Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Oncohematological diseases have an increased incidence in Rheumatoid Arthritis (RA) patients. In the last years numerous studies have appeared exploring the relationship between these diseases, RA and its treatments. The introduction of biological therapies and new therapeutic strategies have emerged in the last decades implying an important change in the management and evolution of RA. However, the trend of oncohematological diseases in RA in Spain is unknown. Our objective was to analyze the incidence and trend of hospital admissions for lymphomas and leukemias in patients with RA in Spain during the period between 1999 and 2015.
We performed an observational retrospective population study analyzing the spanish national administrative database that includes a Minimun Basic Data Set (MBDS) of hospital admissions of patients with RA during the period 1999 to 2015. We selected the MBDSs for lymphomas and leukemias. Cases were identified by the presence in primary and secondary diagnosis of ICD 9 codes. The population at risk was estimated through the population census of the National Institute of Statistics, with an estimated prevalence of RA of 0,5% (0,8% in women and 0,2% in men). Crude and adjusted rates of the selected CVDs were calculated, and the trend was analyzed using the Generalized Linear Model (GLM) with the year as the analysis variable. Statistical analysis was made using SPSS statistical package version 20 (SPSS Inc, Chicago, IL).
338.343 RA hospital admissions were detected in the period, being 3561 (1,1%) due to lymphomas (2190 women and 1371 men, corresponding respectively to 61,5% and 38,5%) and 1664 (0,5%) leukemias (871 women and 793 men, corresponding respectively to 52,3% and 47,7%). Mean age was 68,94 (SD 11,38) in lymphomas and 71,46 (SD 11,24) in leukemias. There were 372 (10,4%) deaths during admission in lymphomas and 257 (15,4%) in leukemias.
Age-adjusted rate during the period for lymphoma was 152,19/105 inhabitants per year (92,05 in women and 240,14 in men). Lymphoma age-adjusted rate increased from 52,46/105 inhabitants per year in 1999 to 187,57 in 2015, both women (from 42,74 in 1999 to 142,95 in 2015) and men (from 280,77 in 1999 to 326,63 in 2015). An annual increase in the lymphoma rate of 6,9% is estimated (RRI 1,069; CI 95% 1,054-1,085).
Age-adjusted rate during the period for leukemia was 90,87/105 inhabitants per year (37,09 in women and 144,65 in men). Leukemia age-adjusted rate increased from 18,86/105 inhabitants per year in 1999 to 94,05 in 2015, both women (from 13,80 in 1999 to 65,93 in 2015) and men (from 38,70 in 1999 to 204,84 in 2015). An annual increase in the leukemia rate of 8,2% is estimated (RRI 1,083; CI 95% 1,069-1,097).
In Spain, in the period between 1999 to 2015, lymphoma and leukemia hospital admissions in patients with RA increased, with an estimation of 6,9% and 8,2% annual increase respectively.
To cite this abstract in AMA style:Morell-Hita JL, Mazzucchelli R, Perez-Fernandez E, Quirós J, Macia-Villa C, Crespí N, Peña M, Barbadillo C, Espinosa M, Godoy H, Fernández M, Galindo M, Garcia-Vadillo A, Guzon-Illescas O, Herranz A, Martinez-Prada C, Morado-Quiñoa C, Villaverde García V. Trends in the Incidence of Lymphomas and Leukemias in Patients with Rheumatoid Arthritis in Spain: An Observational Cohort Study of Hospital Discharges from 1999 to 2015 [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/trends-in-the-incidence-of-lymphomas-and-leukemias-in-patients-with-rheumatoid-arthritis-in-spain-an-observational-cohort-study-of-hospital-discharges-from-1999-to-2015/. Accessed January 18, 2020.
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