ACR Meeting Abstracts

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Abstracts tagged "ACPA"

  • Abstract Number: 1116 • 2016 ACR/ARHP Annual Meeting

    Anti-Citrullinated Protein Antibodies Promote Synovial Fibroblasts Migration and Adhesion through a Peptidylarginine Deiminases (PAD) Dependent Pathway

    Meng Sun1, Vijay Joshua1, Akilan Krishnamurthy1, Yanying Liu2, Aase Hensvold1, Sergiu-Bogdan Catrina3, Caroline Ospelt4, Vivianne Malmström5, Khaled Amara1, Johanna Steen1, Muhammad Sohel Mia1, Marianne Engström1, Heidi Wähämaa1, Jimmy Ytterberg1, Bence Rethi1 and Anca I Catrina1, 1Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 2Rheumatology Unit, Department of Medicine, Peking University People's Hospital, Beijing, China, 3Molecular Medicine and Surgery, Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 4University Hospital Zurich, Center of Experimental Rheumatology, Switzerland, Zurich, Switzerland, 5Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Synovial fibroblasts (SFs) contribute to rheumatoid arthritis (RA) pathogenesis by growing into the synovial space and by producing pro-angiogenic and tissue remodelling factors, chemokines…
  • Abstract Number: 470 • 2016 ACR/ARHP Annual Meeting

    Crucial Involvement of Citrullinated Proteins and ACPA in the Development of Peptide-Glucose-6-Phosphate Isomerase Induced Arthritis

    Hoshimi Kawaguchi1, Isao Matsumoto1, Hiroshi Ebe1, Naoto Umeda1, Yuya Kondo1, Hiroto Tsuboi2 and Takayuki Sumida1, 1Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 2Division of Clinical Immunology, Doctoral Programs in Clinical Science, Graduated School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan

    Background/Purpose: Various citrullinated proteins and anti-citrullinated protein antibodies (ACPA) are increased in patients with rheumatoid arthritis (RA). ACPA have high specificity for RA, and are…
  • Abstract Number: 1273 • 2016 ACR/ARHP Annual Meeting

    Effect of Anti-Cyclic Citrullinated Protein Antibodies and Rheumatoid Factor on Bone Erosions in Early Rheumatoid Arthritis Patients Using HR-pQCT: A Cross-Sectional Study

    JIANG YUE1, James F Griffith2, Lin Shi3, Defeng Wang2, Jiayun Shen4, Priscilla Wong5, Edmund LI5, Martin Li6, Tena K. Li6, Tracy Y. Zhu7, Ling qin8 and Lai-Shan TAM9, 1The Prince of Wales Hospital, The Chinese University of Hong Kong, Department of Medicine and Therapeutics, HONG KONG, Hong Kong, 2The Prince of Wales Hospital, The Chinese University of Hong Kong, Department of Imaging and Interventional Radiology, HONGKONG, Hong Kong, 3Department of Medicine & Therapeutics, Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, 4Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China, 5Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 6Department Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China, 7Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, China, 8Department of Orthopedics & Traumatology, hongkong, Hong Kong, 9Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Background/Purpose: Concomitant presence of anti-cyclic citrullinated peptide antibodies (ACPA) and rheumatoid factor (RF) is associated with higher erosive disease burden in patients with established rheumatoid…
  • Abstract Number: 505 • 2016 ACR/ARHP Annual Meeting

    The Longitudinal Stability of the RA Biomarkers RF and ACPA in Classifying RA Subtypes over Extended Follow up

    Carl Orr, Francis Young and Douglas J. Veale, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland

    Background/Purpose: In recent years several studies suggest that first order stratification of RA should be based on the presence or absence of rheumatoid factor (RF)…
  • Abstract Number: 1549 • 2016 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis and Periodontal Disease: Salivary ACPA Levels and Clinical Presentation

    Zoltan Szekanecz1, Ildiko Tar2, Eva Csösz3, Eva Veiszenbacher4, Edit Végh5, Kinga Bágyi6, Karin Lundberg7, Nastya Kharlamova8 and Ildiko Márton2, 1Department of Rheumatology, University of Debrecen Faculty of Medicine, Debrecen, HU, 2Department of Periodontology, University of Debrecen Faculty of Dentistry, Debrecen, Hungary, 3Center for Molecular Medicine, University of Debrecen Faculty of Medicine, Debrecen, Hungary, 4Faculty of Dentistry, University of Tirgu Mures, Tirgu Mures, Romania, 5Department of Rheumatology, University of Debrecen Faculty of Medicine, Debrecen, Hungary, 6Department of Restorative Dentistry, University of Debrecen Faculty of Dentistry, Debrecen, Hungary, 7Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 8Rheumatology Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden

    Background/Purpose: We evaluated the periodontal involvement of rheumatoid arthritis (RA) patients, and we correlated with various laboratory biomarkers including lipids, autoantibodies, serum vitamin D levels,…
  • Abstract Number: 568 • 2016 ACR/ARHP Annual Meeting

    Triggering Receptor Expressed on Myeloid Cells (TREM) As a Novel Indicator of Disease Progression in ‘at-Risk’ Individuals

    Laura Hunt1, Sahar Musaad1,2, John Stephenson3, Becki Burn2, Isao Matsuura1, Kulveer Mankia1, Jackie L. Nam1 and Paul Emery1, 1NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2Microbiology, Calderdale & Huddersfield NHS Foundation Trust, Huddersfield, United Kingdom, 3Department Health Sciences, University of Huddersfield, Huddersfield, United Kingdom

    Background/Purpose: Whilst the exact aetiology of rheumatoid arthritis (RA) remains unclear, current concepts suggest an environmental link with possible microbial triggers.  Studying individuals at-risk of…
  • Abstract Number: 1589 • 2016 ACR/ARHP Annual Meeting

    Body Mass Index Does Not Impact Abatacept Retention in Biologic-Naive Patients with Rheumatoid Arthritis Who Have Poor Prognostic Factors: A 12-Month Interim Analysis of an Observational, Prospective Study

    R Alten1, H-M Lorenz2, HG Nüßlein3, X Mariette4, M Galeazzi5, A Cantagrel6, M Chartier7, Y Elbez8, C Rauch9 and M Le Bars7, 1Schlosspark-Klinik University Medicine, Berlin, Germany, 2University Hospital, Heidelberg, Germany, 3University of Erlangen, Nürnberg, Germany, 4Université Paris-Sud, Paris, France, 5University of Siena, Siena, Italy, 6Purpan Hospital, Toulouse, France, 7Bristol-Myers Squibb, Rueil-Malmaison, France, 8Excelya, Boulogne-Billancourt, France, 9Bristol-Myers Squibb, Munich, Germany

    Background/Purpose: In patients with RA, obesity may impair clinical response to anti-TNF agents.1,2 In contrast, BMI does not appear to impact treatment retention or clinical…
  • Abstract Number: 55 • 2016 ACR/ARHP Annual Meeting

    Identification of Endogenous Autoantigens Bound to Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis: A Key Role for Citrulline Residues in Histone 4

    Xiaobo Meng1, Peyman Ezzati1, Irene Smolik2, Carol Hitchon3 and Hani El-Gabalawy4, 1UNIVERSITY OF MANITOBA, WINNIPEG, MB, Canada, 2Arthritis Center, University of Manitoba, Winnipeg, MB, Canada, 3University of Manitoba, Winnipeg, MB, Canada, 4University of Manitoba Arthritis Center, Winnipeg, MB, Canada

    Background/Purpose: Anti-Citrullinated Peptides Antibodies (ACPA) aid in rheumatoid arthritis (RA) diagnosis. The nature of autoantigens specifically bound to ACPA immune complex in vivoremains unclear. We…
  • Abstract Number: 571 • 2016 ACR/ARHP Annual Meeting

    High Titer Rheumatoid Arthritis Antibodies Distinguish Between PAD2 and PAD4 Citrullinated Fibrinogen

    Nathalie Blachere1,2, Salina Parveen1, Mayu Frank1, Brian D. Dill1, Henrik Molina1 and Dana E. Orange1,3,4, 1The Rockefeller University, New York, NY, 2Howard Hughes Medical Institute, Chevy Chase, MD, 3Rheumatology, Hospital for Special Surgery, New York, NY, 4The New York Genome Center, New York, NY

    Background/Purpose: Most patients with rheumatoid arthritis (RA) harbor antibodies to citrullinated autoantigens, such as citrullinated fibrinogen. Two isoforms of peptidylarginine deiminase (PAD), PAD2 and PAD4,…
  • Abstract Number: 2035 • 2016 ACR/ARHP Annual Meeting

    Dosage Contribution of a Non-Classical HLA Gene, HLA-Doa, to the Risk of Rheumatoid Arthritis

    Yukinori Okada1, Akari Suzuki2, Katsunori Ikari3, Chikashi Terao4, Yuta Kochi2, Koichiro Ohmura5, Koichiro Higasa5, Masato Akiyama2, Kyoto Ashikawa2, Masahiro Kanai2, Jun Hirata1, Naomasa Suita1, Yik-Ying Teo6, Huji Xu7, Sang-Cheol Bae8, Yukihide Momozawa2, koichi Matsuda9, Shigeki Momohara10, Atsuo Taniguchi10, Ryo Yamada5, Tsuneyo Mimori5, Michiaki Kubo2, Matthew A. Brown11, Soumya Raychaudhuri12, Fumihiko Matsuda5, Hisashi Yamanaka10, Yoichiro Kamatani2 and Kazuhiko Yamamoto9, 1Osaka University, Osaka, Japan, 2Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, 3Inst of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 4Departments of Genetics and Rheumatology, Brigham and Women'’s Hospital, Harvard Medical School, Boston, MA, 5Kyoto University Graduate School of Medicine, Kyoto, Japan, 6Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, 7The Second Military Medical University, Shanghai, Japan, 8Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, The Republic of, 9The University of Tokyo, Tokyo, Japan, 10Tokyo Women's Medical University, Tokyo, Japan, 11The University of Queensland Diamantina Institute, Brisbane, Australia, 12Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Despite the progress in human leukocyte antigen (HLA) causal variant mapping, independent localization of major histocompatibility complex (MHC) risk from classical HLA genes is…
  • Abstract Number: 572 • 2016 ACR/ARHP Annual Meeting

    Anti-Periodontal Bacteria Antibody Titers Are Inversely Correlated with ACPA in RA-Free Individuals with Periodontal Disease Compared to Community Controls

    Emma Weeding1, Londyn Robinson2, Jeremy Sokolove3, Julie Marchesan4, Steven Offenbacher4, William H. Robinson3, Ryan Demmer5, Bryan Michalowicz6 and Jerry A. Molitor7, 1Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 2University of Minnesota, Minneapolis, MN, 3Stanford University School of Medicine, Stanford, CA, 4Department of Periodontology, Dental School, University of North Carolina at Chapel Hill, Chapel Hill, NC, 5Epidemiology, Columbia University Mailman School of Public Health, New York, NY, 6Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, 7Rheumatic/Autoimmune Diseases, University of Minnesota, Minneapolis, MN

    Background/Purpose: Rheumatoid arthritis (RA) and periodontal disease (PD) are comorbid conditions that share multiple underlying risk factors and pathophysiological features. A dysbiotic periodontal microbiome might…
  • Abstract Number: 2107 • 2016 ACR/ARHP Annual Meeting

    Targeting Mir-155 in Rheumatoid Arthritis B Cells Reduces Antibody Production

    Mariola Kurowska-Stolarska1, Iain B McInnes2, Stefano Alivernini3, Aziza Elmesmari4, Gianfranco Ferraccioli5, James Reilly2 and David W. McCarey6,7, 1Institute of Infection,Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 2Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom, 3Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy, 4Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, 5Division of Rheumatology - Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy, 6Glasgow Royal Infirmary, Glasgow, United Kingdom, 7Centre for Rheumatic Diseases, Centre for Rheumatic Diseases, Glasgow, United Kingdom

    Background/Purpose: Better understanding of epigenetic regulatory mechanisms in RA pathogenesis will facilitate the development of new biomarkers or therapeutic strategies.  MicroRNAs are post-transcriptional regulators that…
  • Abstract Number: 575 • 2016 ACR/ARHP Annual Meeting

    Differences in Histological Scores and Histoclinical Correlations in ACPA- Versus ACPA+ Rheumatoid Arthritis Patients

    Fadil Pirbuccus1, Christine Galant1, Adrien Nzeusseu Toukap2, Frédéric A. Houssiau1, Patrick Durez2 and Bernard R. Lauwerys1, 1Pôle de pathologies rhumatismales inflammatoires et systémiques, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium, 2Pôle de Maladies Rhumatismales, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels, Belgium

    Background/Purpose:  Differences in the pathogenesis of ACPA- versus ACPA+ rheumatoid arthritis are still poorly understood. In this study, we compared patterns of synovial changes in…
  • Abstract Number: 2111 • 2016 ACR/ARHP Annual Meeting

    Generation and Characterization of Anti-Citrullinated Protein Antibody-Producing B-Cell Clones

    Kristine Germar1,2, Mark Kwakkenbos3, Sabrina Pollastro1,2, Nathalie van Uden1,2,4, Priscilla Kerkman5, Ellen I.H. van der Voort6, Evan Reed7, Karin Lundberg7, Niek de Vries1,8, Lars Klareskog7, Hans U. Scherer5, René E.M. Toes5, Arjen Bakker3, Hergen Spits3,9,10 and Dominique Baeten1,2,10, 1Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 2Amsterdam Rheumatology and immunology Center, Amsterdam, Netherlands, 3AIMM Therapeutics, Amsterdam, Netherlands, 4Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 5Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 6Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 7Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 8Clinical Immunology and Rheumatology F4-105, Amsterdam Rheumatology and immunology Center, location AMC, Amsterdam, Netherlands, 9Department of Cell Biology and Histology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, 10These authors contributed equally to this work, Amsterdam, Netherlands

    Background/Purpose:  Rheumatoid arthritis (RA) is the most frequent form of autoimmune arthritis with a prevalence of almost 1% worldwide. Anti-citrullinated protein antibodies (ACPA) are the…
  • Abstract Number: 582 • 2016 ACR/ARHP Annual Meeting

    ACPA Induce Pathogenic Cytokines Expression in PBMC of ACPA+-RA Patients and Inhibition of Its Effect By Cit-ME a Synthetic Citrullinated Peptide

    Smadar Gertel1, Gidi Karmon2, Eszter Szarka3, , Esther Houri-Levi4, Edna mozes5, Yehuda Shoenfeld4 and Howard Amital6,7, 1Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, 2Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel, 3Department of Immunology,, Eötvös Loránd University, Budapest,, Budapest, Hungary, 4Zabludowicz Center For Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel, Ramat-Gan, Israel, 5Department of Immunology,, The Weizmann Institute of Science, Rehovot, Israel., Rehovot, Israel, 6Department of Medicine B, Center for Autoimmune Diseases, Sheba Medical Center, Tel-hashomer, Israel, 7Department of Internal Medicine 'D', Sackler Faculty of Medicine, Tel-Aviv University, Kfar-Saba, Israel

     ACPA induce pathogenic cytokines expression in PBMC of ACPA+-RA patients and inhibition of its effect by Cit-ME a synthetic citrullinated peptide.Smadar Gertel1, Gidi Karmon1, Eszter…
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