstract Number: 2379 • ACR Convergence 2023

    A Real-World Descriptive Study of Renal Outcomes Among Patients with ANCA-Associated Vasculitis Initiating Remission Induction Therapy

    Sam Oh1, Sushmitha Inguva2, Pallavi Rane2 and Brian Tumminello3, 1Amgen, Inc., South San Francisco, CA, 2Amgen, Inc., Thousand Oaks, CA, 3Amgen, Inc., San Juan Capistrano, CA

    Background/Purpose: ANCA-associated vasculitis (AAV) is a group of rare autoimmune diseases characterized by inflammation and necrosis of small- to medium-sized blood vessels, commonly affecting the…
  • Abstract Number: 0673 • ACR Convergence 2023

    Reporting of Race, Ethnicity, Sex, Gender, Socioeconomic Status and Representativeness of Race and Ethnicity in ANCA-associated Vasculitis Randomized Trials

    Michele Iudici1, Juan C. Rueda2 and Xavier Puéchal3, 1Division of Rheumatology, Department of Internal Medicine Specialties, Geneva University Hospitals, Geneva, Switzerland, 2Universidad de La Sabana, Chía, Colombia, Chia, Colombia, 3National Referral Center for Rare Systemic Autoimmune Diseases, Paris, France

    Background/Purpose: To assess how and to what extent race, ethnicity, sex, gender and socioeconomic status of participants are reported in ANCA-associated vasculitis (AAV) randomized controlled…
  • Abstract Number: 0705 • ACR Convergence 2023

    Sleep Disturbances in Patients with Vasculitis: Results of the Vasculitis Patient-Powered Research Network Sleep Study (SleepVasc)

    Misa Tanaka1, Saverio Stranges1, Kathy Speechley1, Osvaldo Espin Garcia1, Molly Mason2, Renee Borchin3, Cristina Burroughs3, Christine Yeung4, Indira Gurubhagavatula4, Christian Pagnoux5, Peter Merkel4 and Lillian Barra1, 1Western University, London, ON, Canada, 2Vasculitis Patient Powered Research Network, Philadelphia, PA, 3University of South Florida, Tampa, FL, 4University of Pennsylvania, Philadelphia, PA, 5Mount Sinai Hospital, Toronto, ON, Canada

    Background/Purpose: Sleep deprivation and sleep disorders can impair health-related quality of life and increase the risk of chronic diseases, such as cardiovascular disease, and mental…
  • Abstract Number: 1544 • ACR Convergence 2023

    Increased Risk of Severe Infection in Patients with Antineutrophil Cytoplasmic Antibody-associated Vasculitides: A Population-based Trend Analysis

    Kai Zhao1, J. Antonio Avina-Zubieta2, Hui Xie3, Natasha Dehghan4 and John Esdaile2, 1Arthritis Research Canada, Coquitlam, BC, Canada, 2Arthritis Research Canada, Vancouver, BC, Canada, 3Simon Fraser University, Richmond, BC, Canada, 4University of British Columbia, Vancouver, BC, Canada

    Background/Purpose: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are a group of multisystem inflammatory diseases. One of the most serious and common side-effects of GC and…
  • Abstract Number: 2380 • ACR Convergence 2023

    Renal Survival Rate of ANCA-associated Vasculitis in Korea: A Nationwide Population-Based Study Using Claims Data

    Chan-Bum Choi1, Jung-Min Shin2, Nayeon Choi3 and Soorack Ryu3, 1Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 2Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, South Korea, 3Biostatistical Consulting and Research Lab, Medical Research Collaborating Center, Hanyang University, Seoul, South Korea

    Background/Purpose: ANCA-associated vasculitis (AAV) is a rare systemic autoimmune disease with varying reports of incidence rates and clinical manifestations. Renal involvement is one of the…
  • Abstract Number: 0674 • ACR Convergence 2023

    Efficacy and Safety of Mepolizumab During Maintenance Therapy in Patients with Eosinophilic Granulomatosis with Polyangiitis

    Daiki Sakai1, Kaichi Kaneko1, Karin Furukawa2, Mai Kawazoe2, Yasuo Matsuzawa3 and Toshihiro Nanki2, 1Division of Rheumatology, Department of Internal Medicine, Toho University Sakura Medical Center, Sakura, Japan, 2Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Ota-ku, Japan, 3Division of Respiratory Medicine, Department of Internal Medicine, Toho University Sakura Medical Center, Sakura, Japan

    Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is a small-vessel vasculitis characterized by asthma, hyper-eosinophilia, and progressive multiorgan organ involvement. Mepolizumab (MPZ) is a humanized monoclonal…
  • Abstract Number: 0725 • ACR Convergence 2023

    Real-life Use of the PEXIVAS Reduced-dose Glucocorticoid Regimen in Granulomatosis with Polyangiitis and Microscopic Polyangiitis

    Sophie Nagle1, Yann Nguyen2, Xavier Puéchal3, Dimitri Titeca-Beauport4, Thomas Crépin5, Rafik Mesbah6, Idris Boudhabhay7, Gregory Pugnet8, Juliette Woessner9, Roderau Outh10, Céline Lebas11, Antoine Néel12, alexandre Karras13, Eric Hachulla11, Benjamin Subran14, Philippe Kerschen15, Mathieu Gerfaud-Valentin16, Stéphane Vinzio17, Tiphaine Goulenok18, Raphael Borie19, Sébastien Humbert20, Yurdagul Uzunhan21, Sarah Melboucy-Belkhir22, Jean-Baptiste Gouin23, Mary-Jane Guerry24 and Benjamin Terrier25, 1AP-HP Cochin Hospital, Paris, France, 2Department of Internal Medicine, Hôpital Beaujon, AP-HP, Clichy, France., Montmorency, France, 3National Referral Center for Rare Systemic Autoimmune Diseases, Paris, France, 4CHU Amiens, Amiens, France, 5Amiens University Hospital, Amiens, France, 6Boulogne Hospital (CH), Boulogne, France, 7Necker University Hospital, Paris, France, 8CHU Toulouse Rangueil Service de Medecine Interne et Immunologie Clinique, Toulouse, France, 9Avignon Hospital (CH), Avignon, France, 10Perpignan Hospital (CH), Perpignan, France, 11Lille University Hospital, Lille, France, 12CHU Nantes, Nantes, France, 13HEGP - APHP, Paris, France, 14Croix Saint Simon Hospital, Paris, France, 15Department of Neurology, Luxembourg Hospital Center, Luxembourg City, Luxembourg, 16Lyon University Hospital, Lyon, France, 17Grenoble Hospital (CH), Grenoble, France, 18Assistance Publique Hopitaux de Paris, Paris, France, 19Bichat-Claude Bernard, Universite de Paris, Paris, France, 20Besançon University Hospital, Besançon, France, 21AP-HP, Bobigny, France, 22Saint Quentin Hospital, Saint-Quentin, France, 23Vannes Hospital (CH Bretagne Atlantique), Vannes, France, 24Valenciennes Hospital (CH), Valenciennes, France, 25Department of Internal Medicine, Hôpital Cochin, AP-HP, Paris, France

    Background/Purpose: Glucocorticoids (GCs) in combination with rituximab (RTX) or cyclophosphamide are the cornerstone of treatment for patients with severe granulomatosis with polyangiitis (GPA) and microscopic…
  • Abstract Number: 1545 • ACR Convergence 2023

    Validation of the 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria in Patients with ANCA-associated Vasculitis

    Liubov Petelytska, Vladyslav Kravchenko and Oleg Iaremenko, Bogomolets National Medical University, Kyiv, Ukraine

    Background/Purpose: The early diagnosis of ANCA-associated vasculitis (AAV) and treatment initiation may prevent progression to end organ damage, particularly renal disease. Based on the Vasculitis…
  • Abstract Number: 2381 • ACR Convergence 2023

    ANCA-associated Vasculitis and Renal Disease in a Multidisciplinary Outpatient Clinic in Northern Spain

    Salma Al Fazazi1, Fabricio Benavides2, Vanesa Calvo Río3, maria rodriguez Vidriales2, clara escagedo Cagigas2, monica renuncio garcia2, luis martin penagos4 and Ricardo Blanco5, 1Hospital Universitario Puerta Del Mar, Cádiz, Spain, 2Hospital Universitario Marqués de Valdecilla, Santander, Spain, 3Valdecilla Hospital, Santander, Spain, 4Division of Nephrology, Immunopathology Group, Hospital Universitario Marqués de Valdecilla-DIVAL, Santander, Spain, 5Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

    Background/Purpose: The severity of clinical features and outcomes in previous series of patients reported with renal disease related to ANCA-associated vasculitis (AAV) vary greatly, probably…
  • Abstract Number: 0675 • ACR Convergence 2023

    Investigating the Impact of anti-IL5 Therapy in the Management of Relapsing and Refractory Eosinophilic Granulomatosis with Polyangiitis (EGPA); A Three Year Longitudinal Perspective and Beyond

    allyson egan1, Pasupathy Sivasothy2 and David Jayne3, 1Trinity Health Kidney Centre, Tallaght University Hospital, Ireland, Dublin, Ireland, 2Vasculitis and Lupus Clinic, Addenbrooke's Hospital, Cambridge, United Kingdom, 3University of Cambridge, Cambridge, United Kingdom

    Background/Purpose: In the randomized, placebo-controlled MIRRA trial for relapsing and refractory eosinophilic granulomatosis with polyangiitis (EGPA), adjuvant therapy with 300mg anti-IL5 mAB Mepolizumab [MEPO] for…
  • Abstract Number: 0854 • ACR Convergence 2023

    Long-term Efficacy of Remission-induction Regimens for Eosinophilic Granulomatosis with Polyangiitis

    Martin Dutertre1, Gregory Pugnet2, Claire De Moreuil3, Bernard Bonnotte4, YGAL BENHAMOU5, Dominique Chauveau6, Elisabeth Diot7, Pierre Duffau8, Nicolas Limal9, Antoine Néel10, GEOFFREY URBANSKI11, Noémie Jourde-Chiche12, Nicolas MARTIN SILVA13, Francois Maurier14, Arsène Mekinian15, Nicolas Schleinitz16, Felix ackermann17, Anne-Laure Fauchais18, Antoine Froissart19, Thomas Le Gallou20, Yurdagul Uzunhan21, Jean-Francois Viallard22, Alice Berezne23, laurent chiche24, Bruno Crestani25, Guillaume Direz26, Cecile-Audrey DUREL27, Pascal Godmer28, Jean-Emmanuel Kahn29, Marc Lambert30, Mathilde de Menthon1, Thomas Quemeneur31, Jacques Cadranel1, Pierre Charles32, Antoine Dossier1, Loic Guillevin33, Xavier Puéchal34 and Benjamin Terrier35, 1AP-HP, Paris, France, 2CHU Toulouse Rangueil Service de Medecine Interne et Immunologie Clinique, Toulouse, France, 3CHU de Brest, Brest, France, 4Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, 5rouen university hospital, Rouen, France, 6Hôpital Le Tripode, Bordeaux, France, 7Service de médecine interne et immunologie clinique, CHU Tours, Tours, France, 8CHU Bordeaux, Bordeaux, France, 9AP-HP, Créteil, France, 10CHU de Nantes, Nantes, France, 11CHU Angers, Angers, France, 12AP-HM, Marseille, France, 13CHU Caen, Caen, France, 14Hôpitaux privés de Metz, Vaux / Frankreich, France, 15Department of Internal Medicine, Hôpital Saint-Antoine, AP-HP, Paris, France, 16Aix Marseille university, AP-HM, Marseille, France, 17Hôpital Foch, Suresnes, France, 18Dupuytren Hospital, Limoges, France, 19CHI Créteil, Créteil, France, 20CHU Rennes, Rennes, France, 21AP-HP, Bobigny, France, 22CHU de Bordeaux, Hôpital Haut-Lévêque, Pessac, France, 23CH Annecy, Annecy, France, 24Hopital Europeen, Marseille, France, 25Hopital Bichat, Paris University, Paris, France, 26CH Le Mans, Le Mans, France, 27Hospices Civils de Lyon, Lyon, France, 28CH Bretagne Atlantique, Vannes, France, 29AP-HP, Suresnes Cedex, France, 30CHRU Lille, Lille, France, 31CH Valenciennes, Valenciennes, France, 32Institut Mutualiste Montsouris, Service de Médecine Interne, Paris, France, 33University Paris Descartes, Paris, France, 34National Referral Center for Rare Systemic Autoimmune Diseases, Paris, France, 35Department of Internal Medicine, Hôpital Cochin, AP-HP, Paris, France

    Background/Purpose: The Rituximab in Eosinophilic Granulomatosis With Polyangiitis (REOVAS) trial compared rituximab (RTX) infusions to conventional strategy for remission-induction in eosinophilic granulomatosis with polyangiitis (EGPA).…
  • Abstract Number: 1550 • ACR Convergence 2023

    Importance of Shared Decision-Making for Patients with ANCA-Associated Vasculitis

    Jo Robson1, Montserrat Díaz Encarnación2, Peter Verhoeven3, Raquel Olivenza4, Monica Balcells4, Sara Monti5 and Andreas Kronbichler6, 1University of the West of England, Bristol, United Kingdom, 2Autonoma de Barcelona University, Barcelona, Spain, 3Vasculitis Stichting, Silvolde, Netherlands, 4CSL Vifor, Glattbrugg, Switzerland, 5Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy, 6Department of Internal Medicine IV (Nephrology and Hypertension), Innsbruck, Austria

    Background/Purpose: ANCA-associated vasculitis (AAV) is a rare autoimmune disease associated with significant morbidity. It can present at any age and treatment needs change over time.…
  • Abstract Number: 2382 • ACR Convergence 2023

    Relapse of Patients with ANCA-associated Vasculitis Who Are on Dialysis

    Yeo-Jin Lee1, Hansun Song2, Wook Jang Seo3, Jinseok Kim4, Soo-Min Ahn1, Ji-Seon Oh5, Yong-Gil Kim2, Chang-Keun Lee1, Bin Yoo1 and Seokchan Hong1, 1Asan Medical Center, Seoul, South Korea, 2Department of Rheumatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea, 3Department of Rheumatology, Veteran Health Service Medical Center, Seoul, South Korea, 4Department of Rheumatology, Jeju National University Hospital, Jeju National University School of Medicine, Jeju-si, Jeju-do, South Korea, La Jolla, CA, South Korea, 5Department of Information Medicine, Big Data Research Center, Asan Medical Center, University of Ulsan College of Medicine, Ulsan, South Korea

    Background/Purpose: It is known that disease activity of ANCA-associated vasculitis (AAV) is decreased after dialysis. However, most studies have been conducted on Caucasians, and factors…
  • Abstract Number: 0677 • ACR Convergence 2023

    Analysis of Clinical Outcomes in Eosinophilic Granulomatosis with Polyangiitis (EGPA) Treated with Mepolizumab over 2 Years for Remission Induction or Maintenance: A Single Center Experience in Japan

    SOKO KAWASHIMA1, Yoshinori Komagata1, Mitsumasa Kishimoto2 and Shinya Kaname1, 1Kyorin University School of Medicine, Tokyo, Japan, 2Kyorin University School of Medicine, Yokohoma, Japan

    Background/Purpose: Contrary to Western countries, MPO-ANCA-associated vasculitis (MPO-AAV) is dominant in Japan or Asian countries. It is possible that therapeutic responses to EGPA with mepolizumab…
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