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Session » T Cell Biology & Targets in Autoimmune & Inflammatory Disease Poster

Date: Sunday, November 10, 2019

Time: 9:00AM-11:00AM

Meeting: 2019 ACR/ARP Annual Meeting

9:00AM-11:00AM
Abstract Number: 120
Administration of a CD45 Antibody Drug Conjugate as a Novel, Targeted Approach to Achieve Immune System Reset: A Single Dose of CD45-targeted ADC Safely Conditions for Autologous Transplant and Ameliorates Disease in Multiple Models of Autoimmune Disease
9:00AM-11:00AM
Abstract Number: 110
Bioinformatics Analysis of Transcriptomics Data Reveals That SRSF1 Is a Novel Molecular Brake for the T Cell Activation Program and Controls Key Cytokine Signaling Genes Implicated in Systemic Lupus Erythematosus
9:00AM-11:00AM
Abstract Number: 123
Blockade of Antigen-specific T Cell Activation by a Non-Depleting Anti-HLA-DR Monoclonal Antibody with a Unique Binding Epitope
9:00AM-11:00AM
Abstract Number: 101
CD126 Negative CD4+Foxp3+ Cell Represents a Superior Treg Subset in Treating Autoimmune Diseases
9:00AM-11:00AM
Abstract Number: 115
CD8+ Cytotoxic T Lymphocytes Are Clonally-expanded in IgG4-related Disease and Home to Affected Tissues
9:00AM-11:00AM
Abstract Number: 96
Characterizing the Brain T Cell Receptor Repertoire in Neuropsychiatric Lupus
9:00AM-11:00AM
Abstract Number: 116
Defective EZH2 Expression Attenuates Treg Differentiation in Rheumatoid Arthritis
9:00AM-11:00AM
Abstract Number: 89
Difference of Induced CD4+ and Natural Regulatory T Cells in Targeting Inflamed Synovial Tissues in Autoimmune Arthritis
9:00AM-11:00AM
Abstract Number: 125
Elevated Proliferative Capacity of CD8+ T Cells in Giant Cell Arteritis
9:00AM-11:00AM
Abstract Number: 107
Expanded Peripheral T Helper Cells Characterize the Early Rheumatoid Arthritis Synovium
9:00AM-11:00AM
Abstract Number: 91
Histonedeacetylase 1 (HDAC1): A Key Mediator of T Cells for the Pathogenesis of Rheumatoid Arthritis
9:00AM-11:00AM
Abstract Number: 95
IL-21-mediated Suppression of STAT5 Phosphorylation Underlies Treg Depletion and Dysfunction in SLE
9:00AM-11:00AM
Abstract Number: 112
Impact of Interleukin-9 on the Immune Suppressive Functions of Regulatory T Cells in Rheumatoid Arthritis
9:00AM-11:00AM
Abstract Number: 113
In Vitro Characterization of the Effect of Cenerimod, a Potent and Selective Sphingosine 1-Phosphate Receptor 1 (S1P1) Modulator, on S1P1 Receptor Expression, Receptor Internalization, and Migration of Primary Human T Cells in the Presence or Absence of Glucocorticoids
9:00AM-11:00AM
Abstract Number: 121
In Vitro Human Enthesitis Model with Induced IL-17A and TNFα from CD4+ and CD8+ T Cells and Effect of Pharmacological Antagonism with Janus Kinase and Retinoic Acid Receptor-related Orphan Receptor γ Inhibition
9:00AM-11:00AM
Abstract Number: 106
Increased T Cell Polyreactivity with Marked Accumulation of TNF-α DP (CD4+CD8+) in the Synovial Tissue of pre-RA, Arthralgia Subjects
9:00AM-11:00AM
Abstract Number: 122
Inhibition of Necroptosis Suppresses Muscle Cell Death and Inflammatory Infiltrate, and Improves Muscle Strength in Experimental Polymyositis
9:00AM-11:00AM
Abstract Number: 93
Interferon Pathway Activation in T Follicular Helper (Tfh) Cell Subsets in Human Myositis
9:00AM-11:00AM
Abstract Number: 87
KINE-101, a Novel Synthetic Peptide with Potent Regulatory T Cells Activation to Treat Rheumatoid Arthritis
9:00AM-11:00AM
Abstract Number: 97
Low Frequency of Circulating T Follicular Helper 1 Cells Is Associated to Adequate Response to Adalimumab Therapy in Rheumatoid Arthritis
9:00AM-11:00AM
Abstract Number: 99
Mass Cytometry Immunophenotyping of Synovial Fluid from Checkpoint Inhibitor Related Arthritis
9:00AM-11:00AM
Abstract Number: 119
Mitochondrial Transplantation Suppressed Muscle Inflammation and Improved the Mitochondrial Dysfunction in C Protein-induced Myositis Model
9:00AM-11:00AM
Abstract Number: 108
Mucosal Associated Invariant T Cells in Giant Cell Arteritis
9:00AM-11:00AM
Abstract Number: 92
Negative Immune Checkpoint Molecules on T Regulator Cells Distinguish RA, SLE and Healthy Controls
9:00AM-11:00AM
Abstract Number: 104
Novel, Selective, Orally Active PAD4 Inhibitors for the Treatment of Autoimmune Disorders
9:00AM-11:00AM
Abstract Number: 114
Persistent Synovial Resident Memory T Cells Mediate Arthritis Flares
9:00AM-11:00AM
Abstract Number: 118
Polymorphonuclear Neutrophils and Regulatory T Lymphocytes (Treg) Cooperate to Sustain Treg Activity but This Interaction Is Altered in Rheumatoid Arthritis Patients
9:00AM-11:00AM
Abstract Number: 98
Selective Induction of Functional Regulatory T-Cells in Healthy Volunteers by NKTR-358, a Novel IL-2 Conjugate Treg Stimulator, in Development for the Treatment of Autoimmune Diseases
9:00AM-11:00AM
Abstract Number: 103
Serine Arginine-rich Splicing Factor 1 (SRSF1) Is Indispensable for Homeostasis and Function of Regulatory T Cells
9:00AM-11:00AM
Abstract Number: 102
Serine Arginine-Rich Splicing Factor 1 (SRSF1) Restrains IFN-γ and IL-17 Inflammatory Cytokine Production and Its Selective Deficiency in T Cells Exacerbates Experimental Autoimmune Encephalomyelitis (EAE) and Nephrotoxic Nephritis (NTN)
9:00AM-11:00AM
Abstract Number: 90
SLAMF6 Clustering Is Required to Augment Autoimmune T Cell Activation
9:00AM-11:00AM
Abstract Number: 109
Targeting CD6 Expression Attenuates T Cell Activity in Murine Collagen Induced Arthritis
9:00AM-11:00AM
Abstract Number: 100
Targeting ITK Signaling Ameliorates Collagen-Induced Arthritis via Shifting the Balance Between Th17 and Regulatory Th17 Cells
9:00AM-11:00AM
Abstract Number: 105
The DLEU2/miR-15a/16-1 Cluster Inhibit Foxp3+ Treg Cells in Salivary Glands of pSS via Targeting Foxp3
9:00AM-11:00AM
Abstract Number: 117
The Indole Derivative NecroX Blocks Th17 Cell Differentiation and Fibroblast-like Synoviocytes-mediated Th1/Th17 Responses in Rheumatoid Arthritis
9:00AM-11:00AM
Abstract Number: 111
The Transcription Factor STAT3 Regulates Pathogenic Th17 Responses in Autoimmune Disease via Noncanonical Roles
9:00AM-11:00AM
Abstract Number: 86
THOR-809: An IL-2 Engineered from an Expanded Genetic Alphabet for the Potential Treatment of Autoimmune Disorders
9:00AM-11:00AM
Abstract Number: 124
Treatment with Abatacept but Not with TNF Blockers, Is Associated with a Reduction of Constitutively Elevated Circulating Follicular Helper T Cells in Rheumatoid Arthritis
9:00AM-11:00AM
Abstract Number: 94
Tumor Necrosis Factor Receptor 2 Signaling Potentiates Proliferation and Suppressive Activities of Follicular Regulatory T Cells
9:00AM-11:00AM
Abstract Number: 88
Type I Interferon Signature Activation in Antiphospholipid Syndrome: Gene Expression Heterogeneity Among Disease Subsets

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