ACR Meeting Abstracts

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Abstracts tagged "ACPA"

  • Abstract Number: 51 • 2019 ACR/ARP Annual Meeting

    Cigarette Smoking Has Different Impacts on ACPA and RF Production Depending on Shared Epitope Allele Status in Japanese RA Patients; A Study with the Two Independent Japanese Cohorts (IORRA and KURAMA)

    Yuki Ishikawa1, Motomu Hashimoto 2, Katsunori Ikari 3, Koichiro Ohmura 4, Masao Tanaka 4, Hiromu Ito 4, Atsuo Taniguchi 3, Hisashi Yamanaka 3, Tsuneyo Mimori 4 and Chikashi Terao 5, 1Joslin Diabes Center, Boston, MA, 2Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan, 3Tokyo Women’s Medical University, Tokyo, Japan, 4Graduate School of Medicine, Kyoto University, Kyoto, Japan, 5RIKEN, Tokyo, Japan

    Background/Purpose: In rheumatoid arthritis (RA), cigarette smoking affects both rheumatoid factor (RF) and anti-citrullinated cyclic peptide/protein antibody (ACPA) production, but its association in relation to…
  • Abstract Number: 452 • 2019 ACR/ARP Annual Meeting

    Anti-citrullinated Vimentin Antibodies Are Associated to Early Deterioration of Cortical Bone and Volumetric Bone Mineral Density in Finger Joints in RA-at-risk Patients

    Georg Schett1, David Simon 2, Axel Hueber 2, Holger Bang 3, Jürgen Rech 4, Gerhard Kroenke 5 and Arnd Kleyer 6, 1Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Bayern, Germany, 3Orgentec Diagnostika, 55129 Mainz, Germany, Mainz, 4Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany, 5Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Austria, 6Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany

    Background/Purpose: Autoimmunity, characterized by the presence of anti-modified protein antibodies (AMPA), recognizing citrullinated, carbamylated or acetylated proteins, as well as rheumatoid factor (RF) precedes the…
  • Abstract Number: 500 • 2019 ACR/ARP Annual Meeting

    The Dysregulation of NK Cells and Non-Conventional NK-T and γδ-T Cells in Individuals at Risk of Developing Rheumatoid Arthritis

    Klára Prajzlerová1, Olga Kryštůfková 2, Petra Hánová 3, Hana Hulejová 3, Monika Gregová 1, Nora Petrovská 1, Herman Mann 4, Karel Pavelka 4, Jiří Vencovský 4, Ladislav Senolt 4 and Mária Filková 1, 1Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 2Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague, Czech Republic, 3Institute of Rheumatology, Prague, Czech Republic, 4Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague 2, Czech Republic

    Background/Purpose: The positivity of antibodies against citrullinated proteins (ACPA) precedes the clinical manifestation and significantly increases the risk of rheumatoid arthritis (RA). EULAR characterised individuals…
  • Abstract Number: 1423 • 2019 ACR/ARP Annual Meeting

    Patient-Reported Outcomes of Abatacept in Combination with MTX in Early, MTX-Naïve, ACPA Positive Patients with RA: 1-Year Results from a Phase IIIb Study

    Paul Emery1, Yoshiya Tanaka 2, Vivian Bykerk 3, Clifton Bingham 4, Thomas Huizinga 5, Gustavo Citera 6, Joe Zhuo 7, Kuan-Hsiang Gary Huang 8, Robert Wong 7, Sean Connolly 8, Yedid Elbez 9 and Roy Fleischmann 10, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, 2University of Occupational and Environmental Health Japan, Kitakyushu, Japan, 3Hospital for Special Surgery, New York City, NY, 4Johns Hopkins University, Baltimore, MD, 5Leiden University Medical Center, Leiden, Netherlands, 6Instituto de Rehabilitación Psicofísica, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 7Bristol-Myers Squibb, Princeton, 8Bristol-Myers Squibb, Princeton, NJ, 9Excelya, Boulogne-Billancourt, France, 10Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: Early biologic use can improve long-term control of RA, and early use of abatacept (ABA) + MTX has demonstrated sustained improvements in selected patient-reported…
  • Abstract Number: 2859 • 2019 ACR/ARP Annual Meeting

    Citrulline Reactive B Cells Are Present in the Lungs of Early Untreated RA

    Vijay Joshua1, Malena Loberg-Haarhaus 1, Heidi Wähämaa 2, Aase Hensvold 2, Khaled Amara 1, Lena Israelsson 1, Ragnhild Stålesen 1, Magnus Sköld 3, Johan Grunewald 3, Caroline Grönwall 1, Vivianne Malmström 1 and Anca Catrina 4, 1Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Institutet, Stockholm, Sweden., Stockholm, Sweden, 2Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, 3Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden., Stockholm, Sweden, 4Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden

    Background/Purpose: Structural changes, increased tissue citrullination, signs of local inflammation and anti-citrullinated protein autoantibodies (ACPA) are present in the pulmonary compartment of early untreated seropositive…
  • Abstract Number: 1469 • 2018 ACR/ARHP Annual Meeting

    Measurement of Anti-Amyloid β Autoantibodies in Patients with Rheumatoid Arthritis

    Masao Sato1, Masao Takemura2, Tomohisa Tani3 and Toshiro Ohashi3, 1R, Ohashi-Tani Orthopaedic, Gifu, Japan, 2Advanced Diagnostic System Research Laboratory, Fujita Health University, Toyoake, Japan, 3Ohashi-Tani Orthopaedic, Gifu, Japan

    Background/Purpose: Amyloid β (Aβ) accumulation in the brain is a risk factor for Alzheimer's disease (AD). The incidence of AD increases with age. Rheumatoid arthritis…
  • Abstract Number: 8 • 2018 ACR/ARHP Annual Meeting

    Repertoire Studies in Rheumatoid Arthritis Reveal B-Cell Distortions and Baseline Shifts in Unmutated IgG

    Yan Wang1, Katy A. Lloyd2, Sunithi Gunasekera3, Camilla Eriksson3, Daniel Ramsköld2, Karin Lundberg4, Per-Johan Jakobsson1, Ulf Göransson3, Vivianne Malmström1 and Caroline Grönwall5, 1Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, 3Division of Pharmacognosy, Dept. of Medicinal Chemistry, Uppsala University, Uppsala, Sweden, 4Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 5Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: The immunological hallmark of rheumatoid arthritis (RA) is autoreactivity to citrullinated proteins and rheumatoid factor activity. Hence, the adaptive immune system and B cells…
  • Abstract Number: 1470 • 2018 ACR/ARHP Annual Meeting

    Russell Bodies and Serological Status in Rheumatoid Arthritis

    Michael A. McNamara1, Susan M. Goodman2, Laura T. Donlin3, Dana Orange4, Serene Z. Mirza1, Jackie Szymonifka2, Mark P. Figgie5, Vivian P. Bykerk2 and Edward F. DiCarlo6, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Hospital for Special Surgery, New York, NY, 3Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 4Rockefeller University, New York, NY, 5Surgery, Hospital for Special Surgery, New York, NY, 6Laboratory Medicine, Hospital for Special Surgery, New York, NY

    Russell Bodies and Serological Status in Rheumatoid Arthritis Background/Purpose: Russell bodies (RBs) are globular aggregates of immunoglobulin produced by plasma cells and identified both within…
  • Abstract Number: 11 • 2018 ACR/ARHP Annual Meeting

    PAD4-Independent Interaction of ACPA with Nuclear Antigens in Apoptotic Cells and Neutrophil Extracellular Traps (NETs) Defines a Subset of Autoantibodies

    Gustaf Wigerblad1, Katy A. Lloyd1, Peter Sahlström2, Karine Chemin2, Johanna Steen2, Philip J. Titcombe2,3, Diana Zhou2, Ragnhild Stålesen1, Bianka Marklein4, Elena Ossipova2, Johan Rönnelid5, Luca Piccoli6, Antonio Lanzavecchia6, Daniel L. Mueller3, Karl Skriner4, Lars Klareskog2, Fredrik Wermeling1, Vivianne Malmström2 and Caroline Grönwall7, 1Rheumatology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, 3The Center for Immunology, Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, 4Dept. of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany, 5Dept. of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden, 6Università della Svizzera italiana, Institute for Research in Biomedicine, Bellinzona, Switzerland, 7Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) bind a wide range of citrullinated proteins with high cross-reactivity. Recent findings suggest that certain, but…
  • Abstract Number: 1481 • 2018 ACR/ARHP Annual Meeting

    Are ACPA Associated with More Bone Loss over Time in Patients with RA?

    Emma de Moel1, Josephine Amkreutz1, Lotte Heimans2, Cornelia F. Allaart3, Tom W.J. Huizinga4 and Diane van der Woude4, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Internal Medicine, Leiden University Medical Center, Leiden, Netherlands, 3Department of Rheumatology, LUMC, Leiden, Netherlands, 4Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are one of the most important serological markers for rheumatoid arthritis (RA) and have been suggested to play a pathophysiologic…
  • Abstract Number: 14 • 2018 ACR/ARHP Annual Meeting

    Individual RA-Derived Monoclonal Anti-Citrullinated Protein Autoantibodies (ACPA) Have Extensive Citrulline Multi-Reactivity Demonstrated By a Large-Scale Protein Array Platform

    Peter Sahlström1, Johanna Steen1, Madeleine Jenning2, Philip J. Titcombe1,3, Ute Nonhoff4,5, Ragnhild Stålesen6, Bianka Marklein2, Daniel L. Mueller3, Zoltan Konthur4, Karin Lundberg7, Anca I. Catrina6, Lars Klareskog1, Vivianne Malmström1, Karl Skriner2 and Caroline Grönwall8, 1Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, 2Dept. of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany, 3The Center for Immunology, Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, 4Engine GmbH, Hennigsdorf, Germany, 5Max Planck Institute of Colloids and Interfaces, Potsdam, Germany, 6Rheumatology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, 7Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 8Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: The presence of serum IgG anti-citrullinated protein autoantibodies (ACPA) in rheumatoid arthritis (RA), is associated with more aggressive disease progression. Although ACPA have been…
  • Abstract Number: 1487 • 2018 ACR/ARHP Annual Meeting

    Correlation between Cytokine Levels and Power-Doppler Ultrasound Activity Is BMI Dependent, and Different in ACPA Positive and ACPA Negative RA with Wrist Arthritis

    Ottar Gadeholt1, Erin Arnold2, Corinne Gorman3, Tobias Mueller4 and William Arnold2, 1Rheumatology/Immunology, Medical Clinic II, University Clinic Wuerzburg, Wuerzburg, Germany, 2Orthopedics and Rheumatology of the North Shore, Skokie, IL, 3Orthopaedics & Rheumatology of the North Shore, Skokie, IL, 4Department of Bioinformatics, University of Wuerzburg, Wuerzburg, Germany

    Background/Purpose: Multiple cytokines are assumed to be involved in RA pathogenesis. It has been hypothesized that ACPA-negative RA with wrist affection constitutes a separate entity.…
  • Abstract Number: 22 • 2018 ACR/ARHP Annual Meeting

    Monoclonal Anti-Citrullinated Protein Antibodies Generated from RA-Derived B Cells Recognize Amino Acid Motifs Rather Than Specific Proteins

    Johanna Steen1, Philip J. Titcombe2, Bjorn Forsström3, Caroline Grönwall4, Anca I. Catrina5, Daniel Lightwood6, Peter Nilsson7, Lars Klareskog1 and Vivianne Malmström1, 1Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, 2The Center for Immunology, Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, 3SciLifeLab, Royal Technology Highschool,, Stockholm, Sweden, 4Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 5Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 6Antibody-discovery, UCB-Celltech, Slough, United Kingdom, 7Affinity Proteomics, SciLifeLab, School of Biotechnology, KTH - Royal Institute of Technology, Stockholm, Sweden, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) develop before RA diagnosis, at which point a wide range of citrullinated proteins have been shown…
  • Abstract Number: 1504 • 2018 ACR/ARHP Annual Meeting

    Utility of Serial ACPA Measurements in Rheumatoid Arthritis: Results of a Prospective Cohort Study

    Alistair Reid1,2,3, Michael D Wiese4, Robert Metcalf5, Mihir D Wechalekar6,7, Anita Lee8,9, Catherine Hill2,10,11, Cindy Hall8, Leah McWilliams5, Les Cleland8 and Susanna Proudman12, 1Rheumatology, Royal Adelaide Hospital, NORTH ADELAIDE, Australia, 2Medicine, The University of Adelaide, Adelaide, Australia, 3Medicine, University of Wollongong, Wollongong, Australia, 4School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia, 5Rheumatology Unit, Royal Adelaide Hospital, South Australia, Adelaide, Australia, 6Royal Adelaide Hospital, Adelaide, Australia, 7Rheumatology, Flinders University, Adelaide, Australia, 8Rheumatology, Royal Adelaide Hospital, Adelaide, Australia, 9Rheumatology, University of Adelaide, Adelaide, Australia, 10The Queen Elizabeth Hospital, Adelaide, Australia, 11Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, 12Royal Adelaide Hospital, Rheumatology Unit and University of Adelaide, Discipline of Medicine, Adelaide, Australia

    Background/Purpose: Anti-citrullinated peptide antibody (ACPA) and rheumatoid factor (RF) define “seropositive” rheumatoid arthritis (RA). Both predict disease course, development of extra-articular features and treatment outcomes.…
  • Abstract Number: 54 • 2018 ACR/ARHP Annual Meeting

    In a Macaque Model of RA By Immunization with Citrullinated Peptides, the Valine in the 11 Position of the DRB1 Molecule Has Greater Impacts on T-Cell Response to Citrullinated Peptides Than the 70-74 Position in the Shared Epitope

    Samuel Bitoun1, Pierre Roques2, Roger Le Grand3 and Xavier Mariette4, 1INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, Le Kremlin Bicêtre, France, 2Immunology of viral infections and autoimmune diseases, IDMIT Infrastructure CEA - Université Paris Sud - INSERM U1184, Fontenay-Aux-Roses,, France, 3Immunology of viral infections and autoimmune diseases, IDMIT Infrastructure CEA - Université Paris Sud - INSERM U1184, Fontenay-Aux-Roses, France, 4Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France

    Background/Purpose: Among genetic risk factors of RA, HLA class II molecules confers the highest risk of ACPA positive RA. The shared epitope (SE) hypothesis that…
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