Session Title: Vasculitis
Session Type: Abstract Submissions (ACR)
Background/Purpose The autonomic nervous system, including the sympathetic and parasympathetic nervous systems, has an important role in the triggering of ventricular arrhythmias and sudden cardiac death.
The aim to this study was to investigate autonomic regulations by means of heart rate variability(HRV), influence of conventional cardiovascular risk factors, and relationship with the disease activity in patients with Behcet’s disease (BD)
Methods 50 patients with BD ( Age : 43.8 ± 18.6, female : 40 ) and 50 age-and sex-matched healthy controls were included in this study. All the participants were screened for basic cardiovascular risk factors.
BD activity was studied with Behcet’s disease current activity form (BDCAF) and acute phase indices. HRV was calculated by time domain measures, frequency domain measures and nonlinear/complexity-based measures on 24 hours recording.
Results Patients with BD had decreased HRV in comparison to healthy controls as reflected by decrease of the standard deviation of normal R-R intervals(SDNN) (74.0±37.5 vs. 136.2±62.3ms, respectively, p< 0.01) and of the high frequency(HF) power (130.0±89.9 vs. 383.5±154.2 ms2, respectively, p< 0.005).
SDNN (r = -0.45, p < 0.005 and r = -0.37, p < 0.04) and HF (r = -0.42, p < 0.01 and r = -0.35, p < 0.02) were significantly correlated with BDCAF and CRP, respectively.
Conclusion HRV was shown to be significantly decreased, compared to healthy controls, among BD patients. Patients with BD had impaired autonomic cardiac regulation which is related to the disease activity and presence of systemic inflammation and which could contribute to the increased cardiovascular risk in these patients.
J. W. Lee,
S. G. Lee,
E. K. Park,
G. T. Kim,
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/reduced-heart-rate-variability-in-patients-with-behcets-disease/