Risk Factors of Uveitis in Ankylosing Spondylitis

Feng Wang¹, Qin Xue², Li Sun³ and Niansong Wang⁴, ¹Nephrology and Rheumatology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China, ²Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China, ³Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing, China, ⁴Shanghai Jiao Tong University Affiliated Sixth People's Hospital, shanghai, China

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Ankylosing spondylitis (AS), arthritis and uveitis, Hip, OA

Session Information

Date: Sunday, November 13, 2016

Title: Spondylarthropathies and Psoriatic Arthritis – Clinical Aspects and Treatment - Poster I: Axial and Peripheral Spondyloarthritis – Clinical Aspects, Imaging and Treatment

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose:

Uveitis is the most common extra-articular manifestation in patients with ankylosing spondylitis (AS).The prevalence and characteristics of uveitis in AS have been studied in previous literatures while its associated risk factors have not been clarified. Therefore,this study analysed the risk factors of uveitis in patients with AS.

Methods:

A total of 390 patients with AS who fulfilled the modified New York criteria were enrolled from January to December in 2015.The history of uveitis was accepted only if diagnosed by ophthalmologists.The medical records of the patients were retrospectively reviewed and associated information was collected,such as disease duration,HLA-B27 and the number of peripheral arthritis.Hip-joint lesion was identified by imaging examination.Meanwhile, biochemical examinations were performed to determine the patient’s physical function.

Results: Of 390 patients with AS (80.5% male, mean age 33.3 years), 38 (9.7%) had experienced one or more episodes of uveitis. The incidence rate for hip-joint lesion was obviously higher for patients with uveitis than the non-uveitis group (44.7% vs 22.2%; P<0.01). The number of peripheral arthritis was also larger for the uveitis group than non-uveitis group (2.18±0.23 vs 0.55±0.04; P<0.001). Meanwhile, patients with uveitis had a significantly higher level of antistreptolysin O (ASO) and circulating immune complex (CIC) than those without (P<0.05 and P<0.0001, respectively). However, there were no significant differences in disease duration, HLA-B27, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) between the two groups. Binary logistic regression results showed that ASO (OR=12.2, 95% CI:3.6-41.3, P<0.01) and the number of peripheral arthritis (OR=4.1, 95%CI:2.6-6.3, P<0.01) are significantly associated with uveitis in AS.

Conclusion: This study provides some evidence that hip-joint lesion, the number of peripheral arthritis, ASO and CIC may be associated with higher rates of uveitis in AS. The results of this comprehensive analysis suggest that the possible occurrence of uveitis in AS should not be neglected if the patients have those concomitant risk factors.

Disclosure: F. Wang, None; Q. Xue, None; L. Sun, None; N. Wang, None.

To cite this abstract in AMA style:

Wang F, Xue Q, Sun L, Wang N. Risk Factors of Uveitis in Ankylosing Spondylitis [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/risk-factors-of-uveitis-in-ankylosing-spondylitis/. Accessed .

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