Abstracts tagged "adipose tissue"

Abstract Number: 819 • 2016 ACR/ARHP Annual Meeting
Impaired Adiponectin Signaling in SSc Contributes to Myofibroblast Differentiation and Organ Fibrosis
Roberta Goncalves Marangoni¹, Benjamin Korman², Feng Fang¹, Monique Hinchcliff¹, Laszlo Otvos³, Philipp E. Scherer⁴, Warren Tourtellotte⁵ and John Varga⁶, ¹Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ²Department of Rheumatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ³Temple University, Philadelphia, PA, ⁴University of Texas Southwestern Medical Center, Dallas, TX, ⁵Department of Pathology, Ward, Northwestern University, Chicago, IL, ⁶Rheumatology and Dermatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL
Background/Purpose: In systemic sclerosis (SSc) patients, skin fibrosis is accompanied by involution of dermal white adipose tissue (dWAT), a prominent source of adiponectin (APN). We…
Abstract Number: 851 • 2016 ACR/ARHP Annual Meeting
Perioral Autologous FAT Transplantation Is More Effective THAN Hyaluronic Acid Filler on Scleroderma Skin Fibrosis: Results from a LONG TERM Controlled Study
Nicoletta Del Papa¹, Eleonora Zaccara¹, Romina Andracco¹, Wanda Maglione¹, Francesca Pignataro¹, Fabio Caviggioli², Gabriele Di Luca³, Antonina Prafioriti⁴ and Claudio Vitali⁵, ¹Dept. Rheumatology, G. Pini Hospital, Milano, Italy, ²UOC Chirurgia Plastica, UOC Chirurgia Plastica, Multimedica Holding SpA, Milano, Italy, ³UOS Chirurgia Vascolare,, Osp. G. Pini, Milano, Italy, ⁴Pathology Unit, Istituto G.Pini, Milan, Italy, ⁵Rheumatology Section, Istituto San Giuseppe, Como, Italy
Background/Purpose: Autologous fat tissue grafting (AFTG) has been successfully used in the treatment of different sclerotic conditions, including scleroderma. We evaluated in patients with SSc…
Abstract Number: 1105 • 2016 ACR/ARHP Annual Meeting
Bone Metabolism in Rheumatic Diseases May be Affected By Free Fatty Acids
Klaus W. Frommer¹, Andreas Schäffler², Uwe Lange³, Stefan Rehart⁴, Jürgen Steinmeyer⁵, Markus Rickert⁶, Ulf Müller-Ladner⁷ and Elena Neumann¹, ¹Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ²Department of Internal Medicine III, Endocrinology, Diabetes, Metabolism, Justus-Liebig-University of Giessen, Bad Nauheim, Germany, ³Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁴Orthopedic & Trauma Surgery, Agaplesion Markus-Hospital, Frankfurt, Frankfurt, Germany, ⁵Dept Orthopedics and Experimental Orthopedics, University Hospital of Giessen and Marburg, Giessen, Germany, ⁶Dept of Orthopedics and Orthopedic Surgery, University Hospital of Giessen and Marburg, Gießen, Germany, ⁷Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: Obesity is associated with an increased risk of osteoarthritis also in non-weight bearing joints and increased amounts of visceral fat are associated with lower…
Abstract Number: 1363 • 2016 ACR/ARHP Annual Meeting
Serum Adipokines in Juvenile Dermatomyositis Are Associated with Disease Activities and Cardiac Function
Birgit Nomeland Witczak¹, Kristin Godang², Thomas Schwartz³, Nicoleta Cristina Olarescu⁴, Berit Flatø^5,6, Jens Bollerslev^5,7, Ivar Sjaastad^5,8,9 and Helga Sanner^5,6, ¹Oslo University Hospital, Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ²Department of Specialised Endocrinology, Oslo University Hospital, Section of Specialised Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ³Department of Infectious Diseases, Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁴Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway., Section of Specialised Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ⁵Institute for Clinical Medicine, University of Oslo, Oslo, Norway, Oslo, Norway, ⁶Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ⁷Section of Specialised Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ⁸Department of Cardiology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁹Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, Oslo, Norway
Background/Purpose: We have earlier demonstrated redistribution of adipose tissue in JDM patients. There is an increase in visceral adipose tissue (VAT), a highly active metabolic…
Abstract Number: 1512 • 2016 ACR/ARHP Annual Meeting
Bone Structural Deficits in Rheumatoid Arthritis: Impact of Muscle Mass and Density
Joshua Baker¹, Jin Long², Babette S. Zemel³, Janet E. Dinnella⁴, Prerna Sharma⁵, Said Ibrahim⁶ and Mary B. Leonard⁷, ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Stanford University, Palo Alto, CA, ³Pediatrics, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ⁴Arthritis/Immun Center, U Penn & VA Med Ctr, Philadelphia, PA, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Medicine, University of Pennsylvania, Philadelphia, PA, ⁷Pediatrics, Division of Nephrology, Stanford School of Medicine, Stanford University, Palo Alto, CA
Background/Purpose: Rheumatoid arthritis (RA) is associated with muscle loss, obesity, and osteoporotic fractures. Body composition and muscle quality are important regulators of bone strength among…
Abstract Number: 1858 • 2016 ACR/ARHP Annual Meeting
Phenotypical and Functional Characteristics of in Vitro Expanded Adipose-Derived Mesenchymal Stem Cells from Patients with Systemic Sclerosis
Nicoletta Del Papa¹, Chiara Capelli², Eleonora Zaccara¹, Paola Cipriani³, Paola Di Benedetto⁴, Wanda Maglione¹, Romina Andracco¹, Francesca Pignataro¹, Roberto Giacomelli⁴, Martino Introna⁵ and Claudio Vitali⁶, ¹Dept. Rheumatology, G. Pini Hospital, Milano, Italy, ²Laboratorio di Terapia Cellulare e Genica "G. Lanzani",, Ospedali Riuniti di Bergamo, Bergamo, Italy, ³Department of Biotechnological and Applied Clinical Science, Rheumatology Unit, School of Medicine, University of L’Aquila, L'Aquila, Italy, ⁴Department of Biotechnological and Applied Clinical Science, Rheumatology Unit, School of Medicine, University of L’Aquila, L’Aquila, Italy, ⁵Laboratorio di Terapia Cellulare e Genica "G. Lanzani", Ospedali Riuniti di Bergamo, Bergamo, Italy, ⁶Rheumatology Section, Istituto San Giuseppe, Como, Italy
Background/Purpose: Adult stem cells, namely those of mesenchymal origin (MSCs), have received attention as an ideal source of regenerative cells because of their multi-potential ability…
Abstract Number: 1948 • 2016 ACR/ARHP Annual Meeting
Evaluation of Body Composition Parameters in Granulomatosis with Polyangiitis: Association of Fat Mass Parameters with Disease Activity and Inflammatory Markers
Mariana O Perez¹, Valeria F Caparbo², Mauricio Levy-Neto² and Rosa M R Pereira², ¹Rheumatology Divison, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Granulomatosis with polyangiitis (GPA, Wegener´s) patients are more exposed to traditional cardiovascular risk factor, including obesity. In rheumatic diseases, inflammation has been associated with…
Abstract Number: 330 • 2015 ACR/ARHP Annual Meeting
Calf Muscle Adiposity Is Associated with Impaired Physical Performance in Knee OA
Michael Davison¹, Monica R. Maly², Jonathan D. Adachi³ and Karen A. Beattie⁴, ¹School of Medicine, McMaster University, Hamilton, ON, Canada, ²School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada, ³Division of Rheumatology, McMaster University, Hamilton, ON, Canada, ⁴Medicine, McMaster University, Hamilton, ON, Canada
Background/Purpose: Knee osteoarthritis (OA) is a degenerative disease associated with significant muscle weakness and disability. Ectopic fat in the thigh, including intramuscular fat (intraMF; fat…
Abstract Number: 865 • 2015 ACR/ARHP Annual Meeting
Abdominal Visceral Adipose Tissue Measured By Dual Energy X-Ray Absorptiometry (DXA) As a Novel Surrogate Marker of Cardiovascular Risk in Primary Necrotizing Vasculitides
Bertrand Dunogué¹, Karine Briot², Sami Kolta², Alexis Regent¹, Pascal Cohen¹, Alice Berezne¹, Xavier Puéchal¹, Claire Le Jeunne¹, Luc Mouthon¹, Christian Roux², Loïc Guillevin¹ and Benjamin Terrier¹, ¹Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, ²Rheumatology B Department, Hôpital Cochin, Paris, France
Background/Purpose: Studies have shown a strong prevalence of cardiovascular events among patients with systemic necrotizing vasculitides (SNV). Recent studies indicate that visceral adipose tissue (VAT)…
Abstract Number: 1741 • 2015 ACR/ARHP Annual Meeting
Abdominal Fat Mass Assessment in Recent Onset Spondyloarthritis: Data from the DESIR Cohort
Hélène Che¹, Adrien Etcheto², Camille Souffir³, Sami Kolta⁴, Pascal Richette⁵, Anna Molto⁶, Maxime Dougados², Christian Roux⁴ and Karine Briot⁴, ¹Cochin Hospital, Paris Descartes University, Paris, France, ²Université Paris René Descartes and Hôpital Cochin, Paris, France, ³Service de rhumatologie, Hopital Cochin, Paris, France, ⁴Rheumatology B Department, Hôpital Cochin, Paris, France, ⁵Université Paris Diderot, UFR médicale, Paris, France; APHP Hôpital Lariboisière, Fédération de Rhumatologie and Inserm U1132, Hôpital Lariboisière, Paris, France, ⁶Hopital Cochin, Paris Descartes University, Paris, France
Background/Purpose: Studies have shown a strong prevalence of cardiovascular events among patients with spondyloarthritis (SpA). Recent studies indicate that visceral adipose tissue (VAT) is highly…
Abstract Number: 1823 • 2015 ACR/ARHP Annual Meeting
Visceral Adiposity in Premenopausal Lupus Patients: Correlation with Systemic Inflammation
Luciana Seguro¹, Valéria Caparbo², Eloisa Bonfá¹ and Rosa M R Pereira³, ¹Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: SLE is associated with high prevalence of metabolic syndrome and obesity, which can be related to the high risk of cardiovascular events in this…
Abstract Number: 2053 • 2015 ACR/ARHP Annual Meeting
Adjustment of Skeletal Muscle Mass Estimates for the Extent of Adiposity Strengthens Relationships with Functional Outcomes in Rheumatoid Arthritis
Joshua Baker¹, Jon Giles², Mary Leonard³, David Weber⁴, Jin Long⁵, Erik Jorgenson⁶ and Patricia P. Katz⁷, ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Rheumatology, Columbia University Medical Center, NY, NY, ³Stanford University, Palo Alto, CA, ⁴Rochester University, Rochester, NY, ⁵Children's Hospital of Philadelphia, Philadelphia, PA, ⁶University of Pennsylvania, Philadelphia, PA, ⁷Rheumatology, UCSF, SF, CA
Background/Purpose: Skeletal muscle loss in rheumatoid arthritis (RA) has been described in association with poor physical functioning. Greater adiposity is simultaneously associated with both greater…
Abstract Number: 2703 • 2015 ACR/ARHP Annual Meeting
Reduction in Matrix Metalloproteinase-1 and -2 Secretion from Fibroblast-like Synoviocytes after Induction of Adipogenesis By a Natural Peroxisome Proliferator-Activated Receptor Gamma Ligand, Arterpilin-C
Eiji Sugiyama¹, Satoshi Yamasaki¹ and Je-Tae Woo^2,3, ¹Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan, ²Department of Biological Chemistry, Chubu University, Aichi, Japan, ³JT WOO, Okinawa Research Center Co., Ltd, Okiawa, Japan
Background/Purpose: Fibroblast-like synoviocytes (FLS) play important roles in rheumatoid arthritis (RA) by producing matrix metalloproteinase (MMP) and cytokines, and hence, these cells are a therapeutic…
Abstract Number: 3013 • 2015 ACR/ARHP Annual Meeting
Adipose Loss of Co-Repressor Ncor Attenuates Bleomycin-Induced Skin Fibrosis By Enhancing PPAR-Gamma Signaling
Benjamin Korman¹, Roberta Goncalves Marangoni¹, Warren Tourtellotte² and John Varga³, ¹Division of Rheumatology, Northwestern University, Chicago, IL, ²Department of Pathology, Ward, Northwestern University, Chicago, IL, ³Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL
Background/Purpose: The adipogenesis master regulator PPAR-gamma (PPARg) is regulated by repressors such as NCoR. Systemic sclerosis (SSc) is associated with impaired PPARg expression and function…
Abstract Number: 2799 • 2014 ACR/ARHP Annual Meeting
The Differential Impact of Obesity on the Pathogenesis of RA or Preclinical Models Is Contingent on the Disease Status
Zhenlong Chen¹, Seung-jae Kim¹, Abdul Essani², Michael V. Volin³, Suncica Volkov¹, William Swedler⁴, Shiva Arami², Giamila Fantuzzi², Nadera J. Sweiss⁵ and Shiva Shahrara¹, ¹Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, ²University of Illinois at Chicago, Chicago, IL, ³Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, ⁴Section of Rheumatology, University of Illinois at Chicago, Chicago, IL, ⁵internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: Studies were performed to determine the significance of obesity in the pathogenesis of rheumatoid arthritis (RA) and experimental arthritis models. Methods: Chronic and acute…

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