Session Type: Abstract Submissions (ACR)
Inflammatory components of osteoarthritis including bone marrow lesions (BML) may be a target for therapy. Limited literature quantifies the relation of these markers on MRI with respect to pain and dysfunction in hip osteoarthritis. We sought to correlate the extent of BML using a validated scoring methodology, the Knee Inflammation MRI Scoring System (KIMRISS), with a validated pain score, WOMAC, in patients with hip osteoarthritis. In KIMRISS a score of 0 (no BML) or 1 (BML present) is assigned to each region of bone in each slice using a customized grid overlay with regions each approximately 1 cm x 1 cm in size; a higher KIMRISS BML sum score directly represents a larger volume of BML.
Data for these analyses are from the OAI public use data set(s). MRI scans at enrolment and 1 year follow-up were evaluated in 80 patients for BML score by two readers using KIMRISS methodology. The WOMAC pain score was available for each patient at the same time points. We assessed association of BML status and change scores with WOMAC pain status and change scores using correlation (Pearson chi square) and by multivariate regression adjusted for age, sex, Kellgren-Lawrence grade, and baseline scores for WOMAC pain.
The volume of BML correlated highly with both WOMAC pain score (chi-square 0.86 p <0.0001) and change in WOMAC pain score between enrolment and 1 year (chi-square 0.84 p<0.0001)
KIMRISS BML score correlates highly with pain in patients with hip osteoarthritis, and was highly responsive to change. KIMRISS offers an alternative approach for scoring bone marrow lesions in knee osteoarthritis that is designed to be easily learned and can potentially be automated in future.
W. P. Maksymowych,
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-kimriss-bone-marrow-lesion-score-in-patients-with-osteoarthritis-of-the-knee-correlates-with-womac-pain-status-using-target-lesion-based-scoring-methodology-data-from-the-osteoarthritis-initiativ/