Abstracts tagged "ACPA"

Abstract Number: 1116 • 2016 ACR/ARHP Annual Meeting
Anti-Citrullinated Protein Antibodies Promote Synovial Fibroblasts Migration and Adhesion through a Peptidylarginine Deiminases (PAD) Dependent Pathway
Meng Sun¹, Vijay Joshua¹, Akilan Krishnamurthy¹, Yanying Liu², Aase Hensvold¹, Sergiu-Bogdan Catrina³, Caroline Ospelt⁴, Vivianne Malmström⁵, Khaled Amara¹, Johanna Steen¹, Muhammad Sohel Mia¹, Marianne Engström¹, Heidi Wähämaa¹, Jimmy Ytterberg¹, Bence Rethi¹ and Anca I Catrina¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Peking University People's Hospital, Beijing, China, ³Molecular Medicine and Surgery, Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁴University Hospital Zurich, Center of Experimental Rheumatology, Switzerland, Zurich, Switzerland, ⁵Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Synovial fibroblasts (SFs) contribute to rheumatoid arthritis (RA) pathogenesis by growing into the synovial space and by producing pro-angiogenic and tissue remodelling factors, chemokines…
Abstract Number: 470 • 2016 ACR/ARHP Annual Meeting
Crucial Involvement of Citrullinated Proteins and ACPA in the Development of Peptide-Glucose-6-Phosphate Isomerase Induced Arthritis
Hoshimi Kawaguchi¹, Isao Matsumoto¹, Hiroshi Ebe¹, Naoto Umeda¹, Yuya Kondo¹, Hiroto Tsuboi² and Takayuki Sumida¹, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Division of Clinical Immunology, Doctoral Programs in Clinical Science, Graduated School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan
Background/Purpose: Various citrullinated proteins and anti-citrullinated protein antibodies (ACPA) are increased in patients with rheumatoid arthritis (RA). ACPA have high specificity for RA, and are…
Abstract Number: 1273 • 2016 ACR/ARHP Annual Meeting
Effect of Anti-Cyclic Citrullinated Protein Antibodies and Rheumatoid Factor on Bone Erosions in Early Rheumatoid Arthritis Patients Using HR-pQCT: A Cross-Sectional Study
JIANG YUE¹, James F Griffith², Lin Shi³, Defeng Wang², Jiayun Shen⁴, Priscilla Wong⁵, Edmund LI⁵, Martin Li⁶, Tena K. Li⁶, Tracy Y. Zhu⁷, Ling qin⁸ and Lai-Shan TAM⁹, ¹The Prince of Wales Hospital, The Chinese University of Hong Kong, Department of Medicine and Therapeutics, HONG KONG, Hong Kong, ²The Prince of Wales Hospital, The Chinese University of Hong Kong, Department of Imaging and Interventional Radiology, HONGKONG, Hong Kong, ³Department of Medicine & Therapeutics, Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, ⁴Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China, ⁵Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁶Department Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China, ⁷Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, China, ⁸Department of Orthopedics & Traumatology, hongkong, Hong Kong, ⁹Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong

Background/Purpose: Concomitant presence of anti-cyclic citrullinated peptide antibodies (ACPA) and rheumatoid factor (RF) is associated with higher erosive disease burden in patients with established rheumatoid…
Abstract Number: 505 • 2016 ACR/ARHP Annual Meeting
The Longitudinal Stability of the RA Biomarkers RF and ACPA in Classifying RA Subtypes over Extended Follow up
Carl Orr, Francis Young and Douglas J. Veale, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland
Background/Purpose: In recent years several studies suggest that first order stratification of RA should be based on the presence or absence of rheumatoid factor (RF)…
Abstract Number: 1549 • 2016 ACR/ARHP Annual Meeting
Rheumatoid Arthritis and Periodontal Disease: Salivary ACPA Levels and Clinical Presentation
Zoltan Szekanecz¹, Ildiko Tar², Eva Csösz³, Eva Veiszenbacher⁴, Edit Végh⁵, Kinga Bágyi⁶, Karin Lundberg⁷, Nastya Kharlamova⁸ and Ildiko Márton², ¹Department of Rheumatology, University of Debrecen Faculty of Medicine, Debrecen, HU, ²Department of Periodontology, University of Debrecen Faculty of Dentistry, Debrecen, Hungary, ³Center for Molecular Medicine, University of Debrecen Faculty of Medicine, Debrecen, Hungary, ⁴Faculty of Dentistry, University of Tirgu Mures, Tirgu Mures, Romania, ⁵Department of Rheumatology, University of Debrecen Faculty of Medicine, Debrecen, Hungary, ⁶Department of Restorative Dentistry, University of Debrecen Faculty of Dentistry, Debrecen, Hungary, ⁷Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁸Rheumatology Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden
Background/Purpose: We evaluated the periodontal involvement of rheumatoid arthritis (RA) patients, and we correlated with various laboratory biomarkers including lipids, autoantibodies, serum vitamin D levels,…
Abstract Number: 568 • 2016 ACR/ARHP Annual Meeting
Triggering Receptor Expressed on Myeloid Cells (TREM) As a Novel Indicator of Disease Progression in ‘at-Risk’ Individuals
Laura Hunt¹, Sahar Musaad^1,2, John Stephenson³, Becki Burn², Isao Matsuura¹, Kulveer Mankia¹, Jackie L. Nam¹ and Paul Emery¹, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Microbiology, Calderdale & Huddersfield NHS Foundation Trust, Huddersfield, United Kingdom, ³Department Health Sciences, University of Huddersfield, Huddersfield, United Kingdom
Background/Purpose: Whilst the exact aetiology of rheumatoid arthritis (RA) remains unclear, current concepts suggest an environmental link with possible microbial triggers. Studying individuals at-risk of…
Abstract Number: 1589 • 2016 ACR/ARHP Annual Meeting
Body Mass Index Does Not Impact Abatacept Retention in Biologic-Naive Patients with Rheumatoid Arthritis Who Have Poor Prognostic Factors: A 12-Month Interim Analysis of an Observational, Prospective Study
R Alten¹, H-M Lorenz², HG Nüßlein³, X Mariette⁴, M Galeazzi⁵, A Cantagrel⁶, M Chartier⁷, Y Elbez⁸, C Rauch⁹ and M Le Bars⁷, ¹Schlosspark-Klinik University Medicine, Berlin, Germany, ²University Hospital, Heidelberg, Germany, ³University of Erlangen, Nürnberg, Germany, ⁴Université Paris-Sud, Paris, France, ⁵University of Siena, Siena, Italy, ⁶Purpan Hospital, Toulouse, France, ⁷Bristol-Myers Squibb, Rueil-Malmaison, France, ⁸Excelya, Boulogne-Billancourt, France, ⁹Bristol-Myers Squibb, Munich, Germany
Background/Purpose: In patients with RA, obesity may impair clinical response to anti-TNF agents.1,2 In contrast, BMI does not appear to impact treatment retention or clinical…
Abstract Number: 55 • 2016 ACR/ARHP Annual Meeting
Identification of Endogenous Autoantigens Bound to Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis: A Key Role for Citrulline Residues in Histone 4
Xiaobo Meng¹, Peyman Ezzati¹, Irene Smolik², Carol Hitchon³ and Hani El-Gabalawy⁴, ¹UNIVERSITY OF MANITOBA, WINNIPEG, MB, Canada, ²Arthritis Center, University of Manitoba, Winnipeg, MB, Canada, ³University of Manitoba, Winnipeg, MB, Canada, ⁴University of Manitoba Arthritis Center, Winnipeg, MB, Canada
Background/Purpose: Anti-Citrullinated Peptides Antibodies (ACPA) aid in rheumatoid arthritis (RA) diagnosis. The nature of autoantigens specifically bound to ACPA immune complex in vivoremains unclear. We…
Abstract Number: 571 • 2016 ACR/ARHP Annual Meeting
High Titer Rheumatoid Arthritis Antibodies Distinguish Between PAD2 and PAD4 Citrullinated Fibrinogen
Nathalie Blachere^1,2, Salina Parveen¹, Mayu Frank¹, Brian D. Dill¹, Henrik Molina¹ and Dana E. Orange^1,3,4, ¹The Rockefeller University, New York, NY, ²Howard Hughes Medical Institute, Chevy Chase, MD, ³Rheumatology, Hospital for Special Surgery, New York, NY, ⁴The New York Genome Center, New York, NY
Background/Purpose: Most patients with rheumatoid arthritis (RA) harbor antibodies to citrullinated autoantigens, such as citrullinated fibrinogen. Two isoforms of peptidylarginine deiminase (PAD), PAD2 and PAD4,…
Abstract Number: 2035 • 2016 ACR/ARHP Annual Meeting
Dosage Contribution of a Non-Classical HLA Gene, HLA-Doa, to the Risk of Rheumatoid Arthritis
Yukinori Okada¹, Akari Suzuki², Katsunori Ikari³, Chikashi Terao⁴, Yuta Kochi², Koichiro Ohmura⁵, Koichiro Higasa⁵, Masato Akiyama², Kyoto Ashikawa², Masahiro Kanai², Jun Hirata¹, Naomasa Suita¹, Yik-Ying Teo⁶, Huji Xu⁷, Sang-Cheol Bae⁸, Yukihide Momozawa², koichi Matsuda⁹, Shigeki Momohara¹⁰, Atsuo Taniguchi¹⁰, Ryo Yamada⁵, Tsuneyo Mimori⁵, Michiaki Kubo², Matthew A. Brown¹¹, Soumya Raychaudhuri¹², Fumihiko Matsuda⁵, Hisashi Yamanaka¹⁰, Yoichiro Kamatani² and Kazuhiko Yamamoto⁹, ¹Osaka University, Osaka, Japan, ²Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, ³Inst of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ⁴Departments of Genetics and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁶Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, ⁷The Second Military Medical University, Shanghai, Japan, ⁸Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, The Republic of, ⁹The University of Tokyo, Tokyo, Japan, ¹⁰Tokyo Women's Medical University, Tokyo, Japan, ¹¹The University of Queensland Diamantina Institute, Brisbane, Australia, ¹²Brigham and Women's Hospital, Boston, MA
Background/Purpose: Despite the progress in human leukocyte antigen (HLA) causal variant mapping, independent localization of major histocompatibility complex (MHC) risk from classical HLA genes is…
Abstract Number: 572 • 2016 ACR/ARHP Annual Meeting
Anti-Periodontal Bacteria Antibody Titers Are Inversely Correlated with ACPA in RA-Free Individuals with Periodontal Disease Compared to Community Controls
Emma Weeding¹, Londyn Robinson², Jeremy Sokolove³, Julie Marchesan⁴, Steven Offenbacher⁴, William H. Robinson³, Ryan Demmer⁵, Bryan Michalowicz⁶ and Jerry A. Molitor⁷, ¹Department of Internal Medicine, University of Michigan, Ann Arbor, MI, ²University of Minnesota, Minneapolis, MN, ³Stanford University School of Medicine, Stanford, CA, ⁴Department of Periodontology, Dental School, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵Epidemiology, Columbia University Mailman School of Public Health, New York, NY, ⁶Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, ⁷Rheumatic/Autoimmune Diseases, University of Minnesota, Minneapolis, MN
Background/Purpose: Rheumatoid arthritis (RA) and periodontal disease (PD) are comorbid conditions that share multiple underlying risk factors and pathophysiological features. A dysbiotic periodontal microbiome might…
Abstract Number: 2107 • 2016 ACR/ARHP Annual Meeting
Targeting Mir-155 in Rheumatoid Arthritis B Cells Reduces Antibody Production
Mariola Kurowska-Stolarska¹, Iain B McInnes², Stefano Alivernini³, Aziza Elmesmari⁴, Gianfranco Ferraccioli⁵, James Reilly² and David W. McCarey^6,7, ¹Institute of Infection,Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, ²Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ³Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy, ⁴Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, ⁵Division of Rheumatology - Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy, ⁶Glasgow Royal Infirmary, Glasgow, United Kingdom, ⁷Centre for Rheumatic Diseases, Centre for Rheumatic Diseases, Glasgow, United Kingdom
Background/Purpose: Better understanding of epigenetic regulatory mechanisms in RA pathogenesis will facilitate the development of new biomarkers or therapeutic strategies. MicroRNAs are post-transcriptional regulators that…
Abstract Number: 575 • 2016 ACR/ARHP Annual Meeting
Differences in Histological Scores and Histoclinical Correlations in ACPA- Versus ACPA+ Rheumatoid Arthritis Patients
Fadil Pirbuccus¹, Christine Galant¹, Adrien Nzeusseu Toukap², Frédéric A. Houssiau¹, Patrick Durez² and Bernard R. Lauwerys¹, ¹Pôle de pathologies rhumatismales inflammatoires et systémiques, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, ²Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium
Background/Purpose: Differences in the pathogenesis of ACPA- versus ACPA+ rheumatoid arthritis are still poorly understood. In this study, we compared patterns of synovial changes in…
Abstract Number: 2111 • 2016 ACR/ARHP Annual Meeting
Generation and Characterization of Anti-Citrullinated Protein Antibody-Producing B-Cell Clones
Kristine Germar^1,2, Mark Kwakkenbos³, Sabrina Pollastro^1,2, Nathalie van Uden^1,2,4, Priscilla Kerkman⁵, Ellen I.H. van der Voort⁶, Evan Reed⁷, Karin Lundberg⁷, Niek de Vries^1,8, Lars Klareskog⁷, Hans U. Scherer⁵, René E.M. Toes⁵, Arjen Bakker³, Hergen Spits^3,9,10 and Dominique Baeten^1,2,10, ¹Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Amsterdam Rheumatology and immunology Center, Amsterdam, Netherlands, ³AIMM Therapeutics, Amsterdam, Netherlands, ⁴Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁵Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁶Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁷Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁸Clinical Immunology and Rheumatology F4-105, Amsterdam Rheumatology and immunology Center, location AMC, Amsterdam, Netherlands, ⁹Department of Cell Biology and Histology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ¹⁰These authors contributed equally to this work, Amsterdam, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is the most frequent form of autoimmune arthritis with a prevalence of almost 1% worldwide. Anti-citrullinated protein antibodies (ACPA) are the…
Abstract Number: 582 • 2016 ACR/ARHP Annual Meeting
ACPA Induce Pathogenic Cytokines Expression in PBMC of ACPA+-RA Patients and Inhibition of Its Effect By Cit-ME a Synthetic Citrullinated Peptide
Smadar Gertel¹, Gidi Karmon², Eszter Szarka³, , Esther Houri-Levi⁴, Edna mozes⁵, Yehuda Shoenfeld⁴ and Howard Amital^6,7, ¹Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, ²Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel, ³Department of Immunology,, Eötvös Loránd University, Budapest,, Budapest, Hungary, ⁴Zabludowicz Center For Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel, Ramat-Gan, Israel, ⁵Department of Immunology,, The Weizmann Institute of Science, Rehovot, Israel., Rehovot, Israel, ⁶Department of Medicine B, Center for Autoimmune Diseases, Sheba Medical Center, Tel-hashomer, Israel, ⁷Department of Internal Medicine 'D', Sackler Faculty of Medicine, Tel-Aviv University, Kfar-Saba, Israel
ACPA induce pathogenic cytokines expression in PBMC of ACPA+-RA patients and inhibition of its effect by Cit-ME a synthetic citrullinated peptide.Smadar Gertel1, Gidi Karmon1, Eszter…

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