ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 1769

Abdominal Visceral Adipose Tissue Measured By DXA As a Novel Surrogate Marker of Cardiovascular Risk in Primary Necrotizing Vasculitides

Bertrand Dunogué1, Karine Briot2, Sami Kolta3, Alexis Regent4, Pascal Cohen5, Alice Berezne6, Xavier Puéchal5, Claire Le Jeunne5, Luc Mouthon5, Christian Roux7, Loïc Guillevin for the French Vasculitis Study Group5 and Benjamin Terrier8, 1Internal Medicine, Hôpital Cochin, Paris, France, 2Cochin Hospital, Paris Descartes University, Paris, France, 3Rheumatology B, Paris Descartes University, Cochin hospital, Paris, France, 4Internal Medicine, Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, Paris, France, 5National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, 6Paris Descartes University, Internal Medicine department, Cochin Hospital, Paris, France, 7Paris Descartes University, Cochin Hospital, Paris, France, 8National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: adipose tissue, Cardiovascular disease, risk and vasculitis

  • Tweet
  • Email
  • Print
Session Information

Session Title: Vasculitis

Session Type: Abstract Submissions (ACR)

Background/Purpose

Studies have shown a strong prevalence of cardiovascular events among patients with primary necrotizing vasculitides. Recent studies indicate that visceral adipose tissue (VAT) is highly associated with insulin resistance and cardiovascular events. Dual energy X-ray absorptiometry (DXA) is a validated technique able to accurately determine cross-sectionally the mass of discreet fat deposits.

Objective. To assess the relevance of abdominal adipose tissue measurement as potential surrogate markers for cardiovascular risk in patients with primary necrotizing vasculitides.

Methods

Patients with ANCA-associated vasculitides (AAN) and polyarteritis nodosa (PAN) seen in our department were prospectively included in an ongoing cross-sectional study assessing cardio-vascular complications and other sequelae (OSTEOVAS cohort). Alongside the evaluation of usual clinical and extra-clinical features associated with increased cardiovascular risk, DXA was performed to evaluate body composition and abdominal adipose tissue (subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). 

Results

Sixty-five patients were analyzed (38 females, mean age 50±18 years, mean disease duration of 85±79 months). Diagnoses were granulomatosis with polyangiitis (GPA) in 33 patients, microscopic polyangiitis in 6, eosinophilic GPA in 18, and PAN in 8. Five (7.7%) patients had developed cardiovascular complications. The median daily dose of corticosteroid was 5 mg/day (0-80). High cardiovascular risk defined by the NCEP-ATPIII was found in 11 (16.9%) patients. Using univariate analysis, cumulated dose of corticosteroids (p=0.038), Vascular Damage Index (VDI) (p=0.008), and VAT/SAT ratio (p=0.009) were significantly associated with high cardiovascular risk. Using multivariate analysis, VAT/SAT ratio remained independently associated with high-risk status [OR 1.07 (1.03-1.12), p=0.004]. VAT/SAT ratio was also independently correlated with an increased Framingham cardiovascular risk score (p<0.01).

Among factors correlated with a higher VAT/SAT ratio, we identified male gender (p<0.0001), age (r=+0.31, p=0.014), cumulated corticosteroid dose (r=+0.26, p=0.048), VDI score (r=+0.26, p=0.04), Body Mass Index (r=+0.35, p=0.006), waist circumference (r=+0.56, p<0.0001), and elevated troponin levels at time of assessment (r=+0.36, p=0.007). 

Conclusion

This is the first study showing a significant association between a high VAT/SAT ratio assessed by DXA and cardiovascular risk in patients with primary necrotizing vasculitides. Abdominal adipose tissue seems to be an accurate and independent surrogate marker of cardiovascular risk in these patients.


Disclosure:

B. Dunogué,
None;

K. Briot,
None;

S. Kolta,
None;

A. Regent,
None;

P. Cohen,
None;

A. Berezne,
None;

X. Puéchal,
None;

C. Le Jeunne,
None;

L. Mouthon,
None;

C. Roux,
None;

L. Guillevin for the French Vasculitis Study Group,
None;

B. Terrier,
None.

  • Tweet
  • Email
  • Print

« Back to 2014 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/abdominal-visceral-adipose-tissue-measured-by-dxa-as-a-novel-surrogate-marker-of-cardiovascular-risk-in-primary-necrotizing-vasculitides/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2022 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies