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Session » Systemic Sclerosis & Related Disorders – Basic Science Poster

Date: Monday, November 11, 2019

Time: 9:00AM-11:00AM

Meeting: 2019 ACR/ARP Annual Meeting

9:00AM-11:00AM
Abstract Number: 1071
A Common Transcriptional Signature Is Present in Circulating Classical Monocytes and Skin Macrophages in Systemic Sclerosis
9:00AM-11:00AM
Abstract Number: 1065
Aberrant Expression Levels of Soluble Co-inhibitory Receptors Linked to Disease Activity in Systemic Sclerosis
9:00AM-11:00AM
Abstract Number: 1054
Analysis of Serum Markers Across the Scleroderma Spectrum Shows Subset and Stage Specific Profiles of Fibrogenesis
9:00AM-11:00AM
Abstract Number: 1059
BDCA2 Targeting of Human Plasmacytoid Dendritic Cells via CBS004 Reverts Dependent IFN Activation and Tissue Fibrosis in vitro and in vivo
9:00AM-11:00AM
Abstract Number: 1072
CCR2+ Circulating Monocytes Contribute to the Survival of ADSC in Bleomycin-Induced Skin Fibrosis
9:00AM-11:00AM
Abstract Number: 1064
CD123+ Plasmacytoid Dendritic Cells from Systemic Sclerosis Patients Are Susceptible to the Cytotoxic Activity of Tagraxofusp, a CD123-Targeted Therapy
9:00AM-11:00AM
Abstract Number: 1069
CD4+ T Helper Cell Populations with High PD-1 Expression Are Expanded in Systemic Sclerosis
9:00AM-11:00AM
Abstract Number: 1068
Classical Monocytes from African Ancestry Patients with Systemic Sclerosis Show Transcription and Energy Regulation Gene Expression Signatures
9:00AM-11:00AM
Abstract Number: 1048
Clonally Expanded CD4+ Cytotoxic T Cells, Endothelial Cell Apoptosis and the Pathogenesis of Early Systemic Sclerosis
9:00AM-11:00AM
Abstract Number: 1041
Computational Methods for Drug Repositioning of Systemic Sclerosis Using Gene Fold-Change and Network Analyses
9:00AM-11:00AM
Abstract Number: 1047
CXCL4-L1 Levels Are Elevated in Systemic Sclerosis Patients and Correlate with Pulmonary Arterial Hypertension and Capillaroscopic Indices of Vascular Damage
9:00AM-11:00AM
Abstract Number: 1070
Cytokine Signatures Differentiate Systemic Sclerosis Patients at High versus Low Risk for Pulmonary Arterial Hypertension
9:00AM-11:00AM
Abstract Number: 1057
Dissecting the Cellular Mechanism of Prostacyclin Analog Iloprost in Reversing Vascular Dysfunction in Scleroderma
9:00AM-11:00AM
Abstract Number: 1066
Dysregulated IL-6 Dependent Dermal Adenosine Signaling via Adenosine A2A Receptor May Drive Fibrosis in Systemic Sclerosis
9:00AM-11:00AM
Abstract Number: 1063
Effects of Abatacept on T Regulatory Cells in Early Diffuse Systemic Sclerosis
9:00AM-11:00AM
Abstract Number: 1074
Epigenetic Regulation-Mediated Reduction in the Expression of Prostacyclin Receptor and Prostacyclin Synthase in Scleroderma Skin, Vascular Smooth Muscle Cells, and Microvascular Endothelial Cells
9:00AM-11:00AM
Abstract Number: 1050
Genome-Wide DNA Methylation Signatures in Classical Monocytes from African Ancestry Patients with Systemic Sclerosis
9:00AM-11:00AM
Abstract Number: 1051
Identification of Differential Chromatin Accessibility Using ATAC-seq in a Novel 3D Tissue Culture System of Systemic Sclerosis
9:00AM-11:00AM
Abstract Number: 1073
Identification of Distinct Pro-Fibrotic Monocyte and Macrophage Subsets in Systemic Sclerosis
9:00AM-11:00AM
Abstract Number: 1067
Identification of miRNAs in Systemic Sclerosis Based on Activity and Network Analysis­­­
9:00AM-11:00AM
Abstract Number: 1049
Induction of a Profibrotic Phenotype in Normal Dermal Fibroblasts by Expression of PIM1 Kinase and Demonstration of Antifibrotic Effects of Inhibition of PIM Kinases in Systemic Sclerosis Dermal Fibroblasts
9:00AM-11:00AM
Abstract Number: 1058
Inhibition of Histone Readers Bromodomain and Extraterminal Domain Proteins Alleviates Scleroderma Fibrosis
9:00AM-11:00AM
Abstract Number: 1062
Lymphocyte Subset Abnormalities in Early Diffuse Cutaneous Systemic Sclerosis
9:00AM-11:00AM
Abstract Number: 1045
Myocardial Involvement in SSc: Key Role of Lin-gp38+ Stromal Cells in the Onset of Fibrosis and Defects of the Conduction System
9:00AM-11:00AM
Abstract Number: 1053
Parallel Analysis of Systemic Sclerosis and Keloidal Morphea Skin Biopsies Delineates the Hallmark Profibrotic Gene Expression Profile for Scleroderma in Vivo
9:00AM-11:00AM
Abstract Number: 1061
PI3K-Akt Pathway Plays a Crucial Role in Production of Collagen in Fli1 Deficient Condition and Its Inhibitor Has the Therapeutic Potential in Treating Fibrosis
9:00AM-11:00AM
Abstract Number: 1056
Profibrotic Macrophage Activation in Systemic Sclerosis Is Dependent on the Mechanosensing MRTF-A Pathway
9:00AM-11:00AM
Abstract Number: 1040
Proposition of a Novel Animal Model of Systemic Sclerosis Induced by Type V Collagen in C57BL/6 Mice Reproducing Fibrosis, Vasculopathy and Autoimmunity
9:00AM-11:00AM
Abstract Number: 1055
Proteomic and Transcriptomic Analysis of Human Eosinophilic Fasciitis Fibroblasts
9:00AM-11:00AM
Abstract Number: 1044
TGF-β Isoforms Modulate the RNA Cargo of Extracellular Vesicles (Exosomes) Isolated from Cultured Normal Human Lung Microvascular Endothelial Cells: A Mechanistic Link Between Endothelial Cell Dysfunction and the Establishment of a Profibrotic Phenotype in SSc?
9:00AM-11:00AM
Abstract Number: 1060
The Diversity and Community Metrics of the Esophageal Microbiome of SSc Patients
9:00AM-11:00AM
Abstract Number: 1046
The Effect of Nintedanib versus Mycopheolate Mofetil in the FRA2 Mouse Model of Systemic Sclerosis Associated Interstitial Lung Disease
9:00AM-11:00AM
Abstract Number: 1043
The Metabolic Intermediate Alpha-Ketoglutarate Suppresses the TGFβ-driven Profibrotic Responses of Dermal Fibroblasts
9:00AM-11:00AM
Abstract Number: 1052
The PPAR Agonist Lanifibranor Protects Against Right Ventricular Hypertrophy in a Mouse Model of Systemic Sclerosis Associated Pulmonary Hypertension
9:00AM-11:00AM
Abstract Number: 1042
Thy-1 (CD90) as a Novel Marker for Tracking in Vivo Skin Fibrosis

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