ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2610

The Role of IL-20 in the Pathogenesis of Ankylosing Spondylitis with Peripheral Joint Involvement

Göksal Keskin1, Baris Mavi2, Lale Ozisik3, Rahsan Ilikci4 and Mehmet Yildiz2, 1Immunology, Medical School of Ankara, Ankara, Turkey, 2Internal Medicine, Diskapi Training and Research Hospital, Ankara, Turkey, 3Internal Medicine, MD, Ankara, Turkey, 4Basic Immunology, BC, Ankara, Turkey

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords:

Session Information

Title: Spondyloarthropathies and Psoriatic Arthritis - Clinical Aspects and Treatment III

Session Type: Abstract Submissions (ACR)

Background/Purpose

The interleukin-20 (IL-20) is a pro-inflammatory cytokine of the IL-10 family and sequence amino acid is very similar. It has been reported to be involved in the pathogenesis of several autoimmune diseases, but pathophysiological importance is poorly understood.    TNF alpha plays an important role in AS patients with axial and peripheral joint involvement.  It has been reported that TNF alpha induce IL-20 in macrophage and synovial cells.   For this reason, we investigated serum IL-20 levels in AS patients with axial and peripheral joint involvement who had not received anti- TNF treatment. 

Methods

63 patients with AS (11 female, 52 male) and 17 healthy controls (2 female, 15 male; mean age 26.5 ± 6.9 years) were  enrolled in this study.  Thirty-eight of the AS patients were axial involvement (mean age; 25,9 ± 7.2 years, median disease duration 7 years) and the other 24 patients were peripheral joint involvement (mean age; 27.3 ± 6.9 years, median disease duration; 9 years).  Serum IL-20 levels were determined by ELISA.

Results

The median serum IL-20 levels were 55,2 pg/ml in healthy controls, 308.5 pg/ml in the patients with peripheral joint involvement and 109.3 pg/ml in the patients with axial involvement. Serum IL-20 levels in patients with AS were significantly higher than in healthy controls (p<0.001).  Serum IL-20 levels were significantly high in the patients with peripheral joint involvement compared with in the patients with axial involvement (p<0.001).  in the patients with peripheral joint involvement, there are statistically significant correlation between serum IL-20 and serum CRP and ESR (r=0.645, p <0.001, and r=0.588, p<0.001 respectively). In the patients with axial involvement, it was not correlated with CRP and ESR (r=0.262, p=0.298 and r=0.292, p=0.355  respectively).   

Conclusion

Serum IL-20 levels are high in the AS patients with peripheral joint involvement and, correlated with CRP and ESR. So, it may be involved in  pathogenesis of the disease.

Disclosure:

G. Keskin,
None;

B. Mavi,
None;

L. Ozisik,
None;

R. Ilikci,
None;

M. Yildiz,
None.

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