Session Title: Systemic Lupus Erythematosus – Animal Models - Poster II
Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Methods: Immunoprofiling of B cell function was measured by proliferation, plasmablast differentiation, IgG and IL-6 production, and surface expression of activation markers (CD86, CD40, CD54, and CD69). T cell function was measured by proliferation, and cytokine production. CD8 T cell and NK function was measured by degranulation assays. Monocyte/macrophage and basophil activity was measured by Fcγ Receptor-mediated TNFα production and FcεR-mediated degranulation, respectively. Osteoclast and dendritic cell effects were each assessed by differentiation endpoints from precursor cells. Pathology in the MRL/lpr SLE model was assessed by body, spleen, and lymph node weight gain, dsDNA and ANA autoantibody titers, skin lesions, and kidney function (proteinurea) and lesions (histological assessment).
To cite this abstract in AMA style:Ringheim G, Kosek J, Capone L, Adams M, Hur EM, Schafer PH. Translatable in Vitro Immunocyte Functional Measures of CC-292 and CC-90008 Inhibitors of the Bruton’s Tyrosine Kinase (Btk)/Tec Family and the Pathology Observed in the MLR/Lpr Mouse Model of Systemic Lupus Erythematosus (SLE) [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/translatable-in-vitro-immunocyte-functional-measures-of-cc-292-and-cc-90008-inhibitors-of-the-brutons-tyrosine-kinase-btktec-family-and-the-pathology-observed-in-the-mlrlpr-mouse-model-of-system/. Accessed December 1, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/translatable-in-vitro-immunocyte-functional-measures-of-cc-292-and-cc-90008-inhibitors-of-the-brutons-tyrosine-kinase-btktec-family-and-the-pathology-observed-in-the-mlrlpr-mouse-model-of-system/