Session Title: Rheumatoid Arthritis - Animal Models I
Session Type: Abstract Submissions (ACR)
known to regulate cell division severe disease recognised by the progressive amage
Methods: Survivinproduction was inhibited by a lentiviral construct, which coded for (shSurv) suppressing survivin gene. shSurv was(
Results: Survsurvivin, and in microCTSurvivin inhibition was inversely correlated to an increase of transcription repressors Bcl-6 and Blimp-1 In consistence with overexpression of Blimp-1, shSurv mice had low levels of IL-2, suppressed proliferation response and increased populations of the effector CD4+ and CD8+ cells, followed by high IL-6 and IL10 production. shSurv mice haincreased populations of Tregs (CD4+Foxp3+) and Th2 cells supported by high mRNA of Foxp3 and GATA3, and high release of IL-10 and IL-4. with a sequential impairment of Bcl-6 functions and small follicular T and B cell populations, and poor affinity maturation of antigen-specific antibodies.
Conclusion: is the essential regulator of molecular and cellular events in the pathogenesis of arthritis. It enhances synovial proliferation and aggressive growth and participates in the mounting of antigen-dependent T and B cell responses. Importantly, survivin regulates the Bcl-6 dependent events attracting attention to the important role of this duo in the pathogenesis of rheumatoid arthritis.
I. M. Jonsson,
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/survivin-inhibition-disturbs-bcl-6-and-blimp-1-control-of-lymphocyte-maturation-and-alleviates-antigen-induced-arthritis/