Abstracts tagged "ACPA"

Abstract Number: 1140 • 2014 ACR/ARHP Annual Meeting
Association of Polymorphisms on OPG, RANK and RANKL with ACPA Presence and Erosions: Results of a Meta-Analysis on 1570 Rheumatoid Arthritis Patients from 3 French Cohorts
Adeline Ruyssen Witrand^1,2,3, Sara Scaramuzzino^1,2, Delphine Nigon⁴, Cédric Lukas⁵, Yannick Allanore⁶, Olivier Vittecoq⁷, Thierry Schaeverbeke⁸, Jacques Morel⁹, Jean Sibilia¹⁰, Anne Cambon-Thomsen^1,2, Alain G. Cantagrel¹¹, Philippe Dieude^12,13 and Arnaud Constantin⁴, ¹UMR 1027, Inserm, Toulouse, France, ²UMR 1027, University Paul Sabatier, Toulouse, France, ³Rheumatolgy, CHU Purpan - Hôpital Pierre-Paul Riquet, Toulouse, France, ⁴Rheumatology, CHU Purpan - Hôpital Pierre-Paul Riquet, Toulouse, France, ⁵Immuno-Rhumatologie, Hopital Lapeyronie, Montpellier, France, ⁶Department of Rheumatology, University Paris Descartes and Cochin Hospital, Paris, France, ⁷Rheumatology, Department of Rheumatology, Rouen University Hospital & Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen, France, ⁸Rheumatology, Bordeaux University Hospital, Bordeaux, France, ⁹Department of Rheumatology, Hôpital Lapeyronie, Montpellier, France, ¹⁰Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, ¹¹Centre Hospitalier Universitaire de Toulouse, Toulouse, France, ¹²Rheumatology, Rheumatology departement & INSERM U699, Paris Diderot university, APHP, Bichat hospital, Paris, France, ¹³Rhumatologie, Hopital Bichat Claude Bernard, Paris, France
Background/Purpose Rheumatoid Arthritis (RA) is a multifactorial complex disease characterized by the presence of anti-citrullinated peptides antibodies (ACPA) and joints erosions. The mechanisms of bone…
Abstract Number: 362 • 2014 ACR/ARHP Annual Meeting
14-3-3η Early RA Biomarkers: Does Seronegative RA Exist?
Dirkjan van Schaardenburg¹, Walter P. Maksymowych², Maarten Boers³, Samina Turk⁴, Mairead Murphy⁵ and Anthony Marotta⁶, ¹Dr Jan van Breemenstraat 2, Reade, Amsterdam, Netherlands, ²Department of Medicine, University of Alberta, Edmonton, AB, Canada, ³Deapartment of Epidemiology and Biostatistics, Jan van Breemen Research Institute/Reade, Amsterdam, Netherlands, ⁴Reade, Amsterdam, Netherlands, ⁵Augurex Life Sciences Corp., North Vancouver, BC, Canada, ⁶1423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada
Background/Purpose RF and ACPA are used for early diagnosis and in prediction models for the risk of RA development in arthralgia patients. There remains a…
Abstract Number: 1054 • 2014 ACR/ARHP Annual Meeting
Rheumatoid Factor, Not ACPA, Is Associated with Disease Activity in Rheumatoid Arthritis
Daniel Aletaha¹, Farideh Alasti² and Josef Smolen³, ¹Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³PsAID taskforce, EULAR, Zurich, Switzerland
Background/Purpose To investigate the associations of rheumatoid factor (RF) and autoantibodies against citrullinated proteins (ACPA) with rheumatoid arthritis (RA) disease activity.Methods We analyzed the association…
Abstract Number: 361 • 2014 ACR/ARHP Annual Meeting
Citrullinated 14-3-3η Antibodies Are Specific for Early and Established RA and Are Complementary to ACPA
Anthony Marotta¹, Dirkjan van Schaardenburg², Gilles Boire³, Désirée van der Heijde⁴, Robert Landewé⁵, Maarten Boers⁶, C.F. Allaart⁷, Mairead Murphy⁸, Samina Turk⁹, Vivian P. Bykerk¹⁰, Edward Keystone¹¹, Katherine A. Siminovitch¹¹ and Walter P. Maksymowych¹², ¹1423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada, ²Dr Jan van Breemenstraat 2, Reade, Amsterdam, Netherlands, ³Rheumatology Division, CHUS - Sherbrooke University, Sherbrooke, QC, Canada, ⁴Leiden University Medical Center, Leiden, Netherlands, ⁵Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁶Deapartment of Epidemiology and Biostatistics, Jan van Breemen Research Institute/Reade, Amsterdam, Netherlands, ⁷Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁸Augurex Life Sciences Corp., North Vancouver, BC, Canada, ⁹Reade, Amsterdam, Netherlands, ¹⁰Divison of Rheumatology, Hospital for Special Surgery, New York, NY, ¹¹Mount Sinai Hospital, Toronto, ON, Canada, ¹²Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose Citrullination is a post-translational modification whereby arginine (Arg) is deiminated by PAD enzymes to form citrulline (Cit). In RA, current ACPA assays measure the…
Abstract Number: 993 • 2014 ACR/ARHP Annual Meeting
Anti-Citrullinated Proteins Antibodies Promote Synovial Fibroblast Migration in Rheumatoid Arthritis
Meng Sun¹, Vijay Joshua¹, Aase Haj Hensvold¹, Sergiu-Bogdan Catrina², Lars Klareskog³, Vivianne Malmström⁴, Heidi Wähämaa¹ and Anca I Catrina¹, ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Molecular Medicine and Surgery, Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ³Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, ⁴Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose The presence of anti-citrullinated proteins antibodies (ACPAs) in RA is associated with aggressive disease phenotype and bone destruction. As synovial fibroblasts (SFs) are considered…
Abstract Number: 360 • 2014 ACR/ARHP Annual Meeting
88% of Recent Onset Polyarthritis Patients Are Positive for 14-3-3η Markers and 14-3-3η Auto-Antibodies Inform a Favourable Prognosis
Gilles Boire¹, Nathalie Carrier², Artur Jose de Brum-Fernandes³, Patrick Liang⁴, Ariel Masetto⁵, Yuan Gui⁶, Mairead Murphy⁶, Walter P. Maksymowych⁷ and Anthony Marotta⁸, ¹Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ²Rheumatology, Universite de Sherbrooke, Sherbrooke, QC, Canada, ³Department of Medicine, Universite de Sherbrooke, Sherbrooke, QC, Canada, ⁴Rheumatology Division, CHUS, Sherbrooke, QC, Canada, ⁵Rheumatology, CHUS, Fleurimont, QC, Canada, ⁶Augurex Life Sciences Corp., North Vancouver, BC, Canada, ⁷Department of Medicine, University of Alberta, Edmonton, AB, Canada, ⁸1423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada
Background/Purpose The 14-3-3η protein has been described as a mechanistic marker that is detectable in serum during the very early stages of RA development. A…
Abstract Number: 840 • 2014 ACR/ARHP Annual Meeting
Vascular Calcifications on Hand and Wrist Radiographs Are Associated with Cardiovascular Risk Factors, Antigen-Specific Anti-Citrullinated Protein Antibodies, and Mortality in Rheumatoid Arthritis
E. Blair Solow¹, Fang Yu², Geoffrey M. Thiele³, Jeremy Sokolove^4,5, William H. Robinson^6,7, Zachary M. Pruhs³, Kaleb Michaud^8,9, Alan R. Erickson⁹, Harlan Sayles⁹, Gail S. Kerr¹⁰, Angelo L. Gaffo¹¹, Liron Caplan¹², Lisa A. Davis¹³, Grant W. Cannon¹⁴, Andreas M. Reimold¹⁵, Joshua Baker¹⁶, Pascale Schwab^17,18, Daniel Anderson⁹ and Ted R. Mikuls⁹, ¹Internal Medicine, Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas, TX, ²University of Nebraska Medical Center, Omaha, NE, ³Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁴VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ⁵Stanford University School of Medicine, Stanford, CA, ⁶VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁷Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁸National Data Bank for Rheumatic Diseases, Wichita, KS, ⁹Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ¹⁰Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, ¹¹Medicine, Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, AL, ¹²Div of Rheumatology, Denver VAMC and Univ of Colorado School of Medicine, Aurora, CO, ¹³Denver VAMC and Univ of Colorado School of Medicine, Aurora, CO, ¹⁴Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, ¹⁵Rheumatology, Dallas VA and University of Texas Southwestern, Dallas, TX, ¹⁶Medicine/Rheumatology, University of Pennsylvania and Philadelphia VAMC, Philadelphia, PA, ¹⁷Department of Internal Medicine, Division of Rheumatology, Portland VA Medical Center, Portland, OR, ¹⁸Internal Medicine, Division of Arthritis & Rheumatic Diseases, Oregon Health & Science University, Portland, OR
Background/Purpose: Rheumatoid arthritis (RA) is associated with increased mortality due to cardiovascular disease (CVD). Select antigen-specific anti-citrullinated protein antibodies (ACPA) are associated with atherosclerotic…
Abstract Number: 348 • 2014 ACR/ARHP Annual Meeting
Smoking Status Is Associated with Inflammatory Cytokine Profile and Disease Activity: Decreased Inflammation and Disease Improvement with Smoking Cessation?
Jeremy Sokolove¹, Harlan Sayles², Catriona Wagner³, Lauren J. Lahey¹, Geoffrey M. Thiele⁴, William H. Robinson¹, Andreas Reimold⁵, Gail S. Kerr⁶, Grant W. Cannon⁷ and Ted R. Mikuls², ¹VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ²Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ³VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, ⁴Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁵Rheumatology, Dallas VA and Univ of TX Southwestern Med Ct, Dallas, TX, ⁶Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, ⁷Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT
Background/Purpose: Cigarette smoking is a risk factor for RA and has been associated with increased disease severity and lower rates of disease remission. We examined…
Abstract Number: 815 • 2014 ACR/ARHP Annual Meeting
Netosis Induced Histone Citrullination Facilitates Onset and Propagation of Rheumatoid Arthritis
Dong Hyun Sohn¹, Kazuhiro Onuma¹, Chris Rhodes¹, Xioayan Zhao¹, Tal Gazitt², Rani Shiao¹, Justyna Fert Bober³, Danye Cheng¹, Lauren J. Lahey¹, Heidi Wong⁴, Jennifer van Eyk³, William H. Robinson^1,5 and Jeremy Sokolove¹, ¹VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ²Rheumatology, University of Washington, Seattle, WA, ³Johns Hopkins University and Cedars Sinai Medical Center, Los Angeles, CA, ⁴Stanford University School of Medicine, Stanford, CA, ⁵Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Anti-citrullinated protein antibodies (ACPAs) are characteristic of rheumatoid arthritis however, their presence years before onset of clinical RA is perplexing. Although multiple putative…
Abstract Number: 123 • 2014 ACR/ARHP Annual Meeting
Combination with Joint Power Doppler Signals with Anti-Citrullinated Peptide Antibody Predicts Joint Destruction in Rheumatoid Arthritis
Yohei Kirino¹, Maasa Hama¹, Kaoru Minegishi-Takase¹, Yosuke Kunishita¹, Daiga Kishimoto¹, Ryusuke Yoshimi¹, Yukiko Asami¹, Atsushi Ihata², Shigeru Ohno³, Atsuhisa Ueda¹, Mitsuhiro Takeno⁴ and Ishigatsubo Yoshiaki¹, ¹Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Rheumatology, Yokohama Minami Kyosai Hospital, Yokohama, Japan, ³Center for Rheumatic Diseases, Yokohama City University Medical Center, Yokohama, Japan, ⁴Clinical Laboratory Department, Yokohama City University Hospital, Yokohama, Japan
Background/Purpose , Categorizing RA patients who require intensive treatments is highly warranted to optimize the therapy and to avoid overtreatments. We here evaluated the use…
Abstract Number: 2918 • 2014 ACR/ARHP Annual Meeting
Fine-Mapping Major Histocompatibility Complex Associations in ACPA-Positive Rheumatoid Arthritis Identified Shared HLA Amino Acid Polymorphisms in Asian and European Populations
Yukinori Okada¹, Kwangwoo Kim², Buhm Han³, Nisha E. Pillai⁴, Rick T-H. Ong⁴, Woei-Yuh Saw⁴, Ma Luo⁵, Lei Jiang⁶, Jian Yin⁶, So-Young Bang⁷, Hye-Soon Lee⁷, Matthew A. Brown⁸, Sang-Cheol Bae², Huji Xu⁹, Yik-Ying Teo⁴, Paul IW. de Bakker¹⁰ and Soumya Raychaudhuri³, ¹Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ²Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ⁴National University of Singapore, Singapore, Singapore, ⁵University of Manitoba, Winnipeg, MB, Canada, ⁶The Second Military Medical University, Shanghai, China, ⁷Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea, ⁸University of Queensland Diamantina Institute, Brisbane, Australia, ⁹Shanghai Changzheng Hospital, Shanghai, China, ¹⁰Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) risk is strongly associated with variations within the major histocompatibility complex (MHC) region, and in particular to HLA-DRB1 alleles. We aimed…
Abstract Number: 441 • 2014 ACR/ARHP Annual Meeting
Arthritis Associated Autoantibodies in Non-Rheumatoid Arthritis Patients with Mucosal Inflammation
Koen M. J. Janssen¹, Menke J. de Smit², Elisabeth Brouwer³, Berber Doornbos-van der Meer³, Arie Jan van Winkelhoff^2,4, Arjan Vissink⁵, Josje Altenburg⁶, Nivine Levarht⁷, Marije K. Verheul⁷, Leendert A. Trouw⁷ and Johanna Westra³, ¹Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Center for Dentistry and Oral Hygiene, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁶Department of Pulmonary Diseases, Medical Center Alkmaar, Alkmaar, Netherlands, ⁷Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) associated autoantibodies, such as anti-citrullinated protein antibodies (ACPA), rheumatoid factor (RF) and anti-carbamylated protein antibodies (anti-CarP), can be present in serum…
Abstract Number: 2797 • 2014 ACR/ARHP Annual Meeting
Anti-Citrullinated Proteins Antibodies Promotes Osteoclastogenesis and Bone Destruction in Rheumatoid Arthritis
Akilan Krishnamurthy¹, Vijay Joshua¹, Heidi Wähämaa¹, Catia Cerqueira¹, Lars Klareskog², Vivianne Malmström³, Jimmy Ytterberg¹ and Anca I Catrina¹, ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, ³Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose Presence of anti-citrullinated protein antibodies (ACPA) is a major risk factor for bone erosion in rheumatoid arthritis (RA) and antibodies against modified citrullinated vimentin…
Abstract Number: 450 • 2014 ACR/ARHP Annual Meeting
The Mucosal Anti-Citrullinated Protein Antibody Response in Pre-Clinical Rheumatoid Arthritis
Anneke van der Horst¹, Ivy Y.K. Choi², Dirkjan van Schaardenburg³, D.M Gerlag², Paul Tak², Dörte Hamann¹ and Rogier M. Thurlings², ¹Sanquin Diagnostic Services, Amsterdam, Netherlands, ²Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³Dr Jan van Breemenstraat 2, Reade, Amsterdam, Netherlands
Background/Purpose Recent data suggest rheumatoid arthritis (RA) may originate from an autoimmune response in inflamed mucosa. RA is associated with gingival and airway inflammation and…
Abstract Number: 2456 • 2014 ACR/ARHP Annual Meeting
Associations of Toll-like Receptor (TLR)-4 Single Nucleotide Polymorphisms and Rheumatoid Arthritis Disease Progression
Marshall Davis¹, Tricia LeVan², Fang Yu³, Harlan Sayles⁴, Jeremy Sokolove⁵, William H. Robinson⁶, Kaleb Michaud⁷, Geoffrey M Thiele⁸ and Ted R. Mikuls⁴, ¹Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ²Univ of Nebraska Med Ctr, Omaha, NE, ³University of Nebraska Medical Center, Omaha, NE, ⁴Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁵VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ⁶VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁷National Data Bank for Rheumatic Diseases, Wichita, KS, ⁸Omaha VA and the University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Toll-like receptor (TLR)-4 signaling pathways have been implicated in both the innate and adaptive immune responses that characterize rheumatoid arthritis (RA). In this study,…

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