Session Title: Metabolic & Crystal Arthropathies Poster I: Clinical
Session Type: Poster Session (Sunday)
Session Time: 9:00AM-11:00AM
Background/Purpose: Graft-related complications are among the most serious issues solid-organ transplant recipients and their healthcare teams face post-operatively. Gout is a known frequent co-morbidity in transplant patients. Whether renal transplant patients with gout suffer from higher rates of transplant-related complications, as compared to transplant patients without gout, has not been investigated. We analyzed a large US population database to determine the overall transplant complication rate in patients having a renal transplant with and without gout.
Methods: A retrospective review of Humana Research Database claims data (2007-2017) was undertaken to identify kidney transplant patients with ≥6 months in plan before and after transplant. Diagnostic gout codes (ICD 9/10) were used to categorize patients into gout and non-gout groups. Additionally patients were classified as having gout pre- or post-transplant based on when the first gout code occurred. Transplant complications were determined using the ICD 9 code for complications of transplanted kidney and ICD 10 codes for unspecified and other complications of kidney transplant, kidney transplant rejection, failure, and infection.
Results: The database contained 6085 patients with a kidney transplant and ≥6 months in plan both pre and post-transplant. Of these, 1504 patients had ≥1 gout codes (the first code occurred in 909 patients pre-transplant and 595 post-transplant), and 4581 patients never had a gout code. The renal transplant complication rate in the overall cohort was 36.0%. Patients with gout had a higher complication rate (40.4%) than those without gout (34.6%, OR: 1.28, 95% CI: 1.136–1.443, p< 0.001). The higher complication rate in gout patients was driven by those who developed gout post-transplant.(Table 1)
Conclusion: Our analysis indicates that patients with gout, especially those with gout arising post-transplant, suffered from higher rates of overall transplant-related complications. In addition to more research on this topic, an increased focus on awareness and screening of renal transplant patients for gout is warranted.
To cite this abstract in AMA style:Francis-Sedlak M, LaMoreaux B, Holt R. Renal Transplant Complications in Patients with and Without Gout [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/renal-transplant-complications-in-patients-with-and-without-gout/. Accessed June 5, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/renal-transplant-complications-in-patients-with-and-without-gout/