Date: Sunday, November 5, 2017
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: To understand the RA patient pathway in Latin America from first symptom onset; including time to diagnosis and to first advanced treatment.
Methods: Data from the 2015 RA Disease Specific Programme (DSP), a cross-sectional, multi-national survey of patients and rheumatologists conducted in Brazil, Argentina, Mexico, Colombia, Venezuela were analyzed against 2014 DSP data from the US and 5EU. Rheumatologists (n=188 Latin America, n=113 US, n=340 EU) completed forms containing patient demographics, age at first RA symptoms, age at RA diagnosis, age at csDMARD initiation and age at bDMARD initiation. Continuous data were tested using t tests.
Results: A total of 801 Latin America, 843 US and 2536 EU RA patients were included in this analysis. Current mean age across Latin America was 51.9 years and 82.8% female. Mean age of patients at RA symptom onset was 40.6 years, with age at diagnosis 42.6 years; resulting in a 2.2 year (3.9 SD) wait from first experiencing symptoms to receiving a confirmed diagnosis. Patients in Latin America waited 2.6 years (5.7 SD) from the point of RA diagnosis to initiation of first csDMARD vs. 1.0 years US (3.2 SD) and 1.1 years EU (3.0 SD) (both p<0.001), and 6.4 years (7.4 SD) from RA diagnosis to initiation of first bDMARD therapy vs. 3.9 years US (5.6 SD) and 5.2 years EU (5.7 SD) (both p<0.001).
Conclusion: RA patients in Latin America wait over 2 years from symptom onset to diagnosis and significantly longer than their US and EU counterparts to receive csDMARD and Biologic therapy. This highlights a clear need to shorten RA diagnosis times and time to treatment initiation.
To cite this abstract in AMA style:Pereira I, Azevedo VF, Bautista-Molano W, Casasola J, Guerra G, Vega-Morales D, Soriano ER, Rocio Gil D, Maldonado-Cocco JA, Aldunate L, Lobosco S. Time from First Symptom Onset to First Advanced Therapy Amongst RA Patients in Latin America [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/time-from-first-symptom-onset-to-first-advanced-therapy-amongst-ra-patients-in-latin-america/. Accessed September 24, 2021.
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