Abstracts tagged "ACPA"

Abstract Number: 2613 • 2016 ACR/ARHP Annual Meeting
Seropositivity for RF or ACPA Predicts Long Term Drug Retention with Rituximab, but Not with Abatacept and Tocilizumab : Long-Term Registry Data in 4498 Patients with Rheumatoid Arthritis
Jacques-Eric Gottenberg¹, Jacques Morel², Arnaud Constantin³, Thomas Bardin⁴, Alain G. Cantagrel⁵, Bernard Combe⁶, Maxime Dougados⁷, Rene-Marc Flipo⁸, Alain Saraux⁹, Thierry Schaeverbeke¹⁰, Jean Sibilia¹¹, Martin Soubrier¹², Olivier Vittecoq¹³, Elodie Perrodeau¹⁴, Philippe Ravaud¹⁵, Xavier Mariette¹⁶ and on behalf of the French Society of Rheumatology and of all the investigators participating to the AIR, ORA and REGATE registries, ¹Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²Rheumatology, Department of Rheumatology, Montpellier University Hospital, Montpellier, France, ³Rheumatology, CHU Purpan - Hopital Pierre-Paul Riquet, Toulouse, France, ⁴Clinique de Rhumatologie, Hopital Lariboisiere, Paris Cedex 10, France, ⁵Rheumatology, Centre Hospitalier Universitaire, Toulouse Purpan, Toulouse, France, ⁶Département Rhumatologie, Hôpital Lapeyronie, Montpellier, France, ⁷Rheumatology, Paris Descartes University, Paris, France, ⁸Rheumatology, University Hospital, Lille, France, ⁹Rheumatology, Brest University Hospital, Brest, France, ¹⁰Rheumatology, CHU Bordeaux, Bordeaux, France, ¹¹Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ¹²Rheumatology, Department of Rheumatology, CHU Gabriel Montpied, Clermont-Ferrand, France, ¹³Rheumatology, Rouen University Hospital &INSERM U905, Rouen, France, ¹⁴Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France, ¹⁵Epidemiologist, PARIS, France, ¹⁶Rheumatology, Rheumatology department, Bicetre Hospital, Paris-Sud University, Le Kremlin Bicetre, France
Background/Purpose: Seropositivity for RF or ACPA is associated with a better short-term effectiveness and drug retention of abatacept (ABA) and rituximab (RTX). Data are very…
Abstract Number: 585 • 2016 ACR/ARHP Annual Meeting
Disease Associated Anti-Citrullinated Protein Memory B Cells in Rheumatoid Arthritis Persist in DAS Remission
Adam J. Pelzek¹, Caroline Grönwall², Lelise Getu³, Pamela Rosenthal⁴, Jeffrey D. Greenberg⁵, Mandy J. McGeachy⁶, Larry W. Moreland⁷ and Gregg J. Silverman⁸, ¹New York University School of Medicine, New York, NY, ²Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ³Department of Medicine, New York University School of Medicine, New York, NY, ⁴Rheumatology, New York University School of Medicine, New York, NY, ⁵New York University School of Medicine, Millburn, NJ, ⁶Medicine, University of Pittsburgh, Pittsburgh, PA, ⁷Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁸Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose: B cells are central drivers of seropositive RA, and B cells that express anti-citrullinated protein antibodies (ACPA) may arise from past and/or ongoing breaches…
Abstract Number: 586 • 2016 ACR/ARHP Annual Meeting
Association Between ACPA Fine Specificity and High Resolution Computed Tomography Lung Changes in Patients with Early Rheumatoid Arthritis
Vijay Joshua¹, Katerina Chatzidionysiou¹, Gudrun Reynisdottir¹, Aase Hensvold¹, Monika Hansson¹, Leonor Nogueira², Guy Serre², Johan Grunewald³ and Anca I Catrina¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Unité Différenciation Épidermique et Autoimmunité Rhumatoïde, Unité Mixte de Recherche, INSERM, Toulouse, France, ³Division of Respiratory Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Airways abnormalities that are consistent with inflammation are common in anti-CCP2 positive subjects without inflammatory arthritis. Anti-CCP2 antibodies are associated with high-resolution computed tomography…
Abstract Number: 587 • 2016 ACR/ARHP Annual Meeting
Synovial Immunophenotype and Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Patients: Relationship to Treatment Response and Radiological Prognosis
Carl Orr¹, Aurélie Najm², Monika Biniecka³, Francis Young¹, Ursula Fearon⁴ and Douglas J. Veale¹, ¹Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, ²Rheumatology, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, ³St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland, ⁴Trinity College Dublin, Department of Molecular Rheumatology, Trinity College Dublin, Dublin, Ireland
Background/Purpose: Circulating anti-citrullinated peptide antibodies (ACPA) have been proposed as an important clinical test for stratification of patients presenting with rheumatoid arthritis (RA). ACPA may…
Abstract Number: 590 • 2016 ACR/ARHP Annual Meeting
Microvesicles in the Lungs of Early Rheumatoid Arthritis
Vijay Joshua¹, Fariborz Mobarrez¹, Gudrun Reynisdottir¹, Johan Öckinger², Jan Wahlström², Johan Grunewald², Heidi Wähämaa¹ and Anca I Catrina¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Division of Respiratory Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Structural changes, increased tissue citrullination and signs of local inflammation are present in the pulmonary compartment of early seropositive RA and seropositive individuals at…
Abstract Number: 1035 • 2016 ACR/ARHP Annual Meeting
The Prognostic Value of Different Auto-Antibodies for Arthritis Development in Patients with Clinically Suspect Arthralgia
Robin M ten Brinck¹, Hanna W van Steenbergen¹, Marije K. Verheul¹, Leendert A. Trouw² and Annette HM van der Helm-van Mil³, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology, Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Previous longitudinal studies in arthralgia patients studied Rheumatoid Factor (IgM-RF) and Anti-Citrullinated Protein Antibodies (ACPA) in relation to arthritis development. Participants in these studies…
Abstract Number: 6 • 2016 ACR/ARHP Annual Meeting
Lower Omega-3 Fatty Acid Biomarkers Are Associated with Inflammatory Arthritis in a Population Positive for Anti-Citrullinated Protein Antibodies
Ryan W. Gan¹, Elizabeth A. Bemis¹, M. Kristen Demoruelle², Kevin D. Deane², Christopher C. Striebich³, James H. Goddard⁴, Stacey A. Brake⁴, Michael J. Clare-Salzler⁵, V. Michael Holers⁶ and Jill M. Norris¹, ¹Epidemiology, Colorado School of Public Health, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Division of Rhuematology, University of Colorado School of Medicine, Aurora, CO, ⁴Nine Health Services, Inc., Denver, CO, ⁵Experimental Pathology, University of Florida, College of Medicine, Gainesville, FL, ⁶Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Antibodies to citrullinated protein antigens (ACPA) can be elevated prior to onset of inflammatory arthritis (IA) and RA. However, understanding of factors related to…
Abstract Number: 1108 • 2016 ACR/ARHP Annual Meeting
Protein Citrullinations By PAD Enzymes Promote Dendritic Cell Transdifferentiation into Osteoclast and Generate Targets for RA-Specific Antibodies
Akilan Krishnamurthy¹, Jimmy Ytterberg², Meng Sun¹, Vijay Joshua¹, Heidi Wähämaa¹, Nataliya Tarasova², Khaled Amara¹, Johanna Steen¹, Vivianne Malmström¹, Bence Rethi¹ and Anca I Catrina¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Immature dendritic cells (DCs) can develop into osteoclasts (OCs), however, the mechanisms regulating this differentiation switch are not yet understood. We have shown that…
Abstract Number: 130 • 2016 ACR/ARHP Annual Meeting
Anti-CCP Status Determines the Power Doppler Oscillation Pattern in Rheumatoid Arthritis – a Prospective Study
Ottar Gadeholt¹, Tobias Wech², Sebastian Schuh¹, Eva Christina Scharbatke¹, Eva Niederle¹, Hans-Peter Tony³ and Marc Schmalzing⁴, ¹Rheumatology/Immunology, Medical Clinic II, University Clinic Wuerzburg, Wuerzburg, Germany, ²Experimental Rradiology, University Clinic Wuerzburg, Wuerzburg, Germany, ³Rheumatology/Immunology, Medical Clinic II, University Clinic Wuerzburg, Würzburg, Germany, ⁴Rheumatology/Clinical Immunology, Medical Clinic II, University Clinic Wuerzburg, Würzburg, Germany
Title: Anti-CCP Status Determines the Power Doppler Oscillation Pattern in Rheumatoid Arthritis – a Prospective Study Abstract: Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory…
Abstract Number: 1116 • 2016 ACR/ARHP Annual Meeting
Anti-Citrullinated Protein Antibodies Promote Synovial Fibroblasts Migration and Adhesion through a Peptidylarginine Deiminases (PAD) Dependent Pathway
Meng Sun¹, Vijay Joshua¹, Akilan Krishnamurthy¹, Yanying Liu², Aase Hensvold¹, Sergiu-Bogdan Catrina³, Caroline Ospelt⁴, Vivianne Malmström⁵, Khaled Amara¹, Johanna Steen¹, Muhammad Sohel Mia¹, Marianne Engström¹, Heidi Wähämaa¹, Jimmy Ytterberg¹, Bence Rethi¹ and Anca I Catrina¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Peking University People's Hospital, Beijing, China, ³Molecular Medicine and Surgery, Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁴University Hospital Zurich, Center of Experimental Rheumatology, Switzerland, Zurich, Switzerland, ⁵Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Synovial fibroblasts (SFs) contribute to rheumatoid arthritis (RA) pathogenesis by growing into the synovial space and by producing pro-angiogenic and tissue remodelling factors, chemokines…
Abstract Number: 470 • 2016 ACR/ARHP Annual Meeting
Crucial Involvement of Citrullinated Proteins and ACPA in the Development of Peptide-Glucose-6-Phosphate Isomerase Induced Arthritis
Hoshimi Kawaguchi¹, Isao Matsumoto¹, Hiroshi Ebe¹, Naoto Umeda¹, Yuya Kondo¹, Hiroto Tsuboi² and Takayuki Sumida¹, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Division of Clinical Immunology, Doctoral Programs in Clinical Science, Graduated School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan
Background/Purpose: Various citrullinated proteins and anti-citrullinated protein antibodies (ACPA) are increased in patients with rheumatoid arthritis (RA). ACPA have high specificity for RA, and are…
Abstract Number: 1273 • 2016 ACR/ARHP Annual Meeting
Effect of Anti-Cyclic Citrullinated Protein Antibodies and Rheumatoid Factor on Bone Erosions in Early Rheumatoid Arthritis Patients Using HR-pQCT: A Cross-Sectional Study
JIANG YUE¹, James F Griffith², Lin Shi³, Defeng Wang², Jiayun Shen⁴, Priscilla Wong⁵, Edmund LI⁵, Martin Li⁶, Tena K. Li⁶, Tracy Y. Zhu⁷, Ling qin⁸ and Lai-Shan TAM⁹, ¹The Prince of Wales Hospital, The Chinese University of Hong Kong, Department of Medicine and Therapeutics, HONG KONG, Hong Kong, ²The Prince of Wales Hospital, The Chinese University of Hong Kong, Department of Imaging and Interventional Radiology, HONGKONG, Hong Kong, ³Department of Medicine & Therapeutics, Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, ⁴Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China, ⁵Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁶Department Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China, ⁷Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, China, ⁸Department of Orthopedics & Traumatology, hongkong, Hong Kong, ⁹Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong

Background/Purpose: Concomitant presence of anti-cyclic citrullinated peptide antibodies (ACPA) and rheumatoid factor (RF) is associated with higher erosive disease burden in patients with established rheumatoid…
Abstract Number: 505 • 2016 ACR/ARHP Annual Meeting
The Longitudinal Stability of the RA Biomarkers RF and ACPA in Classifying RA Subtypes over Extended Follow up
Carl Orr, Francis Young and Douglas J. Veale, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland
Background/Purpose: In recent years several studies suggest that first order stratification of RA should be based on the presence or absence of rheumatoid factor (RF)…
Abstract Number: 1549 • 2016 ACR/ARHP Annual Meeting
Rheumatoid Arthritis and Periodontal Disease: Salivary ACPA Levels and Clinical Presentation
Zoltan Szekanecz¹, Ildiko Tar², Eva Csösz³, Eva Veiszenbacher⁴, Edit Végh⁵, Kinga Bágyi⁶, Karin Lundberg⁷, Nastya Kharlamova⁸ and Ildiko Márton², ¹Department of Rheumatology, University of Debrecen Faculty of Medicine, Debrecen, HU, ²Department of Periodontology, University of Debrecen Faculty of Dentistry, Debrecen, Hungary, ³Center for Molecular Medicine, University of Debrecen Faculty of Medicine, Debrecen, Hungary, ⁴Faculty of Dentistry, University of Tirgu Mures, Tirgu Mures, Romania, ⁵Department of Rheumatology, University of Debrecen Faculty of Medicine, Debrecen, Hungary, ⁶Department of Restorative Dentistry, University of Debrecen Faculty of Dentistry, Debrecen, Hungary, ⁷Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁸Rheumatology Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden
Background/Purpose: We evaluated the periodontal involvement of rheumatoid arthritis (RA) patients, and we correlated with various laboratory biomarkers including lipids, autoantibodies, serum vitamin D levels,…
Abstract Number: 568 • 2016 ACR/ARHP Annual Meeting
Triggering Receptor Expressed on Myeloid Cells (TREM) As a Novel Indicator of Disease Progression in ‘at-Risk’ Individuals
Laura Hunt¹, Sahar Musaad^1,2, John Stephenson³, Becki Burn², Isao Matsuura¹, Kulveer Mankia¹, Jackie L. Nam¹ and Paul Emery¹, ¹NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Microbiology, Calderdale & Huddersfield NHS Foundation Trust, Huddersfield, United Kingdom, ³Department Health Sciences, University of Huddersfield, Huddersfield, United Kingdom
Background/Purpose: Whilst the exact aetiology of rheumatoid arthritis (RA) remains unclear, current concepts suggest an environmental link with possible microbial triggers. Studying individuals at-risk of…

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