ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 573

Three-Year Course and Prediction of Physical Functioning in Ankylosing Spondylitis Patients Treated with TNF-Inhibitors

Salima F.E. van Weely1, Eva L. Kneepkens1, Mike T. Nurmohamed1, Joost Dekker1,2 and Irene E. van der Horst-Bruinsma3, 1Reade, centre for Rehabilitation and Rheumatology, Amsterdam, Netherlands, 2Rehabilitation Medicine, Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands, 3Rheumatology, VU University Medical Centre, Amsterdam, Netherlands

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: Ankylosing spondylitis (AS), anti-TNF therapy, outcomes, physical function and physical impairment

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Session Title: Spondyloarthropathies and Psoriatic Arthritis - Clinical Aspects and Treatment I

Session Type: Abstract Submissions (ACR)

Background/Purpose: Currently, only limited information is available on the long-term course of limitations in physical functioning and spinal mobility in Ankylosing Spondylitis (AS) patients receiving TNF inhibiting (TNFi) therapy in daily clinical care. Therefore this study aimed (i) to examine the 3-years course of physical functioning and spinal mobility impairments in patients routinely treated with TNFi; (ii) to predict the 3-years level and (iii) to predict the 3-years course of physical functioning and spinal mobility.

Methods: AS patients eligible for TNFi were followed in a prospective observational cohort for 3 years. Prediction models were developed with linear mixed modelling using 18 baseline variables. The Bath AS Functional Index (BASFI) and Bath AS Metrology Index (BASMI) were used as outcome measures for physical functioning and spinal mobility, respectively.

Results: At baseline 257 patients were included and treated with etanercept (n=174) or adalimumab (n=83). Physical functioning improved significantly during the first 24 weeks after the start of TNFi. The BASFI score decreased from 5.4±2.4 to 3.3±2.6 in week 24, and stabilised thereafter (BASFI 3-years 3.6±2.5; see figure-1). The BASMI showed a stable course over time. Lower baseline BASFI and BASMI-scores predicted a better physical functioning and spinal mobility after 3-years of TNFi therapy. Other predictors for a higher 3-years level and better 3-years course of physical functioning included absence of comorbidity, physical activity, younger age and lower body mass index (BMI) at baseline. However, large between-patient variations were observed.

Conclusion: Improvement of physical functioning in TNFi treated AS patients continues up to 24-weeks and stabilises thereafter. Therefore, the efficacy of treatment should be determined at 6 months. Predictors for the level and course of physical functioning and spinal mobility after 3-years of TNFi treatment include baseline BASFI, BASMI, absence of comorbidity, physical activity and BMI.

 


Disclosure:

S. F. E. van Weely,
None;

E. L. Kneepkens,
None;

M. T. Nurmohamed,
None;

J. Dekker,
None;

I. E. van der Horst-Bruinsma,
None.

  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2014 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/three-year-course-and-prediction-of-physical-functioning-in-ankylosing-spondylitis-patients-treated-with-tnf-inhibitors/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.