Abstracts tagged "adipose tissue"

Abstract Number: 1675 • 2014 ACR/ARHP Annual Meeting
Regional Implantation of Adipose Tissue-Derived Cells Induces a Prompt Healing of Long-Lasting Indolent Digital Ulcers in Patients with Systemic Sclerosis
Nicoletta Del Papa¹, Gabriele Di Luca², Domenico Sambataro^1,3, Eleonora Zaccara⁴, Wanda Maglione⁴, Armando Gabrielli⁵, Paolo Fraticelli⁶, Gianluca Moroncini⁵, Lorenzo Beretta^7,8, Alessandro Santaniello⁹ and Claudio Vitali¹⁰, ¹Rheumatology Unit, Istituto G.Pini, Milan, Italy, ²UOS Chirurgia Vascolare,, Osp. G. Pini, Milano, Italy, ³UOC Day Hospital Reumatologia,, G. Pini Hospital, Milano, Italy, ⁴U.O.C. Day Hospital Reumatologia, Osp. G. Pini, Milano, Italy, ⁵Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy, ⁶Dipartimento di Scienze Cliniche e Molecolari, Clinica Medica, Università Politecnica delle Marche, Ancona, Italy, ⁷Via Francesco Sforza 28, Ospedale Maggiore Policlinico, Milano, Italy, ⁸Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ⁹Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ¹⁰Sezione Reumatologia, Istituto San Giuseppe, Lecco, Italy
Background/Purpose Fingertip digital ulcers (DUs) are a rather frequent and invalidating complication in the course of systemic sclerosis (SSc), often showing a very slow or…
Abstract Number: 864 • 2014 ACR/ARHP Annual Meeting
Association of Coronary Artery Calcification with Brown and White Pericardial Adipose Tissue in SLE
Kelly J. Shields, Medicine, Lupus Center of Excellence / Allegheny Health Network, Pittsburgh, PA
Background/Purpose Women with systemic lupus erythematosus (SLE) have an increased risk of cardiovascular disease (CVD). We have shown that clinically CVD-free women with SLE have…
Abstract Number: 763 • 2014 ACR/ARHP Annual Meeting
Caveolin-1 and Peroxisome Proliferator-Activated Receptor Gamma Co-Regulate the Differentiation of Monocytes to Adipocytes and Myofibroblasts in Vivo and in Vitro
Rebecca Lee¹, Charles Reese², Michael Bonner¹, Beth Perry³, Richard M. Silver⁴, Richard P. Visconti⁵, Stanley Hoffman³ and Elena Tourkina⁶, ¹Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, SC, ³Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Div Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC, ⁵Cell Biology and Regenerative Medicine, Medical University of South Carolina, Charleston, SC, ⁶Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose Skin fibrosis in scleroderma is associated with the loss of subcutaneous adipose tissue (lipodystrophy). The mechanisms underlying lipodystrophy and its relationship to fibrosis are…
Abstract Number: 532 • 2014 ACR/ARHP Annual Meeting
Adipose Tissue Is Prominent in Salivary Glands of Sjögren’s Syndrome Patients and Appears to Influence the Autoimmune Microenvironment in These Organs
Kathrine Skarstein^1,2, Lara Adnan Aqrawi³, Roland Jonsson^4,5 and Janicke Cecilie Liaaen Jensen⁶, ¹Gade Laboratorium for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway, ²Department of Pathology, Haukeland University Hospital, Bergen, Norway, ³Department of Clinical Science, University of Bergen, Bergen, Norway, ⁴Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ⁵Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, ⁶Department of Oral Surgery and Oral Medicine, University of Oslo, Oslo, Norway
Background/Purpose A positive salivary gland (SG) biopsy with a focus score of ≥1 is the only widely accepted pathological finding confirming the salivary gland component…
Abstract Number: 341 • 2014 ACR/ARHP Annual Meeting
Death Receptor 3 Causes Vascular Dysfunction in a Murine Model of Rheumatoid Arthritis
Jessica O Williams¹, Eddie C.Y. Wang², Derek Lang¹ and Anwen S. Williams², ¹Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom, ²Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom
Background/Purpose: Increased cardiovascular (CV) risk is prevalent in several forms of inflammatory arthritides. The mechanisms that regulate CV disease during early inflammatory arthritis are ill-defined.…
Abstract Number: 217 • 2014 ACR/ARHP Annual Meeting
The Relationship of Quadriceps and Hamstrings Intramuscular Fat and Lean Muscle with Power in Women with Knee Osteoarthritis
Michael J. Davison¹, Monica R. Maly², Karen A. Beattie³, Peter J. Keir⁴ and Jonathan D. Adachi⁵, ¹Medical Sciences, McMaster University, Hamilton, ON, Canada, ²School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada, ³Medicine, McMaster University, Hamilton, ON, Canada, ⁴Kinesiology, McMaster University, Hamilton, ON, Canada, ⁵Division of Rheumatology, McMaster University, Hamilton, ON, Canada
Background/PurposeReduced quadriceps and hamstrings strength is a risk factor for knee osteoarthritis (OA). This strength loss is partly due to the loss of lean muscle…
Abstract Number: 216 • 2014 ACR/ARHP Annual Meeting
Hip Adiposity, Not Local Knee Adiposity, Is Associated with Knee Pain Independent of Radiographic Osteoarthritis Severity
Grace H. Lo¹, Ajay Balasubramanyam², Jeffrey B. Driban³, Lori Lyn Price⁴, Charles B. Eaton⁵ and Timothy E. McAlindon⁶, ¹VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Medical Care Line and Research Care Line; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, ²Medicine, Baylor College of Medicine, Houston, TX, ³Tufts Medical Center, Boston, MA, ⁴Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁵Family Medicine, Memorial Hospital of Rhode Island, Pawtucket, RI, ⁶Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose Elevated body mass index (BMI) is associated with pain in knee OA. However, it is unclear if adiposity closer in proximity to the knee…
Abstract Number: 2799 • 2014 ACR/ARHP Annual Meeting
The Differential Impact of Obesity on the Pathogenesis of RA or Preclinical Models Is Contingent on the Disease Status
Zhenlong Chen¹, Seung-jae Kim¹, Abdul Essani², Michael V. Volin³, Suncica Volkov¹, William Swedler⁴, Shiva Arami², Giamila Fantuzzi², Nadera J. Sweiss⁵ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²University of Illinois at Chicago, Chicago, IL, ³Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ⁴Section of Rheumatology, University of Illinois at Chicago, Chicago, IL, ⁵internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: Studies were performed to determine the significance of obesity in the pathogenesis of rheumatoid arthritis (RA) and experimental arthritis models. Methods: Chronic and acute…
Abstract Number: 2474 • 2013 ACR/ARHP Annual Meeting
Fat Mass and Resistin: Predictive Factors For Anti-TNF Therapy Response In Ankylosing Spondylitis Patients
Carla G.S. Saad¹, Andressa Silva Abreu¹, Ana Cristina Medeiros Ribeiro¹, Julio C. B. Moraes², Luiz A. Perandini¹, Thalita Dassouki³, Rosa M. R. Pereira⁴, Eloisa Bonfa⁵ and Ana Lucia S. Pinto¹, ¹Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ⁴Reumatologia, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil, ⁵Rheumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: The adipose tissue immune properties and pharmacokinetic consequences can contribute to the pathogenesis of inflammatory conditions. The hole of fat tissue in active Ankylosing…
Abstract Number: 416 • 2013 ACR/ARHP Annual Meeting
Changes In Body Composition On Two Different Glucocorticoid Regimens In Early RA: Experience From The Cobra-Light Trial
Nicole P.C. Konijn¹, Karin Britsemmer², Marieke M. ter Wee¹, Debby den Uyl¹, Birgit S. Blomjous¹, Maarten Boers^3,4, Dirkjan van Schaardenburg^5,6, Willem F. Lems^1,6 and Michael T Nurmohamed^5,7, ¹Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ²Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ³Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, Netherlands, ⁴Deapartment of Epidemiology and Biostatistics, Jan van Breemen Research Institute/Reade, Amsterdam, Netherlands, ⁵VU University Medical Center, Amsterdam, Netherlands, ⁶Jan van Breemen Research Institute/Reade, Amsterdam, Netherlands, ⁷Rheumatology, Jan van Breemen Research Institute/Reade, Amsterdam, Netherlands
Background/Purpose: Prednisolone improves joint inflammation and disease severity in rheumatoid arthritis (RA), but is associated with multiple cardiovascular, metabolic and endocrine side effects and may…
Abstract Number: 54 • 2013 ACR/ARHP Annual Meeting
ANTI-Fibrotic and ANTI-Hypertrophic Effect Of Adipose Mesenchymal Stromal CELLS On Osteoarthritic Chondrocytes
Marie Maumus¹, C. Manferdini², Karine Toupet¹, A. Piacentini², A. Gabusi², A. Facchini², G. Lisignoli², Christian Jorgensen³ and Daniele Noel⁴, ¹Université Montpellier1, INSERM U844, Montpellier, France, ²Laboratorio di Immunoreumatologia e Rigenerazione tissutale, IOR BOLOGNA, BOLOGNA, Italy, ³Department of therapy & Immuno-Rhumatology, Inserm U844, CHU saint-Eloi, Université Montpellier 1, CHU Lapeyronie, Montpellier, France, ⁴Inserm U844, UM1, Montpellier, France
Background/Purpose: Mesenchymal stem cells (MSC) isolated from bone marrow (MSC) or adipose (ASC) tissues secrete a large amount of trophic factors. The possibility that these…

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