Abstracts tagged "ACPA"

Abstract Number: 51 • 2019 ACR/ARP Annual Meeting
Cigarette Smoking Has Different Impacts on ACPA and RF Production Depending on Shared Epitope Allele Status in Japanese RA Patients; A Study with the Two Independent Japanese Cohorts (IORRA and KURAMA)
Yuki Ishikawa¹, Motomu Hashimoto ², Katsunori Ikari ³, Koichiro Ohmura ⁴, Masao Tanaka ⁴, Hiromu Ito ⁴, Atsuo Taniguchi ³, Hisashi Yamanaka ³, Tsuneyo Mimori ⁴ and Chikashi Terao ⁵, ¹Joslin Diabes Center, Boston, MA, ²Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan, ³Tokyo Women’s Medical University, Tokyo, Japan, ⁴Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁵RIKEN, Tokyo, Japan
Background/Purpose: In rheumatoid arthritis (RA), cigarette smoking affects both rheumatoid factor (RF) and anti-citrullinated cyclic peptide/protein antibody (ACPA) production, but its association in relation to…
Abstract Number: 452 • 2019 ACR/ARP Annual Meeting
Anti-citrullinated Vimentin Antibodies Are Associated to Early Deterioration of Cortical Bone and Volumetric Bone Mineral Density in Finger Joints in RA-at-risk Patients
Georg Schett¹, David Simon ², Axel Hueber ², Holger Bang ³, Jürgen Rech ⁴, Gerhard Kroenke ⁵ and Arnd Kleyer ⁶, ¹Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Bayern, Germany, ³Orgentec Diagnostika, 55129 Mainz, Germany, Mainz, ⁴Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany, ⁵Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Austria, ⁶Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany
Background/Purpose: Autoimmunity, characterized by the presence of anti-modified protein antibodies (AMPA), recognizing citrullinated, carbamylated or acetylated proteins, as well as rheumatoid factor (RF) precedes the…
Abstract Number: 500 • 2019 ACR/ARP Annual Meeting
The Dysregulation of NK Cells and Non-Conventional NK-T and γδ-T Cells in Individuals at Risk of Developing Rheumatoid Arthritis
Klára Prajzlerová¹, Olga Kryštůfková ², Petra Hánová ³, Hana Hulejová ³, Monika Gregová ¹, Nora Petrovská ¹, Herman Mann ⁴, Karel Pavelka ⁴, Jiří Vencovský ⁴, Ladislav Senolt ⁴ and Mária Filková ¹, ¹Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ²Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague, Czech Republic, ³Institute of Rheumatology, Prague, Czech Republic, ⁴Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague 2, Czech Republic
Background/Purpose: The positivity of antibodies against citrullinated proteins (ACPA) precedes the clinical manifestation and significantly increases the risk of rheumatoid arthritis (RA). EULAR characterised individuals…
Abstract Number: 1423 • 2019 ACR/ARP Annual Meeting
Patient-Reported Outcomes of Abatacept in Combination with MTX in Early, MTX-Naïve, ACPA Positive Patients with RA: 1-Year Results from a Phase IIIb Study
Paul Emery¹, Yoshiya Tanaka ², Vivian Bykerk ³, Clifton Bingham ⁴, Thomas Huizinga ⁵, Gustavo Citera ⁶, Joe Zhuo ⁷, Kuan-Hsiang Gary Huang ⁸, Robert Wong ⁷, Sean Connolly ⁸, Yedid Elbez ⁹ and Roy Fleischmann ¹⁰, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, ²University of Occupational and Environmental Health Japan, Kitakyushu, Japan, ³Hospital for Special Surgery, New York City, NY, ⁴Johns Hopkins University, Baltimore, MD, ⁵Leiden University Medical Center, Leiden, Netherlands, ⁶Instituto de Rehabilitación Psicofísica, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, ⁷Bristol-Myers Squibb, Princeton, ⁸Bristol-Myers Squibb, Princeton, NJ, ⁹Excelya, Boulogne-Billancourt, France, ¹⁰Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: Early biologic use can improve long-term control of RA, and early use of abatacept (ABA) + MTX has demonstrated sustained improvements in selected patient-reported…
Abstract Number: 2859 • 2019 ACR/ARP Annual Meeting
Citrulline Reactive B Cells Are Present in the Lungs of Early Untreated RA
Vijay Joshua¹, Malena Loberg-Haarhaus ¹, Heidi Wähämaa ², Aase Hensvold ², Khaled Amara ¹, Lena Israelsson ¹, Ragnhild Stålesen ¹, Magnus Sköld ³, Johan Grunewald ³, Caroline Grönwall ¹, Vivianne Malmström ¹ and Anca Catrina ⁴, ¹Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Institutet, Stockholm, Sweden., Stockholm, Sweden, ²Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, ³Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden., Stockholm, Sweden, ⁴Rheumatology unit Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose: Structural changes, increased tissue citrullination, signs of local inflammation and anti-citrullinated protein autoantibodies (ACPA) are present in the pulmonary compartment of early untreated seropositive…
Abstract Number: 211 • 2018 ACR/ARHP Annual Meeting
Excess in Prevalence of Functional Disability in Patients with Rheumatoid Arthritis: Does Serologic Status Matter?
Elena Myasoedova¹, John M. Davis III¹, Sara J. Achenbach², Eric L. Matteson¹ and Cynthia S. Crowson², ¹Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, ²Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN
Background/Purpose: Despite the advances in treatment of rheumatoid arthritis (RA) over the recent decades, many patients with RA do not achieve remission or full physical…
Abstract Number: 2046 • 2018 ACR/ARHP Annual Meeting
Serum Immunoglobulin G Targets Citrulline-Containing Immunoglobulin G Peptides in Rheumatoid Arthritis Patients Who Test Positive for Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibodies
Mandar Bawadekar¹, Zihao Zheng², Alan J. Bridges^3,4, Michael A. Newton⁵ and Miriam A. Shelef^1,4, ¹Department of Medicine, Division of Rheumatology, University of Wisconsin - Madison, Madison, WI, ²Departments of Statistics, University of Wisconsin - Madison, Madison, WI, ³Medicine, University of Wisconsin - Madison, Madison, WI, ⁴William S. Middleton Memorial Veterans Hospital, Madison, WI, ⁵Departments of Statistics and of Biostatistics and Medical Informatics, University of Wisconsin - Madison, Madison, WI
Background/Purpose: Rheumatoid arthritis patients produce a variety of anti-citrullinated protein antibodies (ACPAs) as well as antibodies that bind homocitrullinated and malondialdehyde-acetaldehyde adducted proteins leading to…
Abstract Number: 542 • 2018 ACR/ARHP Annual Meeting
Incidence and Prevalence of Interstitial Lung Disease in the US Population and in Patients with RA By Anti-Citrullinated Protein Antibody Status
Evo Alemao¹, Roshini Indrakumar², Aarti Rao² and Ying Bao¹, ¹Bristol-Myers Squibb, Princeton, NJ, ²Mu Sigma, Bangalore, India
Background/Purpose: Interstitial lung disease (ILD) is recognized as the most common pulmonary extra-articular manifestation of RA. The hazard ratio for 30-year risk of ILD in…
Abstract Number: 2054 • 2018 ACR/ARHP Annual Meeting
In Rheumatoid Arthritis, Changes in Autoantibody Levels Do Not Associate with Treatment Response, but Are a Reflection of Treatment Intensity
Emma de Moel¹, Veerle Derksen¹, LA Trouw¹, Holger Bang², Gerard Collée³, L.R. Lard⁴, Tom W.J. Huizinga⁵, Cornelia F. Allaart⁶, René E.M. Toes⁵ and Diane van der Woude⁵, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Orgentec Diagnostika GmbH, Mainz, Germany, ³Rheumatology, Haaglanden Medical Center Antoniushove, Leidschendam, Netherlands, ⁴Rheumatology, LUMC, Leiden, Netherlands, ⁵Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁶Department of Rheumatology, LUMC, Leiden, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies like rheumatoid factor (RF), anti-cyclic citrullinated peptide-2 (anti-CCP2), & anti-carbamylated protein (anti-CarP) antibodies. It…
Abstract Number: 544 • 2018 ACR/ARHP Annual Meeting
Does Anti-Citrullinated Protein Antibody Status Modify Treatment Effect of Certain Biologic DMARDs?
Evo Alemao¹, Yedid Elbez², Yogesh Saini³, Sean E. Connolly¹, Aarti Rao³, Christine K Iannaccone⁴, Michael E Weinblatt⁴ and Nancy A. Shadick⁴, ¹Bristol-Myers Squibb, Princeton, NJ, ²Excelya, Boulogne-Billancourt, France, ³Mu Sigma, Bangalore, India, ⁴Brigham and Women's Hospital, Boston, MA
Background/Purpose: Multiple therapeutic options with different mechanistic actions are available to treat patients (pts) with RA. However, selecting therapies by the characteristics of pts with…
Abstract Number: 2057 • 2018 ACR/ARHP Annual Meeting
Alterations of the Splicing Machinery in Leukocyte Subsets of Rheumatoid Arthritis Patients Modulate Their Inflammatory, Autoimmune and Atherothrombotic Profiles
Carlos Perez-Sanchez¹, Alejandro Ibáñez-Costa², Emilia Alors-Perez², Sergio Pedraza-Arévalo², Alejandra Maria Patiño-Trives², María Luque Tevar², Patricia Ruiz-Limon³, Nuria Barbarroja¹, Yolanda Jiménez-Gómez¹, Maria Carmen Abalos-Aguilera⁴, Pedro Segui⁵, Rafaela Ortega-Castro¹, Jerusalem Calvo-Gutierrez¹, Alejandro Escudero-Contreras⁴, Eduardo Collantes Estevez², Justo P Castaño⁶, Raul M Luque⁶ and Chary Lopez-Pedrera², ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Research Group of Endocrine Diseases, Research Laboratory. Biomedical Research Institute of Malaga (IBIMA).Virgen de la Victoria Universitary Hospital, Malaga, Spain., Málaga, MA, Spain, ⁴Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁵Radiology, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁶Department of Cell Biology, Physiology and Immunology. University of Cordoba, Reina Sofia Hospital, IMIBIC, CIBERobn, and ceiA3, Córdoba, Spain
Background/Purpose: 1) To identify and characterize the alterations present in the splicing machinery in leukocyte subsets of Rheumatoid Arthritis (RA) patients, and 2) To evaluate…
Abstract Number: 591 • 2018 ACR/ARHP Annual Meeting
Evaluation of MRI Ramris Score and Clinical Response in Patients with ACPA Positive Undifferentiated Arthritis Treated with Infliximab Versus Placebo
Thomas Kirchgesner¹, Bruno Vande Berg¹, Tatiana Sokolova², Laurent Meric de Bellefon², Adrien Nzeusseu Toukap³, Maria Stoenoiu⁴ and Patrick Durez², ¹Musculoskeletal Imaging Unit, Musculoskeletal Imaging Unit - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ²Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ³Department of Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ⁴Rheumatology department, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium
Background/Purpose: Patients (Pts) with Undifferentiated Arthritis (UA), positive for ACPA antibodies are at high risk of progressing to Rheumatoid Arthritis (RA). TNF play a key…
Abstract Number: 2210 • 2018 ACR/ARHP Annual Meeting
Effects of Anti-Citrullinated Peptide Antibody (ACPA) on Bone Microstructure in Rheumatoid Arthritis: A HR-pQCT Study
Ikuko Tanaka¹, Takashi Kato², Motokazu Kai³, Kunikazu Ogawa³, Hiroaki Mizuno¹, Mari Ushikubo⁴, Keisuke Izumi⁵, Hisaji Oshima⁶ and Shigenori Tamaki¹, ¹Nagoya Rheumatology Clinic, Nagoya, Japan, ²Department of Radiology, National Center for Geratrics and Gerontology, Obu, Japan, ³Mie Rheumatology Clinic, Suzuka, Japan, ⁴National Tokyo Medical Center, Tokyo, Japan, ⁵Department of connective Tissue Disease, National Tokyo Medical Center, Tokyo, Japan, ⁶Department of Connective Tissue Diseases, National Tokyo Medical Center, Tokyo, Japan
Background/Purpose: Rheumatoid arthritis (RA) induces systemic osteoporosis as well as osteoporotic change in the bones having arthritis by RA. Recently immune complex and anti-citrullinated peptide…
Abstract Number: 1203 • 2018 ACR/ARHP Annual Meeting
Tenosynovitis Detected By Ultrasound Predicts Arthritis Onset in Individuals at Risk of Developing Rheumatoid Arthritis
Yogan Kisten¹, Hamed Rezaei¹, Erik af Klint¹, Guozhong Fei^1,2, Aleksandra Antovic^1,2, Aase Hensvold^1,2 and Anca I. Catrina^1,2, ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Stockholm Health Services, Academic Specialist Center, Center for Rheumatology, Stockholm, Sweden
Background/Purpose: The urgent need for identifying imaging and serological markers that early predicts rheumatoid arthritis (RA) is clinically important. We aim to identify ultrasound findings…
Abstract Number: 2500 • 2018 ACR/ARHP Annual Meeting
Association between Anti-Citrullinated Protein Antibody Status, Erosive Disease and Healthcare Resource Utilization in Patients with RA
Leslie R Harrold¹, Lin Guo², Sean E. Connolly³, Evo Alemao³, Sabrina Rebello⁴, Ying Shan⁴ and Joel Kremer⁵, ¹University of Massachusetts Medical School, Worcester, MA, ²Corrona, LLC, Waltham, MA, ³Bristol-Myers Squibb, Princeton, NJ, ⁴Corrona, LLC, Southborough, MA, ⁵Albany Medical College and The Center for Rheumatology, Albany, NY
Background/Purpose: Anti-citrullinated protein antibody (ACPA) is a highly specific biomarker for RA1 and ACPA-seropositive patients have a tendency toward severe erosive disease and more rapid…

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