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Abstracts tagged "Allopurinol and gout"

  • Abstract Number: 359 • 2019 ACR/ARP Annual Meeting

    Impact of Hospital Admissions on Adherence to Allopurinol Therapy After Discharge

    Nicholas Lebedoff1, Andrea Barker 2, Curry L. Koening 3, Trevor Jones 4, Richard Rose 4, Peter Yarbrough 4 and Michael Battistone 5, 1University of Utah, Salt Lake City, 2Salt Lake City Veterans Affairs Medical Center & University of Utah, North Salt Lake, UT, 3University of Utah Hospital, Salt Lake City, UT, 4Salt Lake City Veterans Affairs Medical Center & University of Utah, Salt Lake City, 5Salt Lake City Veterans Affairs Medical Center & University of Utah, Salt Lake City, UT

    Background/Purpose: Gout is a common disease with effective medical therapies, yet many cases are complicated by providers’ hesitancy to prescribe an adequate dose of urate-lowering…
  • Abstract Number: 1266 • 2018 ACR/ARHP Annual Meeting

    ABCG2 rs2231142 Q141K and Oxypurinol Concentration in People with Gout Receiving Allopurinol

    Lisa K. Stamp1, Mary Wallace2, Rebecca Roberts3, Christopher Frampton1, Jeffrey Miner4, Tony R. Merriman3 and Nicola Dalbeth5, 1University of Otago, Christchurch, New Zealand, 2Surgical Sciences, University of Otago, Dunedin, New Zealand, 3University of Otago, Dunedin, New Zealand, 4Viscentio Bio, San Diego, CA, 5University of Auckland, Auckland, New Zealand

    Background/Purpose: Association of ABCG2 Q141K (p.141Lys) with poor urate-lowering response to allopurinol has been reported although the mechanism is unclear. ABCG2 has been reported to…
  • Abstract Number: 2229 • 2018 ACR/ARHP Annual Meeting

    Can We Predict Inadequate Response to Allopurinol Dose Escalation? Analysis of a Randomized Controlled Trial

    Lisa K. Stamp1, Peter T. Chapman2, Murray Barclay3, Anne Horne4, Christopher Frampton1, Paul Tan5, Jill Drake6 and Nicola Dalbeth5, 1University of Otago, Christchurch, New Zealand, 2Christchurch Hospital, Christchurch, New Zealand, 3Medicine, University of Otago, Christchurch, New Zealand, 4Department of Medicine, University of Auckland, Auckland, New Zealand, 5University of Auckland, Auckland, New Zealand, 6University of Otago, Christchurch, Christchurch, New Zealand

    Background/Purpose: The two most common causes of inadequate serum urate (SU) lowering with allopurinol are low adherence and under-dosing. Those who are adherent, but do…
  • Abstract Number: 2230 • 2018 ACR/ARHP Annual Meeting

    Serum Urate Levels in People with Gout on Dialysis – Are We Achieving Treatment Targets?

    Estella Yeo1, Suetonia Palmer2, Peter T. Chapman3, Christopher Frampton4 and Lisa K. Stamp4, 1Canterbury District Health Board, Christchurch, New Zealand, 2University of Otago, Christchurch, Christchurch, New Zealand, 3Christchurch Hospital, Christchurch, New Zealand, 4University of Otago, Christchurch, New Zealand

    Background/Purpose: To explore the number of patients on haemodialysis (HD) or peritoneal dialysis (PD) with gout in Canterbury and to determine how many were receiving…
  • Abstract Number: 1105 • 2017 ACR/ARHP Annual Meeting

    Allopurinol Dose Escalation to Achieve Serum Urate below 6mg/Dl: An Open Label Extension Study

    Lisa K. Stamp1, Peter T. Chapman2, Murray Barclay3, Anne Horne4, Christopher Frampton1, Paul Tan5, Jill Drake6 and Nicola Dalbeth5, 1University of Otago, Christchurch, New Zealand, 2Christchurch Hospital, Christchurch, New Zealand, 3Medicine, University of Otago, Christchurch, New Zealand, 4Department of Medicine, University of Auckland, Auckland, New Zealand, 5University of Auckland, Auckland, New Zealand, 6Rheumatology, Immunology and Allergy, Christchurch Hospital, Christchurch, New Zealand

    Background/Purpose: Allopurinol at higher than CrCL based doses remains controversial due to concerns over increased risk of adverse events (AE). A recent 12month randomized controlled…
  • Abstract Number: 1138 • 2017 ACR/ARHP Annual Meeting

    Investigation on Allele Frequency of Rs3117583 and Rs9263726 in Patients with Hyperuricemia or Gout

    Xiaomin Li1, Qiujing Wei2, Naomi Schlesinger3 and Jieruo Gu2, 1Rheumatology, Third affiliated hospital of Sun Yat-sen University, Guangzhou, China, 2Rheumatology, Third affiliated hospital of Sun Yat-sen Universtiy, Guangzhou, China, 3Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ

    Background/Purpose: Allopurinol, effectively regulates and controls serum uric acid levels but may cause allopurinol-induced life-threating severe cutaneous adverse reaction (SCAR). Previous studies reported that single…
  • Abstract Number: 3078 • 2015 ACR/ARHP Annual Meeting

    ABCG2 rs2231142 predicts Poor Response to Allopurinol in Patients with Gout

    Lisa K. Stamp1, Mary Wallace2, Tony R. Merriman3, Amanda Phipps-Green4, Ruth Topless4,5, Jill Drake6, Paul Tan7, Nicola Dalbeth8 and Rebecca Roberts4, 1Medicine, University of Otago, Christchurch, Christchurch, New Zealand, 2Surgical Sciences, University of Otago, Dunedin, New Zealand, 3Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, 4University of Otago, Dunedin, New Zealand, 5Department of Biochemistry, University of Otago, Dunedin, New Zealand, 6Rheumatology, Immunology and Allergy, Christchurch Hospital, Christchurch, New Zealand, 7University of Auckland, Auckland, New Zealand, 8Department of Medicine, University of Auckland, Auckland, New Zealand

    Background/Purpose: Many patients fail to reach target serum urate (SU) on allopurinol. Although the most common causes of inadequate response are non-adherence and low dosing…
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