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Abstract Number: 2945

Systematic Review: “Efficacy and Safety of Biological Versus Immunosuppressive Therapy Compared to Placebo in the Treatment of Uveitis Associated with BehçEt’s Disease.”

Ana Urruticoechea-Arana1, Tatiana Cobo-Ibáñez2, Virginia Villaverde García3, Montserrat Santos-Gómez4, Kelly Vargas Osorio5, Federico Díaz-González6, Leslie Fariñas Padrón5, Vanesa Calvo-Río7 and Ricardo Blanco Alonso7, 1Hospital Can Misses, Ibiza, Spain, 2Hospital Universitario Reina Sofía, Universidad Europea de Madrid, Madrid, Spain, 3Rheumatology, Hospital Universitario de Móstoles, Móstoles, Spain, 4Rheumatology, Hospital Can Misses, Ibiza, Spain, 5Family and Community Medicine, Hospital Can Misses, Ibiza, Spain, 6Rheumatology, Hospital Universitario de Canarias, S/C Tenerife, Spain, 7Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Behcet's syndrome, Biologic agents, meta-analysis, treatment and uveitis

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Session Information

Date: Tuesday, November 15, 2016

Title: Vasculitis - Poster III: Rarer Vasculitides

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Systemic treatments used in ocular involvement in Behçet’s disease are corticosteroids, synthetic and biological immunosuppressants. Because of irreversible ophthalmic complications,it is a priority to know the efficacy of these drugs. Our purpose was to analyze the efficacy and safety of biological therapy vs. cyclosporine A(CyA),azathioprine(AZA)or placebo in reducing the rate of uveitis and improving the visual prognosis of Behçet’s.

Methods: A systematic search of literature on MEDLINE,EMBASE,and Cochrane Central Register of Controlled Trials was conducted from inception to July 2015.A hand search was performed by reviewing the references of the included studies and the international congress.Criteria for study selection: 1)adults with Behçet’s disease and uveitis, 2)Biological therapies, 3)placebo or active comparator with CyA or AZA, 4)outcome measures to evaluate effectiveness as a number (no.)of recurrence of uveitis,visual prognosis,cystic macular edema, retinal vasculitis,vitritis,hypopyon,etc; and/or adverse events.Meta-analyses,systematic reviews,clinical trials and observational studies of >10 patients with comparator were included.The selection,review and evaluation of quality of the articles was independently conducted by two reviewers.The Oxford Level of Evidence scale was used to determine the quality of the studies.

Results: Of 195 articles,5 met the inclusion criteria:2 retrospective observational studies and 3 randomized clinical trials in 235 patients with Behçet and refractory uveitis.Age range was 12-69 years with male dominance,and follow up was 1-72 months.Evidence with infliximab(IFX) (2studies) is weak and suggests more effectivenes than CyA in reducing the rate of uveitis in short-term(6m) and more effective than CyA+AZA or methotrexate(MTX) to reduce the no. of retinal vasculitis relapse,and severe complications and to improve visual acuity in long term(LE 4).The weak and insufficient evidence of rituximab(RTX) associated with MTX (1study) suggested similar efficacy to cyclophosphamide(CYM)associated with AZA, improving the total adjusted rate of disease activity without improvement in short-term visual acuity (6m) (LE 3b).Regarding secukinumab and daclizumab vs placebo(1study respectively),the small but acceptable level of evidence suggests ineffectiveness in reducing relapses and in the improvement of visual acuity,with sparing effect on immunosuppressants in short-term for secukinumab (LE 2a-2b). Available evidence reveals few significant adverse events. All studies could be applicable in clinical practice.

Conclusion: With the limited evidence found, IFX appears to be safe and more effectiveness than CyA alone or in combination with other immunosuppressants in reducing short term uveitis relapse and the number of severe long-term complications.RTX is similar to CYM paired with AZA in improving rates of inflammatory activity in short term.Secukinumab as well as daclizumab is not effective in reducing relapses of uveitis but could spare immunosuppressants.The results of this review support the benefit of carrying out further well-designed comparative studies with IFX and RTX.


Disclosure: A. Urruticoechea-Arana, None; T. Cobo-Ibáñez, None; V. Villaverde García, None; M. Santos-Gómez, None; K. Vargas Osorio, None; F. Díaz-González, None; L. Fariñas Padrón, None; V. Calvo-Río, None; R. Blanco Alonso, None.

To cite this abstract in AMA style:

Urruticoechea-Arana A, Cobo-Ibáñez T, Villaverde García V, Santos-Gómez M, Vargas Osorio K, Díaz-González F, Fariñas Padrón L, Calvo-Río V, Blanco Alonso R. Systematic Review: “Efficacy and Safety of Biological Versus Immunosuppressive Therapy Compared to Placebo in the Treatment of Uveitis Associated with BehçEt’s Disease.” [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/systematic-review-efficacy-and-safety-of-biological-versus-immunosuppressive-therapy-compared-to-placebo-in-the-treatment-of-uveitis-associated-with-behcets-disease/. Accessed .
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