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Abstracts tagged "ANA"

  • Abstract Number: 1188 • 2018 ACR/ARHP Annual Meeting

    Are Residents Choosing Wisely? Analysis of Adherence to Recommendations of Ordering Anti-Nuclear Antibody Testing in an Internal Medicine Residency Primary Care Clinic

    Aparna Das, Rajarajan Panneerselvan, Annum Faisal, Jubran Rind and Rima Shah, Internal medicine, Michigan state university, grand rapids, MI

    Background/Purpose: A positive anti-nuclear antibody (ANA) is considered very useful for the diagnosis of SLE and systemic sclerosis, and somewhat useful for the diagnosis of…
  • Abstract Number: 1683 • 2018 ACR/ARHP Annual Meeting

    Variation in HEp-2 Antinuclear Antibody (ANA) Titer Is Strongly Associated with the ANA Kit Manufacturer

    Mark Wener1 and Mark H. Wener2, 1Division of Rheumatology, Department of Laboratory Medicine, University of Washington, Seattle, WA, 2Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: Titers of HEp-2 ANAs vary between laboratories, with many contributing factors. We sought to systematically determine the contribution of different ANA kit manufacturers to…
  • Abstract Number: 2107 • 2018 ACR/ARHP Annual Meeting

    Lupus-Prone SLE1.2.3. Mice Exhibit Loss of Thymus-Derived CD4+CD25+Helios+ Tregs

    Nick Huang1, Zhi-Wei Lai1, Gourav Choudhary2, Thomas Winans3, Ryan Kelly4, Katalin Banki5, Laurence Morel6 and Andras Perl1, 1Medicine, SUNY Upstate Medical University, Syracuse, NY, 2Department of Biochemistry and Mol. Biology, SUNY Upstate Medical University, Syracuse, NY, 3SUNY Upstate Medical University, Syracuse, NY, 4SUNY, Syracuse, NY, 5Clinical Pathology, SUNY Upstate Medical University, Syracuse, NY, 6Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a potentially fatal autoimmune disease that is characterized by the production of autoantibodies against nuclear antigens (ANA) and phospholipids…
  • Abstract Number: 2125 • 2018 ACR/ARHP Annual Meeting

    Pleiotropy of a Positive Antinuclear Antibody (ANA) Test: A Phewas and GWAS Approach

    Vivian Kawai1, Jonathan Mosley2, QiPing Feng1, Wei-Qi Wei3, Daniel Carranza Leon2, Cecilia P. Chung4, Andrea Ihegword2 and C Michael Stein1, 1Vanderbilt University Medical Center, Nashville, TN, 2Medicine, Vanderbilt University Medical Center, Nashville, TN, 3Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, 4Department of Medicine, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: ANAs are almost always present in systemic lupus erythematosus (SLE), but they are also present in ~12-20% of the population. A positive ANA (ANA+)…
  • Abstract Number: 2712 • 2018 ACR/ARHP Annual Meeting

    Evaluation of Longitudinal Outcomes in Scleroderma Patients with Negative Immunofluorescent Anti-Nuclear Antibodies

    Mayce Haj-Ali1, Derek Jones2, Sean McNish3, Sarah Stupp3, Marissa Mangini3 and Victoria Shanmugam4, 1Department of Medicince, The George Washington University School of Medicine and Health Sciences, Washington, DC, 2The George Washington University, Washington, DC, 3The George Washington University School of Medicine and Health Sciences, Washington, DC, 4Rheumatology, The George Washington University, Washington, DC

    Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disease characterized by inflammation, fibrosis, and vasculopathy. Historical data indicates approximately 90% of patients with SSc test positive…
  • Abstract Number: 2578 • 2017 ACR/ARHP Annual Meeting

    RAB4A Protects from Antinuclear Antibody Production and Nephritis in the Pristane-Induced Model of SLE

    Gourav Choudhary1, Nick Huang2, Thomas Winans3, Ryan Kelly4, Sarah Blair3, Miguel Beckford3 and Andras Perl2, 1Department of Biochemistry and Mol. Biology, SUNY Upstate Medical University, Syracuse, NY, 2Medicine, SUNY Upstate Medical University, Syracuse, NY, 3SUNY Upstate Medical University, Syracuse, NY, 4SUNY, Syracuse, NY

    Background/Purpose: Systematic lupus erythematosus (SLE) is a multisystem chronic inflammatory disease characterized by circulating antinuclear autoantibodies and dysfunction of B cells, T cells, and dendritic…
  • Abstract Number: 43 • 2017 ACR/ARHP Annual Meeting

    Regulation of TLR7 Signalling By UBE2L3 Dependent Linear Ubiquitination Explains Dimethyl Fumarate Suppression of Autoreactive B Cell Development in SLE

    Daniele Mauro1, Victoria Tsang2, Isabelle A. Clayton-Lucey3, Sara Pagani2, Farah Alam2, Elena Pontarini2, Alessandra Nerviani2, Angela Pakozdi4, Andrea Cove-Smith4, Ravindra Rajakariar4, Debasish Pyne4, Timothy J Vyse5, Costantino Pitzalis2 and Myles J. Lewis4,6, 1Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, 2Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, 3Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, EC1M 6BQ, United Kingdom, 4Barts Lupus Centre, Barts Health NHS Trust, London, United Kingdom, 5Division of Genetics and Molecular Medicine, King's College London, Guy's Hospital, London, United Kingdom, 6Rheumatology, Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

    Background/Purpose: A single risk haplotype spanning UBE2L3 is strongly associated with SLE and multiple autoimmune diseases. The E2 ubiquitin-conjugating enzyme UBE2L3 regulates TNFα and CD40…
  • Abstract Number: 198 • 2017 ACR/ARHP Annual Meeting

    The Impact of Electronic Consults (E-Consults) on Positive ANA Referrals in a Veteran Population

    Veena Patel1,2, Diana Stewart2,3 and Molly Horstman1,2,4, 1Internal Medicine, Baylor College of Medicine, Houston, TX, 2Internal Medicine, Michael E. DeBakey VA Medical Center, Houston, TX, 3Internal Medicine and Pediatrics, Baylor College of Medicine, Houston, TX, 4Center for Innovations in Quality, Effectiveness and Safety (iQUEST), Houston, TX

    Background/Purpose: Referrals to rheumatology for positive ANA in the absence of clinical signs and symptoms is a common practice, which may lead to unnecessary resource…
  • Abstract Number: 476 • 2017 ACR/ARHP Annual Meeting

    Novel Interaction between Anti-Citrulline Monoclonal Antibodies and Apoptotic Cells Is Mediated through Citrullinated Nuclear Antigens

    Katy A. Lloyd1, Peter Sahlström2, Johanna Steen1, Philip J. Titcombe3,4, Diana Zhou1, Christina Lundqvist5, Olov Ekwall6,7, Jimmy Ytterberg1, Johan Rönnelid8, Daniel L. Mueller3, Lars Klareskog1, Vivianne Malmström1 and Caroline Grönwall9, 1Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 2Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 3Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, 4Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Sweden, Sweden, 5Dept. of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden, 6Dept. of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy University of Gothenburg, Göteborg, Sweden, 7Dept of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden, 8Department of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden, 9Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) display broad cross-reactivities and target proteins including a-enolase, filaggrin, vimentin, fibrinogen, and histones. However, every monoclonal ACPA has a distinct…
  • Abstract Number: 559 • 2017 ACR/ARHP Annual Meeting

    Performance of Multiple Platforms for Autoantibody Testing in Sjogren’s Syndrome

    Astrid Rasmussen1, Kiely Grundahl2, Lida Radfar3, C. Erick Kaufman4, David M. Lewis5, Barbara M. Segal6, Nelson L. Rhodus7, Harini Bagavant1, Umesh Deshmukh8, Christopher J Lessard8, R. Hal Scofield1 and Kathy L. Sivils1, 1Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, 3Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, 4College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 5Department of Oral Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, 6Rheumatology, Hennepin County Medical Center, Minneapolis, MN, 7Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, 8Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: The research classification and clinical diagnosis of SjšgrenÕs syndrome (SS) relies heavily on the detection of autoantibodies against Ro/SSA and La/SSB, particularly in the…
  • Abstract Number: 673 • 2017 ACR/ARHP Annual Meeting

    Cell Bound Complement Activation Products Distinguish Systemic Lupus Erythematosus from Other Diseases Among Patients with High Antinuclear Antibody Titers and Normal Complement

    Daniel J. Wallace1, Elena Massarotti2, Rosalind Ramsey-Goldman3, Christopher E. Collins4, Anca Askanase5, Jill P. Buyon6, Richard Furie7, Sonali Narain7, Amit Saxena8, Kenneth C. Kalunian9, Cristina Arriens10, Chaim Putterman11, John Conklin12, Roberta Alexander12, Claudia Ibarra12, Tyler O'Malley13, Tarun Chandra14, Joseph Ahearn15, Susan Manzi16, Arthur Weinstein17 and Thierry Dervieux12, 1Cedars-Sinai Medical Center, UCLA, Los Angeles, CA, 2Brigham and Women's Hospital, Boston, MA, 3FSM, Northwestern University, Chicago, IL, 4Rheumatology, MedStar Washington Hospital Center, Washington, DC, 5Department of Medicine, Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, 6Rheumatology, NYU Langone Medical Center, New York, NY, 7Northwell Health, Great Neck, NY, 8NYU Langone Medical Center, New York, NY, 9Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, 10Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 11Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY, 12Exagen Diagnostics, Inc., Vista, CA, 13Research and Development, Exagen Diagnostics, Inc., Vista, CA, 14EmpiriQA LLC, Long Grove, IL, 15Lupus Center of Excellence, West Penn Allegheny Health System, Pittsburgh, PA, 16Medicine, Allegheny Health Network, Pittsburgh, PA, 17Rheumatology, MedStar Washington Hospital Center/Georgetown University Medical Center, Washington, DC

    Background/Purpose: Patients are often referred to the rheumatologist because of elevated anti-nuclear antibody (ANA) titers. We sought to evaluate the association of cell bound complement…
  • Abstract Number: 700 • 2017 ACR/ARHP Annual Meeting

    Variability in Method of Testing for Antinuclear Antibodies (ANA): A Survey of Participants in the College of American Pathologist’s (CAP) Proficiency Testing Program

    Stanley J. Naides1, Jonathan Genzen2, Gyorgy Abel3, Christine Bashleben4 and Mohammad Qasim Ansari5, 1Immunology, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, 2ARUP Laboratories Inc, Salt Lake City, UT, 3Department of Pathology and Laboratory Medicine, Lahey Clinic Burlington, Burlington, VT, 4College of American Pathologists, Northfield, IL, 5Department of Pathology and Laboratory Medicine, Louis Stokes VAMC, Cleveland, OH

    Background/Purpose: A 2010 American College of Rheumatology position paper designated indirect immunofluorescence assay (IFA) on HEp-2 cells the “gold standard” for ANA testing and that…
  • Abstract Number: 1097 • 2017 ACR/ARHP Annual Meeting

    Investigating Opportunities for Cost Conscious Care: A Review of Physician Practice in Ordering Anti-Nuclear Antibody Testing at an Academic Community Hospital

    Hrudya Abraham, Jorge Espinal and Sindhu Joseph, Internal Medicine, MacNeal Hospital, Berwyn, IL

    Background/Purpose: More than 94,000 ANA tests are performed each year resulting in an estimated cost of 2.24 million dollars annually. The American College of Rheumatology…
  • Abstract Number: 1047 • 2016 ACR/ARHP Annual Meeting

    Negative Results of Antinuclear Antibody (ANA) Testing in Clinical Trials of Systemic Lupus Erythematosus (SLE) May be Due to Assay Variability

    David Pisetsky1, Dana Thompson1, Joseph Wajdula2, Annette Diehl2 and Sudhakar Sridharan3, 1Duke University Medical Center and Durham VAMC, Durham, NC, 2Global Product Development, Pfizer Inc, Collegeville, PA, 3PPD Inc, Rockville, MD

    Background/Purpose:   SLE clinical trials typically require that patients have either a positive ANA serology at a central laboratory during screening or have prior positive…
  • Abstract Number: 1049 • 2016 ACR/ARHP Annual Meeting

    High Titer ANA Not Necessarily a Valid Criterion for Lupus – Proposal of a Modification to the Criteria for Classification of SLE

    Luis E C Andrade1, Jan Damoiseaux2, Minoru Satoh3, Edward K.L. Chan4, Mônica Prado5, Henrique Mariz6, Renan Agustinelli7 and Alessandra Dellavance8, 1Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil, 2Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, Netherlands, 3Department of Clinical Nursing, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan, 4Dept of Oral Biology, University of Florida, Gainesville, FL, 5Rheumatology, Escola Paulista de Medicina - Universidade Federal de São Paulo, Sao Paulo, Brazil, 6Internal Medicine, Hospital das Clínicas - UFPE, Recife, Brazil, 7Rheumatology Division, Escola Paulista de Medicina, São Paulo, Brazil, 8Research and Development Department, Fleury Medicine and Health Laboratories, São Paulo, Brazil

    Background/Purpose:  A positive ANA test is one of ACR Revised Criteria for Classification of SLE, as well as the SLICC classification. The ANA test provides…
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