Abstracts tagged "ANA"

Abstract Number: 2125 • 2018 ACR/ARHP Annual Meeting
Pleiotropy of a Positive Antinuclear Antibody (ANA) Test: A Phewas and GWAS Approach
Vivian Kawai¹, Jonathan Mosley², QiPing Feng¹, Wei-Qi Wei³, Daniel Carranza Leon², Cecilia P. Chung⁴, Andrea Ihegword² and C Michael Stein¹, ¹Vanderbilt University Medical Center, Nashville, TN, ²Medicine, Vanderbilt University Medical Center, Nashville, TN, ³Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, ⁴Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: ANAs are almost always present in systemic lupus erythematosus (SLE), but they are also present in ~12-20% of the population. A positive ANA (ANA+)…
Abstract Number: 2712 • 2018 ACR/ARHP Annual Meeting
Evaluation of Longitudinal Outcomes in Scleroderma Patients with Negative Immunofluorescent Anti-Nuclear Antibodies
Mayce Haj-Ali¹, Derek Jones², Sean McNish³, Sarah Stupp³, Marissa Mangini³ and Victoria Shanmugam⁴, ¹Department of Medicince, The George Washington University School of Medicine and Health Sciences, Washington, DC, ²The George Washington University, Washington, DC, ³The George Washington University School of Medicine and Health Sciences, Washington, DC, ⁴Rheumatology, The George Washington University, Washington, DC
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disease characterized by inflammation, fibrosis, and vasculopathy. Historical data indicates approximately 90% of patients with SSc test positive…
Abstract Number: 11 • 2018 ACR/ARHP Annual Meeting
PAD4-Independent Interaction of ACPA with Nuclear Antigens in Apoptotic Cells and Neutrophil Extracellular Traps (NETs) Defines a Subset of Autoantibodies
Gustaf Wigerblad¹, Katy A. Lloyd¹, Peter Sahlström², Karine Chemin², Johanna Steen², Philip J. Titcombe^2,3, Diana Zhou², Ragnhild Stålesen¹, Bianka Marklein⁴, Elena Ossipova², Johan Rönnelid⁵, Luca Piccoli⁶, Antonio Lanzavecchia⁶, Daniel L. Mueller³, Karl Skriner⁴, Lars Klareskog², Fredrik Wermeling¹, Vivianne Malmström² and Caroline Grönwall⁷, ¹Rheumatology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, ³The Center for Immunology, Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, ⁴Dept. of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany, ⁵Dept. of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁶Università della Svizzera italiana, Institute for Research in Biomedicine, Bellinzona, Switzerland, ⁷Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) bind a wide range of citrullinated proteins with high cross-reactivity. Recent findings suggest that certain, but…
Abstract Number: 89 • 2018 ACR/ARHP Annual Meeting
Anti-Nuclear Antibodies (ANA) and Air Pollution: Ultrafine Particles and Ozone
Sasha Bernatsky¹, Shouao Wang², May Y Choi³, Scott Weichenthal⁴, Marianne Hatzopoulou⁵, Marvin J. Fritzler⁶ and Audrey Smargiassi⁷, ¹Divisions of Rheumatology and Clinical Epidemiology, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ³Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁴Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada, ⁵Civil and Mineral Engineering, University of Toronto, Toronto, ON, Canada, ⁶Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁷Public Health, Université de Montreal, Montreal, QC, Canada
Background/Purpose: Previous studies have suggested links between air pollution (particularly PM2.5) and serum antibodies related to rheumatic diseases. No one has yet examined anti-nuclear antibody…
Abstract Number: 98 • 2018 ACR/ARHP Annual Meeting
Presence of Apoptotic Microparticle Containing Immune Complexes in Asymptomatic ANA+ Individuals Despite the Absence of Inflammation
Carolina Muñoz-Grajales^1,2, Dennisse Bonilla¹, Ariana Karanxha¹, Dario Ferri^1,2, Earl Silverman³, Sindhu Johnson⁴, Arthur Bookman⁵, Zahi Touma^5,6 and Joan E. Wither^1,2,5,7, ¹Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Department of Immunology, Department of Immunology, University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, Mount Sinai Hospital and University Health Network, Toronto, ON, Canada, ⁵Division of Rheumatology, University Health Network, Toronto, ON, Canada, ⁶University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁷Department of Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada
Background/Purpose: Currently, little is known about what distinguishes asymptomatic Anti-Nuclear Antibody (ANA) positive individuals (ANA+NS) who will progress to Systemic Lupus Erythematosus (SLE) from those…
Abstract Number: 43 • 2017 ACR/ARHP Annual Meeting
Regulation of TLR7 Signalling By UBE2L3 Dependent Linear Ubiquitination Explains Dimethyl Fumarate Suppression of Autoreactive B Cell Development in SLE
Daniele Mauro¹, Victoria Tsang², Isabelle A. Clayton-Lucey³, Sara Pagani², Farah Alam², Elena Pontarini², Alessandra Nerviani², Angela Pakozdi⁴, Andrea Cove-Smith⁴, Ravindra Rajakariar⁴, Debasish Pyne⁴, Timothy J Vyse⁵, Costantino Pitzalis² and Myles J. Lewis^4,6, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ²Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, ³Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, EC1M 6BQ, United Kingdom, ⁴Barts Lupus Centre, Barts Health NHS Trust, London, United Kingdom, ⁵Division of Genetics and Molecular Medicine, King's College London, Guy's Hospital, London, United Kingdom, ⁶Rheumatology, Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Background/Purpose: A single risk haplotype spanning UBE2L3 is strongly associated with SLE and multiple autoimmune diseases. The E2 ubiquitin-conjugating enzyme UBE2L3 regulates TNFα and CD40…
Abstract Number: 198 • 2017 ACR/ARHP Annual Meeting
The Impact of Electronic Consults (E-Consults) on Positive ANA Referrals in a Veteran Population
Veena Patel^1,2, Diana Stewart^2,3 and Molly Horstman^1,2,4, ¹Internal Medicine, Baylor College of Medicine, Houston, TX, ²Internal Medicine, Michael E. DeBakey VA Medical Center, Houston, TX, ³Internal Medicine and Pediatrics, Baylor College of Medicine, Houston, TX, ⁴Center for Innovations in Quality, Effectiveness and Safety (iQUEST), Houston, TX
Background/Purpose: Referrals to rheumatology for positive ANA in the absence of clinical signs and symptoms is a common practice, which may lead to unnecessary resource…
Abstract Number: 476 • 2017 ACR/ARHP Annual Meeting
Novel Interaction between Anti-Citrulline Monoclonal Antibodies and Apoptotic Cells Is Mediated through Citrullinated Nuclear Antigens
Katy A. Lloyd¹, Peter Sahlström², Johanna Steen¹, Philip J. Titcombe^3,4, Diana Zhou¹, Christina Lundqvist⁵, Olov Ekwall^6,7, Jimmy Ytterberg¹, Johan Rönnelid⁸, Daniel L. Mueller³, Lars Klareskog¹, Vivianne Malmström¹ and Caroline Grönwall⁹, ¹Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ²Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ³Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, ⁴Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Sweden, Sweden, ⁵Dept. of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden, ⁶Dept. of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy University of Gothenburg, Göteborg, Sweden, ⁷Dept of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden, ⁸Department of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁹Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) display broad cross-reactivities and target proteins including a-enolase, filaggrin, vimentin, fibrinogen, and histones. However, every monoclonal ACPA has a distinct…
Abstract Number: 559 • 2017 ACR/ARHP Annual Meeting
Performance of Multiple Platforms for Autoantibody Testing in Sjogren’s Syndrome
Astrid Rasmussen¹, Kiely Grundahl², Lida Radfar³, C. Erick Kaufman⁴, David M. Lewis⁵, Barbara M. Segal⁶, Nelson L. Rhodus⁷, Harini Bagavant¹, Umesh Deshmukh⁸, Christopher J Lessard⁸, R. Hal Scofield¹ and Kathy L. Sivils¹, ¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, ³Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁴College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Department of Oral Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁶Rheumatology, Hennepin County Medical Center, Minneapolis, MN, ⁷Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, ⁸Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: The research classification and clinical diagnosis of SjšgrenÕs syndrome (SS) relies heavily on the detection of autoantibodies against Ro/SSA and La/SSB, particularly in the…
Abstract Number: 673 • 2017 ACR/ARHP Annual Meeting
Cell Bound Complement Activation Products Distinguish Systemic Lupus Erythematosus from Other Diseases Among Patients with High Antinuclear Antibody Titers and Normal Complement
Daniel J. Wallace¹, Elena Massarotti², Rosalind Ramsey-Goldman³, Christopher E. Collins⁴, Anca Askanase⁵, Jill P. Buyon⁶, Richard Furie⁷, Sonali Narain⁷, Amit Saxena⁸, Kenneth C. Kalunian⁹, Cristina Arriens¹⁰, Chaim Putterman¹¹, John Conklin¹², Roberta Alexander¹², Claudia Ibarra¹², Tyler O'Malley¹³, Tarun Chandra¹⁴, Joseph Ahearn¹⁵, Susan Manzi¹⁶, Arthur Weinstein¹⁷ and Thierry Dervieux¹², ¹Cedars-Sinai Medical Center, UCLA, Los Angeles, CA, ²Brigham and Women's Hospital, Boston, MA, ³FSM, Northwestern University, Chicago, IL, ⁴Rheumatology, MedStar Washington Hospital Center, Washington, DC, ⁵Department of Medicine, Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ⁶Rheumatology, NYU Langone Medical Center, New York, NY, ⁷Northwell Health, Great Neck, NY, ⁸NYU Langone Medical Center, New York, NY, ⁹Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ¹⁰Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹¹Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY, ¹²Exagen Diagnostics, Inc., Vista, CA, ¹³Research and Development, Exagen Diagnostics, Inc., Vista, CA, ¹⁴EmpiriQA LLC, Long Grove, IL, ¹⁵Lupus Center of Excellence, West Penn Allegheny Health System, Pittsburgh, PA, ¹⁶Medicine, Allegheny Health Network, Pittsburgh, PA, ¹⁷Rheumatology, MedStar Washington Hospital Center/Georgetown University Medical Center, Washington, DC
Background/Purpose: Patients are often referred to the rheumatologist because of elevated anti-nuclear antibody (ANA) titers. We sought to evaluate the association of cell bound complement…
Abstract Number: 700 • 2017 ACR/ARHP Annual Meeting
Variability in Method of Testing for Antinuclear Antibodies (ANA): A Survey of Participants in the College of American Pathologist’s (CAP) Proficiency Testing Program
Stanley J. Naides¹, Jonathan Genzen², Gyorgy Abel³, Christine Bashleben⁴ and Mohammad Qasim Ansari⁵, ¹Immunology, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, ²ARUP Laboratories Inc, Salt Lake City, UT, ³Department of Pathology and Laboratory Medicine, Lahey Clinic Burlington, Burlington, VT, ⁴College of American Pathologists, Northfield, IL, ⁵Department of Pathology and Laboratory Medicine, Louis Stokes VAMC, Cleveland, OH
Background/Purpose: A 2010 American College of Rheumatology position paper designated indirect immunofluorescence assay (IFA) on HEp-2 cells the “gold standard” for ANA testing and that…
Abstract Number: 1097 • 2017 ACR/ARHP Annual Meeting
Investigating Opportunities for Cost Conscious Care: A Review of Physician Practice in Ordering Anti-Nuclear Antibody Testing at an Academic Community Hospital
Hrudya Abraham, Jorge Espinal and Sindhu Joseph, Internal Medicine, MacNeal Hospital, Berwyn, IL
Background/Purpose: More than 94,000 ANA tests are performed each year resulting in an estimated cost of 2.24 million dollars annually. The American College of Rheumatology…
Abstract Number: 2578 • 2017 ACR/ARHP Annual Meeting
RAB4A Protects from Antinuclear Antibody Production and Nephritis in the Pristane-Induced Model of SLE
Gourav Choudhary¹, Nick Huang², Thomas Winans³, Ryan Kelly⁴, Sarah Blair³, Miguel Beckford³ and Andras Perl², ¹Department of Biochemistry and Mol. Biology, SUNY Upstate Medical University, Syracuse, NY, ²Medicine, SUNY Upstate Medical University, Syracuse, NY, ³SUNY Upstate Medical University, Syracuse, NY, ⁴SUNY, Syracuse, NY
Background/Purpose: Systematic lupus erythematosus (SLE) is a multisystem chronic inflammatory disease characterized by circulating antinuclear autoantibodies and dysfunction of B cells, T cells, and dendritic…
Abstract Number: 1874 • 2016 ACR/ARHP Annual Meeting
Low Rate of Progression in Cases of Isolated Raynaud’s Phenomenon Screened By Nailfold Videocapillaroscopy and Antinuclear Antibody Status Supports Negative Predictive Value of These Tests
Louise Parker¹, Kevin Howell², Voon H. Ong³ and Christopher P.Denton⁴, ¹Centre for Rheumatology and Connective Diseases, UCL Medical School and Royal Free Hosp, London, United Kingdom, ²Institute of Immunity and Transplantation, University College London, Royal Free Campus, London, United Kingdom, ³Rheumatology, UCL Division of Medicine, London, United Kingdom, ⁴Centre of Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom
Background/Purpose: Raynaud’s phenomenon is common but can progress to definite connective tissue disease. We have observed long term follow up of an unselected consecutive…
Abstract Number: 2147 • 2016 ACR/ARHP Annual Meeting
Lack of Pro-Inflammatory Cyto/Chemokines in ANA+ Individuals with Insufficient Criteria for a Diagnosis of Systemic Autoimmune Rheumatic Disease
Waleed Hafiz¹, Nan-Hua Chang², Babak Noamani³, Dennisse Bonilla³, Larissa Lisnevskaia⁴, Earl Silverman⁵, Arthur Bookman⁶, Sindhu R. Johnson⁷, Carolina Landolt-Marticorena³ and Joan Wither³, ¹Rheumatology, University of Toronto, Toronto, ON, Canada, ²Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ³Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁴Lakeridge Health Services, Oshawa, ON, Canada, ⁵Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁶Rheumatology, University Health Network, Toronto, ON, Canada, ⁷Rheumatology, Mount Sinai Hospital and University Health Network, Toronto, ON, Canada
Background/Purpose: Patients with Systemic Autoimmune Rheumatic Disease (SARD) often have a prolonged pre-clinical phase during which they are anti-nuclear antibody (ANA) positive but lack clinical…

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