Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: Autologous fat tissue grafting (AFTG) has been successfully used in the treatment of different sclerotic conditions, including scleroderma. We evaluated in patients with SSc who complained of a reduced mouth opening, the long-term efficacy of AFTG of the lips in improving mouth opening in comparison with hyaluronic acid (HA) filler. We also investigated whether these procedures may induce some changes in the microvascular architecture and dermal structure of the treated skin area.
Methods: We studied 36 patients with dcSSc, (median age 37
Results: . 3 months after treatment both the inter-incisal distance and oral perimeter significantly increased (p <0.001). At the same time, a significant skin neovascularization became evident, both considering the VC images (p <0.001) and MVD scores in IH sections (p <0.0001). Finally, some skin histological aspects also improved, as shown by the significant changes in DEJ flattening scores (p <0.0001) and collagen content with less abnormal and denser collagen bundles. At 6 and 12 months, despite the disappearance of filling effect, both the functional improvement in mouth opening and the increased number of capillaries were maintained. No effect either on the mouth opening, VC images and skin histological aspects was observed in SSc patients treated by HA filler.
Conclusion: The present study shows that, in SSc patients, AFTG can improve mouth opening, induce a neovascularization, and partially restore the skin structure. All these effects were confirmed in the long-term observation. The lack of functional and biological effects in the control group treated by HA filler, suggests that the observed therapeutic effect of lipostructure may be specifically ascribed to the on site transplantation of fat tissue.
To cite this abstract in AMA style:Del Papa N, Zaccara E, Andracco R, Maglione W, Pignataro F, Caviggioli F, Di Luca G, Prafioriti A, Vitali C. Perioral Autologous FAT Transplantation Is More Effective THAN Hyaluronic Acid Filler on Scleroderma Skin Fibrosis: Results from a LONG TERM Controlled Study [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/perioral-autologous-fat-transplantation-is-more-effective-than-hyaluronic-acid-filler-on-scleroderma-skin-fibrosis-results-from-a-long-term-controlled-study/. Accessed November 23, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/perioral-autologous-fat-transplantation-is-more-effective-than-hyaluronic-acid-filler-on-scleroderma-skin-fibrosis-results-from-a-long-term-controlled-study/