ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 135

The 8-Joint Ultrasound Score Is a Useful Marker for Monitoring Therapeutic Response in Rheumatoid Arthritis

Ryusuke Yoshimi1, Yukihiro Toyota1, Naomi Tsuchida1, Yumiko Sugiyama1, Yosuke Kunishita1, Daiga Kishimoto1, Reikou Kamiyama1, Kaoru Minegishi2, Maasa Tamura1, Yukiko Asami1, Yohei Kirino1, Shigeru Ohno2 and Hideaki Nakajima1, 1Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan, 2Center for Rheumatic Disease, Yokohama City University Medical Center, Yokohama, Japan

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: certolizumab pegol, Imaging, Rheumatoid arthritis (RA), ultrasonography and ultrasound

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Date: Sunday, November 13, 2016

Session Title: Imaging of Rheumatic Diseases - Poster I: Ultrasound and Emerging Technologies

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Musculoskeletal ultrasonography (US) is one of the standard tools for the diagnosis and monitoring of rheumatoid arthritis (RA). Although we and other groups have proposed several sets of US assessment procedures in arbitrary combinations of selected joints, there is still no consensus in defining the joints to evaluate. Here, we investigated whether US assessment in the selected 8 joints which we have advocated as a routine assessment for detecting RA synovitis is also useful for monitoring response to treatment for RA.

Methods: Power Doppler (PD) US was performed in 24 joints, including all PIP, MCP, bilateral wrist and knee joints, as comprehensive evaluation in 15 RA patients treated with certolizumab pegol (CZP). Before and after treatment with CZP, PD signals and gray-scale (GS) images were scored semiquantitatively from 0 to 3 in each joint. Total PD score-24 and total PD score-8 were calculated by summing up PD scores of the 24 joints and the selected 8 joints (bilateral second and third MCP, wrist, and knee joints), respectively. Total GS score-24 and total GS score-8 were also calculated by summing up GS scores of the 24 joints and the selected 8 joints, respectively.

Results: Change amount of total PD score-8 by treatment with CZP exhibited strong correlations with the changes of disease activity indices, SDAI (rs = 0.92, p < 0.01) and DAS28-CRP (rs = 0.89, p < 0.01). Change amount of total PD score-24 also correlated strongly with the changes of SDAI (rs = 0.91, p < 0.01) and DAS28-CRP (rs = 0.86, p < 0.01), and the correlation coefficients were comparable with those for total PD score-8. Although the change of total PD score-8 correlated well with the changes of some components of disease activity indices, including swollen joint count (rs = 0.81, p < 0.01), tender joint count (rs = 0.91, p < 0.01), CRP (rs = 0.82, p < 0.01) and ESR (rs = 0.63, p < 0.01), there were no significant correlations between the changes of total PD score-8 and the changes of patient’s global assessment (rs = 0.39, p > 0.05) and evaluator’s global assessment (rs = 0.22, p > 0.05). The change of total PD score-24 correlated more weakly with the changes of swollen joint count (rs = 0.74, p < 0.01) and tender joint count (rs = 0.86, p < 0.01) as compared to total PD score-8. The correlation coefficients between the change of total PD score-24 and the changes of CRP (rs = 0.85, p < 0.01) and ESR (rs = 0.62, p < 0.01) were comparable with those for total PD score-8. There were no significant correlations between the changes of total PD score-24 and the changes of patient’s global assessment (rs = 0.42, p > 0.05) and evaluator’s global assessment (rs = 0.27, p > 0.05). The changes of total GS score-8 and total GS score-24 correlated to the changes of SDAI with the same level of correlation coefficients (rs = 0.69, p < 0.01, and rs = 0.70, p < 0.01).

Conclusion: This study indicates that the change of the 8-joint US scores by treatment correlated with the changes of disease activity indices as strongly as the change of the comprehensive 24-joint scores. Thus the 8-joint assessment can be a useful method for monitoring response to treatment in RA patients.


Disclosure: R. Yoshimi, None; Y. Toyota, None; N. Tsuchida, None; Y. Sugiyama, None; Y. Kunishita, None; D. Kishimoto, None; R. Kamiyama, None; K. Minegishi, None; M. Tamura, None; Y. Asami, None; Y. Kirino, None; S. Ohno, None; H. Nakajima, None.

To cite this abstract in AMA style:

Yoshimi R, Toyota Y, Tsuchida N, Sugiyama Y, Kunishita Y, Kishimoto D, Kamiyama R, Minegishi K, Tamura M, Asami Y, Kirino Y, Ohno S, Nakajima H. The 8-Joint Ultrasound Score Is a Useful Marker for Monitoring Therapeutic Response in Rheumatoid Arthritis [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/the-8-joint-ultrasound-score-is-a-useful-marker-for-monitoring-therapeutic-response-in-rheumatoid-arthritis/. Accessed January 15, 2021.
  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2016 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-8-joint-ultrasound-score-is-a-useful-marker-for-monitoring-therapeutic-response-in-rheumatoid-arthritis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.