Abstract Number: 177 • 2013 ACR/ARHP Annual Meeting
Differences and Overlap Of Immunological Pathways Implicated In The Aetiology Of Anti-Citrullinated Peptide Antibody Positive and Negative Rheumatoid Arthritis
Background/Purpose: Genome-wide association studies have been successful in identifying single nucleotide polymorphisms (SNPs) associated with disease. However, previous studies have been under-powered to detect differences…Abstract Number: 1421 • 2013 ACR/ARHP Annual Meeting
Treatment Responses and Their Predictors Of Abatacept In Biologic naïve Patients With Rheumatoid Arthritis; Data Form Abroad Study
Background/Purpose: The identification of predictors of good response to biologic therapy is needed in the perspective of personalized medicine. To determine the predicting factors of efficacy…Abstract Number: 2819 • 2013 ACR/ARHP Annual Meeting
Administration Of a Multi-Epitope Citrullinated Peptide Attuneuates adjuvant Induced Arthritis In Rats Via Induction Of Immune Tolerance
Background/Purpose: Antigen-induced peripheral tolerance is a potentially efficient and specific therapeutic approach to attenuate autoimmunity. Citrullinated peptides are major targets of disease-specific autoantibodies in Rheumatoid…Abstract Number: 1389 • 2013 ACR/ARHP Annual Meeting
Serum 14-3-3η Precedes and Independently Predicts The Development Of RA
Background/Purpose: We have previously reported on a risk prediction rule for the development of rheumatoid arthritis (RA) in 374 seropositive (RF and/or ACPA) arthralgia patients,…Abstract Number: 2659 • 2013 ACR/ARHP Annual Meeting
Antibodies To Citrullinated Enolase, Fibrinogen, and Vimentin Are Associated With Markers Of Endothelial Dysfunction In First-Degree Relatives Of Patients With Rheumatoid Arthritis: The Studies Of The Etiology Of Rheumatoid Arthritis
Background/Purpose: Among rheumatoid arthritis (RA) patients, antibodies to citrullinated protein antigens (ACPA) have been detected in atherosclerotic plaques. In particular, antibodies to citrullinated fibrinogen (cit-fib)…Abstract Number: 1396 • 2013 ACR/ARHP Annual Meeting
Survivin–positivity Increases Risk For RA and Has a Strong Additive Effect On The Shared Epitope Alleles and Antibodies To Citrullinated Peptides In Patients Of The Malaysian Epidemiological Investigation Of Rheumatoid Arthritis (MyEIRA) Study Group
Background/Purpose: The human leukocyte antigen (HLA)-DRB1 with alleles that contain common amino acid motif QKRAA termed shared epitope (SE) confer the major locus of genetic…Abstract Number: 2432 • 2013 ACR/ARHP Annual Meeting
Characterization Of Lung Inflammation and Identification Of Shared Citrullinated Targets In The Lungs and Joints Of Early RA
Background/Purpose: To investigate if lung changes are present in rheumatoid arthritis (RA) patients early in the disease process and to address the contribution of these…Abstract Number: 1319 • 2013 ACR/ARHP Annual Meeting
Diagnostic Value Of Anti-Citrullinated Proteins Antibodies In Rheumatoid Arthritis
Background/Purpose: Citrulline and vimentin are some of the proteins used as antigens for anti-citrullinated proteins antibodies (ACPAs) detection for the diagnosis of rheumatoid arthritis (RA).…Abstract Number: 2430 • 2013 ACR/ARHP Annual Meeting
Antibodies To Porphyromonas Gingivalis as An Etiological Clue To The Development Of Anti-Citrullinated Protein Antibody Positive Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is characterized by the production of autoantibodies to citrullinated proteins (ACPA). Citrullinated proteins are generated by the actions of peptidyl arginine…Abstract Number: 1072 • 2013 ACR/ARHP Annual Meeting
Gene-Environment Interaction Between HLA-DRB1 Shared Epitope and Occupational Textile Dust Exposure In The Risk Of ACPA-Positive Rheumatoid Arthritis In Female Patients: Evidence From The Malaysian Epidemiological Investigation Of Rheumatoid Arthritis Case-Control Study
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease with interacting genetic and environmental factors contributing to its etiology. In this study, we investigated…Abstract Number: 2395 • 2013 ACR/ARHP Annual Meeting
Plasma Short-Talin Is a New Rheumatoid Arthritis Monitoring Biomarker Independent Of The Inflammatory Markers
Methods: ). Sixteen (31.4 %) of these 51 patients were untreated, and 18 patients (35.3%) were treated with biologics DMARD at the time of collecting…Abstract Number: 911 • 2013 ACR/ARHP Annual Meeting
Neutralization Of Anti-Citrullinated Protein Antibodies – a Way To Go?
Background/Purpose: In a previous study, we have identified endogeneously citrullinated sites in fibrinogen from RA synovial tissue (Hermansson M. et al. Proteomics Clin Appl, 2010).…Abstract Number: 2363 • 2013 ACR/ARHP Annual Meeting
Positivity Of Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Is Associated With The Response Rate Of Infliximab, But Not Tocilizumab, In Treatment Of Rheumatoid Arthritis
Background/Purpose: Recent reports have shown that positivity for rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) can influence the efficacy of rheumatoid arthritis (RA) treatment.…Abstract Number: 870 • 2013 ACR/ARHP Annual Meeting
How To Predict That Early Arthritis Without Rheumatoid Factor and ACPA Becomes Rheumatoid Arthritis According To ACR/EULAR 2010 After a 3-Years Follow-Up? Results From The Espoir Cohort
Background/Purpose: To describe disease course of patients without rheumatoid factor (RF) and anti-citrullinated protein auto-antibodies (ACPA) in an inception cohort of early arthritis patients. To determine…Abstract Number: 2293 • 2013 ACR/ARHP Annual Meeting
Anti-Citrullinated Peptide/Protein Antibody Specificities and Subclinical Synovitis In Palindromic Rheumatism: Towards a Better Understanding Of The Relationship With Rheumatoid Arthritis
Background/Purpose: Palindromic rheumatism (PR) may evolve to rheumatoid arthritis (RA), especially in anti-citrullinated peptide/protein antibody (ACPA) positive patients, although many do not evolve to RA…
ACR Meeting Abstracts