Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Smoking is a risk factor for systemic lupus erythematosus and in particular for discoid lupus. A recent study, suggested that history of smoking was associated with antiphospholipid antibodies. We investigated the association between smoking and antiphospholipid antibodies in systemic lupus erythematosus as well as the relationship between smoking, antiphospholipid antibodies, and vascular events.
Methods: 2406 patients in a prospective SLE cohort had smoking assessed at baseline (ever, current, never). The lupus anticoagulant was assessed by dRVVT with mixing studies and confirmatory tests.
Results: Table 1 shows the frequency of each antiphospholipid antibody by smoking status. Table 2 shows the association of smoking with thrombotic events among patients with antiphospholipid antibodies. Unadjusted p-values and p-values adjusted for ethnicity are given.
|LAC (RVVT)||Anticardiolipin||Anti-beta2 glycoprotein|
|Ever smoking||245 (28.7%)||411 (48.1%)||149 (30%)|
|Past smoking||145 (29.3%)||246 (49.8%)||103 (32.4%)|
|Current smoking||97 (27.6%)||165 (46.6%)||46 (26.3%)|
|Never smoking||373 (25.3%)||721 (48.9%)||271 (28.6%)|
|P Value (Ever vs. Never)||0.0734||0.6943||0.5635|
|P Value (Past vs. Never)||0.0802||0.734||0.1986|
|P Value (Current vs. Never)||0.3818||0.4361||0.5346|
|adj. P Value (Ever vs. Never)||0.0933||0.6434||0.6169|
|adj. P Value (Past vs. Never)||0.1146||0.8189||0.2484|
|adj. P Value (Current vs. Never)||0.3893||0.4017||0.5779|
|Stroke||Myocardial Infarction||Digital Gangrene||DVT|
|Ever smoking||29 (3.3%)||60 (6.8%)||19 (2.2%)||121 (13.7%)|
|Past smoking||19 (3.8%)||34 (6.7%)||13 (2.6%)||72 (14.2%)|
|Current smoking||10 (2.8%)||26 (7.1%)||6 (1.6%)||47 (12.8%)|
|Never smoking||55 (3.7%)||49 (3.2%)||26 (1.7%)||200 (13.2%)|
|P Value (Ever vs.Never)||0.6901||0.0001||0.4359||0.6891|
|P Value (Past vs.Never)||0.9033||0.0008||0.2288||0.5611|
|P Value (Current vs.Never)||0.4239||0.0009||0.9246||0.8721|
|adj. P Value (Ever vs.Never)||0.5787||0.0001||0.5037||0.8909|
|adj. P Value (Past vs.Never)||0.9203||0.0010||0.2349||0.6928|
|adj. P Value (Current vs.Never)||0.3944||0.0012||0.8303||0.6906|
Conclusion: There was no statistically significant association between past or current smoking and antiphospholipid antibodies in our lupus cohort. Current smokers had a slightly lower frequency of lupus anticoagulant and anti-beta2 glycoprotein 1 than past smokers. Among SLE patients with antiphospholipid antibodies, smoking was associated with myocardial infarction (p<0.01), but not with stroke, digital gangrene or venous thrombosis.
To cite this abstract in AMA style:Petri M, Stojan G, Fu W. Smoking, Antiphospholipid Antibodies and Thrombosis in SLE [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/smoking-antiphospholipid-antibodies-and-thrombosis-in-sle/. Accessed September 26, 2022.
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