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Abstracts tagged "ACPA"

  • Abstract Number: 2859 • 2019 ACR/ARP Annual Meeting

    Citrulline Reactive B Cells Are Present in the Lungs of Early Untreated RA

    Vijay Joshua1, Malena Loberg-Haarhaus 1, Heidi Wähämaa 2, Aase Hensvold 2, Khaled Amara 1, Lena Israelsson 1, Ragnhild Stålesen 1, Magnus Sköld 3, Johan Grunewald 3, Caroline Grönwall 1, Vivianne Malmström 1 and Anca Catrina 4, 1Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Institutet, Stockholm, Sweden., Stockholm, Sweden, 2Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, 3Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden., Stockholm, Sweden, 4Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden

    Background/Purpose: Structural changes, increased tissue citrullination, signs of local inflammation and anti-citrullinated protein autoantibodies (ACPA) are present in the pulmonary compartment of early untreated seropositive…
  • Abstract Number: 51 • 2019 ACR/ARP Annual Meeting

    Cigarette Smoking Has Different Impacts on ACPA and RF Production Depending on Shared Epitope Allele Status in Japanese RA Patients; A Study with the Two Independent Japanese Cohorts (IORRA and KURAMA)

    Yuki Ishikawa1, Motomu Hashimoto 2, Katsunori Ikari 3, Koichiro Ohmura 4, Masao Tanaka 4, Hiromu Ito 4, Atsuo Taniguchi 3, Hisashi Yamanaka 3, Tsuneyo Mimori 4 and Chikashi Terao 5, 1Joslin Diabes Center, Boston, MA, 2Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan, 3Tokyo Women’s Medical University, Tokyo, Japan, 4Graduate School of Medicine, Kyoto University, Kyoto, Japan, 5RIKEN, Tokyo, Japan

    Background/Purpose: In rheumatoid arthritis (RA), cigarette smoking affects both rheumatoid factor (RF) and anti-citrullinated cyclic peptide/protein antibody (ACPA) production, but its association in relation to…
  • Abstract Number: 452 • 2019 ACR/ARP Annual Meeting

    Anti-citrullinated Vimentin Antibodies Are Associated to Early Deterioration of Cortical Bone and Volumetric Bone Mineral Density in Finger Joints in RA-at-risk Patients

    Georg Schett1, David Simon 2, Axel Hueber 2, Holger Bang 3, Jürgen Rech 4, Gerhard Kroenke 5 and Arnd Kleyer 6, 1Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Bayern, Germany, 3Orgentec Diagnostika, 55129 Mainz, Germany, Mainz, 4Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany, 5Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Austria, 6Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany

    Background/Purpose: Autoimmunity, characterized by the presence of anti-modified protein antibodies (AMPA), recognizing citrullinated, carbamylated or acetylated proteins, as well as rheumatoid factor (RF) precedes the…
  • Abstract Number: 500 • 2019 ACR/ARP Annual Meeting

    The Dysregulation of NK Cells and Non-Conventional NK-T and γδ-T Cells in Individuals at Risk of Developing Rheumatoid Arthritis

    Klára Prajzlerová1, Olga Kryštůfková 2, Petra Hánová 3, Hana Hulejová 3, Monika Gregová 1, Nora Petrovská 1, Herman Mann 4, Karel Pavelka 4, Jiří Vencovský 4, Ladislav Senolt 4 and Mária Filková 1, 1Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 2Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague, Czech Republic, 3Institute of Rheumatology, Prague, Czech Republic, 4Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague 2, Czech Republic

    Background/Purpose: The positivity of antibodies against citrullinated proteins (ACPA) precedes the clinical manifestation and significantly increases the risk of rheumatoid arthritis (RA). EULAR characterised individuals…
  • Abstract Number: 1423 • 2019 ACR/ARP Annual Meeting

    Patient-Reported Outcomes of Abatacept in Combination with MTX in Early, MTX-Naïve, ACPA Positive Patients with RA: 1-Year Results from a Phase IIIb Study

    Paul Emery1, Yoshiya Tanaka 2, Vivian Bykerk 3, Clifton Bingham 4, Thomas Huizinga 5, Gustavo Citera 6, Joe Zhuo 7, Kuan-Hsiang Gary Huang 8, Robert Wong 7, Sean Connolly 8, Yedid Elbez 9 and Roy Fleischmann 10, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, 2University of Occupational and Environmental Health Japan, Kitakyushu, Japan, 3Hospital for Special Surgery, New York City, NY, 4Johns Hopkins University, Baltimore, MD, 5Leiden University Medical Center, Leiden, Netherlands, 6Instituto de Rehabilitación Psicofísica, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 7Bristol-Myers Squibb, Princeton, 8Bristol-Myers Squibb, Princeton, NJ, 9Excelya, Boulogne-Billancourt, France, 10Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: Early biologic use can improve long-term control of RA, and early use of abatacept (ABA) + MTX has demonstrated sustained improvements in selected patient-reported…
  • Abstract Number: 22 • 2018 ACR/ARHP Annual Meeting

    Monoclonal Anti-Citrullinated Protein Antibodies Generated from RA-Derived B Cells Recognize Amino Acid Motifs Rather Than Specific Proteins

    Johanna Steen1, Philip J. Titcombe2, Bjorn Forsström3, Caroline Grönwall4, Anca I. Catrina5, Daniel Lightwood6, Peter Nilsson7, Lars Klareskog1 and Vivianne Malmström1, 1Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, 2The Center for Immunology, Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, 3SciLifeLab, Royal Technology Highschool,, Stockholm, Sweden, 4Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 5Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 6Antibody-discovery, UCB-Celltech, Slough, United Kingdom, 7Affinity Proteomics, SciLifeLab, School of Biotechnology, KTH - Royal Institute of Technology, Stockholm, Sweden, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) develop before RA diagnosis, at which point a wide range of citrullinated proteins have been shown…
  • Abstract Number: 1504 • 2018 ACR/ARHP Annual Meeting

    Utility of Serial ACPA Measurements in Rheumatoid Arthritis: Results of a Prospective Cohort Study

    Alistair Reid1,2,3, Michael D Wiese4, Robert Metcalf5, Mihir D Wechalekar6,7, Anita Lee8,9, Catherine Hill2,10,11, Cindy Hall8, Leah McWilliams5, Les Cleland8 and Susanna Proudman12, 1Rheumatology, Royal Adelaide Hospital, NORTH ADELAIDE, Australia, 2Medicine, The University of Adelaide, Adelaide, Australia, 3Medicine, University of Wollongong, Wollongong, Australia, 4School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia, 5Rheumatology Unit, Royal Adelaide Hospital, South Australia, Adelaide, Australia, 6Royal Adelaide Hospital, Adelaide, Australia, 7Rheumatology, Flinders University, Adelaide, Australia, 8Rheumatology, Royal Adelaide Hospital, Adelaide, Australia, 9Rheumatology, University of Adelaide, Adelaide, Australia, 10The Queen Elizabeth Hospital, Adelaide, Australia, 11Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, 12Royal Adelaide Hospital, Rheumatology Unit and University of Adelaide, Discipline of Medicine, Adelaide, Australia

    Background/Purpose: Anti-citrullinated peptide antibody (ACPA) and rheumatoid factor (RF) define “seropositive” rheumatoid arthritis (RA). Both predict disease course, development of extra-articular features and treatment outcomes.…
  • Abstract Number: 54 • 2018 ACR/ARHP Annual Meeting

    In a Macaque Model of RA By Immunization with Citrullinated Peptides, the Valine in the 11 Position of the DRB1 Molecule Has Greater Impacts on T-Cell Response to Citrullinated Peptides Than the 70-74 Position in the Shared Epitope

    Samuel Bitoun1, Pierre Roques2, Roger Le Grand3 and Xavier Mariette4, 1INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, Le Kremlin Bicêtre, France, 2Immunology of viral infections and autoimmune diseases, IDMIT Infrastructure CEA - Université Paris Sud - INSERM U1184, Fontenay-Aux-Roses,, France, 3Immunology of viral infections and autoimmune diseases, IDMIT Infrastructure CEA - Université Paris Sud - INSERM U1184, Fontenay-Aux-Roses, France, 4Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France

    Background/Purpose: Among genetic risk factors of RA, HLA class II molecules confers the highest risk of ACPA positive RA. The shared epitope (SE) hypothesis that…
  • Abstract Number: 1826 • 2018 ACR/ARHP Annual Meeting

    From Cancer to Autoimmunity : A New Model of Rheumatoid Arthritis Emerging from a Constitutional Genetic Approach Used in Low Penetrance Cancers

    Geraldine Falgarone1,2, Morad El Bouchtaoui3, Marcio Do Cruzeiro4, Christophe Leboeuf5,6,7, Irmine Loisel-Ferreira5,6, Carèle Frédonie7, Chrystophe Ferreira8, Rachida Ait El Far5, Marc Espié9, Bruno Cassinat10, Jean-Jacques Kiladjian11, Jean-Paul Feugeas12,13, Anne Janin5,6,14 and Guilhem Bousquet2,5,15, 1HUPSSD, Avicenne Hospital, Rheumatology, APHP, Bobigny, France, 2Paris 13 University, SMBH, Bobigny, France, 3INSERM UMR-S 1165, PARIS, France, 4Plateforme de Recombinaison Homologue, Institut Cochin, INSERM U1016, Paris, France, 5INSERM UMR-S 1165, Paris, France, 6Université Paris Diderot, Paris, France, 7INSERM U944, Paris, France, 8Plateforme ANIMA5, Université Paris Descartes, Paris, France, 9Centre des Maladies du Sein, APHP, Hôpital Saint-Louis, Paris, France, 10Laboratoire de BIologie Cellulaire, APHP, Hôpital Saint-Louis, Paris, France, 11Centre d'Inverstigation Clinique, APHP, Hôpital Saint-Louis, Paris, France, 12INSERM U1137, Paris, France, 13Département de Biologie, Université Franche-Comté, Besançon, France, 14Service de Pathologie, APHP, Hôpital Saint-Louis, Paris, France, 15Service d'Oncologie médicale, APHP, Hôpital Avicenne, Bobigny, France

    Background/Purpose: High-speed technologies for genome sequencing have completely changed the study of disease genetics, but with limited knowledge of the functional value of most genetic…
  • Abstract Number: 67 • 2018 ACR/ARHP Annual Meeting

    Intestinal Inflammation and Netosis Associate with the Presence of Stool IgA ACPA in Subjects at-Risk for RA

    Widian Jubair1, Elizabeth A. Bemis2, Yuko Okamoto3, Marie L. Feser3, Jennifer Seifert3, M. Kristen Demoruelle3, Jill M. Norris4, Kevin D. Deane3, V. Michael Holers5 and Kristine A Kuhn1,6, 1Rheumatology, University of Colorado Denver, Aurora, CO, 2Epidemiology, Colorado School of Public Health, Aurora, CO, 3Division of Rheumatology, University of Colorado Denver, Aurora, CO, 4Department of Epidemiology, Colorado School of Public Health, Aurora, CO, 5Rheumatology Division, University of Colorado Denver, Aurora, CO, 6Mucosal Inflammation Program, University of Colorado Denver, Aurora, CO

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) and inflammation characterized by neutrophil extracellular trap (NET)osis have been detected at mucosal sites such as the lung and periodontium…
  • Abstract Number: 1976 • 2018 ACR/ARHP Annual Meeting

    Sequencing of the MHC Region Defines HLA-DQA1 As Driven Risk for Anti-Citrullinated Protein Antibodies (ACPA)-Positive Rheumatoid Arthritis in Han Population

    Jianping Guo1, Tao Zhang2, Hongzhi Cao2, Xiaowei Li2, Mengru Liu1, Yundong Zou1 and Zhan-Guo Li1, 1Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 2Beijing Genomics Institute (BGI)-Shenzhen, Shenzhen, China

    Background/Purpose: The strong genetic contribution of the major histocompatibility complex (MHC) to rheumatoid arthritis (RA) susceptibility has been generally attributed to HLA-DRB1. However, due to…
  • Abstract Number: 72 • 2018 ACR/ARHP Annual Meeting

    Altered Serologic Responses to Epstein Barr Virus Precede Clinical Disease Development in Rheumatoid Arthritis

    Heather M. Berens1, Elizabeth A. Bemis2, M. Kristen Demoruelle1, John B. Harley3, Judith A. James4, Jess Edison5, Kevin D. Deane1, Jill M. Norris6 and V. Michael Holers1, 1Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 2Epidemiology, Colorado School of Public Health, Aurora, CO, 3Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4University of Oklahoma Health Sciences Center, Oklahoma City, OK, 5Division of Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD, 6Department of Epidemiology, Colorado School of Public Health, Aurora, CO

    Background/Purpose:    EBV infects B cells and is associated with several autoimmune diseases, including RA.  Prior studies have shown that patients with active classified RA…
  • Abstract Number: 2045 • 2018 ACR/ARHP Annual Meeting

    Specific Anti-Citrullinated Protein Antibodies Profiles Are Associated with Rheumatoid Arthritis Related Interstitial Lung Disease

    Pierre-Antoine Juge1, Leonor Nogueira2, Guy Serre2, René-Marc Flipo3, Lidwine Wemeau-Stervinou4, Thierry Schaeverbeke5, Claire Dromer6, Sylvain Adam-Marchand7, Marie-Christophe Boissier8, Hilario Nunes9, Raphaël Borie10, Bruno Crestani10 and Philippe Dieude10, 1Rhumatologie, Hôpital Bichat - Claude Bernard, Paris, France, 2Unité Différenciation Épidermique et Autoimmunité Rhumatoïde, Unité Mixte de Recherche, INSERM, Toulouse, France, 3Hôpital Roger Salengro, Lille, France, 4Pneumologie, CHRU de Lille, Lille, France, 5Department of Rheumatology, Bordeaux University Hospital, BORDEAUX, France, 6Imagerie Thoracique et Cardiovasculaire, CHU Bordeaux, Bordeaux, France, 7Pneumology, Centre Hospitalier Universitaire de Tours, Tours, France, 874 rue Marcel Cachin, INSERM, Bobigny, France, 9Pulmonary diseases department, Avicenne Hospital (AP-HP), Bobigny, France, 10Université Paris-Diderot, Paris, France

    Background/Purpose: The identification of peripheral blood markers of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) may facilitate an earlier diagnosis and provide insight regarding the pathogenesis…
  • Abstract Number: 211 • 2018 ACR/ARHP Annual Meeting

    Excess in Prevalence of Functional Disability in Patients with Rheumatoid Arthritis: Does Serologic Status Matter?

    Elena Myasoedova1, John M. Davis III1, Sara J. Achenbach2, Eric L. Matteson1 and Cynthia S. Crowson2, 1Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, 2Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN

    Background/Purpose: Despite the advances in treatment of rheumatoid arthritis (RA) over the recent decades, many patients with RA do not achieve remission or full physical…
  • Abstract Number: 2046 • 2018 ACR/ARHP Annual Meeting

    Serum Immunoglobulin G Targets Citrulline-Containing Immunoglobulin G Peptides in Rheumatoid Arthritis Patients Who Test Positive for Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibodies

    Mandar Bawadekar1, Zihao Zheng2, Alan J. Bridges3,4, Michael A. Newton5 and Miriam A. Shelef1,4, 1Department of Medicine, Division of Rheumatology, University of Wisconsin - Madison, Madison, WI, 2Departments of Statistics, University of Wisconsin - Madison, Madison, WI, 3Medicine, University of Wisconsin - Madison, Madison, WI, 4William S. Middleton Memorial Veterans Hospital, Madison, WI, 5Departments of Statistics and of Biostatistics and Medical Informatics, University of Wisconsin - Madison, Madison, WI

    Background/Purpose: Rheumatoid arthritis patients produce a variety of anti-citrullinated protein antibodies (ACPAs) as well as antibodies that bind homocitrullinated and malondialdehyde-acetaldehyde adducted proteins leading to…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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